WO2002044183A3 - Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors - Google Patents

Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors Download PDF

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Publication number
WO2002044183A3
WO2002044183A3 PCT/US2001/044815 US0144815W WO0244183A3 WO 2002044183 A3 WO2002044183 A3 WO 2002044183A3 US 0144815 W US0144815 W US 0144815W WO 0244183 A3 WO0244183 A3 WO 0244183A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzoazepine
parp inhibitors
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/044815
Other languages
French (fr)
Other versions
WO2002044183A2 (en
Inventor
Dana V Ferraris
Jia-He Li
Vincent J Kalish
Jie Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
Original Assignee
Guilford Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc filed Critical Guilford Pharmaceuticals Inc
Priority to CA2430363A priority Critical patent/CA2430363C/en
Priority to JP2002546553A priority patent/JP4323802B2/en
Priority to AU3652102A priority patent/AU3652102A/en
Priority to MXPA03004832A priority patent/MXPA03004832A/en
Priority to AT01986053T priority patent/ATE478664T1/en
Priority to DE60142921T priority patent/DE60142921D1/en
Priority to EP01986053A priority patent/EP1339402B1/en
Publication of WO2002044183A2 publication Critical patent/WO2002044183A2/en
Publication of WO2002044183A3 publication Critical patent/WO2002044183A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems

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Abstract

This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
PCT/US2001/044815 2000-12-01 2001-11-30 Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors Ceased WO2002044183A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2430363A CA2430363C (en) 2000-12-01 2001-11-30 Compounds and their uses
JP2002546553A JP4323802B2 (en) 2000-12-01 2001-11-30 Compounds and uses thereof
AU3652102A AU3652102A (en) 2000-12-01 2001-11-30 Compounds and their uses
MXPA03004832A MXPA03004832A (en) 2000-12-01 2001-11-30 Compounds and their uses.
AT01986053T ATE478664T1 (en) 2000-12-01 2001-11-30 AZAPHENANTHRIDONE DERIVATIVES AND THEIR USE AS PARP INHIBITORS
DE60142921T DE60142921D1 (en) 2000-12-01 2001-11-30 AZAPHENANTHRIDONE DERIVATIVES AND THEIR USE AS PARP INHIBITORS
EP01986053A EP1339402B1 (en) 2000-12-01 2001-11-30 Azaphenanthridone derivatives and their use as parp inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25013200P 2000-12-01 2000-12-01
US60/250,132 2000-12-01
US31027401P 2001-08-07 2001-08-07
US60/310,274 2001-08-07

Publications (2)

Publication Number Publication Date
WO2002044183A2 WO2002044183A2 (en) 2002-06-06
WO2002044183A3 true WO2002044183A3 (en) 2003-05-22

Family

ID=26940622

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Application Number Title Priority Date Filing Date
PCT/US2001/044815 Ceased WO2002044183A2 (en) 2000-12-01 2001-11-30 Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors

Country Status (10)

Country Link
US (5) US6887996B2 (en)
EP (1) EP1339402B1 (en)
JP (1) JP4323802B2 (en)
AT (1) ATE478664T1 (en)
AU (1) AU3652102A (en)
CA (1) CA2430363C (en)
DE (1) DE60142921D1 (en)
ES (1) ES2354249T3 (en)
MX (1) MXPA03004832A (en)
WO (1) WO2002044183A2 (en)

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US7915280B2 (en) 2011-03-29
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