WO2002059149A3 - Pro-apoptotic proteins and dna molecules encoding them - Google Patents

Pro-apoptotic proteins and dna molecules encoding them Download PDF

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Publication number
WO2002059149A3
WO2002059149A3 PCT/EP2002/000806 EP0200806W WO02059149A3 WO 2002059149 A3 WO2002059149 A3 WO 2002059149A3 EP 0200806 W EP0200806 W EP 0200806W WO 02059149 A3 WO02059149 A3 WO 02059149A3
Authority
WO
WIPO (PCT)
Prior art keywords
dna molecules
molecules encoding
pro
apoptotic proteins
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/000806
Other languages
French (fr)
Other versions
WO2002059149A2 (en
Inventor
Hartmut Beug
Johannes Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to EP02719729A priority Critical patent/EP1368376A2/en
Publication of WO2002059149A2 publication Critical patent/WO2002059149A2/en
Publication of WO2002059149A3 publication Critical patent/WO2002059149A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a novel proapoptotic inducer protein 'p12', that was identified in myeloid/erythroid cytokine dependent cells, and DNA molecules encoding it. The p12 protein and DNA molecules are useful for therapy and diagnosis of conditions which are associated with a deregulated apoptosis pathway and for screening compounds that modulate p12 activity.
PCT/EP2002/000806 2001-01-26 2002-01-25 Pro-apoptotic proteins and dna molecules encoding them Ceased WO2002059149A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02719729A EP1368376A2 (en) 2001-01-26 2002-01-25 Pro-apoptotic proteins and dna molecules encoding them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101800.9 2001-01-26
EP01101800A EP1227106A1 (en) 2001-01-26 2001-01-26 Pro-apoptotic proteins and DNA molecules encoding them

Publications (2)

Publication Number Publication Date
WO2002059149A2 WO2002059149A2 (en) 2002-08-01
WO2002059149A3 true WO2002059149A3 (en) 2002-10-10

Family

ID=8176305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000806 Ceased WO2002059149A2 (en) 2001-01-26 2002-01-25 Pro-apoptotic proteins and dna molecules encoding them

Country Status (2)

Country Link
EP (2) EP1227106A1 (en)
WO (1) WO2002059149A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7389426B2 (en) 2005-11-29 2008-06-17 Research In Motion Limited Mobile software terminal identifier
WO2007125621A1 (en) * 2006-04-28 2007-11-08 Osaka University Novel use of gene whose expression is increased in hyperplastic pancreatic islet
CN108660108A (en) * 2017-03-31 2018-10-16 四川新生命干细胞科技股份有限公司 A kind of method enhancing umbilical cord mesenchymal stem cells immunoregulation capability

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053051A2 (en) * 1998-04-09 1999-10-21 Genset 5' ests and encoded human proteins
WO2000052165A2 (en) * 1999-03-04 2000-09-08 Corixa Corporation Compositions and methods for breast cancer therapy and diagnosis
JP2000287689A (en) * 1999-04-08 2000-10-17 Japan Science & Technology Corp Screening method for apoptosis inhibitor or promoter

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053051A2 (en) * 1998-04-09 1999-10-21 Genset 5' ests and encoded human proteins
WO2000052165A2 (en) * 1999-03-04 2000-09-08 Corixa Corporation Compositions and methods for breast cancer therapy and diagnosis
JP2000287689A (en) * 1999-04-08 2000-10-17 Japan Science & Technology Corp Screening method for apoptosis inhibitor or promoter

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BONALDO FATIMA DE M ET AL: "NORMALIZATION AND SUBTRACTION: TWO APPROACHES TO FACILITATE GENE DISCOVERY", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 6, no. 9, 1 September 1996 (1996-09-01), pages 791 - 806, XP002039972, ISSN: 1088-9051 *
DATABASE EMBL [online] 1 February 2000 (2000-02-01), M. YE ET AL.: "Human partial CDS from cd34+ stem cells", XP002168870, Database accession no. AF161386 *
DATABASE EMBL [online] 1 October 2000 (2000-10-01), NATIONAL CANCER INSTITUTE, NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE, BRAIN TUMOR GENOME ANATOMY PROJECT, CGAP/BTGAP: "7g29h04.x1 NCI_CGAP_Brn23 Homo sapiens cDNA clone IMAGE:3307927 3' , mRNA sequence EST", XP002168873, Database accession no. BE857372 *
DATABASE EMBL [online] 21 December 1999 (1999-12-21), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "tx35b09.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE:2271545 3' , mRNA EST", XP002168874, Database accession no. AI680820 *
DATABASE EMBL [online] 21 December 1999 (1999-12-21), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "tx50g08.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE:2273054 3', mRNA sequence EST", XP002168872, Database accession no. AI681934 *
DATABASE EMBL [online] 23 October 2000 (2000-10-23), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "7n51a06.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE:3568019 3', mRNA sequence EST", XP002168871, Database accession no. BF110215 *
DATABASE EMBL [online] 3 March 2000 (2000-03-03), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "gk03a08.x1 NCI_CGAP_Kid3 Homo sapiens cDNA clone IMAGE:1867862 3' , mRNA sequence EST", XP002168876, Database accession no. AI264128 *
DATABASE EMBL [online] 4 March 2000 (2000-03-04), M. MARRA ET AL.: "mc47d09.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE:351665 5' , mRNA sequence EST", XP002168877, Database accession no. MM42315 *
DATABASE EMBL [online] NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "gm88g06.x1 NCI_CGAP_Lu Homo sapiens cDNA clone IMAGE:1895866 3', mRNA sequence EST", XP002168875, Database accession no. AI292139 *
GABIG T G ET AL: "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 47, 25 November 1994 (1994-11-25), pages 29515 - 29519, XP002119059, ISSN: 0021-9258 *
LADEANA HILLIER ET AL: "Generation and analysis of 280,000 human expressed sequence tags", PCR METHODS AND APPLICATIONS, COLD SPRING HARBOR, NY, US, vol. 6, no. 9, September 1996 (1996-09-01), pages 807 - 828, XP002140684, ISSN: 1054-9803 *
SANZ C ET AL: "Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 95, no. 9, 1 May 2000 (2000-05-01), pages 2742 - 2747, XP002168869, ISSN: 0006-4971 *
SHIMIZU S ET AL: "Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells", THE JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, US, vol. 152, no. 2, 22 January 2001 (2001-01-22), pages 237 - 250, XP002168868, ISSN: 0021-9525 *
WILLIAMS G T ET AL: "HEMOPOIETIC COLONY STIMULATING FACTORS PROMOTE CELL SURVIVAL BY SUPPRESSING APOPTOSIS", NATURE (LONDON), vol. 343, no. 6253, 1990, pages 76 - 79, XP001084190, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
EP1368376A2 (en) 2003-12-10
WO2002059149A2 (en) 2002-08-01
EP1227106A1 (en) 2002-07-31

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