WO2002040668A3 - Proteine und den proteinen zugrundeliegende dna-sequenzen mit funktion bei entzündungsereignissen - Google Patents

Proteine und den proteinen zugrundeliegende dna-sequenzen mit funktion bei entzündungsereignissen Download PDF

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Publication number
WO2002040668A3
WO2002040668A3 PCT/EP2001/012545 EP0112545W WO0240668A3 WO 2002040668 A3 WO2002040668 A3 WO 2002040668A3 EP 0112545 W EP0112545 W EP 0112545W WO 0240668 A3 WO0240668 A3 WO 0240668A3
Authority
WO
WIPO (PCT)
Prior art keywords
dna sequences
proteins
gene products
treating inflammations
sequences underlying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/012545
Other languages
English (en)
French (fr)
Other versions
WO2002040668A2 (de
Inventor
Juerg Tschopp
Fabio Martinon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Topotarget Switzerland SA
Original Assignee
Apoxis SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10059595A external-priority patent/DE10059595A1/de
Application filed by Apoxis SA filed Critical Apoxis SA
Priority to EP01996605A priority Critical patent/EP1349933A2/de
Priority to US10/416,935 priority patent/US20040053292A1/en
Priority to AU2002218269A priority patent/AU2002218269A1/en
Publication of WO2002040668A2 publication Critical patent/WO2002040668A2/de
Anticipated expiration legal-status Critical
Publication of WO2002040668A3 publication Critical patent/WO2002040668A3/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft DNA-Sequenzen, die für mindestens eine PYD-Domäne codieren, Expressionsvektoren, die derartige DNA-Sequenzen enthalten, Wirtszellen, die mit derartigen Expressionsvektoren transformiert sind, aufgereinigte Genprodukte der vorgenannten DNA-Sequenzen, Antikörper gegen für vorgenannten Genprodukte, sowie Verfahren zur Isolierung und/oder zur Expression der vorgenannten Genprodukte. Darüber hinaus betrifft die vorliegende Erfindung die Verwendung der vorgenannten DNA-Sequenzen oder von deren Genprodukten zur Behandlung von Entzündungsereignissen.
PCT/EP2001/012545 2000-11-15 2001-10-30 Proteine und den proteinen zugrundeliegende dna-sequenzen mit funktion bei entzündungsereignissen Ceased WO2002040668A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01996605A EP1349933A2 (de) 2000-11-15 2001-10-30 Proteine und den proteinen zugrundeliegende dna-sequenzen mit funktion bei entzündungsereignissen
US10/416,935 US20040053292A1 (en) 2000-11-15 2001-10-30 Proteins and dna sequences underlying these proteins used for treating inflammations
AU2002218269A AU2002218269A1 (en) 2000-11-15 2001-10-30 Proteins and dna sequences underlying these proteins used for treating inflammations

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10056687 2000-11-15
DE10056687.1 2000-11-15
DE10059595A DE10059595A1 (de) 2000-11-15 2000-11-30 Proteine und den Proteinen zugrundeliegende DNA-Sequenzen mit Funktion bei Entzündungsereignissen
DE10059595.2 2000-11-30

Publications (2)

Publication Number Publication Date
WO2002040668A2 WO2002040668A2 (de) 2002-05-23
WO2002040668A3 true WO2002040668A3 (de) 2003-07-03

Family

ID=26007674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012545 Ceased WO2002040668A2 (de) 2000-11-15 2001-10-30 Proteine und den proteinen zugrundeliegende dna-sequenzen mit funktion bei entzündungsereignissen

Country Status (4)

