WO2003042661A3 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer - Google Patents

Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Download PDF

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Publication number
WO2003042661A3
WO2003042661A3 PCT/US2002/036810 US0236810W WO03042661A3 WO 2003042661 A3 WO2003042661 A3 WO 2003042661A3 US 0236810 W US0236810 W US 0236810W WO 03042661 A3 WO03042661 A3 WO 03042661A3
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WO
WIPO (PCT)
Prior art keywords
methods
cancer
diagnosis
compositions
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/036810
Other languages
French (fr)
Other versions
WO2003042661A2 (en
WO2003042661A8 (en
Inventor
Daniel Afar
Natasha Aziz
Wendy M Ginsburg
Kurt C Gish
Richard Glynne
Peter A Hevezi
David H Mack
Richard Murray
Susan R Watson
Keith E Wilson
Albert Zlotnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PDL Biopharma Inc
Original Assignee
Protein Design Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Design Labs Inc filed Critical Protein Design Labs Inc
Priority to EP02792272A priority Critical patent/EP1497454A2/en
Priority to CA002467433A priority patent/CA2467433A1/en
Priority to AU2002357734A priority patent/AU2002357734A1/en
Priority to JP2003544445A priority patent/JP2005525789A/en
Publication of WO2003042661A2 publication Critical patent/WO2003042661A2/en
Publication of WO2003042661A8 publication Critical patent/WO2003042661A8/en
Anticipated expiration legal-status Critical
Publication of WO2003042661A3 publication Critical patent/WO2003042661A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Described herein are genes whose expression are up-regulated or down-regulated in specific cancers or other diseases, or are otherwise regulated in disease. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of these selected conditions.
PCT/US2002/036810 2001-11-13 2002-11-13 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer Ceased WO2003042661A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02792272A EP1497454A2 (en) 2001-11-13 2002-11-13 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
CA002467433A CA2467433A1 (en) 2001-11-13 2002-11-13 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
AU2002357734A AU2002357734A1 (en) 2001-11-13 2002-11-13 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
JP2003544445A JP2005525789A (en) 2001-11-13 2002-11-13 Cancer diagnosis method, cancer modulator screening composition and method

Applications Claiming Priority (37)

Application Number Priority Date Filing Date Title
US35066601P 2001-11-13 2001-11-13
US60/350,666 2001-11-13
US33246401P 2001-11-21 2001-11-21
US60/332,464 2001-11-21
US33439301P 2001-11-29 2001-11-29
US60/334,393 2001-11-29
US33539401P 2001-12-03 2001-12-03
US60/335,394 2001-12-03
US34037601P 2001-12-14 2001-12-14
US60/340,376 2001-12-14
US34721102P 2002-01-08 2002-01-08
US60/347,211 2002-01-08
US34734902P 2002-01-10 2002-01-10
US60/347,349 2002-01-10
US35525002P 2002-02-08 2002-02-08
US35525702P 2002-02-08 2002-02-08
US60/355,250 2002-02-08
US35671402P 2002-02-13 2002-02-13
US60/356,714 2002-02-13
US35907702P 2002-02-20 2002-02-20
US60/359,077 2002-02-20
US36880902P 2002-03-29 2002-03-29
US60/368,809 2002-03-29
US37011002P 2002-04-04 2002-04-04
US60/370,110 2002-04-04
US37224602P 2002-04-12 2002-04-12
US60/372,246 2002-04-12
US38661402P 2002-06-05 2002-06-05
US60/386,614 2002-06-05
US39683902P 2002-07-16 2002-07-16
US60/396,839 2002-07-16
US39784502P 2002-07-22 2002-07-22
US39777502P 2002-07-22 2002-07-22
US60/397,845 2002-07-22
US60/397,775 2002-07-22
US40945002P 2002-09-09 2002-09-09
US60/409,450 2002-09-09

Publications (3)

Publication Number Publication Date
WO2003042661A2 WO2003042661A2 (en) 2003-05-22
WO2003042661A8 WO2003042661A8 (en) 2003-10-16
WO2003042661A3 true WO2003042661A3 (en) 2004-10-28

Family

ID=32097246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036810 Ceased WO2003042661A2 (en) 2001-11-13 2002-11-13 Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer

Country Status (1)

Country Link
WO (1) WO2003042661A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840887B2 (en) 2007-09-26 2014-09-23 Genentech, Inc. Antibodies

