WO2003008410A3 - Polypyrroles as agents for treating cancer, treating viral diseases and causing immunosuppression - Google Patents

Polypyrroles as agents for treating cancer, treating viral diseases and causing immunosuppression Download PDF

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Publication number
WO2003008410A3
WO2003008410A3 PCT/CA2002/001104 CA0201104W WO03008410A3 WO 2003008410 A3 WO2003008410 A3 WO 2003008410A3 CA 0201104 W CA0201104 W CA 0201104W WO 03008410 A3 WO03008410 A3 WO 03008410A3
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WO
WIPO (PCT)
Prior art keywords
treating
compositions
pyrrole
useful
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2002/001104
Other languages
French (fr)
Other versions
WO2003008410A2 (en
WO2003008410A8 (en
Inventor
Gordon C Shore
Madiraju S R Murthy
Roy A Johnson
Giorgio Attardo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gemin X Pharmaceuticals Canada Inc
Original Assignee
Gemin X Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemin X Biotechnologies Inc filed Critical Gemin X Biotechnologies Inc
Priority to DE60223571T priority Critical patent/DE60223571T2/en
Priority to EP02753971A priority patent/EP1427722B1/en
Priority to JP2003513969A priority patent/JP4303586B2/en
Priority to MXPA04000402A priority patent/MXPA04000402A/en
Priority to US10/484,652 priority patent/US7144912B2/en
Priority to CA002453636A priority patent/CA2453636A1/en
Publication of WO2003008410A2 publication Critical patent/WO2003008410A2/en
Publication of WO2003008410A3 publication Critical patent/WO2003008410A3/en
Anticipated expiration legal-status Critical
Publication of WO2003008410A8 publication Critical patent/WO2003008410A8/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel Pyrrole-Type compounds (I), compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for causing immunosuppression. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing an autoimmune disease.
PCT/CA2002/001104 2001-07-18 2002-07-18 Polypyrroles as agents for treating cancer, treating viral diseases and causing immunosuppression Ceased WO2003008410A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE60223571T DE60223571T2 (en) 2001-07-18 2002-07-18 COMPOUNDS OF PYRROLYPTIC, COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER, FOR THE TREATMENT OF VIRUS DISEASES AND FOR THE SUPPRESSION OF IMMUNE RESPONSE
EP02753971A EP1427722B1 (en) 2001-07-18 2002-07-18 Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression
JP2003513969A JP4303586B2 (en) 2001-07-18 2002-07-18 Pyrrole-type compounds, compositions, and methods for cancer treatment, viral disease treatment, and immunosuppression
MXPA04000402A MXPA04000402A (en) 2001-07-18 2002-07-18 Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression.
US10/484,652 US7144912B2 (en) 2001-07-18 2002-07-18 Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression
CA002453636A CA2453636A1 (en) 2001-07-18 2002-07-18 Polypyrroles as agents for treating cancer, treating viral diseases and causing immunosuppression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30587001P 2001-07-18 2001-07-18
US60/305,870 2001-07-18

Publications (3)

Publication Number Publication Date
WO2003008410A2 WO2003008410A2 (en) 2003-01-30
WO2003008410A3 true WO2003008410A3 (en) 2003-07-17
WO2003008410A8 WO2003008410A8 (en) 2004-04-01

Family

ID=23182716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001104 Ceased WO2003008410A2 (en) 2001-07-18 2002-07-18 Polypyrroles as agents for treating cancer, treating viral diseases and causing immunosuppression

Country Status (9)

Country Link
US (1) US7144912B2 (en)
EP (1) EP1427722B1 (en)
JP (1) JP4303586B2 (en)
AT (1) ATE378329T1 (en)
CA (1) CA2453636A1 (en)
DE (1) DE60223571T2 (en)
ES (1) ES2304135T3 (en)
MX (1) MXPA04000402A (en)
WO (1) WO2003008410A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2382377T3 (en) * 2003-05-30 2012-06-07 Gemin X Pharmaceuticals Canada Inc. Triheterocyclic compounds, compositions, and methods of treating cancer
WO2006069441A1 (en) * 2004-12-28 2006-07-06 Gemin X Biotechnologies Inc. Dipyrrole compounds, compositions, and methods for treating cancer or viral diseases
CN116869998A (en) * 2023-06-25 2023-10-13 南方海洋科学与工程广东省实验室(湛江) A kind of azole alkaloid, azole alkaloid composition and its application in preparing drugs with antiviral effect

