WO2002035232A3 - Method for detecting ovarian cancer based on human kallikrein 6 (hk6) - Google Patents

Method for detecting ovarian cancer based on human kallikrein 6 (hk6) Download PDF

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Publication number
WO2002035232A3
WO2002035232A3 PCT/CA2001/001505 CA0101505W WO0235232A3 WO 2002035232 A3 WO2002035232 A3 WO 2002035232A3 CA 0101505 W CA0101505 W CA 0101505W WO 0235232 A3 WO0235232 A3 WO 0235232A3
Authority
WO
WIPO (PCT)
Prior art keywords
ovarian cancer
cancer based
human kallikrein
detecting ovarian
binds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2001/001505
Other languages
French (fr)
Other versions
WO2002035232A2 (en
Inventor
Eleftherios P Diamandis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mt Sinai Hospital
Original Assignee
Mt Sinai Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mt Sinai Hospital filed Critical Mt Sinai Hospital
Priority to JP2002538164A priority Critical patent/JP2004511810A/en
Priority to US10/399,013 priority patent/US20040096915A1/en
Priority to EP01982003A priority patent/EP1330652B1/en
Priority to AU2002213704A priority patent/AU2002213704A1/en
Priority to CA002426286A priority patent/CA2426286A1/en
Priority to DE60129151T priority patent/DE60129151T2/en
Publication of WO2002035232A2 publication Critical patent/WO2002035232A2/en
Publication of WO2002035232A3 publication Critical patent/WO2002035232A3/en
Priority to PCT/CA2002/001556 priority patent/WO2003034068A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method for the diagnosis, prognosis, and monitoring of ovarian cancer in a subject by detecting hK6 in a sample from the subject, preferably a serum sample or tumor tissue extract. hK6 may be measured using a reagent that detects or binds to hK6 preferably antibodies specifically reactive with hK6 or a part thereof. Imaging methods for tumors associated with hK6 are also described using an agent that binds to hK6 which has a label for imaging the tumor.
PCT/CA2001/001505 2000-10-27 2001-10-26 Method for detecting ovarian cancer based on human kallikrein 6 (hk6) Ceased WO2002035232A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2002538164A JP2004511810A (en) 2000-10-27 2001-10-26 Ovarian cancer detection method
US10/399,013 US20040096915A1 (en) 2000-10-27 2001-10-26 Methods for detecting ovarian cancer
EP01982003A EP1330652B1 (en) 2000-10-27 2001-10-26 Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
AU2002213704A AU2002213704A1 (en) 2000-10-27 2001-10-26 Method for detecting ovarian cancer based on human kallikrein 6 (HK6)
CA002426286A CA2426286A1 (en) 2000-10-27 2001-10-26 Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
DE60129151T DE60129151T2 (en) 2000-10-27 2001-10-26 METHOD FOR DETECTING EGG CANCER BY MEANS OF HUMAN CALLIQUE (HK6)
PCT/CA2002/001556 WO2003034068A1 (en) 2001-10-16 2002-10-16 Localization of disorders associated with kallikreins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24378900P 2000-10-27 2000-10-27
US60/243,789 2000-10-27

Publications (2)

Publication Number Publication Date
WO2002035232A2 WO2002035232A2 (en) 2002-05-02
WO2002035232A3 true WO2002035232A3 (en) 2002-09-26

Family

ID=22920140

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/001505 Ceased WO2002035232A2 (en) 2000-10-27 2001-10-26 Method for detecting ovarian cancer based on human kallikrein 6 (hk6)

Country Status (9)

