WO2002093232A3 - Vorrichtung zur untersuchung chemischer und/oder biologischer proben - Google Patents

Vorrichtung zur untersuchung chemischer und/oder biologischer proben Download PDF

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Publication number
WO2002093232A3
WO2002093232A3 PCT/EP2002/005069 EP0205069W WO02093232A3 WO 2002093232 A3 WO2002093232 A3 WO 2002093232A3 EP 0205069 W EP0205069 W EP 0205069W WO 02093232 A3 WO02093232 A3 WO 02093232A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological samples
sample support
objective
support wall
examining chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/005069
Other languages
English (en)
French (fr)
Other versions
WO2002093232A2 (de
Inventor
Stefan Hummel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Evotec OAI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec OAI AG filed Critical Evotec OAI AG
Priority to JP2002589856A priority Critical patent/JP4443832B2/ja
Priority to DE50210460T priority patent/DE50210460D1/de
Priority to EP02732704A priority patent/EP1386189B1/de
Priority to US10/478,016 priority patent/US7304793B2/en
Priority to AU2002304621A priority patent/AU2002304621A1/en
Priority to DK02732704T priority patent/DK1386189T3/da
Publication of WO2002093232A2 publication Critical patent/WO2002093232A2/de
Publication of WO2002093232A3 publication Critical patent/WO2002093232A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/33—Immersion oils, or microscope systems or objectives for use with immersion fluids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Vorrichtung zur Untersuchung chemischer und/oder biologischer Proben. Eine Vorrichtung zur Untersuchung chemischer und/oder biologischer Proben weist einen Probenträger (14) zur Aufnahme von Proben (16) auf. Ferner weist die Vorrichtung ein Objektiv (10) zur Beobachtung der Probe (16) durch eine Probenträgerwand (18) auf. Zwischen einer Außenfläche (20) der Probenträgerwand (18) und einer Austrittslinse (12) des Objektivs (10) ist ein Spalt (22) ausgebildet. Erfindungsgemäß ist eine automatische Zuführeinrichtung (24) zum automatischen Zuführen von Immersionsmedium (46) zwischen der Außenfläche (20) der Probenträgerwand (18) und die Austrittslinse (12) des Objektivs (10) vorgesehen.
PCT/EP2002/005069 2001-05-11 2002-05-08 Vorrichtung zur untersuchung chemischer und/oder biologischer proben Ceased WO2002093232A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002589856A JP4443832B2 (ja) 2001-05-11 2002-05-08 化学的及び／または生物学的な試料の検査用装置
DE50210460T DE50210460D1 (de) 2001-05-11 2002-05-08 Vorrichtung zur untersuchung chemischer und/oder biologischer proben
EP02732704A EP1386189B1 (de) 2001-05-11 2002-05-08 Vorrichtung zur untersuchung chemischer und/oder biologischer proben
US10/478,016 US7304793B2 (en) 2001-05-11 2002-05-08 Apparatus for examination of chemical and/or biological samples
AU2002304621A AU2002304621A1 (en) 2001-05-11 2002-05-08 Device for examining chemical and/or biological samples
DK02732704T DK1386189T3 (da) 2001-05-11 2002-05-08 Anordning til undersögelse af kemiske og/eller biologiske pröver

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10123027A DE10123027B4 (de) 2001-05-11 2001-05-11 Vorrichtung zur Untersuchung chemischer und/oder biologischer Proben
DE10123027.3 2001-05-11

Publications (2)

Publication Number Publication Date
WO2002093232A2 WO2002093232A2 (de) 2002-11-21
WO2002093232A3 true WO2002093232A3 (de) 2003-03-06

Family

ID=7684477

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005069 Ceased WO2002093232A2 (de) 2001-05-11 2002-05-08 Vorrichtung zur untersuchung chemischer und/oder biologischer proben

Country Status (8)

