WO2002046746A3 - Method for detection of vitamin d metabolites - Google Patents

Method for detection of vitamin d metabolites Download PDF

Info

Publication number
WO2002046746A3
WO2002046746A3 PCT/GB2001/005395 GB0105395W WO0246746A3 WO 2002046746 A3 WO2002046746 A3 WO 2002046746A3 GB 0105395 W GB0105395 W GB 0105395W WO 0246746 A3 WO0246746 A3 WO 0246746A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
metabolite
sample
metabolites
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/005395
Other languages
French (fr)
Other versions
WO2002046746A2 (en
Inventor
David Laurie
Alexander Kirkley Barnes
Michael James Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunodiagnostic Systems Ltd
Original Assignee
Immunodiagnostic Systems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunodiagnostic Systems Ltd filed Critical Immunodiagnostic Systems Ltd
Priority to JP2002548433A priority Critical patent/JP3787121B2/en
Priority to AU2002220900A priority patent/AU2002220900A1/en
Priority to DE60120487T priority patent/DE60120487T2/en
Priority to US10/433,923 priority patent/US7482162B2/en
Priority to EP01999806A priority patent/EP1352238B1/en
Publication of WO2002046746A2 publication Critical patent/WO2002046746A2/en
Publication of WO2002046746A3 publication Critical patent/WO2002046746A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

The present invention relates to a method for measuring the amount of vitamin D metabolite in a sample of plasma or serum, comprising the step of (a) adding to a serum or plasma sample a non-competitive displacement agent to effect separation of any vitamin D metabolite in the sample form protein to which it is bound, such that any vitamin D metabolite may be detected and/or measured; and (b) detecting or measuring the amount of vitamin D metabolite in the sample of (a). Such methods are useful in determining the vitamin D status of the subject, for example in the diagnosis of disease. Also provide are agents and kits for use in performing the methods of the invention.
PCT/GB2001/005395 2000-12-06 2001-12-06 Method for detection of vitamin d metabolites Ceased WO2002046746A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002548433A JP3787121B2 (en) 2000-12-06 2001-12-06 Method for detecting vitamin D metabolites
AU2002220900A AU2002220900A1 (en) 2000-12-06 2001-12-06 Method for detection of vitamin d metabolites
DE60120487T DE60120487T2 (en) 2000-12-06 2001-12-06 METHOD FOR DETECTING VITAMIN D METABOLITES
US10/433,923 US7482162B2 (en) 2000-12-06 2001-12-06 Determination of vitamin D metabolite and displacement from plasma or serum binding proteins
EP01999806A EP1352238B1 (en) 2000-12-06 2001-12-06 Method for detection of vitamin d metabolites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0029729.1A GB0029729D0 (en) 2000-12-06 2000-12-06 Method for detection of vitamin D metabolites
GB0029729.1 2000-12-06

Publications (2)

Publication Number Publication Date
WO2002046746A2 WO2002046746A2 (en) 2002-06-13
WO2002046746A3 true WO2002046746A3 (en) 2003-04-24

Family

ID=9904543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005395 Ceased WO2002046746A2 (en) 2000-12-06 2001-12-06 Method for detection of vitamin d metabolites

Country Status (10)

Country Link
US (1) US7482162B2 (en)
EP (1) EP1352238B1 (en)
JP (1) JP3787121B2 (en)
AT (1) ATE329260T1 (en)
AU (1) AU2002220900A1 (en)
DE (1) DE60120487T2 (en)
DK (1) DK1352238T3 (en)
ES (1) ES2263691T3 (en)
GB (1) GB0029729D0 (en)
WO (1) WO2002046746A2 (en)

Cited By (1)

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US9341552B2 (en) 2005-09-29 2016-05-17 Roche Diagnostics Operations, Inc. Release reagent for vitamin D compounds

