WO2002049763A3 - Vorrichtung zur aufnahme und abgabe von flüssigen substanzen - Google Patents

Vorrichtung zur aufnahme und abgabe von flüssigen substanzen Download PDF

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Publication number
WO2002049763A3
WO2002049763A3 PCT/EP2001/014953 EP0114953W WO0249763A3 WO 2002049763 A3 WO2002049763 A3 WO 2002049763A3 EP 0114953 W EP0114953 W EP 0114953W WO 0249763 A3 WO0249763 A3 WO 0249763A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid substances
capillary channels
chamber
receiving
channels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/014953
Other languages
English (en)
French (fr)
Other versions
WO2002049763A2 (de
Inventor
Jens Albert
Thomas Henkel
Guenter Mayer
Andreas Schober
Gregor Schlingloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut fuer Physikalische Hochtechnologie eV
Original Assignee
Institut fuer Physikalische Hochtechnologie eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Physikalische Hochtechnologie eV filed Critical Institut fuer Physikalische Hochtechnologie eV
Priority to EP01985897A priority Critical patent/EP1343587A2/de
Priority to US10/450,979 priority patent/US20040168728A1/en
Publication of WO2002049763A2 publication Critical patent/WO2002049763A2/de
Publication of WO2002049763A3 publication Critical patent/WO2002049763A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Die Erfindung betrifft eine Vorrichtung zur kontrollierten Aufnahme und Abgabe von flüssigen Substanzen. Die Aufgabe der Erfindung, eine Vorrichtung anzugeben, mit Hilfe derer aus Mikro- oder Nanotiterplatten gleichzeitig eine Vielzahl auch unterschiedlicher flüssiger Substanzen aufnehm- und wieder abgebbar sind, wobei die Möglichkeit zur Durchführung einer oder mehrerer chemischer oder biologischer Reaktionen in der Vorrichtung selbst gegeben und eine gleichzeitige Aufnahme von flüssigen Substanzen unterschiedlicher Viskosität ermöglicht sein soll, wird dadurch gelöst, daß in einer Zeile voneinander gleichbeabstandete Kapillarkanülen (1) vorgesehen sind, die gemeinsam mit einer mit einem Über- oder Unterdruck beaufschlagbaren Kammer (2) in eine kommunizierende Verbindung gebracht sind, wobei die Kapillarkanülen (1) in eine Platte (3) eingelassen sind und zumindest den druckkammerinnenseitigen Kapillarkanülenenden (11) eine siebartige Membran (4) zugeordnet ist und oberhalb jedes Kapillarkanülenendes jeweils ein Raum (5) zur Aufnahmemöglichkeit einer flüssigen Substanz vorgesehen ist, wobei die Räume (5) voneinander getrennt und alle Räume (5) gemeinsam innerhalb der mit einem Über- oder Unterdruck beaufschlagbaren Kammer (2) angeordnet sind.
PCT/EP2001/014953 2000-12-18 2001-12-18 Vorrichtung zur aufnahme und abgabe von flüssigen substanzen Ceased WO2002049763A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01985897A EP1343587A2 (de) 2000-12-18 2001-12-18 Vorrichtung zur aufnahme und abgabe von flüssigen substanzen
US10/450,979 US20040168728A1 (en) 2000-12-18 2001-12-18 Device for receiving and discharging liquid substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10063733.7 2000-12-18
DE10063733 2000-12-18

Publications (2)

Publication Number Publication Date
WO2002049763A2 WO2002049763A2 (de) 2002-06-27
WO2002049763A3 true WO2002049763A3 (de) 2002-10-10

Family

ID=7668092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/014953 Ceased WO2002049763A2 (de) 2000-12-18 2001-12-18 Vorrichtung zur aufnahme und abgabe von flüssigen substanzen

Country Status (3)

Country Link
US (1) US20040168728A1 (de)
EP (1) EP1343587A2 (de)
WO (1) WO2002049763A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055589A2 (de) * 2001-12-31 2003-07-10 Institut für Physikalische Hochtechnologie e.V. Mikrotiterplatte für die parallele mikrosynthese, insbesondere bei erhöhten temperaturen
FR2853565A1 (fr) * 2003-04-11 2004-10-15 Commissariat Energie Atomique Microdispositif de transfert collectif d'une pluralite de liquide
DE10356752A1 (de) 2003-12-04 2005-06-30 Roche Diagnostics Gmbh Beschichtete Testelemente
US7588724B2 (en) 2004-03-05 2009-09-15 Bayer Healthcare Llc Mechanical device for mixing a fluid sample with a treatment solution
US7771655B2 (en) * 2006-07-12 2010-08-10 Bayer Healthcare Llc Mechanical device for mixing a fluid sample with a treatment solution
DE102007005323A1 (de) * 2007-01-29 2008-07-31 Bioplan Consulting Gmbh Absaugeinrichtung
CN114308149B (zh) * 2021-11-29 2024-03-01 北京机械设备研究所 一种芯片密封装置和自封模块化的芯片设备