Country Link
US (1) US7304793B2 (de)
EP (1) EP1386189B1 (de)
JP (1) JP4443832B2 (de)
AT (1) ATE366947T1 (de)
AU (1) AU2002304621A1 (de)
DE (2) DE10123027B4 (de)
DK (1) DK1386189T3 (de)
WO (1) WO2002093232A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10308610B4 (de) 2003-02-27 2006-04-13 Carl Zeiss Immersionsflüssigkeit für die Mikroskopie bei Wasserimmersion
JP4902201B2 (ja) * 2003-04-07 2012-03-21 株式会社ニコン 露光装置、露光方法及びデバイス製造方法
KR20170016014A (ko) 2003-04-11 2017-02-10 가부시키가이샤 니콘 액침 리소그래피에 의한 광학기기의 세정방법
TWI424470B (zh) 2003-05-23 2014-01-21 尼康股份有限公司 A method of manufacturing an exposure apparatus and an element
US6809794B1 (en) * 2003-06-27 2004-10-26 Asml Holding N.V. Immersion photolithography system and method using inverted wafer-projection optics interface
DE10333326B4 (de) * 2003-07-23 2007-03-15 Evotec Technologies Gmbh Vorrichtung und Verfahren zur Untersuchung chemischer und/oder biologischer Proben sowie Objektivaufsatz
US20050094258A1 (en) * 2003-10-31 2005-05-05 Hamamatsu Photonics K.K. Solid immersion lens moving device and microscope using the same
DE602004030481D1 (de) * 2003-12-15 2011-01-20 Nippon Kogaku Kk Bühnensystem, belichtungsvorrichtung und belichtungsverfahren
JP4253592B2 (ja) * 2004-01-06 2009-04-15 オリンパス株式会社 液浸対物レンズ、蛍光分析装置および倒立型顕微鏡。
EP2256535B1 (de) * 2004-02-16 2012-07-04 Olympus Corporation Rückhaltemechanismus für ein Immersionsmedium und Herstellungsverfahren dafür
WO2005122218A1 (ja) 2004-06-09 2005-12-22 Nikon Corporation 露光装置及びデバイス製造方法
DE102004033195A1 (de) * 2004-07-09 2006-02-23 Leica Microsystems Semiconductor Gmbh Vorrichtung zur Inspektion eines mikroskopischen Bauteils
DE102004033208B4 (de) * 2004-07-09 2010-04-01 Vistec Semiconductor Systems Gmbh Vorrichtung zur Inspektion eines mikroskopischen Bauteils mit einem Immersionsobjektiv
EP1855140A4 (de) * 2005-02-28 2012-04-04 Nikon Corp Adapter zur mikroskopverwendung und mikroskopeinrichtung
JP4823557B2 (ja) 2005-04-26 2011-11-24 オリンパス株式会社 顕微鏡装置
US7532393B2 (en) * 2005-06-22 2009-05-12 The Regents Of The University Of California Microscope immersion fluid applicator
DE102006042088B4 (de) * 2006-09-07 2011-08-25 European Molecular Biology Laboratory (EMBL), 69117 Vorrichtung und Verfahren zum Ausbilden eines Immersionsfilmes
US8199407B2 (en) 2006-09-07 2012-06-12 Leica Microsystems Cms Gmbh Immersion objective, apparatus for forming an immersion film and method