Country Link
US (1) US20040053292A1 (de)
EP (1) EP1349933A2 (de)
AU (1) AU2002218269A1 (de)
WO (1) WO2002040668A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048362A2 (en) * 2000-11-15 2002-06-20 Incyte Genomics, Inc. Embryogenesis associated proteins
US6949363B2 (en) 2000-12-22 2005-09-27 Brilstol-Myers Squibb Polynucleotides encoding novel human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
JP2004536566A (ja) 2000-12-22 2004-12-09 ブリストル−マイヤーズ　スクイブ　カンパニー 小腸において優先的に発現される新規なヒトロイシンリッチリピート含有タンパク質ｈｌｒｒｓｉ１
US7160695B2 (en) 2001-01-31 2007-01-09 Wyeth Molecules of the PYRIN/NBS/LRR protein family and uses thereof
US7041643B2 (en) 2001-01-31 2006-05-09 Millennium Pharmaceuticals, Inc. Molecules of the PYRIN/NBS/LRR protein family and uses thereof
DE10139874A1 (de) 2001-08-10 2003-04-30 Schering Ag Humane Mater-Proteine
US20040002593A1 (en) * 2002-04-04 2004-01-01 Reed John C. PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use
US20030224438A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Novel molecules of the PYRIN/NBS/LRR protein family and uses thereof
US9163071B2 (en) * 2005-04-07 2015-10-20 University Of South Florida POP2: NKκB-inhibiting polypeptides, nucleic acids and methods of use
WO2008066483A1 (en) * 2006-11-27 2008-06-05 Mohammad Alimohammadi Use of nalp5 in methods for diagnosis and therapy of parathyroid related disorders
US8685400B2 (en) 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
GB0724735D0 (en) * 2007-12-19 2008-01-30 Psynova Neurotech Ltd Methods and biomarkers for diagnosing and monitoring psychotic disorders
GB0818660D0 (en) * 2008-10-10 2008-11-19 Cambridge Entpr Ltd Biomarkers
WO2012021407A2 (en) * 2010-08-13 2012-02-16 Morehouse School Of Medicine Biomarkers for stroke
CA2821651A1 (en) 2010-12-20 2012-06-28 Cambridge Enterprise Limited Biomarkers
GB201021502D0 (en) 2010-12-20 2011-02-02 Cambridge Entpr Ltd Biomarkers
GB201404189D0 (en) 2014-03-10 2014-04-23 Cambridge Entpr Ltd Novel biomarkers
GB201411037D0 (en) * 2014-06-20 2014-08-06 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047669A2 (de) * 1998-03-20 1999-09-23 Metagen Gesellschaft Für Genomforschung Mbh Menschliche nukleinsäuresequenzen aus brusttumorgewebe
WO2000070047A2 (en) * 1999-05-14 2000-11-23 Incyte Genomics, Inc. Full-length molecules expressed in human tissues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047669A2 (de) * 1998-03-20 1999-09-23 Metagen Gesellschaft Für Genomforschung Mbh Menschliche nukleinsäuresequenzen aus brusttumorgewebe
WO2000070047A2 (en) * 1999-05-14 2000-11-23 Incyte Genomics, Inc. Full-length molecules expressed in human tissues

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BERTIN J ET AL: "THE PYRIN DOMAIN: A NOVEL MOTIF FOUND IN APOPTOSIS AND INFLAMMATION PROTEINS", CELL DEATH AND DIFFERENTIATION, EDWARD ARNOLD, OXFORD, GB, vol. 12, no. 7, December 2000 (2000-12-01), pages 1273 - 1274, XP008006072, ISSN: 1350-9047 *
DATABASE EMBL [online] 1 December 1999 (1999-12-01), retrieved from EBI Database accession no. AB023416 *
DATABASE EMBL [online] 3 September 1998 (1998-09-03), XP002213126, retrieved from EBI Database accession no. AF086332 *
DATABASE EPOP [online] 5 September 2000 (2000-09-05), XP002213127, retrieved from EBI Database accession no. AX017324 *
DATABASE GSP [online] 9 March 2001 (2001-03-09), XP002213128, retrieved from EBI Database accession no. AAB36608 *
FAIRBROTHER W J ET AL: "THE PYRIN DOMAIN: A MEMBER OF THE DEATH DOMAIN-FOLD SUPERFAMILY", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 9, no. 10, September 2001 (2001-09-01), pages 1911 - 1918, XP008006069, ISSN: 0961-8368 *
HOFMANN K: "The modular nature of apoptotic signaling proteins", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, BASEL, CH, vol. 55, July 1999 (1999-07-01), pages 1113 - 1128, XP002171651, ISSN: 1420-682X *
INOHARA N ET AL: "Genes with homology to mammalian apoptosis regulators identified in zebrafish.", CELL DEATH AND DIFFERENTIATION. ENGLAND MAY 2000, vol. 7, no. 5, May 2000 (2000-05-01), pages 509 - 510, XP002213121, ISSN: 1350-9047 *
MARTINON F ET AL: "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.", CURRENT BIOLOGY: CB. ENGLAND 20 FEB 2001, vol. 11, no. 4, 20 February 2001 (2001-02-20), pages R118 - R120, XP002213125, ISSN: 0960-9822 *
MASUMOTO J ET AL: "ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 48, 26 November 1999 (1999-11-26), pages 33835 - 33838, XP002191744, ISSN: 0021-9258 *
MASUMOTO J ET AL: "Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 26 JAN 2001, vol. 280, no. 3, 26 January 2001 (2001-01-26), pages 652 - 655, XP002213123, ISSN: 0006-291X *
PAWLOWSKI K ET AL: "PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.", TRENDS IN BIOCHEMICAL SCIENCES. ENGLAND FEB 2001, vol. 26, no. 2, February 2001 (2001-02-01), pages 85 - 87, XP002213122, ISSN: 0968-0004 *
STAUB E ET AL: "The DAPIN family: a novel domain links apoptotic and interferon response proteins.", TRENDS IN BIOCHEMICAL SCIENCES. ENGLAND FEB 2001, vol. 26, no. 2, February 2001 (2001-02-01), pages 83 - 85, XP002213124, ISSN: 0968-0004 *

Also Published As

Publication number Publication date
EP1349933A2 (de) 2003-10-08
AU2002218269A1 (en) 2002-05-27
US20040053292A1 (en) 2004-03-18
WO2002040668A2 (de) 2002-05-23

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