WO2003033475A1 - Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones - Google Patents
Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones Download PDFInfo
- Publication number
- WO2003033475A1 WO2003033475A1 PCT/EP2002/011280 EP0211280W WO03033475A1 WO 2003033475 A1 WO2003033475 A1 WO 2003033475A1 EP 0211280 W EP0211280 W EP 0211280W WO 03033475 A1 WO03033475 A1 WO 03033475A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- malondiimidate
- propan
- preparation
- pyrimidin
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Definitions
- the invention relates to a process for the preparation of l-(pyrimidin-2-yl)propan-2-ones of the general formula
- R is in each case a -io-alkyl group, a C 3 _ 8 -cycloal yl group, an allyl group or an aryl-d- -al yl group.
- C ⁇ o-Alkyl groups are understood here and below as meaning all linear or branched primary, secondary or tertiary alkyl groups having 1 to 10 carbon atoms, thus, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, .sec-butyl, tert-butyl, pentyl, isopentyl, tert-pentyl, neopentyl, hexyl, heptyl, octyl, nonyl or decyl.
- C 3 - 8 -Cycloalkyl are to be understood as meaning, in particular, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
- Aryl-Ci- -alkyl groups are the groups composed of an aryl group and an alkyl group having 1 to 4 carbon atoms, aryl groups being understood as meaning, in particular, phenyl or naphthyl groups.
- the aryl groups may also be substituted by one or more d- -alkyl groups,
- Ci- -alkoxy groups or halogen atoms are, in particular, benzyl, 1-phenylethyl, 2-phenylethyl and 3-phenylpropyl.
- the object is achieved by the process of Claim 1. It has been found that the malondiimidates, which are readily available from malodinitrile and the corresponding alcohols (DE-A-2426 913, EP-A-0 024 200), of the general formula
- the malondiimidates (H) can either be used without a diluent (as free base) or else be formed in situ from a corresponding salt and a base.
- the latter may be an inorganic base or an organic base such as a tertiary amine.
- the malondiimidates are preferably used without a diluent. For this, they can, for example, be extracted with a solvent of low polarity, such as dichloromethane or diethyl ether, from a neutralized solution of one of their salts and be isolated by evaporating the solvent (EP-A-0 024200).
- the salts of the malondiimidates (II) used are preferably the dihydrochlorides.
- the process according to the invention is advantageously carried out in a solvent which is essentially inert under the reaction conditions, such as, for example, aromatic hydrocarbons like toluene or xylene or ketones like acetone.
- the reaction temperature is advantageously 50 to 150 °C for the aromatic solvents or 0 to 100 °C for ketone solvents.
- Dimethyl malondiimidate dihydrochloride (90.0 kg, 443 mol, 1 eq) and acetone (330 1) were placed under nitrogen in a 630 1 stirred vessel. The suspension was cooled to 0 to 5 °C and triethylamine (98.7 kg, 975 mol, 2.2 eq) was added over the course of 120 min at 0 to 5 °C. The suspension was stirred for another 30 min at 0 to 5 °C and then warmed to 25 °C. Diketene (44.7 kg, 531 mol, 1.2 eq) was added within 90 min at ca. 25 °C.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones of general formula (I), in which R is in each case a C1-10-alkyl group, a C3-8-cycloalkyl group, an alkyl group or an aryl-C1-4-alkyl group. For this, a malondiimidate of the general formula (II), in which R has the meaning given above, is reacted with diketene. The compounds which can be prepared according to the invention are intermediates for the synthesis of agrochemical active ingredients.
Description
Process for the preparation of l-(pyrimidin-2-yl)propan-2-ones
The invention relates to a process for the preparation of l-(pyrimidin-2-yl)propan-2-ones of the general formula
in which R is in each case a -io-alkyl group, a C3_8-cycloal yl group, an allyl group or an aryl-d- -al yl group. C^o-Alkyl groups are understood here and below as meaning all linear or branched primary, secondary or tertiary alkyl groups having 1 to 10 carbon atoms, thus, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, .sec-butyl, tert-butyl, pentyl, isopentyl, tert-pentyl, neopentyl, hexyl, heptyl, octyl, nonyl or decyl.
C3-8-Cycloalkyl are to be understood as meaning, in particular, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.
