WO2002089981A3 - Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis - Google Patents

Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis Download PDF

Info

Publication number
WO2002089981A3
WO2002089981A3 PCT/US2001/047780 US0147780W WO02089981A3 WO 2002089981 A3 WO2002089981 A3 WO 2002089981A3 US 0147780 W US0147780 W US 0147780W WO 02089981 A3 WO02089981 A3 WO 02089981A3
Authority
WO
WIPO (PCT)
Prior art keywords
tubes
microchip
inlet ports
filling
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/047780
Other languages
French (fr)
Other versions
WO2002089981A2 (en
Inventor
David J Roach
Robert T Loder Jr
Thomas M Armstrong
Dennis W Harris
Stevan B Jovanovich
Richard F Johnston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integenx Acquisition Corp
Original Assignee
Amersham Biosciences SV Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences SV Corp filed Critical Amersham Biosciences SV Corp
Priority to DE60138300T priority Critical patent/DE60138300D1/en
Priority to EP01987359A priority patent/EP1344050B1/en
Priority to AU2002239584A priority patent/AU2002239584A1/en
Publication of WO2002089981A2 publication Critical patent/WO2002089981A2/en
Anticipated expiration legal-status Critical
Publication of WO2002089981A3 publication Critical patent/WO2002089981A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0099—Cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00039—Transport arrangements specific to flat sample substrates, e.g. pusher blade
    • G01N2035/00059—Transport arrangements specific to flat sample substrates, e.g. pusher blade vacuum chucks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
PCT/US2001/047780 2000-12-13 2001-12-10 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis Ceased WO2002089981A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE60138300T DE60138300D1 (en) 2000-12-13 2001-12-10 METHOD AND DEVICE FOR REPLENISHING AND CLEANING CHANNELS AND INTAKE CHANNELS FOR MICROCHIPS USED IN BIOLOGICAL ANALYSIS
EP01987359A EP1344050B1 (en) 2000-12-13 2001-12-10 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
AU2002239584A AU2002239584A1 (en) 2000-12-13 2001-12-10 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/737,675 US6787111B2 (en) 1998-07-02 2000-12-13 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US09/737,675 2000-12-13

Publications (2)

Publication Number Publication Date
WO2002089981A2 WO2002089981A2 (en) 2002-11-14
WO2002089981A3 true WO2002089981A3 (en) 2003-06-19

Family

ID=24964841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047780 Ceased WO2002089981A2 (en) 2000-12-13 2001-12-10 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis

Country Status (7)

