WO2003044213A3 - Cell and tissue arrays and microarrays and methods of use - Google Patents

Cell and tissue arrays and microarrays and methods of use Download PDF

Info

Publication number
WO2003044213A3
WO2003044213A3 PCT/US2002/037054 US0237054W WO03044213A3 WO 2003044213 A3 WO2003044213 A3 WO 2003044213A3 US 0237054 W US0237054 W US 0237054W WO 03044213 A3 WO03044213 A3 WO 03044213A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological
microarrays
arrays
methods
cellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/037054
Other languages
French (fr)
Other versions
WO2003044213A2 (en
Inventor
Gretchen Frantz
Trent Landon
Franklin Jr V Peale
Thinh Quang Pham
Jean-Philippe F Stephan
Debra Y Dunlap
Kenneth J Hillan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to AU2002352787A priority Critical patent/AU2002352787A1/en
Priority to IL16197602A priority patent/IL161976A0/en
Priority to EP02789740A priority patent/EP1451358A2/en
Priority to CA002467563A priority patent/CA2467563A1/en
Priority to JP2003545834A priority patent/JP2005509870A/en
Publication of WO2003044213A2 publication Critical patent/WO2003044213A2/en
Publication of WO2003044213A3 publication Critical patent/WO2003044213A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00673—Slice arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention relates to biological arrays, biological microarrays, and methods of using the arrrays and microarrays to detect the amount and/or presence of a biological molecule in a biological sample. Biological arrays of the invention comprise a solidified, sectionable matrix comprising a plurality of wells disposed therein and one or more biological samples disposed within the plurality of wells, which biological arrays optionally comprise an internal standard preparation and/or an orientation marker. Sections or slices of the biological arrays are mounted on a planar substrate surface to form cellular microarrays of the invention. In alternative cellular microarrays of the invention, the matrix material is a temperature-sensitive material removable from the microarray leaving cellular biological material on the substrate surface.
PCT/US2002/037054 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use Ceased WO2003044213A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2002352787A AU2002352787A1 (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use
IL16197602A IL161976A0 (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methodsof use
EP02789740A EP1451358A2 (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use
CA002467563A CA2467563A1 (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use
JP2003545834A JP2005509870A (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US33229301P 2001-11-20 2001-11-20
US60/332,293 2001-11-20
US33263501P 2001-11-21 2001-11-21
US60/332,635 2001-11-21
US35520502P 2002-02-07 2002-02-07
US60/355,205 2002-02-07
US35956302P 2002-02-22 2002-02-22
US60/359,563 2002-02-22
US38961002P 2002-06-17 2002-06-17
US60/389,610 2002-06-17
US39355102P 2002-07-02 2002-07-02
US60/393,551 2002-07-02

Publications (2)

Publication Number Publication Date
WO2003044213A2 WO2003044213A2 (en) 2003-05-30
WO2003044213A3 true WO2003044213A3 (en) 2003-08-28

Family

ID=27559749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/037054 Ceased WO2003044213A2 (en) 2001-11-20 2002-11-20 Cell and tissue arrays and microarrays and methods of use

Country Status (7)

