WO2003014336A1 - Process for preparing hematopoietic stem cells - Google Patents

Process for preparing hematopoietic stem cells Download PDF

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Publication number
WO2003014336A1
WO2003014336A1 PCT/JP2002/008087 JP0208087W WO03014336A1 WO 2003014336 A1 WO2003014336 A1 WO 2003014336A1 JP 0208087 W JP0208087 W JP 0208087W WO 03014336 A1 WO03014336 A1 WO 03014336A1
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
hematopoietic stem
preparing hematopoietic
preparing
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/008087
Other languages
English (en)
French (fr)
Inventor
Mitsuo Nishikawa
Masatake Osawa
Takahiko Ishiguro
Kiyoshi Yasukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Tosoh Corp
Original Assignee
Kirin Brewery Co Ltd
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd, Tosoh Corp filed Critical Kirin Brewery Co Ltd
Priority to US10/486,224 priority Critical patent/US20040235160A1/en
Priority to KR10-2004-7001887A priority patent/KR20040023724A/ko
Priority to JP2003519466A priority patent/JPWO2003014336A1/ja
Priority to EP02760579A priority patent/EP1424389A4/en
Publication of WO2003014336A1 publication Critical patent/WO2003014336A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/JP2002/008087 2001-08-07 2002-08-07 Process for preparing hematopoietic stem cells Ceased WO2003014336A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/486,224 US20040235160A1 (en) 2001-08-07 2002-08-07 Process for preparing hematopoietic stem cells
KR10-2004-7001887A KR20040023724A (ko) 2001-08-07 2002-08-07 조혈 간세포의 제조법
JP2003519466A JPWO2003014336A1 (ja) 2001-08-07 2002-08-07 造血幹細胞の製造法
EP02760579A EP1424389A4 (en) 2001-08-07 2002-08-07 METHOD FOR PRODUCING HEMATOPOETIC STEM CELLS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-239576 2001-08-07
JP2001239576 2001-08-07

Publications (1)

Publication Number Publication Date
WO2003014336A1 true WO2003014336A1 (en) 2003-02-20

Family

ID=19070304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008087 Ceased WO2003014336A1 (en) 2001-08-07 2002-08-07 Process for preparing hematopoietic stem cells

Country Status (6)

Country Link
US (1) US20040235160A1 (ja)
EP (1) EP1424389A4 (ja)
JP (1) JPWO2003014336A1 (ja)
KR (1) KR20040023724A (ja)
CN (1) CN1564864A (ja)
WO (1) WO2003014336A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006345726A (ja) * 2005-06-14 2006-12-28 Hamamatsu Univ School Of Medicine 脳腫瘍治療用発現ベクター
JP2007537752A (ja) * 2004-05-19 2007-12-27 ザ クリーブランド クリニック ファウンデーション 治療的応用法のための遺伝的に改変された細胞
WO2009148057A1 (ja) * 2008-06-02 2009-12-10 協和発酵キリン株式会社 血球細胞の初期化法
JPWO2010084970A1 (ja) * 2009-01-23 2012-07-19 国立大学法人大阪大学 標的細胞誘導用フィーダー細胞
US8513213B2 (en) 2009-08-28 2013-08-20 The Cleveland Clinic Foundation SDF-1 delivery for treating ischemic tissue
US8679477B2 (en) 2007-12-14 2014-03-25 The Cleveland Clinic Foundation Use of SDF-1 to mitigate scar formation
US9226978B2 (en) 2002-08-22 2016-01-05 The Cleveland Clinic Foundation Method of treating ischemic disorders

