WO2002059623A3 - Methods for determining platelet activity with antiplatelet compositions - Google Patents

Methods for determining platelet activity with antiplatelet compositions Download PDF

Info

Publication number
WO2002059623A3
WO2002059623A3 PCT/US2002/002102 US0202102W WO02059623A3 WO 2002059623 A3 WO2002059623 A3 WO 2002059623A3 US 0202102 W US0202102 W US 0202102W WO 02059623 A3 WO02059623 A3 WO 02059623A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
particles
combination
antiplatelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/002102
Other languages
French (fr)
Other versions
WO2002059623A8 (en
WO2002059623A2 (en
Inventor
Victor Manneh
Lisa Swaim
Ted Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SenDx Medical Inc
Original Assignee
SenDx Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SenDx Medical Inc filed Critical SenDx Medical Inc
Priority to EP02703225A priority Critical patent/EP1370874A2/en
Publication of WO2002059623A2 publication Critical patent/WO2002059623A2/en
Publication of WO2002059623A3 publication Critical patent/WO2002059623A3/en
Anticipated expiration legal-status Critical
Publication of WO2002059623A8 publication Critical patent/WO2002059623A8/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods, compositions and kits are disclosed for the determination of platelet activity on samples such as whole blood that have been affected by exposure to an antiplatelet therapeutic agent such as, e.g., aspiring or a thienopyridine. A combination is provided in a reaction medium wherein the combination comprises the sample and a particle reagent comprising a GP IIb/IIIa receptor ligand such as fibrinogen covalently attached to particles. The medium further comprises a polyhydroxy aromatic compound and a metal cation. The combination is incubated under conditions for agglutinating the particles. The extent of agglutination of the particles is determined and is related to the platelet function activity of the sample. The methods and compositions have particular application to the detection of platelet sensitivity to therapy using aspirin or a thienopyridine and the assessment of the efficacy of such therapy.
PCT/US2002/002102 2001-01-24 2002-01-23 Methods for determining platelet activity with antiplatelet compositions Ceased WO2002059623A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02703225A EP1370874A2 (en) 2001-01-24 2002-01-23 Methods for determining platelet activity with antiplatelet compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26383801P 2001-01-24 2001-01-24
US60/263,838 2001-01-24

Publications (3)

Publication Number Publication Date
WO2002059623A2 WO2002059623A2 (en) 2002-08-01
WO2002059623A3 true WO2002059623A3 (en) 2003-02-20
WO2002059623A8 WO2002059623A8 (en) 2003-12-18

Family

ID=23003438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002102 Ceased WO2002059623A2 (en) 2001-01-24 2002-01-23 Methods for determining platelet activity with antiplatelet compositions

Country Status (2)

Country Link
EP (1) EP1370874A2 (en)
WO (1) WO2002059623A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005245271A1 (en) * 2004-05-13 2005-12-01 Boehringer Ingelheim International Gmbh Use of dipyridamole for treatment of resistance to platelet inhibitors
US20160320415A1 (en) * 2013-12-16 2016-11-03 Xen Biofluidx, Inc. Fast reconstituting reagent pellets
CN104792982B (en) * 2015-03-10 2016-09-28 山东盛百灵医药科技有限公司 A kind of aspirin Monitoring of drug resistance reagent
EP4118219A4 (en) * 2020-03-11 2024-04-17 Shanghai Belief-Delivery Biomed Co., Ltd. NOVEL USE OF ASPIRIN COMPOUND TO INCREASE NUCLEIC ACID EXPRESSION

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451509A (en) * 1990-04-17 1995-09-19 Analytical Control Systems, Inc. Coagulation assays and reagents
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
WO2000073792A1 (en) * 1999-05-28 2000-12-07 Sendx Medical, Inc. Control for methods for determining platelet count and platelet function

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451509A (en) * 1990-04-17 1995-09-19 Analytical Control Systems, Inc. Coagulation assays and reagents
US5709889A (en) * 1990-04-17 1998-01-20 Analytical Control Systems, Inc. Coagulation assays and reagents
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
WO2000073792A1 (en) * 1999-05-28 2000-12-07 Sendx Medical, Inc. Control for methods for determining platelet count and platelet function

