WO2003027151A1 - Recombinant anti-osteopontin antibody and use thereof - Google Patents

Recombinant anti-osteopontin antibody and use thereof Download PDF

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Publication number
WO2003027151A1
WO2003027151A1 PCT/JP2002/009868 JP0209868W WO03027151A1 WO 2003027151 A1 WO2003027151 A1 WO 2003027151A1 JP 0209868 W JP0209868 W JP 0209868W WO 03027151 A1 WO03027151 A1 WO 03027151A1
Authority
WO
WIPO (PCT)
Prior art keywords
rheumatism
osteopontin
antibody
remedy
inhibits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/009868
Other languages
English (en)
French (fr)
Inventor
Toshimitsu Uede
Shigeyuki Kon
Nobuchika Yamamoto
Hirofumi Higuchi
Masaharu Torikai
Yoshiyuki Tokieda
Toshihiro Nakashima
Hiroaki Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Immuno Biological Laboratories Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Immuno Biological Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR10-2004-7004266A priority Critical patent/KR20040048899A/ko
Priority to JP2003530737A priority patent/JPWO2003027151A1/ja
Priority to EP02768058A priority patent/EP1431310A4/en
Priority to HU0402049A priority patent/HUP0402049A3/hu
Priority to BR0213078-5A priority patent/BR0213078A/pt
Priority to HK06104204.8A priority patent/HK1084127B/xx
Priority to AU2002332290A priority patent/AU2002332290B2/en
Priority to NZ531818A priority patent/NZ531818A/en
Application filed by Fujisawa Pharmaceutical Co Ltd, Immuno Biological Laboratories Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to US10/489,866 priority patent/US7241873B2/en
Priority to CA002461529A priority patent/CA2461529A1/en
Priority to MXPA04002837A priority patent/MXPA04002837A/es
Publication of WO2003027151A1 publication Critical patent/WO2003027151A1/ja
Priority to NO20041225A priority patent/NO20041225L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/JP2002/009868 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof Ceased WO2003027151A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2002332290A AU2002332290B2 (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof
EP02768058A EP1431310A4 (en) 2001-09-25 2002-09-25 RECOMBINANT ANTI-OSTEOPONTIN ANTIBODY AND ITS USE
HU0402049A HUP0402049A3 (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof
BR0213078-5A BR0213078A (pt) 2001-09-25 2002-09-25 Anticorpo recombinante anti-osteopontina e uso do mesmo
HK06104204.8A HK1084127B (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof
NZ531818A NZ531818A (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use in the treatment of autoimmune diseases such as rheumatoid arthritis and osteoarthritis
US10/489,866 US7241873B2 (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof
KR10-2004-7004266A KR20040048899A (ko) 2001-09-25 2002-09-25 재조합 항-오스테오폰틴 항체 및 그의 용도
JP2003530737A JPWO2003027151A1 (ja) 2001-09-25 2002-09-25 組換え抗オステオポンチン抗体およびその用途
CA002461529A CA2461529A1 (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof
MXPA04002837A MXPA04002837A (es) 2001-09-25 2002-09-25 Anticuerpo de anti-osteopontina recombinante y uso del mismo.
NO20041225A NO20041225L (no) 2001-09-25 2004-03-23 Rekombinant anti-osteopontinantistoff og anvendelse derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-290700 2001-09-25
JP2001290700 2001-09-25

Publications (1)

Publication Number Publication Date
WO2003027151A1 true WO2003027151A1 (en) 2003-04-03

Family

ID=19112969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009868 Ceased WO2003027151A1 (en) 2001-09-25 2002-09-25 Recombinant anti-osteopontin antibody and use thereof

Country Status (15)

Country Link
US (1) US7241873B2 (ja)
EP (1) EP1431310A4 (ja)
JP (1) JPWO2003027151A1 (ja)
KR (1) KR20040048899A (ja)
CN (1) CN100352844C (ja)
AU (1) AU2002332290B2 (ja)
BR (1) BR0213078A (ja)
CA (1) CA2461529A1 (ja)
HU (1) HUP0402049A3 (ja)
MX (1) MXPA04002837A (ja)
NO (1) NO20041225L (ja)
NZ (1) NZ531818A (ja)
PL (1) PL369446A1 (ja)
RU (1) RU2305111C2 (ja)
WO (1) WO2003027151A1 (ja)

