WO2003013536A3 - Methods for treatment of cancer using irinotecan based on ugt1a1 - Google Patents

Methods for treatment of cancer using irinotecan based on ugt1a1 Download PDF

Info

Publication number
WO2003013536A3
WO2003013536A3 PCT/EP2002/008217 EP0208217W WO03013536A3 WO 2003013536 A3 WO2003013536 A3 WO 2003013536A3 EP 0208217 W EP0208217 W EP 0208217W WO 03013536 A3 WO03013536 A3 WO 03013536A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
allele
present
wild type
polypeptide encoded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/008217
Other languages
French (fr)
Other versions
WO2003013536A9 (en
WO2003013536A2 (en
Inventor
Guenther Heinrich
Reinhold Kerb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epidauros Biotechnologie AG
Original Assignee
Epidauros Biotechnologie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epidauros Biotechnologie AG filed Critical Epidauros Biotechnologie AG
Priority to EP02764762A priority Critical patent/EP1408974A2/en
Priority to JP2003518545A priority patent/JP2005505526A/en
Priority to CA002454640A priority patent/CA2454640A1/en
Priority to AU2002328950A priority patent/AU2002328950A1/en
Publication of WO2003013536A2 publication Critical patent/WO2003013536A2/en
Publication of WO2003013536A3 publication Critical patent/WO2003013536A3/en
Anticipated expiration legal-status Critical
Publication of WO2003013536A9 publication Critical patent/WO2003013536A9/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to the use of irinotecan or a derivative thereof for the preparation of a pharmaceutical composition for treating colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer in a patient having a genotype with a varient allele which comprises a polynucleotide in accordance with the present invention. Preferably, a nucleotide deletion, addition and/or substitution comprised by said polynucleotide results in a altered expression of a variant allele compared to the corresponding wild type allele or an altered activity of the polypeptide encoded by the variant allele compared to the polypeptide encoded by the corresponding wild type allele. Finally, the present invention relates to a method for selecting a suitable therapy for a subject suffering from colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer.
PCT/EP2002/008217 2001-07-23 2002-07-23 Methods for treatment of cancer using irinotecan based on ugt1a1 Ceased WO2003013536A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02764762A EP1408974A2 (en) 2001-07-23 2002-07-23 Methods for treatment of cancer using irinotecan based on ugt1a1
JP2003518545A JP2005505526A (en) 2001-07-23 2002-07-23 Means and method for improving cancer treatment based on UGT1A1
CA002454640A CA2454640A1 (en) 2001-07-23 2002-07-23 Methods for treatment of cancer using irinotecan based on ugt1a1
AU2002328950A AU2002328950A1 (en) 2001-07-23 2002-07-23 Methods for treatment of cancer using irinotecan based on ugt1a1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01117608 2001-07-23
EP01117608.8 2001-07-23
EP02011710 2002-05-24
EP02011710.7 2002-05-24

Publications (3)

Publication Number Publication Date
WO2003013536A2 WO2003013536A2 (en) 2003-02-20
WO2003013536A3 true WO2003013536A3 (en) 2003-12-18
WO2003013536A9 WO2003013536A9 (en) 2004-04-29

Family

ID=26076655

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/EP2002/008218 Ceased WO2003013537A2 (en) 2001-07-23 2002-07-23 Irinotecan for treatment of cancer
PCT/EP2002/008200 Ceased WO2003013533A2 (en) 2001-07-23 2002-07-23 Methods for improved treatment of cancer with irinotecan based on mrp1
PCT/EP2002/008220 Ceased WO2003013535A2 (en) 2001-07-23 2002-07-23 Use of irinotecan for improved treatment of cancer based on mdr1
PCT/EP2002/008219 Ceased WO2003013534A2 (en) 2001-07-23 2002-07-23 Methods for the treatment of cancer with irinotecan based on cyp3a5
PCT/EP2002/008217 Ceased WO2003013536A2 (en) 2001-07-23 2002-07-23 Methods for treatment of cancer using irinotecan based on ugt1a1

Family Applications Before (4)