Aryl-Ci- -alkyl groups are the groups composed of an aryl group and an alkyl group having 1 to 4 carbon atoms, aryl groups being understood as meaning, in particular, phenyl or naphthyl groups. The aryl groups may also be substituted by one or more d- -alkyl groups,
Ci- -alkoxy groups or halogen atoms. Examples of aryl-C1_ -alkyl groups are, in particular, benzyl, 1-phenylethyl, 2-phenylethyl and 3-phenylpropyl.
Compounds of the formula I, in particular the dimethoxy compound (R = Me) are potential intermediates in the synthesis of agrochemical active ingredients.
Syntheses of these compounds have hitherto not been described in the prior art.
It was an object of the present invention to provide a preparation process which is simple and suitable for an industrial scale.
According to the invention, the object is achieved by the process of Claim 1. It has been found that the malondiimidates, which are readily available from malodinitrile and the corresponding alcohols (DE-A-2426 913, EP-A-0 024 200), of the general formula
in which R has the meaning given above, react with diketene of the formula
directly and in a good yield to give the desired compounds (I).
The malondiimidates (H) can either be used without a diluent (as free base) or else be formed in situ from a corresponding salt and a base. The latter may be an inorganic base or an organic base such as a tertiary amine. The malondiimidates are preferably used without a diluent. For this, they can, for example, be extracted with a solvent of low polarity, such as dichloromethane or diethyl ether, from a neutralized solution of one of their salts and be isolated by evaporating the solvent (EP-A-0 024200).
The salts of the malondiimidates (II) used are preferably the dihydrochlorides.
The process according to the invention is preferably used for the preparation of l-(4,6-dimethoxypyrimidin-2-yl)propan-2-one, by using dimethyl malondiimidate (R = Me) as malondiimidate (II).
The process according to the invention is advantageously carried out in a solvent which is essentially inert under the reaction conditions, such as, for example, aromatic hydrocarbons like toluene or xylene or ketones like acetone. The reaction temperature is advantageously 50 to 150 °C for the aromatic solvents or 0 to 100 °C for ketone solvents.
The examples below illustrate how the process according to the invention is carried out, but are not intended to impose any limitation.
Example 1 l-(4,6-Dimethoxypyrimidin-2-yl)propan-2-one
A solution of dimethyl malondiimidate (80 g, 0.61 mol) in toluene (240 ml) was heated to 80 °C. Diketene (103.44 g, 1.23 mmol) was added over the course of 2 h, the temperature
being held at 80 °C. The reaction mixture was held at 80 °C for a further 2 h and then cooled to room temperature. Following the addition of water (200 ml), it was stirred for 0.5 h and then the phases were separated. The aqueous phase was extracted with toluene (590 ml) and the combined organic phases were dried over sodium sulfate. Filtration and evaporation of the solvent in vacuo gave 117.3 g of crude product in the form of a reddish liquid. The crude product was purified by distillation on a 20 cm Nigreux column.
Yield: 61.29 g, purity (GC) >98% (55% of theory, based on dimethyl malondiimidate). B.p.: 90 °C/0.4 mbar 1H ΝMR (CDC13): δ = 5.92 (s, 1H); 3.91 (s, 6H); 3.86 (s, 2H); 2.27 (s, 3H). In addition, the spectrum also has the signals of the enol form.
Example 2 l-(4,6-Dimethoxypyrimidin-2-yl)propan-2-one
Dimethyl malondiimidate dihydrochloride (90.0 kg, 443 mol, 1 eq) and acetone (330 1) were placed under nitrogen in a 630 1 stirred vessel. The suspension was cooled to 0 to 5 °C and triethylamine (98.7 kg, 975 mol, 2.2 eq) was added over the course of 120 min at 0 to 5 °C. The suspension was stirred for another 30 min at 0 to 5 °C and then warmed to 25 °C. Diketene (44.7 kg, 531 mol, 1.2 eq) was added within 90 min at ca. 25 °C. After the addition the mixture was heated to 30 °C and after 2 h reaction time at the same temperature the excess diketene was destroyed by adding methanol (15 1) and 4-(dimethylamino)pyridine (0.5 kg). The precipitated triethylammonium chloride (ca. 160 kg) was filtered off and the filter cake was washed with acetone (2x113 1). The combined filtrates were concentrated by distilling off acetone (450-500 1) at ambient pressure. The residual solution was cooled to 40 °C and water (198 1) was added. In order to remove the acetone completely, the solution was subjected to another distillation at 100 to 200 mbar until a head temperature of ca. 45 °C had been reached (after ca. 5 h) and ca. 150-1801 of distillate had been obtained. The residue was cooled to 30 °C, seeded by adding l-(4,6-dimethoxypyrimidin-2-yl)propan-2-one crystals (0.6 kg) and subsequently cooled to 0 °C within 60 min. After another 60 min at 0 °C the product was filtered, washed with cold water (135 1) and dried at 35 °C/<100 mbar (16 h). Yield: 49 kg (55%) slightly yellowish solid, purity >95%.