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000921A (en) * 1986-10-24 1991-03-19 Hanaway Richard W Multiple pipette samples
EP0725267A2 (de) * 1995-02-01 1996-08-07 Forschungszentrum Rossendorf e.V. Elektrisch steuerbare Mikro-Pipette
US5560811A (en) * 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
EP0776700A1 (de) * 1995-12-08 1997-06-04 The Institute of Physical and Chemical Research ( RIKEN) Verfahren zur Reinigung und Übertragung von sequenzierten DNA-Proben nach Trenn-/Feststellungssystem und Platte dafür
EP0865824A1 (de) * 1997-03-20 1998-09-23 F. Hoffmann-La Roche Ag Mikromechanische Pipettiervorrichtung
GB2353093A (en) * 1999-08-13 2001-02-14 Glaxo Group Ltd Liquid sample handling or transferring device
WO2001077640A2 (en) * 2000-04-05 2001-10-18 Alexion Pharmaceuticals, Inc. Methods and devices for storing and dispensing liquids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833155A1 (de) * 1978-07-28 1980-02-14 Metallgesellschaft Ag Vorrichtung zum dosieren und/oder verteilen von fluessigen medien
DE3171592D1 (en) * 1980-09-25 1985-09-05 Terumo Corp Plasma separator
US4816155A (en) * 1986-07-14 1989-03-28 Klr Machines, Inc. Juice drainage system
FR2617963B1 (fr) * 1987-07-10 1991-12-06 Cohen Daniel Procede et dispositif de repartition d'un volume primaire d'un fluide avantageusement un liquide, en un nombre determine de volumes secondaires presentant une relation predefinie entre eux, par l'emploi d'orifices d'evacuation repartis symetriquement dans une chambre de repartition elle-meme symetrique
US5002667A (en) * 1990-10-30 1991-03-26 National Research Council Of Canada Fluid fractionating, stacked permeable membrane envelope assembly, and a fluid distributing and permeable membrane sealing collar
US5209259A (en) * 1991-01-15 1993-05-11 E. I. Du Pont De Nemours And Company Fluid distribution system having noise reduction mechanism
US5407274A (en) * 1992-11-27 1995-04-18 Texaco Inc. Device to equalize steam quality in pipe networks
US6289914B1 (en) * 2000-08-16 2001-09-18 Novartis Ag Microflow splitter

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000921A (en) * 1986-10-24 1991-03-19 Hanaway Richard W Multiple pipette samples
EP0725267A2 (de) * 1995-02-01 1996-08-07 Forschungszentrum Rossendorf e.V. Elektrisch steuerbare Mikro-Pipette
US5560811A (en) * 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
EP0776700A1 (de) * 1995-12-08 1997-06-04 The Institute of Physical and Chemical Research ( RIKEN) Verfahren zur Reinigung und Übertragung von sequenzierten DNA-Proben nach Trenn-/Feststellungssystem und Platte dafür
EP0865824A1 (de) * 1997-03-20 1998-09-23 F. Hoffmann-La Roche Ag Mikromechanische Pipettiervorrichtung
GB2353093A (en) * 1999-08-13 2001-02-14 Glaxo Group Ltd Liquid sample handling or transferring device
WO2001077640A2 (en) * 2000-04-05 2001-10-18 Alexion Pharmaceuticals, Inc. Methods and devices for storing and dispensing liquids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRCHNAK V: "SEMI-AUTOMATED HIGH THROUGHPUT COMBINATORIAL SOLID-PHASE ORGANIC SYNTHESIS", BIOTECHNOLOGY AND BIOENGINEERING - COMBINATORIAL CHEMISTRY, WILEY, NEW YORK, NY, US, vol. 61, no. 3, 1999, pages 135 - 141, XP001010790, ISSN: 0006-3592 *

Also Published As

Publication number Publication date
WO2002049763A2 (de) 2002-06-27
US20040168728A1 (en) 2004-09-02
EP1343587A2 (de) 2003-09-17

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