WO2003041496A1 - Transgenic animal - Google Patents

Transgenic animal Download PDF

Info

Publication number
WO2003041496A1
WO2003041496A1 PCT/JP2002/011843 JP0211843W WO03041496A1 WO 2003041496 A1 WO2003041496 A1 WO 2003041496A1 JP 0211843 W JP0211843 W JP 0211843W WO 03041496 A1 WO03041496 A1 WO 03041496A1
Authority
WO
WIPO (PCT)
Prior art keywords
substance
memory
screening
learning
improving learning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/011843
Other languages
English (en)
French (fr)
Inventor
Akira Miyake
Yukihiro Nakamura
Jianwei Ni
Shinobu Mochizuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to EP02781760A priority Critical patent/EP1444889A4/en
Priority to US10/493,943 priority patent/US7094948B2/en
Priority to CA002465337A priority patent/CA2465337A1/en
Priority to JP2003543396A priority patent/JP3679403B2/ja
Publication of WO2003041496A1 publication Critical patent/WO2003041496A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Husbandry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/JP2002/011843 2001-11-14 2002-11-13 Transgenic animal Ceased WO2003041496A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02781760A EP1444889A4 (en) 2001-11-14 2002-11-13 TRANSGENE ANIMAL
US10/493,943 US7094948B2 (en) 2001-11-14 2002-11-13 Transgenic animals
CA002465337A CA2465337A1 (en) 2001-11-14 2002-11-13 Transgenic animal
JP2003543396A JP3679403B2 (ja) 2001-11-14 2002-11-13 トランスジェニック動物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-349288 2001-11-14
JP2001349288 2001-11-14

Publications (1)

Publication Number Publication Date
WO2003041496A1 true WO2003041496A1 (en) 2003-05-22

Family

ID=19161979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/011843 Ceased WO2003041496A1 (en) 2001-11-14 2002-11-13 Transgenic animal

Country Status (5)

Country Link
US (1) US7094948B2 (ja)
EP (1) EP1444889A4 (ja)
JP (1) JP3679403B2 (ja)
CA (1) CA2465337A1 (ja)
WO (1) WO2003041496A1 (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100875362B1 (ko) * 2002-02-05 2008-12-22 아스텔라스세이야쿠 가부시키가이샤 2,4,6-트리아미노-1,3,5-트리아진 유도체
EP1919497B1 (en) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Light-activated cation channel and uses thereof
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
DE102006021257A1 (de) * 2006-04-28 2007-11-08 Eberhard-Karls-Universität Tübingen Universitätsklinikum Nachweis von transgener DNA (t DNA)
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
MY169771A (en) 2008-04-23 2019-05-15 Univ Leland Stanford Junior Systems, methods and compositions for optical stimulation of target cells
EP2303405A4 (en) 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Apparatus and methods for controlling cellular development
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
KR101036338B1 (ko) 2009-03-27 2011-05-23 경상대학교산학협력단 Ｔｒｅｓｋ 유전자를 과발현하는 형질전환 동물 및 이의 제조방법
US8399663B2 (en) * 2009-04-03 2013-03-19 Astellas Pharma Inc. Salt of 1,3,5-triazine-2,4,6-triamine derivative
MX2011012743A (es) 2009-05-29 2012-04-20 Astellas Pharma Inc Nueva composicion farmaceutica para la prevencion y/0 tratamiento del trastorno por deficit de atencion/hiperactividad.
WO2012061679A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
CN106376525A (zh) 2010-11-05 2017-02-08 斯坦福大学托管董事会 记忆功能的控制和表征
CN106106368A (zh) 2010-11-05 2016-11-16 斯坦福大学托管董事会 光控cns功能障碍
ES2684307T3 (es) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
AU2011323235B2 (en) 2010-11-05 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA2859364C (en) 2011-12-16 2019-05-07 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
EP3205374B1 (en) 2012-02-21 2019-03-27 The Board of Trustees of The Leland Stanford Junior University Compositions for treating neurogenic disorders of the pelvic floor
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
AU2014260101B2 (en) 2013-04-29 2018-07-26 Humboldt-Universitat Zu Berlin Devices, systems and methods for optogenetic modulation of action potentials in target cells
EP3033427A4 (en) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Compositions and methods for controlling pain
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027677A1 (en) * 1997-11-26 1999-06-03 V-One Corporation Session key recovery system and method
WO1999043696A1 (en) * 1998-02-25 1999-09-02 Icagen Inc. Human potassium channel genes
WO2000005346A1 (en) * 1998-07-21 2000-02-03 Millennium Pharmaceuticals, Inc. Novel potassium channel molecules and uses therefor
WO2000009534A1 (en) * 1998-08-14 2000-02-24 Elan Pharmaceuticals, Inc. Novel esk potassium channel polypeptide and polynucleotide compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1982799A (en) 1998-01-23 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel potassium channel protein
WO2000001819A1 (en) 1998-07-01 2000-01-13 Icagen, Incorporated Human elk, a voltage-gated potassium channel subunit
FR2781979B1 (fr) * 1998-08-05 2001-06-08 Fond Jean Dausset Ceph Modele animal presentant une deficience de la memoire et/ou des troubles comportementaux
EP1002863A1 (en) 1998-10-13 2000-05-24 Sanofi-Synthelabo A potassium channel member of the erg family
WO2003016475A2 (en) 2001-08-14 2003-02-27 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027677A1 (en) * 1997-11-26 1999-06-03 V-One Corporation Session key recovery system and method
WO1999043696A1 (en) * 1998-02-25 1999-09-02 Icagen Inc. Human potassium channel genes
WO2000005346A1 (en) * 1998-07-21 2000-02-03 Millennium Pharmaceuticals, Inc. Novel potassium channel molecules and uses therefor
WO2000009534A1 (en) * 1998-08-14 2000-02-24 Elan Pharmaceuticals, Inc. Novel esk potassium channel polypeptide and polynucleotide compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAYFORD M. ET AL: "The 3'-untranslated region of CaMKIIalpha is a cis-acting signal for the localization and translation of mRNA in dendrites", PROC. NATL. ACAD. SCI. USA, vol. 93, 27 August 1996 (1996-08-27), pages 13250 - 13255, XP002918895 *
See also references of EP1444889A4 *