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
ATE425249T1 (en) 2000-06-16 2009-03-15 Biogen Idec Inc RENAL REGULATORY ELEMENTS AND THEIR USE
US20060035237A1 (en) 2002-08-26 2006-02-16 Markowitz Sanford D Methods and compositions for categorizing patients
US7118912B2 (en) * 2002-08-26 2006-10-10 Case Western Reserve University Methods and compositions for categorizing patients
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
DK1401869T3 (en) 2001-06-01 2008-04-28 Biogen Idec Inc Molecules and Methods for Inhibiting Germ Excretion 1
DE60238143D1 (en) 2001-09-18 2010-12-09 Genentech Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS OF TUMORS
US20040001840A1 (en) * 2002-03-04 2004-01-01 Young Paul E. Cancer-linked gene as target for chemotherapy
AU2003228336B2 (en) * 2002-03-19 2009-07-30 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP2365004B1 (en) * 2002-06-21 2016-01-06 Johns Hopkins University School of Medicine Membrane associated tumor endothelium markers
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
US20090110702A1 (en) 2002-07-12 2009-04-30 The Johns Hopkins University Mesothelin Vaccines and Model Systems and Control of Tumors
CA2492160A1 (en) 2002-07-12 2004-01-22 The Johns Hopkins University Mesothelin vaccines and model systems
EP1575993A4 (en) * 2002-08-26 2007-07-25 Univ Case Western Reserve METHODS OF PATIENT TREATMENT AND THERAPEUTIC IDENTIFICATION
WO2004024063A2 (en) * 2002-09-11 2004-03-25 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
BRPI0315666B8 (en) * 2002-10-23 2021-05-25 Ludwig Inst For Cancer Res Ltd a34 and a33 type 3 DNA, proteins, their antibodies and treatment methods using them
EP2025345A1 (en) 2002-12-30 2009-02-18 Biogen Idec MA Inc. KIM-1 antagonists and use to modulate immune system
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
EP1603585A2 (en) 2003-03-14 2005-12-14 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
US20060100132A1 (en) * 2003-06-06 2006-05-11 Brit Corneliussen Method for diagnosing inflammatory bowel disease
EP1644406B1 (en) 2003-07-11 2012-08-15 DeveloGen Aktiengesellschaft Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
US7294704B2 (en) 2003-08-15 2007-11-13 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk
US20070178458A1 (en) * 2003-09-05 2007-08-02 O'brien Philippa Methods of diagnosis and prognosis of ovarian cancer II
MXPA06003402A (en) 2003-10-07 2006-06-27 Millennium Pharm Inc MOLECULES OF NUCLEIC ACIDS AND PROTEINS FOR THE IDENTIFICATION, EVALUATION, PREVENTION AND TREATMENT OF CANCER OF OVARY.
EP2478912B1 (en) 2003-11-06 2016-08-31 Seattle Genetics, Inc. Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
WO2005054864A2 (en) * 2003-11-22 2005-06-16 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with potassium channel, subfamily k, member 1 (kcnk1)
JP2005230011A (en) * 2004-02-20 2005-09-02 Samsung Electronics Co Ltd Breast cancer-related protein, gene encoding the same, and protein and diagnostic method for breast cancer using the gene
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
JP2005314397A (en) * 2004-03-31 2005-11-10 Mitsubishi Chemicals Corp Anti-chondromodulin-1 specific antibody and use thereof
EP2070546A1 (en) * 2004-04-09 2009-06-17 Takeda Pharmaceutical Company Limited Preventives/remedies for cancer
NZ579482A (en) 2004-06-01 2011-02-25 Genentech Inc Antibody drug conjugates and methods
US20080038255A1 (en) * 2004-06-04 2008-02-14 Aplied Research Systems Ars Holding N.V. Splice Variant of Unc5h2
US20060024677A1 (en) * 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
EP1794314A2 (en) * 2004-07-23 2007-06-13 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with vasoactive intestinal peptide receptor 1 (vpac1)
US20090214517A1 (en) * 2004-07-27 2009-08-27 Justin Wong Compositions and methods of use for modulators of nectin 4, semaphorin 4b, igsf9, and kiaa0152 in treating disease
DE102004045705A1 (en) 2004-09-21 2006-04-06 B.R.A.H.M.S Ag Uses of carbamoyl phosphate synthetase 1 (CPS) as a humoral biomarker for the diagnosis of tumors and inflammatory bowel disease
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