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COLLER B S: "INTERACTION OF NORMAL, THROMBASTHENIC, AND BERNARD-SOULIER PLATELETS WITH IMMOBILIYED FIBRINOGEN: DEFECTIVE PLATELET- FIBRINOGEN INTERACTION IN THROMBASTHENIA", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 55, no. 2, February 1980 (1980-02-01), pages 169 - 178, XP002911350, ISSN: 0006-4971 *
FRELINGER ANDREW L III ET AL: "Novel methods for assessing platelet function.", AMERICAN HEART JOURNAL, vol. 135, no. 5 PART 2, May 1998 (1998-05-01), pages S184 - S186, XP001119048, ISSN: 0002-8703 *
HARRISON PAUL: "Progress in the assessment of platelet function.", BRITISH JOURNAL OF HAEMATOLOGY, vol. 111, no. 3, December 2000 (2000-12-01), pages 733 - 744, XP002222103, ISSN: 0007-1048 *
KEREIAKES D J ET AL: "Efficacy of abciximab induced platelet blockade using a rapid point of care assay.", JOURNAL OF THROMBOSIS AND THROMBOLYSIS. NETHERLANDS JUN 1999, vol. 7, no. 3, June 1999 (1999-06-01), pages 265 - 276, XP001119050, ISSN: 0929-5305 *
SMITH JEFFREY W ET AL: "Rapid platelet-function assay: An automated and quantitative cartridge-based method.", CIRCULATION, vol. 99, no. 5, 9 February 1999 (1999-02-09), pages 620 - 625, XP002222102, ISSN: 0009-7322 *
YOKO MINAMOTO ET AL: "DETECTION OF PLATELET ADHESION/AGGREGATION TO IMMOBILIZED LIGANDS ON MICROBEADS BY AN AGGREGOMETER", THROMBOSIS AND HAEMOSTASIS, STUTTGART, DE, vol. 76, no. 6, 1996, pages 1072 - 1079, XP002921232, ISSN: 0340-6245 *

Also Published As

Publication number Publication date
WO2002059623A8 (en) 2003-12-18
WO2002059623A2 (en) 2002-08-01
EP1370874A2 (en) 2003-12-17

Similar Documents

Publication Publication Date Title
Hanhauser et al. Solid-phase extraction, preservation, storage, transport, and analysis of trace contaminants for water quality monitoring of heavy metals
Schoonen et al. Mineral-induced formation of reactive oxygen species
Fowle et al. Experimental measurements of the reversibility of metal–bacteria adsorption reactions
Khan et al. Chemical analysis of air and water
Pietrogrande et al. Effect of filter extraction solvents on the measurement of the oxidative potential of airborne PM2. 5
AU4806285A (en) Assay technique and equipment
DE69103420D1 (en) INDEPENDENT TEST ARRANGEMENT.
WO2000004388A3 (en) System for the quantification of platelet activation
Hanioka et al. In VitroMetabolism of Chlorotriazines: Characterization of Simazine, Atrazine, and Propazine Metabolism Using Liver Microsomes from Rats Treated with Various Cytochrome P450 Inducers
Heiss et al. Dip-and-read test strips for the determination of trinitrotoluene (TNT) in drinking water
WO2002059623A8 (en) Methods for determining platelet activity with antiplatelet compositions
Kiba et al. Determination of nano-molar levels of formaldehyde in drinking water using flow-injection system with immobilized formaldehyde dehydrogenase after off-line solid-phase extraction
Hiradate et al. Adsorption of 2, 4‐dichlorophenoxyacetic acid by an Andosol
Kibanova et al. Lipid peroxidation induced by expandable clay minerals
Ytreberg et al. Effect of organic complexation on copper accumulation and toxicity to the estuarine red macroalga Ceramium tenuicorne: a test of the free ion activity model
Neff et al. Influence of basin characteristics on baseflow and stormflow chemistry in the Great Smoky Mountains National Park, USA
CA2417161A1 (en) Method for immuno-detection of epitopes
Kuramochi et al. Rapid determination of lead extracted by acetic acid from glazed ceramic surfaces by flow injection on-line preconcentration and spectrophotometric detection
Infante et al. Vesicle-mediated high performance liquid chromatography coupled to hydride generation inductively coupled plasma mass spectrometry for cadmium speciation in fish cytosols
Carrasco et al. Development and application of immunoaffinity chromatography for the determination of the triazinic biocides in seawater
WO1992022797A3 (en) Assay for the detection of specific ligands
Castro-Jiménez et al. Immunoassay-based screening of polychlorinated biphenyls (PCB) in sediments: requirements for a new generation of test kits
Li et al. Sorption behavior of phthalic acid esters on reference soils evaluated by soil column chromatography
Pulido-Tofino et al. Analysis of isoproturon at trace level by solid phase competitive fluoroimmunosensing after enrichment in a sol–gel immunosorbent
Dai et al. Colloidal crystal templated molecular imprinted polymer for the detection of 2-butoxyethanol in water contaminated by hydraulic fracturing

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EC EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2002703225

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002703225

Country of ref document: EP

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 31/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2002703225

Country of ref document: EP