WO2002061134A3 - Reagents and methods for identifying and modulating expression of tumor senescence genes - Google Patents

Reagents and methods for identifying and modulating expression of tumor senescence genes Download PDF

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Publication number
WO2002061134A3
WO2002061134A3 PCT/US2001/050574 US0150574W WO02061134A3 WO 2002061134 A3 WO2002061134 A3 WO 2002061134A3 US 0150574 W US0150574 W US 0150574W WO 02061134 A3 WO02061134 A3 WO 02061134A3
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WO
WIPO (PCT)
Prior art keywords
methods
expression
reagents
genes
senescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/050574
Other languages
French (fr)
Other versions
WO2002061134A9 (en
WO2002061134A2 (en
Inventor
Igor B Roninson
Bey-Dih Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Priority to EP01997143A priority Critical patent/EP1414995A2/en
Priority to AU2002248262A priority patent/AU2002248262B2/en
Priority to CA002432976A priority patent/CA2432976A1/en
Publication of WO2002061134A2 publication Critical patent/WO2002061134A2/en
Publication of WO2002061134A9 publication Critical patent/WO2002061134A9/en
Anticipated expiration legal-status Critical
Publication of WO2002061134A3 publication Critical patent/WO2002061134A3/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression constructs that express a reporter gene under the transcriptional control of a promoter for a gene the expression of which is modulated in senescent cells, and methods for using such cells to identify compounds that modulate expression of these cellular genes.
PCT/US2001/050574 2000-12-21 2001-12-21 Reagents and methods for identifying and modulating expression of tumor senescence genes Ceased WO2002061134A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01997143A EP1414995A2 (en) 2000-12-21 2001-12-21 Reagents and methods for identifying and modulating expression of tumor senescence genes
AU2002248262A AU2002248262B2 (en) 2000-12-21 2001-12-21 Reagents and methods for identifying and modulating expression of tumor senescence genes
CA002432976A CA2432976A1 (en) 2000-12-21 2001-12-21 Reagents and methods for identifying and modulating expression of tumor senescence genes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25790700P 2000-12-21 2000-12-21
US60/257,907 2000-12-21
US34142501P 2001-12-17 2001-12-17
US60/341,425 2001-12-17

Publications (3)

Publication Number Publication Date
WO2002061134A2 WO2002061134A2 (en) 2002-08-08
WO2002061134A9 WO2002061134A9 (en) 2002-12-05
WO2002061134A3 true WO2002061134A3 (en) 2004-02-26

Family

ID=26946282

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050574 Ceased WO2002061134A2 (en) 2000-12-21 2001-12-21 Reagents and methods for identifying and modulating expression of tumor senescence genes

Country Status (5)

Country Link
US (2) US20040058320A1 (en)
EP (1) EP1414995A2 (en)
AU (1) AU2002248262B2 (en)
CA (1) CA2432976A1 (en)
WO (1) WO2002061134A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE271691T1 (en) * 2000-01-12 2004-08-15 Ventana Med Syst Inc METHOD FOR DETECTING THE EFFECTIVENESS OF CANCER THERAPY
US20070128596A1 (en) * 2002-07-03 2007-06-07 Roninson Igor B Reagents and methods for identifying and modulating expression of tumor senescence genes
US20060134622A1 (en) * 2002-12-20 2006-06-22 Meena Augustus Amplified cancer target genes useful in diagnosis and thereapeutic screening
CA2555145A1 (en) 2004-02-06 2005-08-25 Wyeth Diagnosis and therapeutics for cancer
US8021428B2 (en) * 2004-06-30 2011-09-20 Depuy Spine, Inc. Ceramic disc prosthesis
ATE465406T1 (en) * 2004-11-15 2010-05-15 Erasmus Mc PREMATURE AGING MICE TO DEMONSTRATE THE ROLE OF DNA DAMAGE IN AGING AND INTERVENTION ON AGE-RELATED PATHOLOGY
WO2007130469A2 (en) * 2006-05-02 2007-11-15 Ordway Research Institute, Inc. Induction of intracellular and secreted growth inhibitors and paracrine tumor-suppressive activity by rar ligands
CN103424541B (en) 2006-05-18 2018-01-30 分子压型学会股份有限公司 It is determined that the system and method intervened for the personalized medicine of symptom
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
US20100047783A1 (en) * 2006-06-20 2010-02-25 El-Diery Wafik S Small molecule modulators of p53 family signaling
WO2009085216A2 (en) 2007-12-20 2009-07-09 Squicor Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
KR101861260B1 (en) 2014-12-24 2018-05-25 한국원자력의학원 Biomarker composition and method for diagnosing aging of cell

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010479A1 (en) * 1997-08-26 1999-03-04 Lexicon Genetics Incorporated Impaired brca2 function in cells and non-human transgenic animals
WO2000061751A1 (en) * 1999-04-09 2000-10-19 Board Of Trustees Of The University Of Illinois REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF GENES REGULATED BY p21

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010479A1 (en) * 1997-08-26 1999-03-04 Lexicon Genetics Incorporated Impaired brca2 function in cells and non-human transgenic animals
WO2000061751A1 (en) * 1999-04-09 2000-10-19 Board Of Trustees Of The University Of Illinois REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF GENES REGULATED BY p21

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHANG B D ET AL: "ROLE OF P53 AND P21 WAF1/CIP1 IN SENESCENCE-LIKE TERMINAL PROLIFERATION ARREST INDUCED IN HUMAN TUMOR CELLS BY CHEMOTHERAPEUTIC DRUGS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 18, August 1999 (1999-08-01), pages 4808 - 4818, XP000922555, ISSN: 0950-9232 *
CHANG B-D ET AL: "EFFECTS OF P21WAF1/CIP1/SDI1 ON CELLULAR GENE EXPRESSION: IMPLICATIONS FOR CARCINOGENESIS, SENESCENCE, AND AGE-RELATED DISEASES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 8, April 2000 (2000-04-01), pages 4291 - 4296, XP000921392, ISSN: 0027-8424 *
CHANG BEY-DIH ET AL: "A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.", CANCER RESEARCH, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3761 - 3767, XP002245658, ISSN: 0008-5472 *
GONOS EFSTATHIOS S ET AL: "Cloning and identification of genes that associate with mammalian replicative senescence", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 240, no. 1, 10 April 1998 (1998-04-10), pages 66 - 74, XP002207761, ISSN: 0014-4827 *
KRAMER DEBORA L ET AL: "Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.", CANCER RESEARCH, vol. 61, no. 21, 1 November 2001 (2001-11-01), pages 7754 - 7762, XP001152964, ISSN: 0008-5472 *
PRIMLANO THOMAS ET AL: "Activation of accelerated senescence by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) in prostate carcinoma cell lines.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, no. 41, March 2000 (2000-03-01), 91st Annual Meeting of the American Association for Cancer Research.;San Francisco, California, USA; April 01-05, 2000, March, 2000, pages 852, XP001152963, ISSN: 0197-016X *

Also Published As

Publication number Publication date
EP1414995A2 (en) 2004-05-06
WO2002061134A9 (en) 2002-12-05
US20090208935A1 (en) 2009-08-20
WO2002061134A2 (en) 2002-08-08
CA2432976A1 (en) 2002-08-08
AU2002248262B2 (en) 2007-11-01
US20040058320A1 (en) 2004-03-25

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