WO2003042247A3 - Modified anti-tnf alpha antibody - Google Patents

Modified anti-tnf alpha antibody Download PDF

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Publication number
WO2003042247A3
WO2003042247A3 PCT/EP2002/012566 EP0212566W WO03042247A3 WO 2003042247 A3 WO2003042247 A3 WO 2003042247A3 EP 0212566 W EP0212566 W EP 0212566W WO 03042247 A3 WO03042247 A3 WO 03042247A3
Authority
WO
WIPO (PCT)
Prior art keywords
tnf alpha
modified anti
modified
alpha antibody
cell epitopes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/012566
Other languages
French (fr)
Other versions
WO2003042247A2 (en
Inventor
Koen Hellendoorn
Matthew Baker
Francis J Carr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0213565-5A priority Critical patent/BR0213565A/en
Priority to CA002466592A priority patent/CA2466592A1/en
Priority to AU2002351957A priority patent/AU2002351957B2/en
Priority to AT02787636T priority patent/ATE469176T1/en
Priority to HU0402333A priority patent/HUP0402333A3/en
Priority to JP2003544082A priority patent/JP4304073B2/en
Priority to US10/495,146 priority patent/US7524502B2/en
Priority to EP02787636A priority patent/EP1448602B1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to MXPA04004417A priority patent/MXPA04004417A/en
Priority to DE60236536T priority patent/DE60236536D1/en
Publication of WO2003042247A2 publication Critical patent/WO2003042247A2/en
Publication of WO2003042247A3 publication Critical patent/WO2003042247A3/en
Anticipated expiration legal-status Critical
Priority to US11/005,726 priority patent/US7754853B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to the modification of antibodies reactive to human tumor necrosis factor alpha (TNF alpha) to result in anti-TNF alpha antibodies that are substantially non-immunogenic or less immunogenic than any non-modified parental antibody when used in vivo. The invention relates also to peptide molecules comprising T-cell epitopes of the V-regions of the parental antibody which are modified by amino acid alteration in order to reduce or eliminate said T-cell epitopes.
PCT/EP2002/012566 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody Ceased WO2003042247A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US10/495,146 US7524502B2 (en) 2001-11-12 2002-11-11 Modified anti-TNF alpha antibody
AU2002351957A AU2002351957B2 (en) 2001-11-12 2002-11-11 Modified anti-TNF alpha antibody
AT02787636T ATE469176T1 (en) 2001-11-12 2002-11-11 MODIFIED ANTI-TNF ANTIBODIES
HU0402333A HUP0402333A3 (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody
JP2003544082A JP4304073B2 (en) 2001-11-12 2002-11-11 Modified anti-TNFα antibody
EP02787636A EP1448602B1 (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody
MXPA04004417A MXPA04004417A (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody.
BR0213565-5A BR0213565A (en) 2001-11-12 2002-11-11 Modified alpha anti-tnf antibody
CA002466592A CA2466592A1 (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody
DE60236536T DE60236536D1 (en) 2001-11-12 2002-11-11 MODIFIED ANTI-TNF ANTIBODY
US11/005,726 US7754853B2 (en) 2001-11-12 2004-12-07 TNF alpha-binding polypeptide compositions and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01126858 2001-11-12
EP01126858.8 2001-11-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10495146 A-371-Of-International 2002-11-11
US11/005,726 Continuation-In-Part US7754853B2 (en) 2001-11-12 2004-12-07 TNF alpha-binding polypeptide compositions and methods

Publications (2)

Publication Number Publication Date
WO2003042247A2 WO2003042247A2 (en) 2003-05-22
WO2003042247A3 true WO2003042247A3 (en) 2004-03-11

Family

ID=8179220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012566 Ceased WO2003042247A2 (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody

Country Status (17)

