WO2002097441A3 - Mammalian diabetes-mediating proteins - Google Patents

Mammalian diabetes-mediating proteins Download PDF

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Publication number
WO2002097441A3
WO2002097441A3 PCT/DK2002/000368 DK0200368W WO02097441A3 WO 2002097441 A3 WO2002097441 A3 WO 2002097441A3 DK 0200368 W DK0200368 W DK 0200368W WO 02097441 A3 WO02097441 A3 WO 02097441A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
mediating
mediating proteins
proteins
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2002/000368
Other languages
French (fr)
Other versions
WO2002097441A2 (en
Inventor
Peter Mose Larsen
Stephen J Fey
Allan E Karlsen
Thomas Sparre
Joern Nerup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern Denmark
Original Assignee
University of Southern Denmark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern Denmark filed Critical University of Southern Denmark
Priority to EP02742844A priority Critical patent/EP1421390A2/en
Priority to AU2002344252A priority patent/AU2002344252A1/en
Publication of WO2002097441A2 publication Critical patent/WO2002097441A2/en
Anticipated expiration legal-status Critical
Publication of WO2002097441A3 publication Critical patent/WO2002097441A3/en
Priority to US10/960,652 priority patent/US7279274B2/en
Priority to US11/869,546 priority patent/US20080145868A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable of altering the expression of a diabetes-mediating protein.
PCT/DK2002/000368 2001-05-29 2002-05-29 Mammalian diabetes-mediating proteins Ceased WO2002097441A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02742844A EP1421390A2 (en) 2001-05-29 2002-05-29 Mammalian diabetes-mediating proteins
AU2002344252A AU2002344252A1 (en) 2001-05-29 2002-05-29 Mammalian diabetes-mediating proteins
US10/960,652 US7279274B2 (en) 2001-05-29 2004-10-07 Method for diagnosing diabetes in a mammal
US11/869,546 US20080145868A1 (en) 2001-05-29 2007-10-09 Method for diagnosing diabetes in a mammal

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200100852 2001-05-29
DKPA200100852 2001-05-29
DKPA200200446 2002-03-22
DKPA200200446 2002-03-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10479530 A-371-Of-International 2002-05-29
US10/960,652 Continuation US7279274B2 (en) 2001-05-29 2004-10-07 Method for diagnosing diabetes in a mammal

Publications (2)

Publication Number Publication Date
WO2002097441A2 WO2002097441A2 (en) 2002-12-05
WO2002097441A3 true WO2002097441A3 (en) 2004-03-25

Family

ID=26069028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000368 Ceased WO2002097441A2 (en) 2001-05-29 2002-05-29 Mammalian diabetes-mediating proteins

Country Status (3)

Country Link
EP (1) EP1421390A2 (en)
AU (1) AU2002344252A1 (en)
WO (1) WO2002097441A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521193B2 (en) * 2002-03-20 2009-04-21 Pride Proteomics A/S Human diabetes-mediating proteins
FR2910025A1 (en) * 2006-12-19 2008-06-20 Biomerieux Sa METHOD FOR THE DIAGNOSIS OF DIABETES
EP2419536A4 (en) * 2009-04-14 2012-09-05 Merck Sharp & Dohme MICRO RNA AS A BIOMARKER FOR THE MOBILIZATION OF CELLS BETA OF PANCREATIC ISLANDS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019271A1 (en) * 1996-10-25 1998-05-07 Peter Mose Larsen Proteome analysis for characterization of up- and down-regulated proteins in biological samples
WO2001001130A1 (en) * 1999-06-25 2001-01-04 Proteome Sciences Plc METHODS AND COMPOSITIONS RELATING TO PANCREATIC ISLET AND β-CELL DYSFUNCTION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503676A (en) * 1999-06-01 2003-01-28 プロティオーム・サイエンシィズ・ピーエルシー Methods and compositions relating to insulin resistance disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998019271A1 (en) * 1996-10-25 1998-05-07 Peter Mose Larsen Proteome analysis for characterization of up- and down-regulated proteins in biological samples
WO2001001130A1 (en) * 1999-06-25 2001-01-04 Proteome Sciences Plc METHODS AND COMPOSITIONS RELATING TO PANCREATIC ISLET AND β-CELL DYSFUNCTION

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDERSEN H.U. ET AL.: "Interleukin-1beta induced changes in the protein expression of rat islets : a computerized database.", ELECTROPHORESIS, vol. 18, 1997, pages 2091 - 2103, XP002902695 *
CHRISTENSEN U.B. ET AL.: "Islet protein expression changes during diabetes development in islet syngrafts in BB-DP islet allografts.", AUTOIMMUNITY, vol. 32, 2000, pages 1 - 15, XP002902697 *
JOHN N.E. ET AL.: "Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.", DIABETES, vol. 49, November 2000 (2000-11-01), pages 1819 - 1829, XP002236131 *
MOSE LARSEN P. ET AL.: "Proteome analysis of interleukin-1beta-induced changes in protein expression in rat islets of Langerhans.", DIABETES, vol. 50, May 2001 (2001-05-01), pages 1056 - 1063, XP002236130 *
See also references of EP1421390A2 *

Also Published As

Publication number Publication date
EP1421390A2 (en) 2004-05-26
AU2002344252A1 (en) 2002-12-09
WO2002097441A2 (en) 2002-12-05

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