Claims
1. Process for the preparation of l-(pyrimidin-2-yl)propan-2-ones of the general formula
in which R is in each case a d-io-alkyl group, a C3_8-cycloalkyl group, an allyl group or an aryl-d- -alkyl group, characterized in that a malondiimidate of the general formula
in which R has the meaning given above, is reacted with diketene of the formula
2. Process according to Claim 1, characterized in that the malondiimidate (H) is prepared in situ from a corresponding salt and a base.
3. Process according to Claim 2, characterized in that the salt of the malondiimidate (IT) used is the dihydrochloride.
4. Process according to Claim 2 or 3, characterized in that the base is a tertiary amine.
5. Process according to one of Claims 1 to 4, characterized in that the malondiimidate (II) used is dimethyl malondiimidate.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE60225578T DE60225578T2 (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of 1- (pyrimidin-2-yl) propan-2-ones |
| JP2003536215A JP4353801B2 (en) | 2001-10-15 | 2002-10-09 | Process for producing 1- (pyrimidin-2-yl) propan-2-ones |
| EP02777297A EP1440063B1 (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones |
| US10/491,281 US7141670B2 (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones |
| HU0401844A HU228816B1 (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of-1(pyrimidin-2-yl)propan-2-ones |
| HK05102899.3A HK1070353B (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01124587.5 | 2001-10-15 | ||
| EP01124587 | 2001-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003033475A1 true WO2003033475A1 (en) | 2003-04-24 |
Family
ID=8178969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2002/011280 Ceased WO2003033475A1 (en) | 2001-10-15 | 2002-10-09 | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7141670B2 (en) |
| EP (1) | EP1440063B1 (en) |
| JP (1) | JP4353801B2 (en) |
| KR (1) | KR100854612B1 (en) |
| CN (1) | CN1262544C (en) |
| AT (1) | ATE388942T1 (en) |
| DE (1) | DE60225578T2 (en) |
| ES (1) | ES2303555T3 (en) |
| HU (1) | HU228816B1 (en) |
| RU (1) | RU2325380C2 (en) |
| WO (1) | WO2003033475A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935793B (en) * | 2000-10-17 | 2010-06-23 | 庵原化学工业株式会社 | Process for producing substituted aniline compound |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2705562A1 (en) * | 1977-02-10 | 1978-08-17 | Basf Ag | METHOD FOR MANUFACTURING PYRIDONS |
| US4874873A (en) * | 1988-12-27 | 1989-10-17 | Ici Americas Inc. | Process for the preparation of 3-acylpyrrolidones |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2426913A1 (en) | 1974-06-04 | 1975-12-11 | Ferring Arzneimittel Gmbh | Malonic or succinic acid di(imido ester) prodn. - by reacting dicarboxylic acid dinitriles with anhydrous lower alcohols |
| AR225772A1 (en) | 1979-08-14 | 1982-04-30 | Du Pont | NEW 3-AMINO-3-ALCOXI-N-CIANO-2-ALKYL PROPENIMIDATE AND PROCEDURES FOR ITS PREPARATION AND OF PYRIMIDINES STARTING FROM THOSE |
-
2002
- 2002-10-09 AT AT02777297T patent/ATE388942T1/en active
- 2002-10-09 KR KR1020047005534A patent/KR100854612B1/en not_active Expired - Fee Related
- 2002-10-09 WO PCT/EP2002/011280 patent/WO2003033475A1/en not_active Ceased
- 2002-10-09 DE DE60225578T patent/DE60225578T2/en not_active Expired - Lifetime
- 2002-10-09 EP EP02777297A patent/EP1440063B1/en not_active Expired - Lifetime
- 2002-10-09 JP JP2003536215A patent/JP4353801B2/en not_active Expired - Fee Related
- 2002-10-09 US US10/491,281 patent/US7141670B2/en not_active Expired - Fee Related
- 2002-10-09 CN CNB028202295A patent/CN1262544C/en not_active Expired - Fee Related