Application Number Title Priority Date Filing Date
PCT/EP2002/008218 Ceased WO2003013537A2 (en) 2001-07-23 2002-07-23 Irinotecan for treatment of cancer
PCT/EP2002/008200 Ceased WO2003013533A2 (en) 2001-07-23 2002-07-23 Methods for improved treatment of cancer with irinotecan based on mrp1
PCT/EP2002/008220 Ceased WO2003013535A2 (en) 2001-07-23 2002-07-23 Use of irinotecan for improved treatment of cancer based on mdr1
PCT/EP2002/008219 Ceased WO2003013534A2 (en) 2001-07-23 2002-07-23 Methods for the treatment of cancer with irinotecan based on cyp3a5

Country Status (6)

Country Link
US (1) US20050032724A1 (en)
EP (5) EP1408973A2 (en)
JP (5) JP2005501840A (en)
AU (5) AU2002328945A1 (en)
CA (5) CA2454627A1 (en)
WO (5) WO2003013537A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4096037B2 (en) * 2002-08-12 2008-06-04 国立大学法人滋賀医科大学 Prediction method of drug metabolic activity by mutation analysis of glucuronyltransferase gene
US6916627B2 (en) 2002-11-27 2005-07-12 St. Jude Children's Research Hospital ATM kinase compositions and methods
US7108992B2 (en) 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
ES2308208T3 (en) 2003-05-30 2008-12-01 University Of Chicago METHODS AND COMPOSITIONS TO PREACH IRINOTECHAN TOXICITY.
WO2005028645A1 (en) * 2003-09-24 2005-03-31 Kyushu Tlo Company, Limited SNPs IN 5’ REGULATORY REGION OF MDR1 GENE
BRPI0415079A (en) * 2003-10-06 2006-12-12 Novartis Ag biomarkers for prognosis of drug-induced diarrhea
JP2005245362A (en) * 2004-03-05 2005-09-15 Kyowa Medex Co Ltd Method for forecasting onset risk rate of lung cancer, and head and neck part carcinoma
US20070207149A1 (en) * 2004-04-27 2007-09-06 Wellstat Biologics Corporation Cancer treatment using viruses and camptothecins
ES2429041T3 (en) * 2004-06-18 2013-11-12 Genentech, Inc. Combination of a chemotherapeutic agent and an antagonist of a gene product to treat tumors
WO2006076288A2 (en) * 2005-01-11 2006-07-20 Five Prime Therapeutics, Inc. Dna constructs for long-term expression of intravascularly injected naked dna
JP2007060967A (en) * 2005-08-30 2007-03-15 Tokyo Institute Of Technology Genetic polymorphism detection method and drug screening method
US20090325156A1 (en) * 2005-11-10 2009-12-31 Government of the United States of America, as Represented by Secretary, Dept. of Human Services Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment
KR101107911B1 (en) * 2006-11-30 2012-01-25 아크레이 가부시키가이샤 Primer set for amplification of ugt1a1 gene, reagent for amplification of ugt1a1 gene comprising the same, and use of the same
WO2010099508A1 (en) * 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
WO2011031974A1 (en) * 2009-09-10 2011-03-17 Southern Research Institute Acridine analogs in the treatment of gliomas
EP2542155B1 (en) 2010-03-01 2015-11-04 TAU Therapeutics LLC Method for imaging a disease
JP2011250726A (en) * 2010-06-01 2011-12-15 Toyo Kohan Co Ltd Method for determining potential risk of side effect of irinotecan, and kit therefor
JP5945270B2 (en) 2010-07-20 2016-07-05 バヴァリアン・ノルディック・アクティーゼルスカブ Method for collecting expression products
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
KR102271848B1 (en) * 2013-11-01 2021-07-01 피트니 파마슈티컬스 피티와이 리미티드 Pharmaceutical combinations for the treatment of cancer
CA2962476C (en) * 2014-09-26 2023-09-26 Hi-Stem Ggmbh Novel methods for sub-typing and treating cancer
JP2016088919A (en) * 2014-11-11 2016-05-23 国立研究開発法人産業技術総合研究所 Anticancer agent comprising ivermectin or milbemycin d as active ingredient
CN107208163B (en) * 2015-02-17 2021-01-08 国立大学法人山口大学 Method for aiding in the prediction of the risk of occurrence of irinotecan side-effects
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
JP7042739B2 (en) 2015-08-20 2022-03-28 イプセン バイオファーム リミティド Combination therapy with liposomal irinotecan and PARP inhibitors for cancer treatment
TW202400181A (en) 2015-08-21 2024-01-01 英商益普生生物製藥有限公司 Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin
CN110402163A (en) 2016-11-02 2019-11-01 易普森生物制药有限公司 Use the combination therapy to treat gastric cancer for including liposome Irinotecan, oxaliplatin, 5 FU 5 fluorouracil (and formyl tetrahydrofolic acid)
CN109939115B (en) * 2019-05-06 2021-11-02 河南中医药大学 A compound suppository for treating radiation proctitis
US20230310478A1 (en) * 2020-09-02 2023-10-05 Ann And Robert H. Lurie Children's Hospital Of Chicago Methods and compositions for the treatment of pulmonary hypertension and cancer
CN114224875B (en) * 2021-11-04 2023-08-11 中南大学湘雅医院 New use of alcohol compound and antitumor drug

