WO2002039990A3 - Method for screening anti-proliferative compounds and inhibiting tumor growth - Google Patents

Method for screening anti-proliferative compounds and inhibiting tumor growth Download PDF

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Publication number
WO2002039990A3
WO2002039990A3 PCT/EP2001/013076 EP0113076W WO0239990A3 WO 2002039990 A3 WO2002039990 A3 WO 2002039990A3 EP 0113076 W EP0113076 W EP 0113076W WO 0239990 A3 WO0239990 A3 WO 0239990A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumor growth
inhibiting tumor
screening anti
proliferative compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/013076
Other languages
French (fr)
Other versions
WO2002039990A2 (en
Inventor
Penny Elisabeth Phillips
Patrick Andre Schindler
Harry Towbin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to EP01996369A priority Critical patent/EP1337854A2/en
Priority to JP2002542365A priority patent/JP2004514122A/en
Priority to AU2002217020A priority patent/AU2002217020A1/en
Priority to US10/416,669 priority patent/US20040048318A1/en
Publication of WO2002039990A2 publication Critical patent/WO2002039990A2/en
Publication of WO2002039990A3 publication Critical patent/WO2002039990A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a novel method for evaluating the antiproliferative activity of compounds having MetAP inhibitory activity, as well as a method for screening compounds that inhibit angiogenesis or growth of tumors. The invention additionally provides a method for monitoring the progress of treatment for controlling angiogenesis or the growth of tumors.
PCT/EP2001/013076 2000-11-14 2001-11-12 Method for screening anti-proliferative compounds and inhibiting tumor growth Ceased WO2002039990A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01996369A EP1337854A2 (en) 2000-11-14 2001-11-12 Method for screening anti-proliferative compounds and inhibiting tumor growth
JP2002542365A JP2004514122A (en) 2000-11-14 2001-11-12 Methods for screening antiproliferative compounds and inhibiting tumor growth
AU2002217020A AU2002217020A1 (en) 2000-11-14 2001-11-12 Method for screening anti-proliferative compounds and inhibiting tumor growth
US10/416,669 US20040048318A1 (en) 2000-11-14 2001-12-11 Method for screening anti-proliferative compounds and method for inhibiting tumor growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24848900P 2000-11-14 2000-11-14
US60/248,489 2000-11-14

Publications (2)

Publication Number Publication Date
WO2002039990A2 WO2002039990A2 (en) 2002-05-23
WO2002039990A3 true WO2002039990A3 (en) 2003-03-13

Family

ID=22939368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013076 Ceased WO2002039990A2 (en) 2000-11-14 2001-11-12 Method for screening anti-proliferative compounds and inhibiting tumor growth

Country Status (4)

Country Link
EP (1) EP1337854A2 (en)
JP (1) JP2004514122A (en)
AU (1) AU2002217020A1 (en)
WO (1) WO2002039990A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1856486A (en) 2003-07-25 2006-11-01 诺瓦提斯公司 Substituted lactams and their use as anti-cancer agents
US7153846B2 (en) 2003-10-24 2006-12-26 Sanofi-Aventis Deutschland Gmbh Bengamide derivatives, process for preparing them, and their use
FR2878525B1 (en) 2004-11-29 2007-02-23 Aventis Pharma Sa BENGAMIDES HAVING SUBSTITUTED CAPROLACTAM CYCLE, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2878528B1 (en) * 2004-11-29 2008-05-16 Aventis Pharma Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901555A1 (en) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZOTHIAZEPINE, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901556A1 (en) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE DERIVATIVES, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901554B1 (en) 2006-05-24 2011-04-01 Sanofi Aventis 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINE, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2926463B1 (en) * 2008-01-22 2010-08-13 Centre Nat Rech Scient USE OF AMINOPEPTIDASE INHIBITORS OR AZAINDOLE COMPOUNDS FOR PREVENTING OR TREATING CANCER METASTASES OF EPITHELIAL ORIGIN
WO2010051882A1 (en) * 2008-11-06 2010-05-14 Merck Patent Gmbh Use of eef1a as biomarker and a method of screening metap2 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056372A1 (en) * 1997-06-09 1998-12-17 Massachusetts Institute Of Technology TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056372A1 (en) * 1997-06-09 1998-12-17 Massachusetts Institute Of Technology TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARTIN H ET AL: "ANTIBODIES AGAINST THE MAJOR BRAIN ISOFORMS OF 14-3-3 PROTEIN AN ANTIBODY SPECIFIC FOR THE N-ACETYLATED AMINO-TERMINUS OF A PROTEIN", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 331, no. 3, 1 October 1993 (1993-10-01), pages 296 - 303, XP002063495, ISSN: 0014-5793 *
PIETROMONACO S F ET AL: "Association of 14-3-3 proteins with centrosomes.", BLOOD CELLS, MOLECULES & DISEASES. UNITED STATES 1996, vol. 22, no. 3, 1996, pages 225 - 237, XP002222680, ISSN: 1079-9796 *
YAFFE M B ET AL: "The structural basis for 14-3-3: phosphopeptide binding specificity", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 91, no. 7, 26 December 1997 (1997-12-26), pages 961 - 971, XP002090547, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
EP1337854A2 (en) 2003-08-27
JP2004514122A (en) 2004-05-13
WO2002039990A2 (en) 2002-05-23
AU2002217020A1 (en) 2002-05-27

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