WO2003018047A3 - Hdl for the treatment of stroke and other ischemic conditions - Google Patents

Hdl for the treatment of stroke and other ischemic conditions Download PDF

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Publication number
WO2003018047A3
WO2003018047A3 PCT/EP2002/009294 EP0209294W WO03018047A3 WO 2003018047 A3 WO2003018047 A3 WO 2003018047A3 EP 0209294 W EP0209294 W EP 0209294W WO 03018047 A3 WO03018047 A3 WO 03018047A3
Authority
WO
WIPO (PCT)
Prior art keywords
hdl
stroke
treatment
ischemic conditions
ischemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/009294
Other languages
French (fr)
Other versions
WO2003018047A2 (en
Inventor
Alphonse Hubsch
Markus G Lang
Peter G Lerch
Roberto Paterno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring AG
Original Assignee
ZLB Bioplasma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01120026A external-priority patent/EP1285662A1/en
Priority to EP02774525A priority Critical patent/EP1425031B8/en
Application filed by ZLB Bioplasma AG filed Critical ZLB Bioplasma AG
Priority to CA2457840A priority patent/CA2457840C/en
Priority to AU2002340825A priority patent/AU2002340825B2/en
Priority to JP2003522564A priority patent/JP4284177B2/en
Priority to HK04107205.2A priority patent/HK1064304B/en
Priority to DE60226881T priority patent/DE60226881D1/en
Priority to US10/487,224 priority patent/US20040266660A1/en
Priority to ES02774525T priority patent/ES2304452T3/en
Publication of WO2003018047A2 publication Critical patent/WO2003018047A2/en
Publication of WO2003018047A3 publication Critical patent/WO2003018047A3/en
Priority to ZA2004/01360A priority patent/ZA200401360B/en
Anticipated expiration legal-status Critical
Priority to US11/744,780 priority patent/US7491693B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a method for the prophylaxis and/or treatment of stroke and other ischemic injury, wherein HDL is administered to a subject in need thereof, particularly by intravenous infusion.
PCT/EP2002/009294 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions Ceased WO2003018047A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US10/487,224 US20040266660A1 (en) 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions
DE60226881T DE60226881D1 (en) 2001-08-20 2002-08-20 HIGH-DENSITY LIPOPROTEIN FOR THE TREATMENT OF IMPACT AND ISCHEMIA STATE
CA2457840A CA2457840C (en) 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions
AU2002340825A AU2002340825B2 (en) 2001-08-20 2002-08-20 HDL for the treatment of stroke and other ischemic conditions
JP2003522564A JP4284177B2 (en) 2001-08-20 2002-08-20 HDL for the treatment of stroke and other ischemic conditions
HK04107205.2A HK1064304B (en) 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions
ES02774525T ES2304452T3 (en) 2001-08-20 2002-08-20 AN HDL FOR THE TREATMENT OF AN ICTUS AND OTHER ISCHEMICAL CONDITIONS.
EP02774525A EP1425031B8 (en) 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions
ZA2004/01360A ZA200401360B (en) 2001-08-20 2004-02-19 Hdl for the treatment of stroke and other ischemic conditions
US11/744,780 US7491693B2 (en) 2001-08-20 2007-05-04 HDL for the treatment of stroke and other ischemic conditions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31360501P 2001-08-20 2001-08-20
US60/313,605 2001-08-20
EP01120026A EP1285662A1 (en) 2001-08-20 2001-08-20 Reconstituted HDL for the treatment of stroke and ischemic conditions
EP01120026.8 2001-08-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10487224 A-371-Of-International 2002-08-20
US11/744,780 Continuation US7491693B2 (en) 2001-08-20 2007-05-04 HDL for the treatment of stroke and other ischemic conditions

Publications (2)

Publication Number Publication Date
WO2003018047A2 WO2003018047A2 (en) 2003-03-06
WO2003018047A3 true WO2003018047A3 (en) 2004-01-29

Family

ID=26076691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009294 Ceased WO2003018047A2 (en) 2001-08-20 2002-08-20 Hdl for the treatment of stroke and other ischemic conditions

Country Status (10)