Country Link
US (2) US7524502B2 (en)
EP (1) EP1448602B1 (en)
JP (1) JP4304073B2 (en)
KR (1) KR20050044405A (en)
CN (1) CN1585778A (en)
AT (1) ATE469176T1 (en)
AU (1) AU2002351957B2 (en)
BR (1) BR0213565A (en)
CA (1) CA2466592A1 (en)
DE (1) DE60236536D1 (en)
ES (1) ES2346517T3 (en)
HU (1) HUP0402333A3 (en)
MX (1) MXPA04004417A (en)
PL (1) PL369739A1 (en)
RU (1) RU2004117915A (en)
WO (1) WO2003042247A2 (en)
ZA (1) ZA200404626B (en)

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EP0979102A4 (en) * 1997-04-30 2005-11-23 Enzon Inc SINGLE-CHAIN POLYPEPTIDES MODIFIED BY POLYALKYLENE OXIDE
US20040009166A1 (en) * 1997-04-30 2004-01-15 Filpula David R. Single chain antigen-binding polypeptides for polymer conjugation
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US8147832B2 (en) * 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
US7264806B2 (en) * 2003-11-01 2007-09-04 Biovation Ltd. Modified anti-CD52 antibody
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
GB0425713D0 (en) 2004-11-23 2004-12-22 Baker Matthew Immunogencity testing and antibody selection methods
AU2006210724A1 (en) 2005-02-03 2006-08-10 Antitope Limited Human antibodies and proteins
CA2602035C (en) * 2005-03-18 2015-06-16 Medimmune, Inc. Framework-shuffling of antibodies
EP1904078A4 (en) * 2005-05-12 2009-09-02 Attenuon Llc Treatment of inflammatory bowel disease (ibd) with anti-angiogenic compounds
US8188223B2 (en) 2005-05-18 2012-05-29 Ablynx N.V. Serum albumin binding proteins
DK1919951T3 (en) * 2005-08-04 2015-02-16 Janssen Biotech Inc Anti-tnf-alpha antibodies and methods of use
EP2450368A1 (en) * 2007-01-30 2012-05-09 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
AU2008279550B2 (en) 2007-06-21 2012-08-09 Angelica Therapeutics, Inc. Modified toxins
WO2009110944A1 (en) 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
US8926976B2 (en) 2009-09-25 2015-01-06 Xoma Technology Ltd. Modulators
EP2480888B1 (en) 2009-09-25 2016-11-30 XOMA Technology Ltd. Screening methods
JP5697677B2 (en) 2009-10-26 2015-04-08 ネステク ソシエテ アノニム Assays for detection of anti-TNF drugs and autoantibodies
KR101712874B1 (en) * 2010-09-30 2017-03-07 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 HUMANIZED ANTI-TNF-α ANTIBODY AND ANTIGEN-BINDING FRAGMENT (Fab) THEREOF AND USE OF THE SAME
US8962804B2 (en) * 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
JP6157352B2 (en) 2010-10-08 2017-07-05 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Monoclonal antibody framework binding interface for meditope, meditope delivery system, and uses thereof
NZ609363A (en) 2010-10-18 2015-04-24 Nestec Sa Methods for determining anti-drug antibody isotypes
CN102675460B (en) * 2011-02-28 2015-08-19 珠海市丽珠单抗生物技术有限公司 The humanized antibody of Tumor necrosis factorα
KR20140047628A (en) 2011-07-06 2014-04-22 네스텍 소시에테아노님 Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc Modified toxins
WO2014193973A2 (en) * 2013-05-28 2014-12-04 Dcb-Usa Llc Antibody locker for the inactivation of protein drug
RU2556816C1 (en) * 2014-03-12 2015-07-20 Открытое акционерное общество "Фармацевтический импорт, экспорт" (ОАО "Фармимэкс") Strain of cells of chinese hamster ovaries - producer of recombinant antibody against tumour necrosis factor alpha of human being
CN107250798A (en) 2014-12-05 2017-10-13 雀巢产品技术援助有限公司 Indirect Homogeneous Mobility Shift Assay for Detection of Biologicals in Patient Samples
CN105820246A (en) 2015-01-07 2016-08-03 上海张江生物技术有限公司 Method for preparing novel recombinant anti-TNF alpha chimeric monoclonal antibody and application thereof
US10947305B2 (en) 2015-03-20 2021-03-16 Full Spectrum Genetics, Inc. Anti-TNFα binding compounds and uses thereof
US20180126000A1 (en) 2016-06-02 2018-05-10 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
EP3602314A4 (en) 2017-03-30 2021-03-03 Blonder Tongue Laboratories, Inc. ENTERPRISE CONTENT GATEWAY
BR112020010694A2 (en) 2017-12-01 2020-11-10 Abbvie Inc. glucocorticoid receptor agonist and immunoconjugates of the same
US20220389092A1 (en) * 2019-04-05 2022-12-08 The Regents Of The University Of California Methods and compositions involving chimeric binding polypeptides
CN111909267B (en) * 2019-05-07 2022-03-25 北京天成新脉生物技术有限公司 Low-immunogenicity anti-TNF-alpha humanized monoclonal antibody TCX063 and its application
GB202004916D0 (en) * 2020-04-02 2020-05-20 Univ Oxford Innovation Ltd Antibodies
WO2022087435A1 (en) * 2020-10-23 2022-04-28 Hq Han Bifunctional antagonists of tumor necrosis factor-alpha and transforming growth factor-beta and uses thereof
CN121548746A (en) * 2023-06-08 2026-02-17 辛特里亚公司 Methods for detecting neutralizing antibodies (NAb) against anti-TNFα antibodies

