WO2002069232A3 - Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity - Google Patents

Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity Download PDF

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Publication number
WO2002069232A3
WO2002069232A3 PCT/EP2002/001688 EP0201688W WO02069232A3 WO 2002069232 A3 WO2002069232 A3 WO 2002069232A3 EP 0201688 W EP0201688 W EP 0201688W WO 02069232 A3 WO02069232 A3 WO 02069232A3
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WO
WIPO (PCT)
Prior art keywords
identification
cell epitopes
immunogenicity
reeduced
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/001688
Other languages
French (fr)
Other versions
WO2002069232A2 (en
Inventor
Francis J Carr
Graham Carter
Tim Jones
Stephen Williams
Anita Hamilton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0207281-5A priority Critical patent/BR0207281A/en
Priority to US10/468,496 priority patent/US7430476B2/en
Priority to AU2002256624A priority patent/AU2002256624B2/en
Priority to MXPA03007316A priority patent/MXPA03007316A/en
Priority to KR1020037010860A priority patent/KR100899970B1/en
Priority to HU0303199A priority patent/HUP0303199A2/en
Priority to ES02726112T priority patent/ES2309167T3/en
Priority to EP02726112A priority patent/EP1366455B1/en
Priority to CA002438652A priority patent/CA2438652A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE60227344T priority patent/DE60227344D1/en
Priority to JP2002568279A priority patent/JP4279554B2/en
Priority to PL02362414A priority patent/PL362414A1/en
Publication of WO2002069232A2 publication Critical patent/WO2002069232A2/en
Publication of WO2002069232A3 publication Critical patent/WO2002069232A3/en
Anticipated expiration legal-status Critical
Priority to ZA2003/07324A priority patent/ZA200307324B/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to a novel approach for identification of T-cell epitopes, that give rise to an immune reaction in a living host. By means of this novel method biological compounds can be generated which have a no or at least a reduced immunogenicity when exposed to the immune system of a given species and compared with the relevant non-modified entity. Thus the invention relates also to novel biological molecules, especially proteins and antibodies, obtained by the method according to the invention.
PCT/EP2002/001688 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity Ceased WO2002069232A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002438652A CA2438652A1 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
AU2002256624A AU2002256624B2 (en) 2001-02-19 2002-02-18 Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
MXPA03007316A MXPA03007316A (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity.
KR1020037010860A KR100899970B1 (en) 2001-02-19 2002-02-18 Method for identification of T-cell epitopes and use for the preparation of molecules with reduced immunogenicity
HU0303199A HUP0303199A2 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
ES02726112T ES2309167T3 (en) 2001-02-19 2002-02-18 METHOD FOR IDENTIFYING T-CELL EPITOTS AND METHOD FOR PREPARING MOLECULES WITH REDUCED IMMUNOGENICITY.
EP02726112A EP1366455B1 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity
BR0207281-5A BR0207281A (en) 2001-02-19 2002-02-18 Method for Identifying T-Cell Epitopes and Use for Preparing Reduced Immunogenicity Molecules
DE60227344T DE60227344D1 (en) 2001-02-19 2002-02-18 METHOD FOR THE IDENTIFICATION OF T-CELL PITOPES AND THEIR APPLICATION FOR THE PREPARATION OF MOLECULES WITH REDUCED IMMUNOGENICITY
US10/468,496 US7430476B2 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity
JP2002568279A JP4279554B2 (en) 2001-02-19 2002-02-18 Method for identifying T cell epitopes and method for producing molecules having reduced immunogenicity
PL02362414A PL362414A1 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
ZA2003/07324A ZA200307324B (en) 2001-02-19 2003-09-18 Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
EP01103954 2001-02-19
EP01103954.2 2001-02-19
EP01105777 2001-03-08
EP01105777.5 2001-03-08
EP01106538.0 2001-03-15
EP01106536.4 2001-03-15
EP01106538 2001-03-15
EP01106536 2001-03-15
EP01107012.5 2001-03-20
EP01107012 2001-03-20
EP01106899 2001-03-20
EP01106899.6 2001-03-20
EP01107568.6 2001-03-27
EP01107568 2001-03-27
EP01110220.9 2001-04-25
EP01110220 2001-04-25
EP01113228.9 2001-05-30
EP01113228 2001-05-30
EP01124965 2001-10-19
EP01124965.3 2001-10-19
EP01126859.6 2001-11-12
EP01126859 2001-11-12

Publications (2)

Publication Number Publication Date
WO2002069232A2 WO2002069232A2 (en) 2002-09-06
WO2002069232A3 true WO2002069232A3 (en) 2003-02-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001688 Ceased WO2002069232A2 (en) 2001-02-19 2002-02-18 Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity

Country Status (14)

Country Link
US (1) US7430476B2 (en)
EP (2) EP1998266A3 (en)
JP (1) JP4279554B2 (en)
KR (1) KR100899970B1 (en)
CN (1) CN100404673C (en)
AT (1) ATE400030T1 (en)
AU (1) AU2002256624B2 (en)
CA (1) CA2438652A1 (en)
ES (1) ES2309167T3 (en)
HU (1) HUP0303199A2 (en)
MX (1) MXPA03007316A (en)
PL (1) PL362414A1 (en)
WO (1) WO2002069232A2 (en)
ZA (1) ZA200307324B (en)

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US7169904B2 (en) 2002-12-17 2007-01-30 Emd Lexigen Research Center Corp. Immunocytokine sequences and uses thereof
US7323549B2 (en) 2003-12-30 2008-01-29 Emd Lexigen Research Center Corp. IL-7 fusion proteins
US7557190B2 (en) 2005-07-08 2009-07-07 Xencor, Inc. Optimized proteins that target Ep-CAM
US8609094B2 (en) 2009-09-30 2013-12-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
US8691952B2 (en) 2005-12-30 2014-04-08 Merck Patent Gmbh Anti-CD19 antibodies with reduced immunogenicity
US8852586B2 (en) 2004-11-12 2014-10-07 Xencor, Inc. Fc variants with altered binding to FcRn
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
US8937158B2 (en) 2003-03-03 2015-01-20 Xencor, Inc. Fc variants with increased affinity for FcγRIIc
US9011852B2 (en) 2010-04-30 2015-04-21 Alexion Pharmaceuticals, Inc. Anti-C5a antibodies
US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn
US9555110B2 (en) 2011-02-11 2017-01-31 Merck Patent Gmbh Anti-alpha-V integrin antibody for the treatment of prostate cancer
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US10155820B2 (en) 2014-11-12 2018-12-18 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US10195281B2 (en) 2012-09-05 2019-02-05 Tracon Pharmaceuticals, Inc. Antibody formulations and uses thereof

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ATE329622T1 (en) * 1998-04-15 2006-07-15 Lexigen Pharm Corp ENHANCEMENT OF ANTIBODY-CYTOKINE-FUSION PROTEIN-MEDIATED IMMUNE RESPONSE BY CO-ADMINISTRATION WITH AN ANGIOGENESIS HIBITOR
CA2372794A1 (en) * 1999-05-14 2000-11-23 Mcgill University Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
BR0013231A (en) * 1999-08-09 2002-07-23 Lexigen Pharm Corp Multiple cytokine-antibody complexes
JP5390055B2 (en) * 2000-06-29 2014-01-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Enhancement of antibody-cytokine fusion protein-mediated immune response by combined therapy with immune cytokine uptake enhancer
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
HUP0303428A2 (en) 2001-03-07 2004-01-28 Merck Patent Gmbh. Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
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ATE401344T1 (en) * 2002-08-09 2008-08-15 Merck Patent Gmbh T-CELL EPITOPES IN ERYTHROPOIETIN
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AU2004245038A1 (en) * 2003-06-02 2004-12-16 Alexion Pharmaceuticals, Inc. De-immunized anti-CD3 antibody
EP1636264A2 (en) * 2003-06-24 2006-03-22 MERCK PATENT GmbH Tumour necrosis factor receptor molecules with reduced immunogenicity
US8147832B2 (en) * 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
US20050069521A1 (en) * 2003-08-28 2005-03-31 Emd Lexigen Research Center Corp. Enhancing the circulating half-life of interleukin-2 proteins
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
US20070148170A1 (en) 2005-10-03 2007-06-28 Desjarlais John R Fc Variants With Optimized Fc Receptor Binding Properties
ZA200601699B (en) 2003-10-16 2007-05-30 Micromet Ag Multispecific deimmunized CD3-binders
CN1898267B (en) * 2003-11-01 2012-05-23 默克专利股份有限公司 Modified anti-CD52 antibody
JP2007512846A (en) * 2003-12-04 2007-05-24 ゼンコー・インコーポレイテッド Method for producing mutant protein having increased host string content and composition thereof
US20060122783A1 (en) * 2004-08-24 2006-06-08 Ishikawa Muriel Y System and method for heightening a humoral immune response
ATE457458T1 (en) * 2003-12-18 2010-02-15 Genencor Int BETA-LACTAMASE CD4+ T CELL EPITOPES
BRPI0417916A (en) 2003-12-31 2007-04-10 Merck Patent Gmbh fc-erythropoietin fusion protein with improved pharmacokinetics
AU2005206277B2 (en) * 2004-01-22 2011-06-23 Merck Patent Gmbh Anti-cancer antibodies with reduced complement fixation
PL1737961T3 (en) * 2004-03-19 2013-12-31 Merck Patent Gmbh Modified bouganin proteins, cytotoxins and methods and uses thereof
WO2005092925A2 (en) 2004-03-24 2005-10-06 Xencor, Inc. Immunoglobulin variants outside the fc region
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
EP3342782B1 (en) 2004-07-15 2022-08-17 Xencor, Inc. Optimized fc variants
US20060073563A1 (en) * 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
RU2437893C2 (en) * 2004-12-09 2011-12-27 Мерк Патент Гмбх Il-7 versions with low immunising capacity
EP2388271A3 (en) * 2005-02-03 2012-08-01 Antitope Limited Human Antibodies and Proteins
AU2012209017B2 (en) * 2005-02-03 2014-06-26 Antitope Limited Human antibodies and proteins
EP1966238B1 (en) * 2005-12-30 2012-04-25 Merck Patent GmbH Interleukin-12p40 variants with improved stability
US8075884B2 (en) 2006-01-12 2011-12-13 Alexion Pharmaceuticals, Inc. Antibodies to OX-2/CD200 and uses thereof
US20080095756A1 (en) * 2006-09-05 2008-04-24 Biosynexus Incorporated Compositions Comprising Lysostaphin Variants And Methods Of Using The Same
WO2009014835A2 (en) 2007-06-21 2009-01-29 Angelica Therapeutics, Inc. Modified toxins
EP2526967A1 (en) 2007-07-17 2012-11-28 Merck Patent GmbH Engineered anti-alpha v-integrin hybrid antibodies
CN101918532B (en) 2007-08-22 2016-03-30 普罗柏欧贞股份公司 Culture systems and methods for in vitro testing of immunogenicity and immune function
AU2008345242B2 (en) 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
US12492253B1 (en) 2008-02-25 2025-12-09 Xencor, Inc. Anti-human C5 antibodies
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