WO2002082089A3 - Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases - Google Patents

Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases Download PDF

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Publication number
WO2002082089A3
WO2002082089A3 PCT/CA2002/000416 CA0200416W WO02082089A3 WO 2002082089 A3 WO2002082089 A3 WO 2002082089A3 CA 0200416 W CA0200416 W CA 0200416W WO 02082089 A3 WO02082089 A3 WO 02082089A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
hepatitis
diagnosis
antibodies against
related disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/000416
Other languages
French (fr)
Other versions
WO2002082089A2 (en
Inventor
Michael D Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Network Ltd
Original Assignee
Immune Network Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Network Ltd filed Critical Immune Network Ltd
Priority to US10/474,296 priority Critical patent/US7374876B2/en
Priority to CA002480464A priority patent/CA2480464A1/en
Priority to EP02716568A priority patent/EP1377832A2/en
Publication of WO2002082089A2 publication Critical patent/WO2002082089A2/en
Publication of WO2002082089A3 publication Critical patent/WO2002082089A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • C07K16/4225—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig against anti-HIV Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides methods for the diagnosis, prognosis and treatment of HCV-related disease. The method takes advantage of a novel reactive mechanism of the murine monoclonal antibody (mAb) 1F7 against human antibodies specific for different proteins of the Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV). 1F7 recognizes antibodies against HCV core protein in a majority of HCV-infected individuals and antibodies against HCV non-structural proteins 3 (NS3) and NS4 in some HCV-infected individuals. 1F7 also recognizes antibodies against the putative principle neutralizing determinant (hypervariable and conserved region 1 of the HCV E2 protein) of HCV. The antibody can be used in various methods to detect HCV related disease and formulated with physiologically acceptable carriers in various compositions to treat HCV infection.
PCT/CA2002/000416 2001-04-03 2002-04-02 Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases Ceased WO2002082089A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/474,296 US7374876B2 (en) 2001-04-03 2002-04-02 Anti-idiotypic antibody and its use in diagnosis and therapy of Hepatitis C Virus related diseases
CA002480464A CA2480464A1 (en) 2001-04-03 2002-04-02 Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases
EP02716568A EP1377832A2 (en) 2001-04-03 2002-04-02 Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28128001P 2001-04-03 2001-04-03
US60/281,280 2001-04-03

Publications (2)

Publication Number Publication Date
WO2002082089A2 WO2002082089A2 (en) 2002-10-17
WO2002082089A3 true WO2002082089A3 (en) 2002-12-05

Family

ID=23076643

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000416 Ceased WO2002082089A2 (en) 2001-04-03 2002-04-02 Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases

Country Status (5)

Country Link
US (1) US7374876B2 (en)
EP (1) EP1377832A2 (en)
AU (1) AU2008202625A1 (en)
CA (1) CA2480464A1 (en)
WO (1) WO2002082089A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051466A1 (en) * 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849583A (en) * 1992-03-09 1998-12-15 Sidney Kimmel Cancer Center Anti-idiotypic antibody and its use in diagnosis and therapy in HIV-related disease
FR2809106A1 (en) * 2000-05-17 2001-11-23 Istac New human Ro/SSA-like polypeptide, useful for treatment, prevention and diagnosis of e.g. autoimmune disease and viral infection, also related nucleic acid and antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI943524A0 (en) * 1992-12-29 1994-07-27 Akzo Nobel Nv Anti-hepatitis C virus monoclonal antibodies and anti-idiotypic antibodies
US7052696B2 (en) * 1998-07-10 2006-05-30 The United States Of America As Represented By The Department Of Health And Human Services Antigenic epitopes and mosaic polypeptides of hepatitis C virus proteins
WO2000026418A1 (en) * 1998-11-05 2000-05-11 The Board Of Trustees Of Leland Stanford Junior University Human pan-hcv human monoclonal antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849583A (en) * 1992-03-09 1998-12-15 Sidney Kimmel Cancer Center Anti-idiotypic antibody and its use in diagnosis and therapy in HIV-related disease
FR2809106A1 (en) * 2000-05-17 2001-11-23 Istac New human Ro/SSA-like polypeptide, useful for treatment, prevention and diagnosis of e.g. autoimmune disease and viral infection, also related nucleic acid and antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GRANT MICHAEL D: "Antibody convergence along a common idiotypic axis in immunodeficiency virus and hepatitis C virus infections.", JOURNAL OF MEDICAL VIROLOGY. UNITED STATES JAN 2002, vol. 66, no. 1, January 2002 (2002-01-01), pages 13 - 21, XP001084812, ISSN: 0146-6615 *
KENNEDY R C ET AL: "Antigen mimicry by anti-idiotype antibodies that recognize a common anti-hepatitis B surface antigen idiotype.", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. UNITED STATES 1985, vol. 185, 1985, pages 139 - 147, XP001087876, ISSN: 0065-2598 *
NEWS BITES, March 2000 (2000-03-01), XP002205111, Retrieved from the Internet <URL:www.askemilyss.com/bites/bite0300/imm.htm> [retrieved on 20020624] *
See also references of EP1377832A2 *

Also Published As

Publication number Publication date
CA2480464A1 (en) 2002-10-17
EP1377832A2 (en) 2004-01-07
US20040146857A1 (en) 2004-07-29
US7374876B2 (en) 2008-05-20
AU2008202625A1 (en) 2008-07-03
WO2002082089A2 (en) 2002-10-17

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