JP5021287B2 (ja) 2006-12-20 2012-09-05 オリンパス株式会社 蛍光撮像方法及び蛍光撮像装置
JP4328359B2 (ja) 2007-01-15 2009-09-09 オリンパス株式会社 液浸対物レンズを備えた観察装置
JP5047671B2 (ja) 2007-04-10 2012-10-10 オリンパス株式会社 顕微鏡装置
EP2895909B1 (de) * 2012-09-13 2022-07-06 Brandeis University Kühlsysteme und -verfahren für hochauflösende cryofluoreszenzlicht-mikroskopie und andere anwendungen
DE102013011544A1 (de) 2013-07-11 2015-01-15 Carl Zeiss Microscopy Gmbh Vorrichtung zum Ausbilden eines Immersionfilmes
DE102014003684B4 (de) 2014-03-14 2024-02-29 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zum Beenden der Immersion an einem Mikroskop
DE102015200927A1 (de) 2015-01-21 2016-07-21 Carl Zeiss Microscopy Gmbh Vorrichtung und Verfahren zur Ausbildung eines Immersionsmittelfilms
JP6534889B2 (ja) 2015-07-31 2019-06-26 オリンパス株式会社 倒立型顕微鏡および倒立型顕微鏡システム
JP6399037B2 (ja) 2016-05-18 2018-10-03 横河電機株式会社 対物レンズユニット及び液浸顕微鏡
US10310248B2 (en) 2016-08-18 2019-06-04 Olympus Corporation Microscope including a medium container containing an immersion medium in which a specimen container containing an immersion medium and a sample is immersed
DE202017000475U1 (de) 2017-01-28 2017-02-10 Carl Zeiss Microscopy Gmbh Vorrichtung zum Aufbringen eines Immersionsmediums
DE102017217389A1 (de) 2017-09-29 2019-04-04 Carl Zeiss Microscopy Gmbh Optische Linse zur Verwendung in einer Medienzuführungsvorrichtung sowie Objektiv, Medienzuführungsvorrichtung und Mikroskop
DE102018126527A1 (de) 2018-10-24 2020-04-30 Carl Zeiss Microscopy Gmbh Vorrichtung und Verfahren zum Aufbringen eines flüssigen Immersionsmittels in einen Spalt zwischen einem Mikroskopobjektiv und einer zu mikroskopierenden Probe
DE102018126526A1 (de) 2018-10-24 2020-04-30 Carl Zeiss Microscopy Gmbh Immersionsmittelaufbringung mittels einer Strahldüse
US10948707B2 (en) 2019-02-05 2021-03-16 Molecular Devices, Llc Liquid immersion microscope objective assembly and related systems and methods
WO2021158515A1 (en) 2020-02-04 2021-08-12 Idex Health & Science Llc Fluid immersion control for inverted microscopy
DE102020111716A1 (de) 2020-04-29 2021-11-04 Carl Zeiss Microscopy Gmbh Immersionsnachrüstset und verfahren zum nachrüsten eines immersionsobjektivs
DE102020111715A1 (de) 2020-04-29 2021-11-04 Carl Zeiss Microscopy Gmbh Immersionsobjektiv und verfahren zur immersionsmikroskopie
DE102020211702A1 (de) 2020-09-18 2022-03-24 Carl Zeiss Microscopy Gmbh Verfahren zum Überwachen einer Immersionsflüssigkeit in einem Mikroskop