Country Link
US (1) US20030157523A1 (en)
EP (1) EP1451358A2 (en)
JP (1) JP2005509870A (en)
AU (1) AU2002352787A1 (en)
CA (1) CA2467563A1 (en)
IL (1) IL161976A0 (en)
WO (1) WO2003044213A2 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU2464U (en) 2002-06-25 2003-03-28 Szekeres Gyoergy Dr Hand instrument set for constructing tissue array
WO2004048928A2 (en) * 2002-11-25 2004-06-10 The United States Of America As Represented By The Secretary Of Health And Human Services, Nih Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array
CN1217003C (en) * 2003-02-20 2005-08-31 北京博奥生物芯片有限责任公司 Micro array reaction apparatus and uses thereof
CN1289904C (en) * 2003-08-01 2006-12-13 博奥生物有限公司 Micro array reaction unit and its use
WO2005047536A2 (en) * 2003-11-13 2005-05-26 Novartis Ag Detection of genomic amplification and deletion in cancer
WO2005113147A2 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US7682572B2 (en) * 2004-06-18 2010-03-23 Covance, Inc. Frozen tissue microarray
US7854899B2 (en) * 2004-08-26 2010-12-21 The United States Of America As Represented By The Secretary Of Health And Human Services Template methods and devices for preparing sample arrays
WO2006039396A2 (en) * 2004-10-01 2006-04-13 Ambion, Inc. Non-embedded tissue microarray technology for protein and nucleic acid analyses
US7595149B1 (en) 2004-11-08 2009-09-29 University Of Kentucky Research Foundation Methods for cancer detection
CN101061383B (en) * 2004-11-24 2012-08-22 李荣山 Cytoblock preparation method
US20060154299A1 (en) * 2005-01-08 2006-07-13 Harvey Michael A Protein microarray device having internal calibrators and methods of using therefor
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
EP1804045B1 (en) 2005-12-30 2014-03-12 QIAGEN GmbH Method and Kit for treating a biological sample
KR100829213B1 (en) * 2006-12-06 2008-05-14 송승민 The framework of the recipe block and its uses
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US20080299555A1 (en) * 2007-05-30 2008-12-04 Hiroaki Nitta Multicolor chromogenic detection of biomarkers
US8911682B2 (en) * 2007-06-08 2014-12-16 Array Science, Llc Method for producing tissue microarray blocks
JP2010185673A (en) * 2009-02-10 2010-08-26 Hamamatsu Univ School Of Medicine Tissue microarray preparation method
GB0908142D0 (en) * 2009-05-12 2009-06-24 Cancer Res Inst Royal Sample cutter and production of tissue arrays
JP5652769B2 (en) * 2009-10-30 2015-01-14 株式会社パソロジー研究所 Tissue array manufacturing equipment
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CN101943641B (en) * 2010-08-27 2013-07-03 华南理工大学 Lower sample loader
WO2012051332A1 (en) 2010-10-12 2012-04-19 Life Technologies Corporation Method of preparing quality control material for ffpe
US20140193052A1 (en) * 2011-08-23 2014-07-10 Yoshiko Yoshihara Information processing system, information processing method, information processing apparatus, control method thereof and control program
WO2013033060A1 (en) * 2011-09-02 2013-03-07 Emory University Devices having a calibration control region, systems and methods for immunohistochemical analyses
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
US20130166251A1 (en) * 2011-12-23 2013-06-27 Robert A. Latimer Particle monitoring with secure data logging
WO2013115476A1 (en) 2012-01-31 2013-08-08 국립암센터 Composition for aggregating biological sample, method for preparing paraffin block using same, and method for preparing specimen of cell block using the paraffin block for cell microarray
US10197479B1 (en) * 2012-03-14 2019-02-05 Alamak Biosciences Incorporation Company Limited In vitro homogenous DNA and RNA cell blocks made using a multi-chambered rotating apparatus
US9395283B1 (en) * 2012-03-14 2016-07-19 Alamak Biosciences Incorporation Company Limited In vitro homogenous cell block, method of making and using
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
US10746740B2 (en) 2015-01-22 2020-08-18 Konica Minolta, Inc. Biological substance quantitation method, pathological diagnosis support system, and recording medium storing computer readable program
JP5972412B2 (en) * 2015-02-05 2016-08-17 国立大学法人秋田大学 Standard sample using cultured cells and method for producing the same
ES2946184T3 (en) 2015-12-08 2023-07-13 Biomatrica Inc Reduced erythrocyte sedimentation rate
WO2017106542A1 (en) * 2015-12-18 2017-06-22 Biofire Defense, Llc Solid fluorescence standard
WO2017161046A1 (en) * 2016-03-15 2017-09-21 Abbott Laboratories Nucleic acid amplification and detection devices, systems and methods
US11300486B1 (en) 2016-11-23 2022-04-12 Array Science, Llc Apparatus for producing high yield cores for use in a microarray block, method for using same
US11231347B2 (en) 2016-11-29 2022-01-25 S2 Genomics, Inc. Method and apparatus for processing tissue samples
EP3351938A1 (en) 2017-01-18 2018-07-25 BIOCRATES Life Sciences AG New biomarkers for assessing ovarian cancer
US10913070B2 (en) * 2017-05-31 2021-02-09 Centrillion Technologies Taiwan Co. LTD. Microarray carrier assembly
EP3690015A4 (en) * 2017-09-29 2020-11-18 Toppan Printing Co., Ltd. CELL TRANSPLANT DEVICE AND CELL TRANSPLANT UNIT
KR20200096939A (en) * 2017-12-06 2020-08-14 제넨테크, 인크. Synthetic control for immunohistochemistry
CN108593380B (en) * 2018-04-25 2021-05-18 复旦大学附属中山医院 Mass production manufacturing method of tissue chips
US11618876B2 (en) 2018-06-01 2023-04-04 S2 Genomics, Inc. Method and apparatus for processing tissue samples
WO2020046661A2 (en) * 2018-08-22 2020-03-05 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Spatially co-registered genomic and imaging (scorgi) data elements for fingerprinting microdomains
CN110142068B (en) * 2019-06-12 2024-02-02 杭州华得森生物技术有限公司 An epithelial-mesenchymal mixed circulating tumor cell detection kit and method
CN111426532A (en) * 2020-04-09 2020-07-17 北京大学深圳医院 Method for making bacterial wax blocks and bacterial wax blocks as a method for positive quality control of acid-fast staining
EP4153720A4 (en) * 2020-05-18 2024-05-01 S2 Genomics, Inc. METHOD AND APPARATUS FOR PROCESSING ARCHIVED FABRIC SAMPLES
CN112414828A (en) * 2020-10-20 2021-02-26 创芯国际生物科技(广州)有限公司 Method for pre-embedding organoid tissue pathology
CN114018680B (en) * 2021-10-28 2022-10-21 上海交通大学医学院附属第九人民医院 Manufacturing method of choroid melanoma specimen wax block and chip
WO2023200297A1 (en) * 2022-04-15 2023-10-19 주식회사 씨젠 Method for estimating whether plate is contaminated, and computer device
CN115060570A (en) * 2022-06-30 2022-09-16 中国人民解放军东部战区总医院 Embedding method suitable for micro tissues such as organoid
CN116296687B (en) * 2023-03-31 2024-09-10 中国中医科学院医学实验中心 Tissue sample preparation device and application thereof
JP2025064611A (en) * 2023-10-06 2025-04-17 住友化学株式会社 Cell chip