WO2006053442A1 (en) * 2004-11-22 2006-05-26 Diagnocure Inc. Calml3 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis
JP4993645B2 (en) 2004-12-01 2012-08-08 ジェネンテック， インコーポレイテッド Antibody drug conjugates and methods
WO2006090389A2 (en) * 2005-02-24 2006-08-31 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
ES2364670T3 (en) 2005-02-25 2011-09-12 Oncotherapy Science, Inc. PEPTIDE VACCINES FOR LUNG CANCERS EXPRESSING TTK POLYPEPTIDES.
KR101213894B1 (en) 2005-03-02 2012-12-20 바이오겐 아이덱 엠에이 인코포레이티드 Kim-1 antibodies for treatment of th2-mediated conditions
EP1869207A1 (en) * 2005-04-07 2007-12-26 AstraZeneca AB METHOD FOR ASSESSING THE PRESDISPOSITION AND/OR SUSCEPTIBILITY TO COPD BY ANALYSING FGF-BPl
CA2604852A1 (en) * 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Methylation markers for diagnosis and treatment of cancers
EA013634B1 (en) 2005-04-15 2010-06-30 Эпиджиномикс Аг METHODS AND NUCLEIC ACIDS FOR ANALYSIS OF CELLULAR PROLIFERATIVE DISTURBANCES
GB0508863D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Peptide
CA2607133A1 (en) 2005-05-02 2006-11-09 Toray Industries, Inc. Composition and method for diagnosing esophageal cancer and metastasis of esophageal cancer
EP1885751B1 (en) 2005-05-27 2011-11-16 BBS - Bioactive Bone Substitutes Oy Bone morphogenetic protein 6 containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
EA017812B1 (en) 2005-12-08 2013-03-29 Медарекс, Инк. Isolated monoclonal antibody or antigen-binding portion thereof that binds to human protein tyrosine kinase 7 (ptk7) and use thereof
NZ615012A (en) 2006-03-21 2015-11-27 Genentech Inc Combinatorial therapy involving alpha5beta1 antagonists
WO2007115213A2 (en) * 2006-03-30 2007-10-11 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
CA2649777C (en) * 2006-04-17 2018-08-14 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
WO2008008983A2 (en) * 2006-07-13 2008-01-17 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
EP1932854A1 (en) * 2006-12-15 2008-06-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Lysosomal associated membrane protein (LAMP) - like polypeptide, ligands to the same, and use of the same in the frame of detection and purification of human plasmacytoid dendritic cells
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
WO2008104805A2 (en) * 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
CN103864893B (en) 2007-07-27 2017-01-04 伊玛提克斯生物技术有限公司 The immunogenic epitopes of immunotherapy
AU2012244137B2 (en) * 2007-07-27 2015-06-11 Immatics Biotechnologies Gmbh Novel immunotherapy against neuronal and brain tumours
HRP20150820T1 (en) 2007-07-27 2015-09-11 Immatics Biotechnologies Gmbh NEW IMMUNOTHERAPY AGAINST NEURAL TUMORS AND BRAIN TUMORS
EP2198306A1 (en) 2007-09-06 2010-06-23 Case Western Reserve University Methods for diagnosing and treating cancers
KR101720760B1 (en) 2008-01-25 2017-03-28 오르후스 우니베르시테트 Selective exosite inhibition of papp-a activity against igfbp-4
DK2257301T3 (en) 2008-03-03 2014-04-28 Univ Miami Immunotherapy based on allogeneic cancer cells.
ES2532896T5 (en) * 2008-05-14 2018-03-20 Immatics Biotechnologies Gmbh Innovative and potent MHC class II peptides derived from survivin and neurocan
KR20110034602A (en) 2008-05-21 2011-04-05 도레이 카부시키가이샤 Compositions and methods for esophageal cancer determination
KR101771714B1 (en) * 2008-05-30 2017-08-25 제넨테크, 인크. Variant hhip1 protein and methods and uses thereof
AU2009270988A1 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
EP2568044B1 (en) 2008-09-29 2015-04-08 The Trustees of The University of Pennsylvania Tumor vascular marker-targeted vaccines
NZ594343A (en) 2009-03-25 2013-10-25 Genentech Inc Novel anti-alpha5beta1 antibodies and uses thereof
US9290577B2 (en) 2009-07-03 2016-03-22 Avipep Pty Limited Immuno-conjugates and methods for producing them
JP2013504585A (en) 2009-09-09 2013-02-07 セントローズ， エルエルシー Extracellular targeted drug complex
JP2013514788A (en) 2009-12-23 2013-05-02 アビペップ ピーティーワイ リミテッド Immunoconjugate and production method 2
SI2528625T1 (en) 2010-04-15 2013-11-29 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
CA2799540A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