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10120563A (en) * 1996-10-23 1998-05-12 Akou Kasei Kk Immunosuppressant

Family Cites Families (18)

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US2673855A (en) 1951-02-05 1954-03-30 Commercial Solvents Corp Prodigiosin gluconate
JPS55162758A (en) 1979-04-02 1980-12-18 Kissei Pharmaceut Co Ltd Novel phenylacetamide derivative
JPS61280429A (en) 1985-06-06 1986-12-11 Chugai Pharmaceut Co Ltd Immunosuppressant
JPH02250828A (en) 1989-03-23 1990-10-08 Nippon Kayaku Co Ltd New immunosuppressive agent
GB9326284D0 (en) 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation
JPH0930967A (en) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd Anti-ulcer agent
GB9603212D0 (en) 1996-02-15 1996-04-17 Pharmacia Spa Process for the preparation of 2,2'-bipyrrolyl-pyrromethane derivatives
GB9619706D0 (en) 1996-09-20 1996-11-06 Pharmacia Spa Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole comp und
JP3949198B2 (en) 1996-10-23 2007-07-25 赤穂化成株式会社 V-ATPase uncoupled H + pump inhibitor
GB9705035D0 (en) 1997-03-11 1997-04-30 Pharmacia & Upjohn Spa Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
KR100252197B1 (en) 1997-09-20 2000-04-15 박호군 Prodigiosin purified from culture broth of serratia marcescens strain for immun inhibition agent
JPH11209283A (en) 1997-10-01 1999-08-03 Ako Kasei Co Ltd Anticancer agent
GB9726130D0 (en) 1997-12-10 1998-02-11 Pharmacia & Upjohn Spa 2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I
GB9802745D0 (en) 1998-02-09 1998-04-08 Pharmacia & Upjohn Spa Benzyloxy prodigiosine compounds
US6359096B1 (en) * 1999-10-25 2002-03-19 Dow Corning Corporation Silicone resin compositions having good solution solubility and stability
US6407244B1 (en) * 2000-01-26 2002-06-18 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
KR20010081515A (en) 2000-02-15 2001-08-29 복성해 Novel use of prodigiosin for treating diabetes mellitus
US20030119894A1 (en) * 2001-07-20 2003-06-26 Gemin X Biotechnologies Inc. Methods for treatment of cancer or neoplastic disease and for inhibiting growth of cancer cells and neoplastic cells

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOGER D L ET AL: "TOTAL SYNTHESIS OF PRODIGIOSIN, PRODIGIOSENE AND DESMETHOXYPRODIGIOSIN: DIELS-ALDER REACTIONS OF HETERCYCLIC AZADIENES AND DEVELOPMENT OF AN EFFECTIVE PALLADIUM(II)-PROMOTED 2,2'-BIPYRROLE COUPLING PROCEDURE", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 53, no. 7, 1988, pages 1405 - 1415, XP002072029, ISSN: 0022-3263 *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 10 31 August 1998 (1998-08-31) *

Also Published As

Publication number Publication date
WO2003008410A2 (en) 2003-01-30
DE60223571D1 (en) 2007-12-27
DE60223571T2 (en) 2008-07-24
JP2004536861A (en) 2004-12-09
US20050049292A1 (en) 2005-03-03
EP1427722B1 (en) 2007-11-14
US7144912B2 (en) 2006-12-05
ES2304135T3 (en) 2008-09-16
EP1427722A2 (en) 2004-06-16
ATE378329T1 (en) 2007-11-15
CA2453636A1 (en) 2003-01-30
JP4303586B2 (en) 2009-07-29
WO2003008410A8 (en) 2004-04-01
MXPA04000402A (en) 2004-03-18

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