Country Link
US (1) US6787111B2 (en)
EP (1) EP1344050B1 (en)
AT (1) ATE428111T1 (en)
AU (1) AU2002239584A1 (en)
DE (1) DE60138300D1 (en)
ES (1) ES2323408T3 (en)
WO (1) WO2002089981A2 (en)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19754000A1 (en) * 1997-12-05 1999-06-17 Max Planck Gesellschaft Device and method for the electrically triggered microdrop delivery with a dispensing head
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
EP1040349B2 (en) 1997-12-17 2012-12-19 Ecole Polytechnique Federale De Lausanne (Epfl) Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US6627157B1 (en) * 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6351690B1 (en) * 2000-01-21 2002-02-26 Virologic, Inc. Automated method and system for performing antiviral drug susceptibility and resistance testing
US6749812B2 (en) * 2000-06-26 2004-06-15 Vistalab Technologies Automatic pipette detipping
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US7514046B2 (en) 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
CN1253238C (en) * 2001-01-26 2006-04-26 阿德维昂生物科学公司 Robotic autosampler for automated electrospray from microfluidic chip
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US6982063B2 (en) * 2001-05-25 2006-01-03 Matrix Technologies Corp Automated pipetting system
US6669432B2 (en) 2001-08-13 2003-12-30 Matrix Technologies Corp. Apparatus and method for handling pipetting tip magazines
US20030044320A1 (en) * 2001-08-31 2003-03-06 Shun Luo High throughput screening micro array platform
EP1434850A2 (en) * 2001-09-05 2004-07-07 Essen Instruments, Inc. High-throughput electrophysiological measurement system
KR100414157B1 (en) * 2001-09-28 2004-01-13 삼성전자주식회사 Apparatus for sampling a fluid sample and fluid analyzer having the same
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
JP3818926B2 (en) * 2002-02-04 2006-09-06 富士写真フイルム株式会社 Receptor-ligand association reaction method
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
JP4268933B2 (en) * 2002-05-28 2009-05-27 バイオストランド，インク． SAMPLE DISTRIBUTION DEVICE, COATING MANUFACTURING METHOD, SAMPLE DISTRIBUTION METHOD, AND SUBSTRATE ACTIVATION DEVICE
US7445926B2 (en) 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
US7249529B2 (en) * 2003-03-28 2007-07-31 Protedyne Corporation Robotically manipulable sample handling tool
AU2004245123A1 (en) * 2003-06-05 2004-12-16 Bioprocessors Corp. System and method for process automation
US7341652B2 (en) * 2003-06-20 2008-03-11 Groton Biosytems, Llc Stationary capillary electrophoresis system
US7601545B2 (en) 2003-06-20 2009-10-13 Groton Biosystems, Llc Automated macromolecule sample preparation system
US20040260414A1 (en) * 2003-06-20 2004-12-23 Groton Biosystems, Llc Method and apparatus for operating an automated biomolecular preparation system
US7169599B2 (en) 2003-06-20 2007-01-30 Groton Biosystems, Llc Fluid interface for bioprocessor systems
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
DE602004022559D1 (en) * 2003-08-04 2009-09-24 Caliper Life Sciences Inc METHOD AND SYSTEM FOR MACHINING COMPONENTS IN THE MICROMASSETTE FOR RE-USE
DK2322278T3 (en) 2003-10-24 2017-04-10 Aushon Biosystems Inc Apparatus and method for dispensing liquid, semi-solid and solid samples
AU2004308278B2 (en) * 2003-12-19 2010-10-28 Gilson, Inc. Method and apparatus for liquid chromatography automated sample loading
US20050214737A1 (en) * 2004-03-26 2005-09-29 Dejneka Matthew J Transparent filtered capillaries
US7455814B2 (en) * 2004-04-23 2008-11-25 Giblin Leonard J Metered dispenser and aspirator device
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
WO2006017737A2 (en) * 2004-08-06 2006-02-16 Cetek Corporation Microtiter plate scrubbing device
CN101073002B (en) 2004-09-15 2012-08-08 英特基因有限公司 microfluidic device
US8986614B2 (en) * 2010-02-23 2015-03-24 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
GB0502556D0 (en) * 2005-02-08 2005-03-16 Lab901 Ltd Analysis instrument
JP4328788B2 (en) * 2005-10-04 2009-09-09 キヤノン株式会社 Nucleic acid sample testing equipment
US8192698B2 (en) * 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc Microfluidic devices
US20070190828A1 (en) * 2006-02-10 2007-08-16 Bio-Rad Laboratories, Inc. Method for substantially preventing contamination of electrical contacts
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DE102006034245C5 (en) 2006-07-21 2014-05-28 Stratec Biomedical Systems Ag Positioning device for positioning pipettes
EP2069800B1 (en) * 2006-09-22 2012-03-28 Fujifilm Corporation Clinical analysis apparatus
JP4893209B2 (en) * 2006-10-03 2012-03-07 株式会社島津製作所 Electrophoresis device
US7942973B2 (en) * 2006-10-16 2011-05-17 Lam Research Corporation Methods and apparatus for wet cleaning electrode assemblies for plasma processing apparatuses
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2098588B1 (en) * 2006-11-22 2013-01-02 Altair Corporation Pipette core member, pipette, and pipette device
GB2457851B (en) 2006-12-14 2011-01-05 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale fet arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
GB2445739A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
EP2142314A4 (en) * 2007-03-30 2012-04-25 Fujifilm Corp Method of cleaning micro-flow passages
CA2687061A1 (en) * 2007-05-11 2008-11-20 Bio-Rad Laboratories, Inc. Wash ring assembly and method of use
AU2013205256B8 (en) * 2007-07-13 2015-10-22 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
CN101910399B (en) * 2007-10-30 2015-11-25 考利达基因组股份有限公司 Apparatus for high-throughput sequencing of nucleic acids
EP2217903B1 (en) * 2007-11-02 2019-04-03 Biocius Life Sciences, Inc. Sample injection system
US8032258B2 (en) * 2007-12-04 2011-10-04 Ludwig Lester F Multi-channel chemical transport bus for microfluidic and other applications
KR20110030415A (en) 2008-01-22 2011-03-23 인터젠엑스 인크. Use in universal sample preparation systems and integrated analysis systems
WO2009134786A2 (en) * 2008-04-30 2009-11-05 The Board Of Regents Of The University Of Texas System Quality control method and micro/nano-channeled devices
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8759113B2 (en) * 2008-10-31 2014-06-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for receiving a liquid and also device for applying liquids on sample carriers and method for this purpose