MX347954B (en) 2010-09-29 2017-05-19 Agensys Inc Antibody drug conjugates (adc) that bind to 191p4d12 proteins.
US20120121615A1 (en) 2010-11-17 2012-05-17 Flygare John A Alaninyl maytansinol antibody conjugates
JP6038121B2 (en) 2011-04-21 2016-12-07 ガーバン インスティテュート オブ メディカル リサーチ Modified variable domain molecules and methods for their production and use B
US8679767B2 (en) 2011-05-12 2014-03-25 Genentech, Inc. Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
WO2013045464A1 (en) * 2011-09-26 2013-04-04 Roche Diagnostics Gmbh Cdna biomarkers in whole blood for colorectal cancer assessment
BR112014009050B1 (en) 2011-10-14 2022-06-21 Medimmune Limited Pyrrolbenzodiazepine antibody-drug conjugate, pharmaceutical composition comprising the same, as well as pyrrolebenzodiazepine compounds
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
DK2891663T3 (en) 2012-08-31 2018-03-26 Vasculead Inc PSF1-Derived Peptide
HRP20182129T1 (en) 2012-10-12 2019-02-08 Adc Therapeutics Sa CONJUGATES ANTIBODY - PIROLOBENZODIAZEPINE
JP6392765B2 (en) 2012-10-12 2018-09-19 エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ Pyrrolobenzodiazepine-antibody conjugate
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
RS57694B1 (en) 2012-10-12 2018-11-30 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
MX338711B (en) 2012-10-12 2016-04-28 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof.
EP2906296B1 (en) 2012-10-12 2018-03-21 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
ES2680153T3 (en) 2012-10-12 2018-09-04 Adc Therapeutics Sa Anti-PSMA-pyrrolobenzodiazepine antibody conjugates
CN110627797A (en) 2012-12-21 2019-12-31 麦迪穆有限责任公司 Asymmetric pyrrolobenzodiazepine dimers for the treatment of proliferative and autoimmune diseases
CN105189507A (en) 2012-12-21 2015-12-23 斯皮罗根有限公司 Pyrrolobenzodiazepines and conjugates thereof
AU2014229529B2 (en) 2013-03-13 2018-02-15 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
MX362970B (en) 2013-03-13 2019-02-28 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof.
TWI680766B (en) 2013-03-13 2020-01-01 英商梅迪繆思有限公司 Pyrrolobenzodiazepines and conjugates thereof
BR112016002829A2 (en) 2013-08-12 2017-09-19 Genentech Inc COMPOUND AND PROCESS FOR PREPARING ANTIBODY-DRUG CONJUGATE COMPOUND, PHARMACEUTICAL COMPOSITION, CANCER TREATMENT METHOD, CANCER TREATMENT KIT, DRUG LINKER INTERMEDIATE, CBI DIMER DRUG MOUNT AND COMPOUND
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
CN105745224B (en) 2013-10-11 2019-11-05 牛津生物疗法有限公司 Conjugated antibodies against LY75 for the treatment of cancer
EP3054983B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015095227A2 (en) 2013-12-16 2015-06-25 Genentech, Inc. Peptidomimetic compounds and antibody-drug conjugates thereof
EP3082876B1 (en) 2013-12-16 2018-01-17 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
JP6671292B2 (en) 2013-12-16 2020-03-25 ジェネンテック， インコーポレイテッド Peptidomimetic compounds and antibody-drug conjugates thereof
GB201408100D0 (en) * 2014-05-07 2014-06-18 Sec Dep For Health The Detection method
EP3193940A1 (en) 2014-09-10 2017-07-26 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
SG11201701128YA (en) 2014-09-12 2017-03-30 Genentech Inc Cysteine engineered antibodies and conjugates
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107073136A (en) 2014-09-17 2017-08-18 健泰科生物技术公司 Pyrrolobenzodiazepines Zhuo and its antibody disulphide conjugate
CN107148285B (en) 2014-11-25 2022-01-04 Adc治疗股份有限公司 Pyrrolobenzodiazepine-antibody conjugates
AU2015358532C1 (en) 2014-12-03 2020-10-29 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
CR20180243A (en) 2015-10-02 2018-07-31 Genentech Inc PIRROLOBENZODIAZEPIN ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
EP3365025B1 (en) 2015-10-20 2020-07-15 Genentech, Inc. Calicheamicin-antibody-drug conjugates and methods of use
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN108700598A (en) 2016-03-25 2018-10-23 豪夫迈·罗氏有限公司 The drug of the total antibody of multichannel and antibody conjugate quantifies measuring method
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN118436801A (en) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 PROTAC antibody conjugates and methods of use thereof