Country Link
US (1) US20040096915A1 (en)
EP (1) EP1330652B1 (en)
JP (1) JP2004511810A (en)
AT (1) ATE365922T1 (en)
AU (1) AU2002213704A1 (en)
CA (1) CA2426286A1 (en)
DE (1) DE60129151T2 (en)
ES (1) ES2287169T3 (en)
WO (1) WO2002035232A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022497B1 (en) * 1999-03-11 2006-04-04 Mt. Sinai Hospital Human kallikrein-like genes
US7199229B2 (en) * 2000-08-11 2007-04-03 Mount Sinai Hospital Kallikrein gene
CA2426571A1 (en) * 2000-11-01 2002-05-10 Eleftherios P. Diamandis Detection of ovarian cancer
US20040203012A1 (en) * 2001-05-25 2004-10-14 Eleftherios Diamandis Method of detecting and monitoring prostate and ovarian cancers
WO2003034068A1 (en) * 2001-10-16 2003-04-24 Mount Sinai Hospital Localization of disorders associated with kallikreins
CA2463920A1 (en) * 2001-10-16 2003-04-24 Mount Sinai Hospital Methods for detecting ovarian cancer
WO2004021009A2 (en) * 2002-08-28 2004-03-11 Mount Sinai Hospital Methods for detecting endocrine cancer using kallikrein 13 (klk13) as a biomarker
AU2003269618A1 (en) * 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting breast and ovarian cancer
AU2003271456A1 (en) * 2002-09-26 2004-04-19 Mount Sinai Hospital Methods for detecting endocrine cancer
CA2516591A1 (en) * 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
US20060141471A1 (en) * 2003-02-27 2006-06-29 Mount Sinai Hospital Assay for detection of renal cell carcinoma
CA2468651A1 (en) * 2003-06-13 2004-12-13 Eleftherios P. Diamandis Detection of neurodegenerative diseases
US20060269971A1 (en) * 2003-09-26 2006-11-30 Mount Sinai Hospital Methods for detecting prostate cancer
CN102989009B (en) * 2003-12-31 2015-06-03 宾夕法尼亚州研究基金会 Methods for predicting and overcoming resistance to chemotherapy in ovarian cancer and for predicting colon cancer occurrence
EP1718975A2 (en) * 2004-02-18 2006-11-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 6 (klk6)
DE102005004294A1 (en) * 2005-01-28 2006-08-03 Bayer Healthcare Ag Determining diagnostic quality of diagnostic tests using measured values involves calculating discordance analysis characteristics specificities for two diagnostic tests for each cut-off pair
US8329399B2 (en) 2006-10-27 2012-12-11 Siu K W Michael Endometrial biomarkers
EP2271917A1 (en) * 2008-04-09 2011-01-12 Smiths Detection Inc. Multi-dimensional spectral analysis for improved identification and confirmation of radioactive isotopes
US7851230B2 (en) * 2008-04-14 2010-12-14 Chang Gung Memorial Hospital Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
EP2721417A4 (en) * 2011-06-17 2015-05-06 Univ Arkansas NEW MARKERS FOR EARLY DIAGNOSIS OF OVARIAN CANCER, MONITORING DURING THERAPY, AND NEW THERAPEUTIC OPTIONS DURING AND AFTER CHEMOTHERAPY
CN103675278A (en) * 2013-11-19 2014-03-26 上海裕隆医学检验所股份有限公司 Carbohydrate antigen-125 quantitative determination kit and application thereof
EP4245376A3 (en) 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof
EP3888021B1 (en) 2018-11-30 2024-02-21 Caris MPI, Inc. Next-generation molecular profiling
CA3163319A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor

Citations (4)

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Publication number Priority date Publication date Assignee Title
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
WO1998011238A2 (en) * 1996-09-13 1998-03-19 Dana-Farber Cancer Institute Protease m, a novel serine protease
WO1998041656A1 (en) * 1997-03-19 1998-09-24 The Board Of Trustees Of The University Of Arkansas Compositions and method for the early diagnosis of ovarian cancer
WO2001059158A1 (en) * 2000-02-11 2001-08-16 The Board Of Trustees Of The University Of Arkansas Compositions and methods for the early diagnosis of ovarian cancer

Family Cites Families (21)