Country Link
US (2) US20040266660A1 (en)
EP (1) EP1425031B8 (en)
JP (1) JP4284177B2 (en)
AT (1) ATE396736T1 (en)
AU (1) AU2002340825B2 (en)
CA (1) CA2457840C (en)
DE (1) DE60226881D1 (en)
ES (1) ES2304452T3 (en)
WO (1) WO2003018047A2 (en)
ZA (1) ZA200401360B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0310100A (en) * 2002-05-17 2007-04-27 Esperion Therapeutics Inc methods to treat, prevent or reduce ischemic reperfusion injury in a tissue or organ, and to prevent or treat a condition associated with oxygen deprivation, followed by increased oxygen supply to a tissue or organ in need of it
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
WO2007000924A1 (en) * 2005-06-28 2007-01-04 Osaka University Pharmaceutical composition comprising substance capable of inhibiting or promoting progranulin activity and screening method for substance capable of inhibiting or promoting progranulin activity
US20070110751A1 (en) * 2005-10-25 2007-05-17 Maclellan Robb Compositions and methods for reducing infarct size
JP5601750B2 (en) * 2007-03-01 2014-10-08 シーエスエル、リミテッド Treatment of abnormal endothelial function in diabetic patients
AU2007200908B2 (en) * 2007-03-01 2012-08-16 Csl Limited Treatment of endothelial dysfunction in diabetic patients
WO2010151096A1 (en) 2009-06-25 2010-12-29 Tetra, Sia Therapeutic combinations of nicotinic acid and meldonium
JP2012532919A (en) * 2009-07-16 2012-12-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル HDL containing therapeutic factors and use in therapy
US12419839B2 (en) 2009-10-09 2025-09-23 Signablok, Inc. Methods and compositions for targeted delivery of protein fragments
US10525152B2 (en) 2009-10-09 2020-01-07 Signablok, Inc. Methods and compositions for targeted imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
US20120189612A1 (en) * 2011-01-25 2012-07-26 The Cleveland Clinic Foundation Compositions and methods for treating cancer while preventing or reducing cardiotoxicity and/or cardiomyopathy
HUE042314T2 (en) 2011-02-07 2019-06-28 Cerenis Therapeutics Holding Sa Lipoprotein complexes and their production and applications
AU2012236889A1 (en) * 2011-03-25 2013-05-09 The Trustees Of Columbia University In The City Of New York Pegylated human HDL particle and process for production thereof
EP2853259A1 (en) 2013-09-30 2015-04-01 Université Pierre et Marie Curie (Paris 6) Reconstituted high density lipoproteins composition and uses thereof
CA2947127A1 (en) 2014-05-02 2015-11-19 Cerenis Therapeutics Holding Sa Hdl therapy markers
ES2984286T3 (en) 2017-08-10 2024-10-29 Abionyx Pharma Sa Apomers
EP3668600B1 (en) 2017-08-10 2024-05-15 Abionyx Pharma SA Cargomers
WO2021191266A1 (en) 2020-03-25 2021-09-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolization of hdl for the treatment of lung infections
MX2022012969A (en) 2020-04-16 2022-11-09 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein- based complexes.
IL301769A (en) 2020-10-01 2023-05-01 Abionyx Pharma Sa Methods for treating eye diseases by using complexes based on lipid-binding proteins
US12599677B2 (en) 2020-10-05 2026-04-14 Northwestern University Targeted PH sensitive liposomes
MX2023012223A (en) 2021-04-15 2023-10-26 Abionyx Pharma Sa Use of lipid binding protein-based complexes in organ preservation solutions.
AU2023250345A1 (en) 2022-04-06 2024-11-14 Abionyx Pharma Sa Methods for treating eye diseases using lipid binding protein-based complexes
CN119317440A (en) 2022-04-06 2025-01-14 阿比奥尼克斯制药公司 Methods of treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes
JP2025519606A (en) 2022-06-10 2025-06-26 アビオニクス ファーマ エスエー Methods for treating acute conditions using lipid-binding protein-based conjugates - Patents.com
IL317448A (en) 2022-06-10 2025-02-01 Abionyx Pharma Sa Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes
IL322074A (en) 2023-01-13 2025-09-01 Abionyx Pharma Sa Lipid binding protein molecule therapy
WO2025093929A1 (en) 2023-10-31 2025-05-08 Abionyx Pharma Sa Lipid binding protein molecule therapy
WO2026008645A1 (en) 2024-07-02 2026-01-08 Institut National de la Santé et de la Recherche Médicale Aerosolization of apolipoprotein a1 nanoparticles enriched with alpha-1-antitrypsin for the treatment of pulmonary emphysema in patients suffering from alpha-1 antitrypsin deficiency

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780592A (en) * 1995-12-20 1998-07-14 Hoechst Aktiengesellschaft Compositions comprising lipoproteins and crotonamide derivatives
WO2001003705A1 (en) * 1999-07-08 2001-01-18 Tularik Inc. Compositions and methods for raising hdl cholesterol levels
WO2001013939A1 (en) * 1999-08-19 2001-03-01 Queen Mary And Westfield College High density lipoprotein against organ dysfunction following haemorrhagic shock

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ429399A0 (en) 1999-11-26 1999-12-23 Heart Research Institute, The Oxidized apolipoproteins and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780592A (en) * 1995-12-20 1998-07-14 Hoechst Aktiengesellschaft Compositions comprising lipoproteins and crotonamide derivatives
WO2001003705A1 (en) * 1999-07-08 2001-01-18 Tularik Inc. Compositions and methods for raising hdl cholesterol levels
WO2001013939A1 (en) * 1999-08-19 2001-03-01 Queen Mary And Westfield College High density lipoprotein against organ dysfunction following haemorrhagic shock

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COCKERILL G. W. ET AL.: "HIGH-DENSITY LIPOPROTEINS RESCUE END-STAGE ORGAN FAILURE IN A RAT MODEL OF HAEMORRHAGIC SHOCK", JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY, vol. 32, no. 3, 1 July 2000 (2000-07-01), pages 353, XP001073434 *
KLIMOV A N ET AL: "EFFECT OF HIGH DENSITY LIPOPROTEINS ON PERMEABILITY OF RABBIT AORTA TO LOW-DENSITY LIPOPROTEINS", ATHEROSCLEROSIS, vol. 55, no. 2, 1985, pages 217 - 224, XP001073581, ISSN: 0021-9150 *

Also Published As

Publication number Publication date
EP1425031B1 (en) 2008-05-28
ZA200401360B (en) 2005-08-31
ES2304452T3 (en) 2008-10-16
WO2003018047A2 (en) 2003-03-06
CA2457840C (en) 2011-10-11
CA2457840A1 (en) 2003-03-06
DE60226881D1 (en) 2008-07-10
JP2005501110A (en) 2005-01-13
US20080108550A1 (en) 2008-05-08
JP4284177B2 (en) 2009-06-24
ATE396736T1 (en) 2008-06-15
EP1425031A2 (en) 2004-06-09
EP1425031B8 (en) 2008-09-03
US20040266660A1 (en) 2004-12-30
AU2002340825B2 (en) 2007-07-05
HK1064304A1 (en) 2005-01-28
US7491693B2 (en) 2009-02-17

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