KR20110111449A (en) 2008-12-31 2011-10-11 인터젠엑스 인크. Mechanisms with Microfluidic Chips
KR101602414B1 (en) * 2009-03-16 2016-03-11 삼성전자주식회사 Apparatus for fluidic control
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
CN102459565A (en) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 Fluidic devices with diaphragm valves
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
DE102009052828A1 (en) * 2009-11-13 2011-05-19 Stiftung Caesar Center Of Advanced European Studies And Research Method for producing micro cavity in infra red sensor, involves removing structure parts with filled micro cavities from liquid after complete immersion of structure parts that are guided together and interconnected to micro cavities
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
ES2649559T3 (en) 2009-11-23 2018-01-12 Cyvek, Inc. Method and apparatus for testing
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2539719B1 (en) * 2010-02-23 2019-12-25 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US9102979B2 (en) 2010-02-23 2015-08-11 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
EP2553233B1 (en) * 2010-03-31 2023-08-16 ATS Automation Tooling Systems Inc. Wet bench apparatus
US8367022B2 (en) * 2010-05-03 2013-02-05 Integra Biosciences Corp. Unintended motion control for manually directed multi-channel electronic pipettor
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
TWI465716B (en) 2010-06-30 2014-12-21 生命技術公司 Transistor circuit for detecting and measuring chemical reactions and compounds
EP2588851B1 (en) 2010-06-30 2016-12-21 Life Technologies Corporation Ion-sensing charge-accumulation circuit and method
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
CN101881706B (en) * 2010-07-05 2014-04-02 深圳迈瑞生物医疗电子股份有限公司 Sampling device and method
JP5830230B2 (en) * 2010-07-20 2015-12-09 アークレイ株式会社 Analysis apparatus and analysis method
JP5462738B2 (en) * 2010-08-03 2014-04-02 アークレイ株式会社 Analysis equipment
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
ES2683032T3 (en) * 2010-12-17 2018-09-24 Biomerieux, Inc Methods of isolation, accumulation, characterization and / or identification of microorganisms using a sample filtration and transfer device, and said device
WO2012103005A2 (en) * 2011-01-24 2012-08-02 Cornell University Deposition of materials for edible solid freeform fabrication
WO2012129455A2 (en) 2011-03-22 2012-09-27 Cyvek, Inc Microfluidic devices and methods of manufacture and use
ES2769028T3 (en) 2011-04-15 2020-06-24 Becton Dickinson Co Real-time scanning microfluidic thermocycler
ES2645966T3 (en) 2011-09-30 2017-12-11 Becton, Dickinson And Company Unified test strip
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN104040238B (en) 2011-11-04 2017-06-27 汉迪拉布公司 Polynucleotides sample preparation apparatus
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
DE102012206239A1 (en) 2012-04-17 2013-10-17 Hamilton Bonaduz Ag Dosing device, in particular automatic pipetting with disposal container
EP2838659A4 (en) 2012-04-18 2016-05-25 Biofire Diagnostics Llc Microspotting device
EP2703820B1 (en) * 2012-08-31 2019-08-28 F. Hoffmann-La Roche AG Mobile tip waste rack
JP2014119387A (en) * 2012-12-18 2014-06-30 Sony Corp Dispensing apparatus, analyzer and method for controlling dispensing apparatus
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
EP2969211B1 (en) 2013-03-15 2019-06-26 Becton, Dickinson and Company Process tube and carrier tray
CN105264366B (en) 2013-03-15 2019-04-16 生命科技公司 Chemical sensors with consistent sensor surface area
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
CN114471756B (en) 2013-11-18 2024-04-16 尹特根埃克斯有限公司 Cartridges and instruments for sample analysis
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
CN107106983B (en) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 Systems and methods for sample preparation, processing and analysis
KR102593647B1 (en) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 High data rate integrated circuit with transmitter configuration
US9255905B1 (en) * 2015-05-11 2016-02-09 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
GB201614150D0 (en) * 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
CN105424883B (en) * 2015-11-17 2017-05-24 重庆大学 Movable gantry type micro array sensor preparing device
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
WO2017204868A1 (en) * 2016-05-23 2017-11-30 Becton, Dickinson And Company Liquid dispenser with manifold mount for modular independently-actuated pipette channels
JP2020501107A (en) 2016-08-22 2020-01-16 ミロキュラス インコーポレイテッド Feedback system for parallel droplet control in digital microfluidic devices
WO2018126082A1 (en) 2016-12-28 2018-07-05 Miroculis Inc. Digital microfluidic devices and methods
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. Digital microfluidics systems and methods with integrated plasma collection device
JP7341124B2 (en) 2017-09-01 2023-09-08 ミロキュラス インコーポレイテッド Digital microfluidic device and its usage
US11725175B2 (en) * 2017-09-23 2023-08-15 Hewlett-Packard Development Company, L.P. Electroporation
US11402400B2 (en) * 2017-10-13 2022-08-02 Hewlett-Packard Development Company, L.P. Partition liquid into samples
WO2019201231A1 (en) * 2018-04-16 2019-10-24 Nanjingjinsirui Science & Technology Biology Corp. System for extracting biomolecules from a sample and related methods
WO2019226919A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
CN113543883A (en) 2019-01-31 2021-10-22 米罗库鲁斯公司 Non-fouling compositions and methods for manipulating and treating encapsulated droplets
WO2020176816A1 (en) 2019-02-28 2020-09-03 Miroculus Inc. Digital microfluidics devices and methods of using them
CN119158636A (en) 2019-04-08 2024-12-20 米罗库鲁斯公司 Multi-cassette digital microfluidic device and method of use
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
CN112604725A (en) * 2020-12-17 2021-04-06 广州科技贸易职业学院 Laboratory workbench
CN113368918B (en) * 2021-06-21 2022-04-26 合肥瀚海星点生物科技有限公司 Multi-channel liquid separation device and method based on microfluidic printing
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression
WO2024013323A1 (en) * 2022-07-15 2024-01-18 Lumicks Ca Holding B.V. Systems and methods for cleaning microfluidic chips

