WO2002099413A3 - Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit - Google Patents

Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit Download PDF

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Publication number
WO2002099413A3
WO2002099413A3 PCT/DE2002/002067 DE0202067W WO02099413A3 WO 2002099413 A3 WO2002099413 A3 WO 2002099413A3 DE 0202067 W DE0202067 W DE 0202067W WO 02099413 A3 WO02099413 A3 WO 02099413A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
small quantities
dosing
evaporating small
drop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2002/002067
Other languages
English (en)
French (fr)
Other versions
WO2002099413A2 (de
Inventor
Udo Gellert
Arno Steckenborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Siemens Corp
Original Assignee
Siemens AG
Siemens Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG, Siemens Corp filed Critical Siemens AG
Priority to DE50214472T priority Critical patent/DE50214472D1/de
Priority to EP02748570A priority patent/EP1393057B1/de
Publication of WO2002099413A2 publication Critical patent/WO2002099413A2/de
Publication of WO2002099413A3 publication Critical patent/WO2002099413A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7246—Nebulising, aerosol formation or ionisation by pneumatic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/12—Preparation by evaporation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4022—Concentrating samples by thermal techniques; Phase changes
    • G01N2001/4027—Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/12—Preparation by evaporation
    • G01N2030/126—Preparation by evaporation evaporating sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)

Abstract

Um insbesondere für die Gaschromatographie eine automatisch durchführbare genaue Dosierung und gleichmäßige Verdampfung kleiner Mengen einer Flüssigkeit zu ermöglichen, ist ein Tropfengenerator (4) vorgesehen, der bei Anregung einen Flüssigkeitstropfen (8) entgegen einer Gasströmung (12) aus einem kalten Bereich (13) in einen beheizbaren Bereich (14) schießt.
PCT/DE2002/002067 2001-06-06 2002-06-06 Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit Ceased WO2002099413A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE50214472T DE50214472D1 (de) 2001-06-06 2002-06-06 Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit
EP02748570A EP1393057B1 (de) 2001-06-06 2002-06-06 Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001127353 DE10127353B4 (de) 2001-06-06 2001-06-06 Vorrichtung zum Dosieren und Verdampfen kleiner Mengen einer Flüssigkeit
DE10127353.3 2001-06-06

Publications (2)

Publication Number Publication Date
WO2002099413A2 WO2002099413A2 (de) 2002-12-12
WO2002099413A3 true WO2002099413A3 (de) 2003-10-09

Family

ID=7687317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/002067 Ceased WO2002099413A2 (de) 2001-06-06 2002-06-06 Vorrichtung zum dosieren und verdampfen kleiner mengen einer flüssigkeit

Country Status (3)

Country Link
EP (1) EP1393057B1 (de)
DE (2) DE10127353B4 (de)
WO (1) WO2002099413A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006030310B3 (de) * 2006-06-30 2008-02-07 Technotrans Ag Verfahren zur Analyse einer Flüssigkeit aus einem Flüssigkeitsstrom oder -vorrat, sowie Vorrichtung zur Durchführung dieses Verfahrens
DE102009001860A1 (de) * 2009-03-25 2010-09-30 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Verfahren zum Bestimmen einer Anzahl von Tropfen
DE102009059963B4 (de) 2009-12-22 2011-11-24 Siemens Aktiengesellschaft Flüssigdosier-Vorrichtung für einen Gasanalysator
CN109355178B (zh) * 2018-10-24 2022-04-26 四川大学华西医院 一种连续体积梯度毛细管数字pcr装置及其使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405344A (en) * 1980-09-30 1983-09-20 Carlo Erba Strumentazione S.P.A. Method and equipment for volumetrically controlled and reproducible introduction of small amounts of liquid samples into chromatographic analysis systems
US4958529A (en) * 1989-11-22 1990-09-25 Vestec Corporation Interface for coupling liquid chromatography to solid or gas phase detectors
US5306412A (en) * 1991-05-21 1994-04-26 Analytica Of Branford, Inc. Method and apparatus for improving electrospray ionization of solute species
US5359196A (en) * 1993-05-24 1994-10-25 Hewlett-Packard Company Mass spectrometry with gas counterflow for particle beam
EP1063523A2 (de) * 1999-06-11 2000-12-27 ThermoQuest Italia S.p.A. Ein Verfahren und Vorrichtung zur verdampfenden Injektion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5400665A (en) * 1991-09-25 1995-03-28 Cetac Technologies Incorporated Sample introduction system for inductively coupled plasma and other gas-phase, or particle, detectors utilizing an enclosed filter solvent removal system, and method of use
US5412208A (en) * 1994-01-13 1995-05-02 Mds Health Group Limited Ion spray with intersecting flow
DE19626428A1 (de) * 1996-07-01 1998-01-15 Heinzl Joachim Tröpfchenwolkenerzeuger
DE19938239B4 (de) * 1999-08-12 2004-11-25 Hirschmann, Karl-Heinz, Prof.Dr. Mikropumpe zum Fördern, Dosieren und Plazieren von Flüssigkeiten
DE10047341C1 (de) * 2000-09-25 2002-02-28 Siemens Ag Vorrichtung zum kontinuierlichen Verdampfen kleiner Mengen einer Flüssigkeit
DE10114947B4 (de) * 2001-03-27 2004-08-19 Gerstel Systemtechnik Gmbh & Co.Kg Verfahren und Vorrichtung zum Herstellen eines mindestens eine gasförmige Komponente enthaltenden Gasgemisches, insbesondere eines Kalibriergases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405344A (en) * 1980-09-30 1983-09-20 Carlo Erba Strumentazione S.P.A. Method and equipment for volumetrically controlled and reproducible introduction of small amounts of liquid samples into chromatographic analysis systems
US4958529A (en) * 1989-11-22 1990-09-25 Vestec Corporation Interface for coupling liquid chromatography to solid or gas phase detectors
US5306412A (en) * 1991-05-21 1994-04-26 Analytica Of Branford, Inc. Method and apparatus for improving electrospray ionization of solute species
US5359196A (en) * 1993-05-24 1994-10-25 Hewlett-Packard Company Mass spectrometry with gas counterflow for particle beam
EP1063523A2 (de) * 1999-06-11 2000-12-27 ThermoQuest Italia S.p.A. Ein Verfahren und Vorrichtung zur verdampfenden Injektion

Also Published As

Publication number Publication date
EP1393057B1 (de) 2010-06-02
DE50214472D1 (de) 2010-07-15
EP1393057A2 (de) 2004-03-03
DE10127353B4 (de) 2005-02-24
DE10127353A1 (de) 2002-12-19
WO2002099413A2 (de) 2002-12-12

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