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037892A1 (en) * 1997-02-27 1998-09-03 Pharmacia & Upjohn Company Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea
WO2000037107A2 (en) * 1998-12-23 2000-06-29 G.D. Searle & Co. Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
WO2001049299A2 (en) * 2000-01-06 2001-07-12 Moore Malcolm J Prevention of ironotecan induced diarrhea with activated carbon
WO2001054678A2 (en) * 2000-01-26 2001-08-02 Schering Corporation Combination therapy for cancer
WO2001087306A2 (en) * 2000-05-15 2001-11-22 Celgene Corp. Compositions and methods for the treatment of colorectal cancer
WO2002028380A2 (en) * 2000-10-06 2002-04-11 Bristol-Myers Squibb Company Oral dosage forms for administration of the combination of tegafur, uracil, folinic acid, and irinotecan and method of using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037892A1 (en) * 1997-02-27 1998-09-03 Pharmacia & Upjohn Company Tamoxifen as a therapy to reduce irinotecan hydrochloride-induced diarrhea
WO2000037107A2 (en) * 1998-12-23 2000-06-29 G.D. Searle & Co. Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
WO2001049299A2 (en) * 2000-01-06 2001-07-12 Moore Malcolm J Prevention of ironotecan induced diarrhea with activated carbon
WO2001054678A2 (en) * 2000-01-26 2001-08-02 Schering Corporation Combination therapy for cancer
WO2001087306A2 (en) * 2000-05-15 2001-11-22 Celgene Corp. Compositions and methods for the treatment of colorectal cancer
WO2002028380A2 (en) * 2000-10-06 2002-04-11 Bristol-Myers Squibb Company Oral dosage forms for administration of the combination of tegafur, uracil, folinic acid, and irinotecan and method of using the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDO Y ET AL: "POLYMORPHISMS OF UDP-GLUCURONOSYLTRANSFERASE GENE AND IRINOTECAN TOXICITY: A PHARMACOGENETIC ANALYSIS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, 15 December 2000 (2000-12-15), pages 6921 - 6926, XP002909302, ISSN: 0008-5472 *
FRIEDMAN HENRY S ET AL: "Irinotecan therapy in adults with recurrent or progressive malignant glioma.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 5, May 1999 (1999-05-01), pages 1516 - 1525, XP008018482, ISSN: 0732-183X *
INNOCENTI F ET AL: "PHARMACOGENETICS OF ANTICANCER AGENTS: LESSONS FROM AMONAFIDE AND IRINOTECAN", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS., BALTIMORE, MD, US, vol. 29, no. 4, PART 2, April 2001 (2001-04-01), pages 596 - 600, XP001008560, ISSN: 0090-9556 *
IYER L ET AL: "GENETIC PREDISPOSITION TO THE METABOLISM OF IRINOTECAN (CPT-11) ROLE OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE ISOFORM 1A1 IN THE GLUCURONIDATION OF ITS ACTIVE METABOLITE (SN-38) IN HUMAN LIVER MICROSOMES", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 101, no. 4, 15 February 1998 (1998-02-15), pages 847 - 854, XP001120443, ISSN: 0021-9738 *