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10148628A (en) * 1996-11-19 1998-06-02 Shimadzu Corp Microchip electrophoresis device
WO2000002038A1 (en) * 1998-07-02 2000-01-13 Molecular Dynamics, Inc. Robotic microchannel bioanalytical instrument
WO2000030751A2 (en) * 1998-11-25 2000-06-02 Affymetrix, Inc. Microplate sample and reagent loading system
WO2000052376A1 (en) * 1999-03-02 2000-09-08 Perseptive Biosystems, Inc. Microfluidic connector
US20010005489A1 (en) * 1998-07-02 2001-06-28 Roach David J. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59119383U (en) * 1983-02-01 1984-08-11 エーザイ株式会社 cleaning nozzle
US4554839A (en) 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
US4952518A (en) 1984-10-01 1990-08-28 Cetus Corporation Automated assay machine and assay tray
US4803050A (en) 1985-07-22 1989-02-07 Sequoia-Turner Corporation Method and apparatus for liquid addition and aspiration in automated immunoassay techniques
US5108703A (en) 1986-03-26 1992-04-28 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
US4938080A (en) 1986-04-17 1990-07-03 Helena Laboratories, Inc. Automatic pipetting apparatus
GR871619B (en) 1986-10-31 1988-03-03 Genetic Systems Corp Automated patient sample analysis instrument
US4909920A (en) 1987-03-16 1990-03-20 Helena Laboratories Automatic electrophoresis apparatus and method
US5648266A (en) * 1989-02-24 1997-07-15 Astle; Thomas W. Cell harvester system
US5274240A (en) 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5460709A (en) 1993-06-21 1995-10-24 Helena Laboratories Corporation Automatic electrophoresis method and apparatus
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5635050A (en) 1995-08-23 1997-06-03 Beckman Instruments, Inc. Electrophoretic system including means for replacing separation medium
US5716825A (en) 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5906723A (en) 1996-08-26 1999-05-25 The Regents Of The University Of California Electrochemical detector integrated on microfabricated capillary electrophoresis chips
US5885430A (en) 1996-10-04 1999-03-23 Spectrumedix Corporation Capillary tube holder for an electrophoretic apparatus
US5851370A (en) 1997-01-24 1998-12-22 Motorola Corporation Automated electrophoresis system and method
JP3736007B2 (en) 1997-03-03 2006-01-18 株式会社島津製作所 Microchip electrophoresis device
US5948359A (en) * 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
DE19845950C1 (en) * 1998-10-06 2000-03-23 Eppendorf Geraetebau Netheler Mechanism for the separation of a tip from a pipette has an ejection unit operated by a pull drive to exert an axial separation between the pipette and its mounting without contamination
AU2001249236A1 (en) * 2000-03-17 2001-10-03 Spectrumedix Corporation Electrophoresis microchip and system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10148628A (en) * 1996-11-19 1998-06-02 Shimadzu Corp Microchip electrophoresis device
WO2000002038A1 (en) * 1998-07-02 2000-01-13 Molecular Dynamics, Inc. Robotic microchannel bioanalytical instrument
US20010005489A1 (en) * 1998-07-02 2001-06-28 Roach David J. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
WO2000030751A2 (en) * 1998-11-25 2000-06-02 Affymetrix, Inc. Microplate sample and reagent loading system
WO2000052376A1 (en) * 1999-03-02 2000-09-08 Perseptive Biosystems, Inc. Microfluidic connector