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DE10144905C2 (en) * 2001-09-12 2003-07-31 Immundiagnostik Ag Determination of vitamin D directly in serum or plasma
US7888000B2 (en) 2002-07-12 2011-02-15 Morehouse School Of Medicine Method for identifying salt-sensitive persons
US7700365B2 (en) 2004-10-29 2010-04-20 Mayo Foundation For Medical Education And Research Vitamin D deficiencies
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
DE602007003833D1 (en) * 2006-06-06 2010-01-28 Roche Diagnostics Gmbh IMPROVED VITAMIN D MEASUREMENT
ES2348126T3 (en) 2007-02-01 2010-11-30 Immundiagnostik Ag DIRECT DETERMINATION OF VITAMIN D IN SERUM OR PLASMA.
GB0709322D0 (en) * 2007-05-15 2007-06-20 Nordic Bioscience As Exposure agent for detection of vitamin d
US7972868B2 (en) * 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
US20110212534A1 (en) * 2008-08-11 2011-09-01 Taylor Robert L Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
JP5739903B2 (en) 2009-12-11 2015-06-24 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド Mass spectrometry of steroidal compounds in complex samples
CN102753964A (en) 2009-12-11 2012-10-24 奎斯特诊断投资公司 Mass spectrometric determination of non-derivatized, non-metabolized vitamin d
EP2372365A1 (en) * 2010-04-01 2011-10-05 Future Diagnostics B.V. Direct immunoassay for vitamin D
CA2796576C (en) * 2010-05-20 2015-06-23 F. Hoffmann-La Roche Ag Release reagent for vitamin d compounds
ES2614817T3 (en) 2010-12-28 2017-06-02 Future Diagnostics B.V. Vitamin D release reagent
US9052308B2 (en) 2011-01-07 2015-06-09 The General Hospital Corporation Assays and methods of treatment relating to vitamin D insufficiency
WO2012094550A2 (en) * 2011-01-07 2012-07-12 The General Hospital Corporation Assays and methods of treatment relating to vitamin d insufficiency
WO2014179737A2 (en) 2013-05-03 2014-11-06 The General Hospital Corporation Assays and methods of treatment relating to vitamin d insufficiency
GB201101801D0 (en) * 2011-02-02 2011-03-16 Axis Shield Diagnostics Ltd Binding molecule and method for measuring
US20140370616A1 (en) * 2011-03-25 2014-12-18 Nanospeed Diagnostics Inc. Lateral flow immunoassay for detecting vitamins
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
KR102108582B1 (en) 2011-11-18 2020-05-08 에프. 호프만-라 로슈 아게 Release reagent for vitamin d compounds
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
US20140162294A1 (en) * 2012-12-06 2014-06-12 General Atomics Methods and compositions for assaying vitamin d
JP6171333B2 (en) * 2012-12-26 2017-08-02 東ソー株式会社 Stabilized vitamin D standard solution
JP6281497B2 (en) * 2013-02-06 2018-02-21 富士レビオ株式会社 Vitamin D measurement method and measurement kit
US9618523B2 (en) 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes
US20140273021A1 (en) * 2013-03-14 2014-09-18 Enzo Biochem, Inc. Vitamin d assays
DE102013205055A1 (en) 2013-03-21 2014-09-25 Orgentec Diagnostika Gmbh Method and reagent for the determination of vitamin D metabolites
US20140308751A1 (en) * 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
AU2014322925B2 (en) * 2013-09-17 2020-07-02 Biomerieux Solution for dissociating vitamin D from vitamin D-binding protein, associated detection method and use
US20150212099A1 (en) 2014-01-30 2015-07-30 General Atomics Methods and compositions for assaying vitamin d
US20160161473A1 (en) * 2014-12-08 2016-06-09 Calbiotech, Inc. Biotin conjugates of analytes containing amino, hydroxyl, or thiol functional groups for use in immunodiagnostic assays
WO2017039574A1 (en) * 2015-08-28 2017-03-09 Enzo Life Sciences, Inc. Vitamin d assays
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
AU2017209523A1 (en) 2016-01-22 2018-08-09 Affimedix, Inc. Device for detection of vitamin D metabolites
JP6602952B2 (en) 2016-02-29 2019-11-06 富士フイルム株式会社 Kit for quantifying bile acids in biological samples and method for quantifying bile acids in biological samples
JP7177767B2 (en) 2016-07-29 2022-11-24 ダイアザイム ラボラトリーズ， インコーポレイテッド Methods and compositions for assaying vitamin D
CN109030472A (en) * 2018-06-12 2018-12-18 福州大学 A kind of method of Visual retrieval dibutyl phthalate content
CN110441537B (en) * 2019-08-23 2022-09-13 北京丹大生物技术有限公司 Method for measuring content of 25-hydroxy vitamin D
CN112557675B (en) * 2020-12-11 2024-08-02 郑州安图生物工程股份有限公司 Dissociation agent for 25-hydroxy vitamin D and metabolite thereof, and preparation method and application thereof
CN118311281B (en) * 2023-01-09 2025-12-19 广州达安基因股份有限公司 25-Hydroxy vitamin D dissociating agent, preparation method and kit thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9341552B2 (en) 2005-09-29 2016-05-17 Roche Diagnostics Operations, Inc. Release reagent for vitamin D compounds

Also Published As

Publication number Publication date
EP1352238A2 (en) 2003-10-15
DE60120487D1 (en) 2006-07-20
JP2004515763A (en) 2004-05-27
EP1352238B1 (en) 2006-06-07
DE60120487T2 (en) 2006-12-14
US7482162B2 (en) 2009-01-27
DK1352238T3 (en) 2006-10-02
ES2263691T3 (en) 2006-12-16
WO2002046746A2 (en) 2002-06-13
US20040096900A1 (en) 2004-05-20
ATE329260T1 (en) 2006-06-15
GB0029729D0 (en) 2001-01-17
AU2002220900A1 (en) 2002-06-18
JP3787121B2 (en) 2006-06-21

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