Also Published As

Publication number Publication date
JP2005508312A (en) 2005-03-31
EP1408975A2 (en) 2004-04-21
EP1408972A2 (en) 2004-04-21
WO2003013537A9 (en) 2004-04-29
WO2003013533A3 (en) 2003-10-09
AU2002328953A1 (en) 2003-02-24
CA2454637A1 (en) 2003-02-20
WO2003013535A2 (en) 2003-02-20
WO2003013534A9 (en) 2004-04-29
WO2003013535A9 (en) 2004-04-29
AU2002331290A1 (en) 2003-02-24
WO2003013537A3 (en) 2003-09-25
WO2003013537A2 (en) 2003-02-20
CA2454640A1 (en) 2003-02-20
US20050032724A1 (en) 2005-02-10
JP2005506971A (en) 2005-03-10
AU2002328952A1 (en) 2003-02-24
EP1438050A2 (en) 2004-07-21
CA2454627A1 (en) 2003-02-20
WO2003013534A3 (en) 2003-10-09
CA2454643A1 (en) 2003-02-20
AU2002328945A1 (en) 2003-02-24
WO2003013535A3 (en) 2003-09-25
WO2003013536A9 (en) 2004-04-29
JP2005501840A (en) 2005-01-20
JP2005504759A (en) 2005-02-17
EP1408974A2 (en) 2004-04-21
EP1408973A2 (en) 2004-04-21
WO2003013533A2 (en) 2003-02-20
WO2003013533A9 (en) 2004-04-29
JP2005505526A (en) 2005-02-24
CA2454648A1 (en) 2003-02-20
AU2002328950A1 (en) 2003-02-24
WO2003013534A2 (en) 2003-02-20
WO2003013536A2 (en) 2003-02-20

Similar Documents

Publication Publication Date Title
WO2003013536A3 (en) Methods for treatment of cancer using irinotecan based on ugt1a1
WO2004098377A3 (en) Methods and compositions for diagnosis and therapy of parkin-associated disorders
WO2000055180A3 (en) Human lung cancer associated gene sequences and polypeptides
IL147271A (en) Isolated peptide ligands that bind her2
HUP0203035A2 (en) Compositions and methods for therapy and diagnosis of prostate cancer
JP2005506971A5 (en)
JP2005505526A5 (en)
WO2004045507A3 (en) Anti-angiogenic uses of il-6 antagonists
WO2003076592A3 (en) Novel method for delivery and intracellular synthesis of sirna molecules
AU2002338852A1 (en) Genes and proteins for prevention, prediction, prognosis and therapy of cardiovascular disease
WO1998045328A3 (en) Compositions and methods for the treatment and diagnosis of breast cancer
ATE457359T1 (en) LPS-RESPONSIVE CHS1/BEIGE-LIKE ANCHOR GENE AND THERAPEUTIC USES THEREOF
WO2002088750A3 (en) Proteins, genes and their use for diagnosis and treatment of breast cancer
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
WO2001018046A3 (en) Ovarian tumor sequences and methods of use therefor
AU2003263712A1 (en) Peptide-based passive immunization therapy for treatment of atherosclerosis
WO2004066933A3 (en) Compositions and methods for treating cancer using igsf9 and liv-1
MXPA02000680A (en) Vgf polypeptides and methods of treating vgf-related disorders.
AU2932100A (en) Neurodegenerative disorder related gene
WO2004030607A3 (en) Peptide-based passive immunization therapy for treatment of atherosclerosis
WO2004087749A3 (en) Nontypeable haemophilus influenzae virulence factors
WO2003014703A3 (en) Nucleic acids, polypeptides, single nucleotide polymorphisms and methods of use thereof
HK1047113A1 (en) A DNA MOLECULE ENCODING A VARIANT α2B-ADRENOCEPTOR PROTEIN, AND USES THEREOF
WO2005011725A3 (en) Anti-angiogenetic agent and its use, in particular in cancer treatment
WO2003080800A3 (en) Prevention and treatment of disease using angiogenesis-and/or tumor antigens

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VN YU ZA ZM

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002764762

Country of ref document: EP

Ref document number: 2454640

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003518545

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2002764762

Country of ref document: EP

COP Corrected version of pamphlet

Free format text: FIGURES 4-28 CORRECTED (SEQUENCE LISTINGS ON ELECTRONIC MEDIUM)

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642