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KR100534215B1 (ko) * 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
KR100560340B1 (ko) * 2003-11-11 2006-03-14 한훈 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
JP2007536936A (ja) 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 幹細胞集団および使用方法
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
GB0503918D0 (en) * 2005-02-25 2005-04-06 Erasmus University Cell
KR101318965B1 (ko) * 2005-03-01 2013-10-17 타타 인스티튜트 오브 펀더멘탈 리서치 인공적인 골수-유사 환경을 형성하는 조성물 및 그의 용도
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
US20080286249A1 (en) * 2006-01-12 2008-11-20 Varney Timothy R Use of mesenchymal stem cells for treating genetic diseases and disorders
WO2009072625A1 (ja) * 2007-12-05 2009-06-11 Nissan Chemical Industries, Ltd. ヘテロ環化合物による造血幹細胞の増幅方法
KR101585276B1 (ko) * 2007-12-05 2016-01-13 닛산 가가쿠 고교 가부시키 가이샤 헤테로 고리 화합물에 의한 조혈 줄기 세포의 증폭 방법
JP5573159B2 (ja) * 2007-12-05 2014-08-20 日産化学工業株式会社 ヘテロ環化合物による造血幹細胞の増幅方法
CN102337268B (zh) * 2010-07-16 2013-04-24 北京大学 人类ctrp4基因、其编码的蛋白质及它们的应用
JP6283223B2 (ja) 2010-09-07 2018-02-21 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 多能性幹細胞を培養するための新規な方法および培養培地
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
HK1202581A1 (en) 2012-02-13 2015-10-02 Gamida-Cell Ltd. Mesenchymal stem cells conditioned medium and methods of generating and using the same
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
CN111879948A (zh) 2013-10-17 2020-11-03 综合医院公司 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
CN104745668A (zh) * 2014-01-15 2015-07-01 上海吉泉生物技术有限公司 一种新型造血干细胞检测试剂制备方法和应用
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US20170106021A1 (en) * 2014-05-12 2017-04-20 The General Hospital Corporation Compositions enriched for hox11+ stem cells and methods of preparing the same
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP6660635B2 (ja) * 2015-08-21 2020-03-11 株式会社ＡｄｉｐｏＳｅｅｄｓ 細胞表面におけるｃ−ＭＰＬ受容体の発現が促進された間葉系細胞の製造方法
US20190135929A1 (en) 2015-08-28 2019-05-09 The General Hospital Corporation Agonistic anti-tumor necrosis factor receptor 2 antibodies
EP3355914B1 (en) 2015-09-29 2024-03-06 The General Hospital Corporation A composition comprising bcg for reducing cholesterol.
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
WO2019169371A1 (en) * 2018-03-02 2019-09-06 University Of Florida Research Foundation, Incorporated Drug stabilized therapeutic transgenes delivered by adeno-associated virus expression
CN113302205B (zh) 2018-11-15 2024-12-06 综合医院公司 激动性肿瘤坏死因子受体超家族多肽
US20240043800A1 (en) 2021-02-05 2024-02-08 Sungkwang Medical Foundation Method for differentiating pluripotent stem cell-derived hemogenic endothelial cells into lymphoid lineage cells
EP4314244B1 (en) 2021-03-23 2025-07-23 Terumo BCT, Inc. Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668352A1 (en) * 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
WO1996015230A2 (en) * 1994-11-16 1996-05-23 Amgen Inc. Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
WO1999003980A1 (en) * 1997-07-16 1999-01-28 Kirin Beer Kabushiki Kaisha Agm-derived stroma cells
EP1094081A1 (en) * 1998-07-06 2001-04-25 Tosoh Corporation Fused protein with direct bond of il-6-receptor to il-6

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WO2003023018A2 (en) * 2001-09-12 2003-03-20 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use

Patent Citations (4)

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EP0668352A1 (en) * 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
WO1996015230A2 (en) * 1994-11-16 1996-05-23 Amgen Inc. Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
WO1999003980A1 (en) * 1997-07-16 1999-01-28 Kirin Beer Kabushiki Kaisha Agm-derived stroma cells
EP1094081A1 (en) * 1998-07-06 2001-04-25 Tosoh Corporation Fused protein with direct bond of il-6-receptor to il-6

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9226978B2 (en) 2002-08-22 2016-01-05 The Cleveland Clinic Foundation Method of treating ischemic disorders
JP2007537752A (ja) * 2004-05-19 2007-12-27 ザ クリーブランド クリニック ファウンデーション 治療的応用法のための遺伝的に改変された細胞
JP2006345726A (ja) * 2005-06-14 2006-12-28 Hamamatsu Univ School Of Medicine 脳腫瘍治療用発現ベクター
US8679477B2 (en) 2007-12-14 2014-03-25 The Cleveland Clinic Foundation Use of SDF-1 to mitigate scar formation
WO2009148057A1 (ja) * 2008-06-02 2009-12-10 協和発酵キリン株式会社 血球細胞の初期化法
JPWO2010084970A1 (ja) * 2009-01-23 2012-07-19 国立大学法人大阪大学 標的細胞誘導用フィーダー細胞
US8513213B2 (en) 2009-08-28 2013-08-20 The Cleveland Clinic Foundation SDF-1 delivery for treating ischemic tissue
US8513007B2 (en) 2009-08-28 2013-08-20 The Cleveland Clinic Foundation SDF-1 delivery for treating ischemic tissue
US8883756B2 (en) 2009-08-28 2014-11-11 Juventas Therapeutics, Inc. SDF-1 delivery for treating ischemic tissue
US9844581B2 (en) 2009-08-28 2017-12-19 The Cleveland Clinic SDF-1 delivery for treating ischemic tissue

Also Published As

Publication number Publication date
JPWO2003014336A1 (ja) 2004-11-25
KR20040023724A (ko) 2004-03-18
EP1424389A4 (en) 2004-08-25
EP1424389A1 (en) 2004-06-02
CN1564864A (zh) 2005-01-12
US20040235160A1 (en) 2004-11-25

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