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202049A (en) * 1961-11-29 1965-08-24 Bausch & Lomb Liquid dispenser for microscope objective
GB1235587A (en) * 1968-05-27 1971-06-16 Aerojet General Co Microscope and slide combination
US3648587A (en) * 1967-10-20 1972-03-14 Eastman Kodak Co Focus control for optical instruments
US3837731A (en) * 1973-06-22 1974-09-24 Corning Glass Works Oil dispenser for microscope objective
DD221563A1 (de) * 1983-09-14 1985-04-24 Mikroelektronik Zt Forsch Tech Immersionsobjektiv fuer die schrittweise projektionsabbildung einer maskenstruktur
JPS63282654A (ja) * 1987-05-15 1988-11-18 Hitachi Ltd 血液像自動分類装置用オイル供給装置
US5715082A (en) * 1995-10-19 1998-02-03 Geno Saccomanno Microscope attached slide dotting device
US6101029A (en) * 1997-10-23 2000-08-08 Leica Microsystems Wetzlar Gmbh Microscope condenser with an integrated catch pan

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE221563C (de)
JPS62643Y2 (de) * 1979-09-03 1987-01-09
JPH04340242A (ja) * 1991-04-03 1992-11-26 Hitachi Ltd 顕微鏡
JP3203698B2 (ja) * 1991-09-02 2001-08-27 株式会社ニコン 顕微鏡の液浸対物レンズ及び防水キャップ
US5719700A (en) * 1991-10-11 1998-02-17 L'oreal Apparatus for in vivo observation of the microscopic structure of the skin or of a similar tissue
JPH06208058A (ja) * 1993-01-13 1994-07-26 Olympus Optical Co Ltd 顕微鏡対物レンズ
JP2603486Y2 (ja) * 1993-12-20 2000-03-13 オリンパス光学工業株式会社 顕微鏡
DE19604363A1 (de) * 1995-02-23 1996-08-29 Zeiss Carl Fa Zusatzmodul zur ortsaufgelösten Fokusvermessung
US5870223A (en) * 1996-07-22 1999-02-09 Nikon Corporation Microscope system for liquid immersion observation
JP3465522B2 (ja) * 1997-03-19 2003-11-10 株式会社日立製作所 液体材料供給方法とその装置、並びに液体吐出用器具とその保持具
US6019472A (en) * 1997-05-12 2000-02-01 Koester; Charles J. Contact lens element for examination or treatment of ocular tissues
JPH11269317A (ja) * 1998-01-23 1999-10-05 Nikon Corp 液浸油
WO1999043994A1 (en) * 1998-02-26 1999-09-02 Lucid, Inc. Confocal microscope for facilitating cryosurgery of tissue
JP2000004871A (ja) * 1998-06-29 2000-01-11 Olympus Optical Co Ltd 培養容器、及び培養容器内の試料を観察する顕微鏡
DE19926476A1 (de) 1999-06-10 2000-12-14 Wavelight Laser Technologie Gm Vorrichtung für eine medizinische Behandlung des Auges mit Laserstrahlung
US6980293B1 (en) * 2002-06-11 2005-12-27 Olympus Optical Co., Ltd. Immersion medium supply apparatus, fluorescence spectrometry inspection apparatus, and culture microscope
US6867844B2 (en) * 2003-06-19 2005-03-15 Asml Holding N.V. Immersion photolithography system and method using microchannel nozzles
US6809794B1 (en) * 2003-06-27 2004-10-26 Asml Holding N.V. Immersion photolithography system and method using inverted wafer-projection optics interface
JP4436633B2 (ja) * 2003-08-19 2010-03-24 オリンパス株式会社 液浸対物レンズの排液装置及び給排液装置

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202049A (en) * 1961-11-29 1965-08-24 Bausch & Lomb Liquid dispenser for microscope objective
US3648587A (en) * 1967-10-20 1972-03-14 Eastman Kodak Co Focus control for optical instruments
GB1235587A (en) * 1968-05-27 1971-06-16 Aerojet General Co Microscope and slide combination
US3837731A (en) * 1973-06-22 1974-09-24 Corning Glass Works Oil dispenser for microscope objective
DD221563A1 (de) * 1983-09-14 1985-04-24 Mikroelektronik Zt Forsch Tech Immersionsobjektiv fuer die schrittweise projektionsabbildung einer maskenstruktur
JPS63282654A (ja) * 1987-05-15 1988-11-18 Hitachi Ltd 血液像自動分類装置用オイル供給装置
US5715082A (en) * 1995-10-19 1998-02-03 Geno Saccomanno Microscope attached slide dotting device
US6101029A (en) * 1997-10-23 2000-08-08 Leica Microsystems Wetzlar Gmbh Microscope condenser with an integrated catch pan

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 013, no. 102 (P - 841) 10 March 1989 (1989-03-10) *

Also Published As

Publication number Publication date
US20040263961A1 (en) 2004-12-30
ATE366947T1 (de) 2007-08-15
EP1386189A2 (de) 2004-02-04
DE50210460D1 (de) 2007-08-23
DK1386189T3 (da) 2007-11-05
DE10123027B4 (de) 2005-07-21
JP4443832B2 (ja) 2010-03-31
AU2002304621A1 (en) 2002-11-25
WO2002093232A2 (de) 2002-11-21
US7304793B2 (en) 2007-12-04
JP2004531765A (ja) 2004-10-14
EP1386189B1 (de) 2007-07-11
DE10123027A1 (de) 2002-11-21

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