WO2002059298A3 - Gab2(p97) gene and methods of use thereof - Google Patents

Gab2(p97) gene and methods of use thereof Download PDF

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Publication number
WO2002059298A3
WO2002059298A3 PCT/US2001/047854 US0147854W WO02059298A3 WO 2002059298 A3 WO2002059298 A3 WO 2002059298A3 US 0147854 W US0147854 W US 0147854W WO 02059298 A3 WO02059298 A3 WO 02059298A3
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WIPO (PCT)
Prior art keywords
gab2
methods
relates
gene
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/047854
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French (fr)
Other versions
WO2002059298A9 (en
WO2002059298A2 (en
Inventor
Haihua Gu
Benjamin G Neel
Jean-Pierre Kinet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
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Beth Israel Deaconess Medical Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Beth Israel Deaconess Medical Center Inc filed Critical Beth Israel Deaconess Medical Center Inc
Priority to AU2002246627A priority Critical patent/AU2002246627A1/en
Priority to EP01994203A priority patent/EP1390498A2/en
Publication of WO2002059298A2 publication Critical patent/WO2002059298A2/en
Publication of WO2002059298A9 publication Critical patent/WO2002059298A9/en
Priority to US10/424,570 priority patent/US20040086893A1/en
Anticipated expiration legal-status Critical
Publication of WO2002059298A3 publication Critical patent/WO2002059298A3/en
Priority to US11/300,682 priority patent/US20060265769A1/en
Ceased legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
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  • Life Sciences & Earth Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to the purification, cloning and characterization of a novel gene, Gab2. In response to extracellular stimuli (e.g., cyokines, growth factors, hormones and antigens), Gab2 binds several signal relay molecules, including the protein-tyrosine phosphatase SHP-2 and phosphatidylinositol-3-OH kinase (PI-3K), which results in the initiation of multiple signaling cascades. Gab2 nucleic acid molecules, peptides, vectors, host cells, probes, antibodies, knockout and transgenic animals are provided. The invention also relates to methods of diagnosis, prevention and treatment of Gab2-mediated conditions such as allergic responses, neoplastic disorders and immune disorders.
PCT/US2001/047854 2000-10-26 2001-10-26 Gab2(p97) gene and methods of use thereof Ceased WO2002059298A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002246627A AU2002246627A1 (en) 2000-10-26 2001-10-26 Gab2(p97) gene and methods of use thereof
EP01994203A EP1390498A2 (en) 2000-10-26 2001-10-26 Gab2(p97) gene and methods of use thereof
US10/424,570 US20040086893A1 (en) 2000-10-26 2003-04-25 Gab2 (p97) gene and methods of use thereof
US11/300,682 US20060265769A1 (en) 2000-10-26 2005-12-13 Gab2 (p97) gene and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24349500P 2000-10-26 2000-10-26
US60/243,495 2000-10-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/424,570 Continuation US20040086893A1 (en) 2000-10-26 2003-04-25 Gab2 (p97) gene and methods of use thereof

Publications (3)

Publication Number Publication Date
WO2002059298A2 WO2002059298A2 (en) 2002-08-01
WO2002059298A9 WO2002059298A9 (en) 2003-04-24
WO2002059298A3 true WO2002059298A3 (en) 2003-12-18

Family

ID=22918969

Family Applications (1)

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PCT/US2001/047854 Ceased WO2002059298A2 (en) 2000-10-26 2001-10-26 Gab2(p97) gene and methods of use thereof

Country Status (4)

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US (1) US20040086893A1 (en)
EP (1) EP1390498A2 (en)
AU (1) AU2002246627A1 (en)
WO (1) WO2002059298A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1432724A4 (en) * 2002-02-20 2006-02-01 Sirna Therapeutics Inc INTERFERENCE MEDIATION INHIBITION OF GENE RNA FROM MAP KINASE
AU2008242625A1 (en) * 2007-04-20 2008-10-30 Kronos Science Laboratory Methods of diagnosing Alzheimer's disease and markers identified by set association
CN120636544A (en) * 2025-06-06 2025-09-12 南方医科大学南方医院 A screening method and application of biomarkers for systemic lupus erythematosus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 18 January 1999 (1999-01-18), GU ET AL., retrieved from EBI Database accession no. AF104244 *
GU HAIHUA ET AL: "Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.", MOLECULAR CELL, vol. 2, no. 6, AF104244, December 1998 (1998-12-01), pages 729 - 740, XP002231345, ISSN: 1097-2765, Retrieved from the Internet <URL:EBI> *

Also Published As

Publication number Publication date
US20040086893A1 (en) 2004-05-06
WO2002059298A9 (en) 2003-04-24
EP1390498A2 (en) 2004-02-25
AU2002246627A1 (en) 2002-08-06
WO2002059298A2 (en) 2002-08-01

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