Cited By (14)

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WO2004103403A1 (ja) * 2003-05-23 2004-12-02 Immuno-Biological Laboratories Co., Ltd. 免疫担当細胞活性化阻害剤およびその用途
JP2007524101A (ja) * 2004-02-27 2007-08-23 エフ．ホフマン−ラ　ロシュ　アーゲー リウマチ因子およびインターロイキン６の測定による慢性関節リウマチの評価方法
JP2007524100A (ja) * 2004-02-27 2007-08-23 エフ．ホフマン−ラ　ロシュ　アーゲー 抗ｃｃｐおよび血清アミロイドａの測定による慢性関節リウマチの評価方法
WO2007139164A1 (ja) 2006-05-31 2007-12-06 Astellas Pharma Inc. ヒト化抗ヒトオステオポンチン抗体
WO2008050907A1 (fr) * 2006-10-26 2008-05-02 Gene Techno Science Co., Ltd. Anticorps dirigé contre rgd dans une séquence d'acides aminés d'une protéine de matrice extracellulaire et procédé de fabrication et utilisation de celui-ci
JP2008539700A (ja) * 2005-05-04 2008-11-20 オーストラリアン ステム セル センター リミテッド 系統拘束された造血幹細胞の選択、培養および作出法
WO2009088064A1 (ja) 2008-01-11 2009-07-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute 改良型ヒト化抗ヒトα９インテグリン抗体
WO2009131256A1 (en) * 2008-04-24 2009-10-29 Gene Techno Science Co., Ltd. Humanized antibodies specific for amino acid sequence rgd of an extracellular matrix protein and the uses thereof
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US7906625B2 (en) * 2005-01-24 2011-03-15 Amgen Inc. Humanized anti-amyloid antibody
WO2011037271A1 (en) * 2009-09-24 2011-03-31 Gene Techno Science Co., Ltd. Humanized antibodies specific for amino acid sequence rgd of an extracellular matrix protein and the uses thereof
EP2369348A1 (en) * 2003-11-07 2011-09-28 Ciphergen Biosystems, Inc. Biomarkers for Alzheimer's disease
JP2014223079A (ja) * 2007-07-13 2014-12-04 バク アイピー ベスローテン フェンノートシャップ 哺乳動物ＩｇＧと結合する単一ドメイン抗原結合タンパク質
JP2022543657A (ja) * 2019-08-09 2022-10-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー オステオポンチンに対する治療用抗体

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KR20180008921A (ko) 2012-11-01 2018-01-24 애브비 인코포레이티드 항-ｖｅｇｆ／ｄｌｌ4 이원 가변 도메인 면역글로불린 및 이의 용도
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Cited By (33)

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EP1637159A4 (en) * 2003-05-23 2009-01-21 Immuno Biological Lab Co Ltd IMMUNOCOMPETENT CELL ACTIVATION INHIBITOR AND USE THEREOF
WO2004103403A1 (ja) * 2003-05-23 2004-12-02 Immuno-Biological Laboratories Co., Ltd. 免疫担当細胞活性化阻害剤およびその用途
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RU2305111C2 (ru) 2007-08-27
MXPA04002837A (es) 2005-11-04
US20060002923A1 (en) 2006-01-05
CN1688604A (zh) 2005-10-26
RU2004112540A (ru) 2005-04-20
NO20041225L (no) 2004-05-25
BR0213078A (pt) 2004-11-23
CA2461529A1 (en) 2003-04-03
JPWO2003027151A1 (ja) 2005-01-06
EP1431310A4 (en) 2005-03-23
PL369446A1 (en) 2005-04-18
HUP0402049A2 (hu) 2005-01-28
KR20040048899A (ko) 2004-06-10
HK1084127A1 (zh) 2006-07-21
US7241873B2 (en) 2007-07-10
NZ531818A (en) 2005-10-28

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