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IL105793A0 (en) * 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
US6316213B1 (en) * 1997-03-19 2001-11-13 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian, breast and lung cancer
US6870027B2 (en) * 1997-03-19 2005-03-22 O'brien Timothy J. Methods for the early diagnosis of ovarian cancer
US6268165B1 (en) * 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
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US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US7022497B1 (en) * 1999-03-11 2006-04-04 Mt. Sinai Hospital Human kallikrein-like genes
US7935531B2 (en) * 2000-02-22 2011-05-03 Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
US7199229B2 (en) * 2000-08-11 2007-04-03 Mount Sinai Hospital Kallikrein gene
US6962793B2 (en) * 2000-10-27 2005-11-08 Mount Sinai Hospital Methods for detecting Alzheimers disease
US20040203012A1 (en) * 2001-05-25 2004-10-14 Eleftherios Diamandis Method of detecting and monitoring prostate and ovarian cancers
CA2463920A1 (en) * 2001-10-16 2003-04-24 Mount Sinai Hospital Methods for detecting ovarian cancer
CA2481093A1 (en) * 2002-04-04 2003-10-16 Mount Sinai Hospital Methods for detecting ovarian cancer
US20040015745A1 (en) * 2002-07-22 2004-01-22 Finisar Corporation Scalable socketed testing tool
WO2004021009A2 (en) * 2002-08-28 2004-03-11 Mount Sinai Hospital Methods for detecting endocrine cancer using kallikrein 13 (klk13) as a biomarker
AU2003269618A1 (en) * 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting breast and ovarian cancer
AU2003271456A1 (en) * 2002-09-26 2004-04-19 Mount Sinai Hospital Methods for detecting endocrine cancer
CA2516591A1 (en) * 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
US20060141471A1 (en) * 2003-02-27 2006-06-29 Mount Sinai Hospital Assay for detection of renal cell carcinoma
CA2468651A1 (en) * 2003-06-13 2004-12-13 Eleftherios P. Diamandis Detection of neurodegenerative diseases
US20060269971A1 (en) * 2003-09-26 2006-11-30 Mount Sinai Hospital Methods for detecting prostate cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
WO1998011238A2 (en) * 1996-09-13 1998-03-19 Dana-Farber Cancer Institute Protease m, a novel serine protease
WO1998041656A1 (en) * 1997-03-19 1998-09-24 The Board Of Trustees Of The University Of Arkansas Compositions and method for the early diagnosis of ovarian cancer
WO2001059158A1 (en) * 2000-02-11 2001-08-16 The Board Of Trustees Of The University Of Arkansas Compositions and methods for the early diagnosis of ovarian cancer

Non-Patent Citations (4)

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Title
ANISOWICZ A ET AL: "A NOVEL PROTEASE HOMOLOG DIFFERENTIALLY EXPRESSED IN BREAST AND OVARIAN CANCER", MOLECULAR MEDICINE, BLACKWELL SCIENCE, CAMBRIDGE, MA, US, vol. 2, no. 5, 1 September 1996 (1996-09-01), pages 624 - 636, XP002060076, ISSN: 1076-1551 *
DIAMANDIS EP ET AL: "the new human kallikrein gene family: implications in carcinogenesis", TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 11, no. 2, November 2000 (2000-11-01), pages 54 - 60, XP002207049 *
ELEFTHERIOS P: "immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications.", CLINICAL BIOCHEMISTRY, vol. 33, no. 5, July 2000 (2000-07-01), pages 369 - 375, XP002207083 *
YOUSEF G M ET AL: "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 254, no. 1-2, 22 August 2000 (2000-08-22), pages 119 - 128, XP004208787, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
DE60129151T2 (en) 2008-03-06
EP1330652B1 (en) 2007-06-27
US20040096915A1 (en) 2004-05-20
WO2002035232A2 (en) 2002-05-02
JP2004511810A (en) 2004-04-15
ES2287169T3 (en) 2007-12-16
AU2002213704A1 (en) 2002-05-06
CA2426286A1 (en) 2002-05-02
EP1330652A2 (en) 2003-07-30
DE60129151D1 (en) 2007-08-09
ATE365922T1 (en) 2007-07-15

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