WO2002055699A3 - Socs (suppressor of cytokine signaling) - Google Patents

Socs (suppressor of cytokine signaling) Download PDF

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Publication number
WO2002055699A3
WO2002055699A3 PCT/US2001/044697 US0144697W WO02055699A3 WO 2002055699 A3 WO2002055699 A3 WO 2002055699A3 US 0144697 W US0144697 W US 0144697W WO 02055699 A3 WO02055699 A3 WO 02055699A3
Authority
WO
WIPO (PCT)
Prior art keywords
socs
suppressor
cytokine signaling
polypeptide
cdna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/044697
Other languages
French (fr)
Other versions
WO2002055699A2 (en
Inventor
Luis A. Parodi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Priority to AU2002243250A priority Critical patent/AU2002243250A1/en
Priority to US10/451,410 priority patent/US20040106784A1/en
Priority to EP01989134A priority patent/EP1341913A2/en
Publication of WO2002055699A2 publication Critical patent/WO2002055699A2/en
Publication of WO2002055699A3 publication Critical patent/WO2002055699A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a cDNA encoding a heretofore unknown polypeptide termed SOCS-8; constructs and recombinant host cells incorporating the cDNA; the SOCS-8 polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.
PCT/US2001/044697 2000-12-14 2001-12-07 Socs (suppressor of cytokine signaling) Ceased WO2002055699A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002243250A AU2002243250A1 (en) 2000-12-14 2001-12-07 Socs (suppressor of cytokine signaling)
US10/451,410 US20040106784A1 (en) 2000-12-14 2001-12-07 Socs (suppressor of cytokine signaling)
EP01989134A EP1341913A2 (en) 2000-12-14 2001-12-07 Socs (suppressor of cytokine signaling)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25577600P 2000-12-14 2000-12-14
US60/255,776 2000-12-14

Publications (2)

Publication Number Publication Date
WO2002055699A2 WO2002055699A2 (en) 2002-07-18
WO2002055699A3 true WO2002055699A3 (en) 2003-04-03

Family

ID=22969810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044697 Ceased WO2002055699A2 (en) 2000-12-14 2001-12-07 Socs (suppressor of cytokine signaling)

Country Status (4)

Country Link
US (1) US20040106784A1 (en)
EP (1) EP1341913A2 (en)
AU (1) AU2002243250A1 (en)
WO (1) WO2002055699A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (en) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents capable of modulating cellular responsiveness to cytokines
WO1999003993A2 (en) * 1997-07-18 1999-01-28 Schering Corporation Suppressors of cytokine signaling; related reagents
WO1999061614A2 (en) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Human socs proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274362B1 (en) * 1999-02-04 2001-08-14 Millennium Pharmaceuticals, Inc. RGS-containing molecules and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020023A1 (en) * 1996-11-01 1998-05-14 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostic agents capable of modulating cellular responsiveness to cytokines
WO1999003993A2 (en) * 1997-07-18 1999-01-28 Schering Corporation Suppressors of cytokine signaling; related reagents
WO1999061614A2 (en) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Human socs proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 15 February 2000 (2000-02-15), HEILIG R ET AL: "Sequencing of the human chromosome 14", XP002221418, retrieved from EBI Database accession no. Al139316 *
ISHIKAWA K-I ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. X. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CAN CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 5, no. 3, 30 June 1998 (1998-06-30), pages 169 - 176, XP000980105, ISSN: 1340-2838 *
MASUHARA M ET AL: "Cloning and characterization of novel CIS family genes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 239, 1 October 1997 (1997-10-01), pages 439 - 446, XP002088457, ISSN: 0006-291X *
STARR R ET AL: "A family of cytokine-inducible inhibitors of signalling", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, 26 June 1997 (1997-06-26), pages 917 - 921, XP002085491, ISSN: 0028-0836 *
STARR ROBYN ET AL: "SOCS: Suppressors of cytokine signalling.", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 30, no. 10, October 1998 (1998-10-01), pages 1081 - 1085, XP002221417, ISSN: 1357-2725 *

Also Published As

Publication number Publication date
AU2002243250A1 (en) 2002-07-24
US20040106784A1 (en) 2004-06-03
WO2002055699A2 (en) 2002-07-18
EP1341913A2 (en) 2003-09-10

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