- 2002-10-09 ES ES02777297T patent/ES2303555T3/en not_active Expired - Lifetime
- 2002-10-09 RU RU2004115022/04A patent/RU2325380C2/en not_active IP Right Cessation
- 2002-10-09 HU HU0401844A patent/HU228816B1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2705562A1 (en) * | 1977-02-10 | 1978-08-17 | Basf Ag | METHOD FOR MANUFACTURING PYRIDONS |
| US4874873A (en) * | 1988-12-27 | 1989-10-17 | Ici Americas Inc. | Process for the preparation of 3-acylpyrrolidones |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1568315A (en) | 2005-01-19 |
| HK1070353A1 (en) | 2005-06-17 |
| KR20050034613A (en) | 2005-04-14 |
| DE60225578T2 (en) | 2009-05-14 |
| ATE388942T1 (en) | 2008-03-15 |
| HUP0401844A3 (en) | 2005-11-28 |
| JP4353801B2 (en) | 2009-10-28 |
| RU2325380C2 (en) | 2008-05-27 |
| JP2005505623A (en) | 2005-02-24 |
| HUP0401844A2 (en) | 2005-01-28 |
| CN1262544C (en) | 2006-07-05 |
| KR100854612B1 (en) | 2008-08-27 |
| US7141670B2 (en) | 2006-11-28 |
| EP1440063A1 (en) | 2004-07-28 |
| DE60225578D1 (en) | 2008-04-24 |
| RU2004115022A (en) | 2005-10-27 |
| HU228816B1 (en) | 2013-05-28 |
| US20040242877A1 (en) | 2004-12-02 |
| ES2303555T3 (en) | 2008-08-16 |
| EP1440063B1 (en) | 2008-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1254883B1 (en) | Process for producing substituted 1,1,1-trifluoro-3-butene-2-ones | |
| US7141670B2 (en) | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones | |
| US5266697A (en) | Process for the production of 2-substituted 4,6-dialkoxypyrimidines | |
| US5442076A (en) | Process for the production of 2-substituted-5-chlorimidazole-4-carbaldehydes | |
| HU195773B (en) | Process for preparing alkyl esters of 4-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid | |
| EP0234514A2 (en) | Pyrazolopyrimidines, intermediates thereof and processes for the preparation of them | |
| US6784296B2 (en) | Preparation of terpyridines | |
| US5162529A (en) | Process for the preparation of 5-hydroxy-3,4,5,6-tetrahydro-pyrimidine derivatives | |
| EP1440064B1 (en) | Process for the preparation of (pyrimidin-2-yl)methyl ketones | |
| KR20090116753A (en) | Novel method for preparing [3,4-d] pyridazin-7 (6H) -one with 3-methyl-4-phenylisoxazolo | |
| EP0066440B1 (en) | Chemical process | |
| US5208337A (en) | Process for the preparation of aminopyrimidines | |
| HK1070353B (en) | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones | |
| US4536574A (en) | Preparation of 2-alkylthiomethyl-4-hydroxypyrimidines | |
| US4892956A (en) | 5-cyano-4,5-dihydro-3,4-dicarboxypyrazole derivatives | |
| US5262402A (en) | Process for preparing pyrimidinetrione derivatives | |
| US4924001A (en) | Process for preparing 5-cyano-4, 5-dihydro-3,4-dicarboxypyrazole derivatives | |
| EP0484702A1 (en) | 1-Azoniabicyclo[3.3.0]oct-1(5)-ene salt derivatives and process for the preparation of the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
| WWE | Wipo information: entry into national phase |
Ref document number: 2002777297 Country of ref document: EP |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 10491281 Country of ref document: US |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 760/CHENP/2004 Country of ref document: IN Ref document number: 20028202295 Country of ref document: CN |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 2003536215 Country of ref document: JP Ref document number: 1020047005534 Country of ref document: KR |
|
| WWP | Wipo information: published in national office |
Ref document number: 2002777297 Country of ref document: EP |
|
| WWG | Wipo information: grant in national office |
Ref document number: 2002777297 Country of ref document: EP |