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199832, Derwent World Patents Index; Class B04, AN 1998-371998, XP002222636 *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 11 30 September 1998 (1998-09-30) *

Also Published As

Publication number Publication date
DE60138300D1 (en) 2009-05-20
EP1344050A2 (en) 2003-09-17
ES2323408T3 (en) 2009-07-15
US6787111B2 (en) 2004-09-07
WO2002089981A2 (en) 2002-11-14
EP1344050B1 (en) 2009-04-08
US20010005489A1 (en) 2001-06-28
ATE428111T1 (en) 2009-04-15
AU2002239584A1 (en) 2002-11-18

Similar Documents

Publication Publication Date Title
WO2002089981A3 (en) Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
US10174278B2 (en) Valved, microwell cell-culture device and method
TWI421495B (en) Microfluidic chip
US6673620B1 (en) Fluid exchange in a chamber on a microscope slide
US7740807B2 (en) Microfluidic device including displaceable material trap, and system
EP1171761B8 (en) Fluid exchange in a chamber on a microscope slide
CN107619785B (en) Fluid Integration Module
EP1473084A3 (en) Biochemical reaction cartridge
US20080000536A1 (en) Method and Device for Flowing a Liquid on a Surface
CN110317726B (en) A divide and annotate washing gas-liquid way unit, gas-liquid way system for DNA synthesizer
WO2005037706A3 (en) Fluid injection system
WO2002095360A3 (en) Method and apparatus for multiple electrospray sample introduction
CN1737576A (en) Minute quantity liquid precise distribution instrument and using method thereof
MXPA04008249A (en) Automatic precision pipetting device.
CN104647903A (en) Printing spray head device based on microfluidic chip
US20100323432A1 (en) Sample processing device for microchip
CN101109760B (en) Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge
EP3306297A1 (en) Sample staining device and sample staining method
CN111943999A (en) DNA synthesizer
CN210765324U (en) Separate injection cleaning gas-liquid path unit for DNA synthesizer and gas-liquid path system
US6557582B2 (en) Flow cell
CN105910878B (en) A device for gas removal in microfluidic channels
AU2001239886A1 (en) Device and method for preparing a sample for analysis
CN109234141B (en) Be provided with micro-fluidic structure's biological reaction device
US6901956B2 (en) Flow cell having endless loop manifold

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2001987359

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001987359

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP