WO2002077614A3 - Apparatus for the automation of chemical reaction kinetics studies - Google Patents

Apparatus for the automation of chemical reaction kinetics studies Download PDF

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Publication number
WO2002077614A3
WO2002077614A3 PCT/US2002/008870 US0208870W WO02077614A3 WO 2002077614 A3 WO2002077614 A3 WO 2002077614A3 US 0208870 W US0208870 W US 0208870W WO 02077614 A3 WO02077614 A3 WO 02077614A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
reaction block
block
robotic device
cold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/008870
Other languages
French (fr)
Other versions
WO2002077614A2 (en
Inventor
Adam M Fermier
Alan R Oyler
Barbara L Armstrong
James V Weber
James Nalasco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Priority to EP02733877A priority Critical patent/EP1390713B1/en
Priority to DE60213792T priority patent/DE60213792T2/en
Publication of WO2002077614A2 publication Critical patent/WO2002077614A2/en
Publication of WO2002077614A3 publication Critical patent/WO2002077614A3/en
Anticipated expiration legal-status Critical
Priority to CY20061101465T priority patent/CY1105702T1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Disclosed is an apparatus which is capable of conducting accelerated automated kinetics studies with user-defined temperature profiles and sampling periods. The apparatus includes at least one hot reaction block for heating reaction vessels and at least one cold reaction block for cooling the reaction vessels. The apparatus includes a robotic device for transferring one reaction vessel from one hot reaction block to one cold reaction block and a controller having a user interface for inputting a predetermined temperature profile and a predetermined sampling interval. The controller is in communication with the plurality of reaction blocks and the robotic device so as to instruct the robotic device to transfer one reaction vessel from one hot reaction block to one cold reaction block at a predefined transfer time within the predetermined sampling interval.
PCT/US2002/008870 2001-03-23 2002-03-21 Apparatus for the automation of chemical reaction kinetics studies Ceased WO2002077614A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02733877A EP1390713B1 (en) 2001-03-23 2002-03-21 Apparatus for the automation of chemical reaction kinetics studies
DE60213792T DE60213792T2 (en) 2001-03-23 2002-03-21 DEVICE FOR AUTOMATING TESTING OF CHEMICAL REACTION KINETICS
CY20061101465T CY1105702T1 (en) 2001-03-23 2006-10-12 DEVICE FOR AUTOMATING CHEMICAL REACTION KINETIC STUDIES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/816,787 US7045288B2 (en) 2001-03-23 2001-03-23 Apparatus for the automation of chemical reaction kinetics studies
US09/816,787 2001-03-23

Publications (2)

Publication Number Publication Date
WO2002077614A2 WO2002077614A2 (en) 2002-10-03
WO2002077614A3 true WO2002077614A3 (en) 2003-03-27

Family

ID=25221602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/008870 Ceased WO2002077614A2 (en) 2001-03-23 2002-03-21 Apparatus for the automation of chemical reaction kinetics studies

Country Status (9)

Country Link
US (1) US7045288B2 (en)
EP (1) EP1390713B1 (en)
AT (1) ATE335997T1 (en)
CY (1) CY1105702T1 (en)
DE (1) DE60213792T2 (en)
DK (1) DK1390713T3 (en)
ES (1) ES2269704T3 (en)
PT (1) PT1390713E (en)
WO (1) WO2002077614A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078131A2 (en) * 2003-03-01 2004-09-16 Symyx Technologies, Inc. Evaluating effects of exposure conditions on drug samples over time
DE602005015220D1 (en) * 2005-09-16 2009-08-13 Mettler Toledo Ag Method for simulating a process on a laboratory scale
US20110202177A1 (en) * 2010-02-15 2011-08-18 Siemens Medical Solutions Usa, Inc. Intuitive Graphical User Interface for Carrying Out Chemical Reactions
US9207251B2 (en) * 2011-04-19 2015-12-08 Roche Molecular Systems, Inc. User interaction with automated analytical apparatus
ES2454916A1 (en) * 2012-09-11 2014-04-11 Universidad Complutense De Madrid Automated thermal cycling device and procedure for dental materials
US10539465B2 (en) * 2017-03-29 2020-01-21 Eaton Intelligent Power Limited Systems, devices, and apparatus for monitoring temperature at remote locations using infrared light

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2633310A1 (en) * 1988-06-24 1989-12-29 Pasteur Institut REPEATED AUTOMATIC EXECUTION APPARATUS FOR A THERMAL CYCLE IN SEVERAL SUCCESSIVE STEPS, IN PARTICULAR FOR THE ENZYMATIC AMPLIFICATION OF NUCLEIC ACID SEQUENCES
WO1997016717A1 (en) * 1995-11-03 1997-05-09 Eli Lilly And Company Automated permeability analysis system
US5964095A (en) * 1995-02-23 1999-10-12 Thermogenesis Corp. Method and apparatus for cryogenic storage of thermolabile products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US7390458B2 (en) * 2000-10-13 2008-06-24 Irm Llc High throughput processing system and method of using

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2633310A1 (en) * 1988-06-24 1989-12-29 Pasteur Institut REPEATED AUTOMATIC EXECUTION APPARATUS FOR A THERMAL CYCLE IN SEVERAL SUCCESSIVE STEPS, IN PARTICULAR FOR THE ENZYMATIC AMPLIFICATION OF NUCLEIC ACID SEQUENCES
US5964095A (en) * 1995-02-23 1999-10-12 Thermogenesis Corp. Method and apparatus for cryogenic storage of thermolabile products
WO1997016717A1 (en) * 1995-11-03 1997-05-09 Eli Lilly And Company Automated permeability analysis system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZHAN X ET AL: "COMPUTER-CONTROLLED HEATING SYSTEM AND NEW COMPUTATIONN FOR RECIPROCAL HEATING STABILITY EXPERIMENT", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 115, no. 2, 1995, pages 167 - 173, XP001126976, ISSN: 0378-5173 *
ZHAN X ET AL: "DETERMINATION OF RATE ORDER FOR DEGRADATION OF DRUGS WITH NONISOTHERMAL STABILITY EXPERIMENT", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 86, no. 10, October 1997 (1997-10-01), pages 1099 - 1104, XP001126975, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
US7045288B2 (en) 2006-05-16
CY1105702T1 (en) 2010-12-22
DE60213792T2 (en) 2007-09-13
ES2269704T3 (en) 2007-04-01
EP1390713B1 (en) 2006-08-09
PT1390713E (en) 2006-11-30
WO2002077614A2 (en) 2002-10-03
US20020177956A1 (en) 2002-11-28
DK1390713T3 (en) 2006-12-11
ATE335997T1 (en) 2006-09-15
DE60213792D1 (en) 2006-09-21
EP1390713A2 (en) 2004-02-25

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