WO2002029041A3 - 32146 and 57259, novel human transporters and uses thereof - Google Patents

32146 and 57259, novel human transporters and uses thereof Download PDF

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Publication number
WO2002029041A3
WO2002029041A3 PCT/US2001/031412 US0131412W WO0229041A3 WO 2002029041 A3 WO2002029041 A3 WO 2002029041A3 US 0131412 W US0131412 W US 0131412W WO 0229041 A3 WO0229041 A3 WO 0229041A3
Authority
WO
WIPO (PCT)
Prior art keywords
tfm
nucleic acid
acid molecules
molecules
expression vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/031412
Other languages
French (fr)
Other versions
WO2002029041A2 (en
Inventor
Rory A J Curtis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to EP01979568A priority Critical patent/EP1356044A2/en
Priority to AU2002211515A priority patent/AU2002211515A1/en
Publication of WO2002029041A2 publication Critical patent/WO2002029041A2/en
Anticipated expiration legal-status Critical
Publication of WO2002029041A3 publication Critical patent/WO2002029041A3/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated TFM-2 and TFM-3 nucleic acid molecules, which encode novel transporter family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TFM-2 and/or TFM-3 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TFM-2 and/or TFM-3 gene has been introduced or disrupted. The invention still further provides isolated TFM-2 and TFM-3 polypeptides, fusion polypeptides, antigenic peptides and anti-TFM-2 and anti-TFM-3 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/031412 2000-10-05 2001-10-05 32146 and 57259, novel human transporters and uses thereof Ceased WO2002029041A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01979568A EP1356044A2 (en) 2000-10-05 2001-10-05 32146 and 57259, novel human transporters and uses thereof
AU2002211515A AU2002211515A1 (en) 2000-10-05 2001-10-05 32146 and 57259, novel human transporters and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23833600P 2000-10-05 2000-10-05
US60/238,336 2000-10-05

Publications (2)

Publication Number Publication Date
WO2002029041A2 WO2002029041A2 (en) 2002-04-11
WO2002029041A3 true WO2002029041A3 (en) 2003-08-21

Family

ID=22897452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031412 Ceased WO2002029041A2 (en) 2000-10-05 2001-10-05 32146 and 57259, novel human transporters and uses thereof

Country Status (4)

Country Link
US (1) US20020103351A1 (en)
EP (1) EP1356044A2 (en)
AU (1) AU2002211515A1 (en)
WO (1) WO2002029041A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364962A1 (en) * 2002-05-24 2003-11-26 Stichting tot bevordering van de wetenschap der Endocrinologie Use of monocarboxylate transporter proteins for thyroid hormone transport
US20050159352A1 (en) * 2002-05-24 2005-07-21 Friesema Edith C.H. Use of monocarboxylate transporter protein for thyroid hormone transport

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041373A2 (en) * 1998-02-11 1999-08-19 Incyte Pharmaceuticals, Inc. Human transport-associated molecules
WO2002012340A2 (en) * 2000-08-03 2002-02-14 Incyte Genomics, Inc. Transporters and ion channels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041373A2 (en) * 1998-02-11 1999-08-19 Incyte Pharmaceuticals, Inc. Human transport-associated molecules
WO2002012340A2 (en) * 2000-08-03 2002-02-14 Incyte Genomics, Inc. Transporters and ion channels

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 24 May 2000 (2000-05-24), ZHANG C. ET AL., XP002214125, Database accession no. AF116652 *
GARCIA C K ET AL: "CDNA CLONING OF THE HUMAN MONACARBOXYLATE TRANSPORTER 1 AND CHROMOSOMAL LOCALIZATION OF THE SLC16A1 LOCUS TO 1P13.2-P12", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 2, no. 23, 15 September 1994 (1994-09-15), pages 500 - 503, XP001085472, ISSN: 0888-7543 *
HALESTRAP ANDREW P ET AL: "The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 343, no. 2, 15 October 1999 (1999-10-15), pages 281 - 299, XP002205906, ISSN: 0264-6021 *
PRICE NT ET AL: "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 329, no. 2, 15 January 1998 (1998-01-15), pages 321 - 328, XP002108394, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
AU2002211515A1 (en) 2002-04-15
WO2002029041A2 (en) 2002-04-11
EP1356044A2 (en) 2003-10-29
US20020103351A1 (en) 2002-08-01

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