Also Published As

Publication number Publication date
JPWO2003041496A1 (ja) 2005-03-03
US7094948B2 (en) 2006-08-22
JP3679403B2 (ja) 2005-08-03
US20040210952A1 (en) 2004-10-21
EP1444889A4 (en) 2006-10-04
CA2465337A1 (en) 2003-05-22
EP1444889A1 (en) 2004-08-11

Similar Documents

Publication Publication Date Title
WO2003041496A1 (en) Transgenic animal
WO2005106090A3 (en) Preform produced by electrospinning, method for producting the same and use of such a preform
WO2005003317A3 (en) Engineered blood vessels
AU2002319249A1 (en) Herbicidal substituted pyridines, method for producing the same and their use as herbicidal agents and plant growth regulators
AU2003285172A8 (en) Human embryonic stem cell cultures, and compositions and methods for growing same
WO2005116199A3 (en) Tobacco nicotine demethylase genomic clone and uses thereof
WO2002009713A3 (de) Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
AU2001244736A1 (en) Method of producing plants, plant cultivating device, and light-emitting panel
AU3842502A (en) Composition for regulating animal growth, method of manufacture and use thereof
WO2003054189A3 (de) Verfahren zur transformation von pflanzlichen plastiden
WO2003014336A1 (en) Process for preparing hematopoietic stem cells
AU2001244677A1 (en) Method of amplifying nucleic acid by using double-stranded nucleic acid as template
PL357079A1 (en) Isoxazolyl- and isoxazolinyl-substituted benzoylcyclohexanediones, production method and use thereof as herbicides and plant growth regulators
WO2004015085A3 (en) Method and compositions relating to 5’-chimeric ribonucleic acids
WO2001070692A3 (de) Heterocyclische acylsulfimide,verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schädlingsbekämpfungsmittel
AU2003276924A1 (en) Compositions and methods for enrichment of neural stem cells using ceramide analogs
WO2006015887A3 (en) Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis
ECSP055803A (es) Ésteres de ácido carbámico con actividad anticolinérgica
WO2006041409A8 (en) Medical solution, method for producing and use thereof
ATE493134T1 (de) Gefriergetrocknetes präparat mit methylcobalamin und verfahren zu seiner herstellung
WO2003070873A3 (de) Kultivierungsverfahren für mikroorganismen und bioreaktor
IL166358A0 (en) Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids
WO2004087929A3 (en) Plants having improved growth characteristics and a method for making the same
WO2001085151A3 (en) Chimeric animal model and treatment of psoriasis
FR2831554B1 (fr) Procede d'enrichissement de cellules souches keratinocytaires

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003543396

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 10493943

Country of ref document: US

Ref document number: 2465337

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002781760

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002781760

Country of ref document: EP