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016553A1 (en) * 1991-03-18 1992-10-01 New York University Monoclonal and chimeric antibodies specific for human tumor necrosis factor
EP0699755A2 (en) * 1994-06-30 1996-03-06 Centro de Inmunologia Molecular Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
WO1998052976A1 (en) * 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
WO1999053038A2 (en) * 1998-04-15 1999-10-21 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
WO2000034317A2 (en) * 1998-12-08 2000-06-15 Biovation Limited Method for reducing immunogenicity of proteins
US20010027249A1 (en) * 1991-03-18 2001-10-04 Centocor, Inc., Anti-TNF antibodies and peptides of human tumor necrosis factor
WO2002012502A2 (en) * 2000-08-07 2002-02-14 Centocor, Inc. Anti-tnf antibodies, compositions, methods and uses
WO2002069232A2 (en) * 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity

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Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1992016553A1 (en) * 1991-03-18 1992-10-01 New York University Monoclonal and chimeric antibodies specific for human tumor necrosis factor
US20010027249A1 (en) * 1991-03-18 2001-10-04 Centocor, Inc., Anti-TNF antibodies and peptides of human tumor necrosis factor
EP0699755A2 (en) * 1994-06-30 1996-03-06 Centro de Inmunologia Molecular Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
WO1998052976A1 (en) * 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
WO1999053038A2 (en) * 1998-04-15 1999-10-21 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
WO2000034317A2 (en) * 1998-12-08 2000-06-15 Biovation Limited Method for reducing immunogenicity of proteins
WO2002012502A2 (en) * 2000-08-07 2002-02-14 Centocor, Inc. Anti-tnf antibodies, compositions, methods and uses
WO2002069232A2 (en) * 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity

Also Published As

Publication number Publication date
US7754853B2 (en) 2010-07-13
US20040260069A1 (en) 2004-12-23
ZA200404626B (en) 2005-10-26
US7524502B2 (en) 2009-04-28
CA2466592A1 (en) 2003-05-22
JP2005510216A (en) 2005-04-21
ES2346517T3 (en) 2010-10-18
DE60236536D1 (en) 2010-07-08
EP1448602A2 (en) 2004-08-25
AU2002351957B2 (en) 2009-09-03
HUP0402333A2 (en) 2005-02-28
US20060018903A1 (en) 2006-01-26
KR20050044405A (en) 2005-05-12
PL369739A1 (en) 2005-05-02
ATE469176T1 (en) 2010-06-15
RU2004117915A (en) 2005-05-10
EP1448602B1 (en) 2010-05-26
MXPA04004417A (en) 2004-08-11
HUP0402333A3 (en) 2007-05-02
CN1585778A (en) 2005-02-23
BR0213565A (en) 2004-10-26
WO2003042247A2 (en) 2003-05-22
JP4304073B2 (en) 2009-07-29

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