EP3465221B1 (en) 2016-05-27 2020-07-22 H. Hoffnabb-La Roche Ag Bioanalytical method for the characterization of site-specific antibody-drug conjugates
WO2017214024A1 (en) 2016-06-06 2017-12-14 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
CN109689111B (en) 2016-08-11 2024-04-05 基因泰克公司 Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS61795B1 (en) 2017-02-08 2021-06-30 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
CN110582505B (en) 2017-04-18 2021-04-02 免疫医疗有限公司 Pyrrolobenzodiazepine* conjugates
WO2018193102A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
CA3064804A1 (en) 2017-06-14 2018-12-20 Adc Therapeutics Sa Dosage regimes for the administration of an anti-cd19 adc
KR102270107B1 (en) 2017-08-18 2021-06-30 메디뮨 리미티드 pyrrolobenzodiazepine conjugate
EP3684773B1 (en) 2017-09-20 2026-04-29 pH Pharma Co., Ltd. Thailanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
JP7708662B2 (en) 2018-10-24 2025-07-15 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Conjugated chemical degraders and methods of use
AU2019392090A1 (en) 2018-12-03 2021-06-17 Agensys, Inc. Pharmaceutical compositions comprising anti-191P4D12 antibody drug conjugates and methods of use thereof
JP2022513198A (en) 2018-12-10 2022-02-07 ジェネンテック， インコーポレイテッド Photocrosslinkable peptide for site-specific conjugation to Fc-containing proteins
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
CN113631560B (en) 2019-03-15 2025-02-18 麦迪穆有限责任公司 Azetidine benzodiazepine dimers and conjugates containing them for treating cancer
CN112083168A (en) * 2019-06-14 2020-12-15 复旦大学附属华山医院 Polypeptide fragment diagnosis model and application thereof in predicting medulloblastoma metastasis risk
CN110819714B (en) * 2019-11-22 2023-01-10 南方医科大学深圳医院 A tumor suppressor gene and its application
CN114350640B (en) * 2019-12-13 2023-09-08 中国科学院天津工业生物技术研究所 Construction of a recombinant strain expressing chitinase and screening of mutants with high enzyme activity
CN115120702A (en) * 2020-03-30 2022-09-30 山东大学齐鲁医院 Application of cortistatin 14 in the preparation of psoriasis therapeutic drugs
CN111748623B (en) * 2020-06-08 2022-11-04 郑州大学第一附属医院 Predictive marker and kit for recurrence of liver cancer patient
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody
AR128331A1 (en) 2022-01-26 2024-04-17 Genentech Inc CHEMICAL DEGRADATION INDUCTORS CONJUGATED WITH ANTIBODIES AND METHODS OF THESE
AR128330A1 (en) 2022-01-26 2024-04-17 Genentech Inc CHEMICAL DEGRADATION INDUCERS CONJUGATED WITH ANTIBODY AND METHODS OF THESE
CN114966062B (en) * 2022-07-29 2022-09-30 北京大学第三医院（北京大学第三临床医学院） Molecular marker for predicting anti-MDA 5 antibody positive dermatomyositis combined with interstitial lung disease and application thereof
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
KR20260012304A (en) 2023-04-17 2026-01-26 피크 바이오, 인크. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates
WO2026006688A2 (en) 2024-06-28 2026-01-02 Firefly Bio, Inc. Degrader antibody conjugates and uses thereof
WO2026006689A2 (en) 2024-06-28 2026-01-02 Firefly Bio, Inc. Bcl-xl degrader antibody conjugates and uses thereof
CN119979588B (en) * 2024-12-30 2025-12-26 江南大学 A sterol C24-reductase mutant that reduces byproducts and a brewer's yeast that produces 7-dehydrocholesterol.
CN119970996B (en) * 2025-02-25 2025-09-09 川北医学院 Application of polypeptide Angio-3 in the preparation of drugs for treating pulmonary fibrosis
CN120539414B (en) * 2025-07-31 2025-09-19 安徽医科大学 Application of FIGN protein in cytoplasm as a marker in the preparation of diagnostic products for lung adenocarcinoma and/or breast cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM J.Y. ET AL: "Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1512, June 2001 (2001-06-01), pages 335 - 344, XP004245520 *
SATO H. ET AL: "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins", J. BIOL. CHEM., vol. 274, no. 17, 23 April 1999 (1999-04-23), pages 11455 - 11458, XP002941607 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840887B2 (en) 2007-09-26 2014-09-23 Genentech, Inc. Antibodies
US9284376B2 (en) 2007-09-26 2016-03-15 Genentech, Inc. Antibodies

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