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6103518A (en) * 1999-03-05 2000-08-15 Beecher Instruments Instrument for constructing tissue arrays
US6110426A (en) * 1994-06-17 2000-08-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6269846B1 (en) * 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1131470A4 (en) * 1998-10-28 2004-11-10 Vysis Inc CELLULAR NETWORKS AND METHODS FOR DETECTION AND USE OF GENETIC DISORDER MARKERS
US6696271B2 (en) * 2001-08-23 2004-02-24 The Regents Of The University Of California Frozen tissue microarray technology for analysis of RNA, DNA, and proteins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110426A (en) * 1994-06-17 2000-08-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6269846B1 (en) * 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
WO1999044062A1 (en) * 1998-02-25 1999-09-02 The United States Of America As Represented By The Secretary Department Of Health And Human Services Cellular arrays for rapid molecular profiling
US6103518A (en) * 1999-03-05 2000-08-15 Beecher Instruments Instrument for constructing tissue arrays

Also Published As

Publication number Publication date
AU2002352787A1 (en) 2003-06-10
IL161976A0 (en) 2005-11-20
JP2005509870A (en) 2005-04-14
CA2467563A1 (en) 2003-05-30
US20030157523A1 (en) 2003-08-21
EP1451358A2 (en) 2004-09-01
WO2003044213A2 (en) 2003-05-30

Similar Documents

Publication Publication Date Title
WO2007001436A3 (en) Surface modification for non-specific adsorption of biological material
WO2003056293A3 (en) Small molecule microarrays
CA2367698A1 (en) Individually addressable micro-electromagnetic unit array chips
Ramage et al. Biofilms of Candida albicans and their associated resistance to antifungal agents
WO2002061387A3 (en) Open substrate platforms suitable for analysis of biomolecules
WO2005042759A3 (en) Expression profiling using microarrays
US20030054342A1 (en) Measurements of multiple molecules using a cryoarray
AU2002307090A1 (en) Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
WO2002026195A3 (en) Oncology tissue microarrays
DE602004023104D1 (en) SIMPLIFIED TISSUE PROCESSING
WO2007022026A3 (en) Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
EP2644615A3 (en) SERS nanotag assays
JP2005515778A5 (en)
EP2125221A1 (en) Sample analyser
WO2007127990A3 (en) Method of manufacture of a plate of releasable elements and its assembly into a cassette
WO2004091384A3 (en) Erbb surface receptor complexes as biomarkers
WO2002055997A3 (en) Substrate for fluorescence analysis
WO2006072042A3 (en) Method for creating a reference region and a sample region on a biosensor and the resulting biosensor
WO2005081801A3 (en) Methods and apparatus for scanning small sample volumes
DE50113911D1 (en) BIOCHIP FOR THE ARCHIVING AND LABORMEDICAL ANALYSIS OF BIOLOGICAL SAMPLING MATERIAL
WO2005052582A3 (en) Methods and apparatus for cell based microarray assays
WO2003039749A3 (en) Sample carrier comprising a structural array for archiving sample material
EP1581646A3 (en) Extraction of dna from biological samples
EP1124131A3 (en) Biosensor and method of producing the same
WO2004045544A8 (en) Autocrine growth factor receptor antibodies and methods

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002352787

Country of ref document: AU

Ref document number: 2467563

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 161976

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2003545834

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002789740

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002789740

Country of ref document: EP