WO2003054005A3 - Bone polypeptide-1 - Google Patents

Bone polypeptide-1 Download PDF

Info

Publication number
WO2003054005A3
WO2003054005A3 PCT/IB2002/005778 IB0205778W WO03054005A3 WO 2003054005 A3 WO2003054005 A3 WO 2003054005A3 IB 0205778 W IB0205778 W IB 0205778W WO 03054005 A3 WO03054005 A3 WO 03054005A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
bone polypeptide
polypeptide
cdna
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2002/005778
Other languages
French (fr)
Other versions
WO2003054005A2 (en
Inventor
Christian Lanctot
Patrick Salois
Pierre Moffatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phenogene Therapeutiques Inc
Original Assignee
Phenogene Therapeutiques Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenogene Therapeutiques Inc filed Critical Phenogene Therapeutiques Inc
Priority to EP02805460A priority Critical patent/EP1458749B1/en
Priority to DE60239763T priority patent/DE60239763D1/en
Priority to US10/499,762 priority patent/US7425531B2/en
Priority to AU2002356392A priority patent/AU2002356392A1/en
Priority to AT02805460T priority patent/ATE505480T1/en
Priority to CA002469972A priority patent/CA2469972A1/en
Publication of WO2003054005A2 publication Critical patent/WO2003054005A2/en
Publication of WO2003054005A3 publication Critical patent/WO2003054005A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone polypeptide-1 as well as sequences of vertebrate homologs .The invention also provides cell lines engineered to express the cDNA, antibodies to detect its translation products, and recombinant adenoviruses to deliver an expressible cDNA into a host. Bone polypeptide-1can be utilized to treat diseases affecting renal and bone functions.
PCT/IB2002/005778 2001-12-20 2002-12-20 Bone polypeptide-1 Ceased WO2003054005A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP02805460A EP1458749B1 (en) 2001-12-20 2002-12-20 Bone polypeptide-1
DE60239763T DE60239763D1 (en) 2001-12-20 2002-12-20 KNOCHENPOLYPEPTID-1
US10/499,762 US7425531B2 (en) 2001-12-20 2002-12-20 Bone polypeptide-1
AU2002356392A AU2002356392A1 (en) 2001-12-20 2002-12-20 Bone polypeptide-1
AT02805460T ATE505480T1 (en) 2001-12-20 2002-12-20 BONE POLYPEPTIDE-1
CA002469972A CA2469972A1 (en) 2001-12-20 2002-12-20 Bone polypeptide-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34122401P 2001-12-20 2001-12-20
US60/341,224 2001-12-20

Publications (2)

Publication Number Publication Date
WO2003054005A2 WO2003054005A2 (en) 2003-07-03
WO2003054005A3 true WO2003054005A3 (en) 2003-10-23

Family

ID=23336705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/005778 Ceased WO2003054005A2 (en) 2001-12-20 2002-12-20 Bone polypeptide-1

Country Status (7)

Country Link
US (2) US7425531B2 (en)
EP (1) EP1458749B1 (en)
AT (1) ATE505480T1 (en)
AU (1) AU2002356392A1 (en)
CA (1) CA2469972A1 (en)
DE (1) DE60239763D1 (en)
WO (1) WO2003054005A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700361B2 (en) 2003-06-16 2010-04-20 Takeda Pharmaceutical Company Limited Secretory or membrane protein expressed in skeletal muscles
CA2559228C (en) 2004-04-21 2016-06-21 Enobia Pharma Inc. Bone delivery conjugates and method of using same to target proteins to bone
WO2005115118A2 (en) 2004-05-25 2005-12-08 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
JP4761812B2 (en) * 2005-04-18 2011-08-31 武田薬品工業株式会社 Musclin receptor and use thereof
US7470668B2 (en) * 2005-08-24 2008-12-30 Enobia Pharma Inc. Method of use of specific natriuretic peptide receptor c ligands, transgenic non-human mammals expressing specific natriuretic peptide receptor c antagonists and cells thereof
EP2067480A4 (en) 2006-09-30 2009-11-25 Takeda Pharmaceutical MUSCLIN RECEPTOR AND USE THEREOF
WO2012088608A1 (en) 2010-12-27 2012-07-05 Enobia Canada Limited Partnership Compositions comprising natriuretic peptides and methods of use thereof
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
MX389350B (en) 2014-12-05 2025-03-19 Alexion Pharma Inc RECOMBINANT ALKALINE PHOSPHATASES AND THEIR USES FOR THE TREATMENT OF SEIZURES.
JP6868561B2 (en) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド How to treat subjects with alkaline phosphatase deficiency
CA2986086A1 (en) 2015-05-29 2016-12-08 Igisu Co., Ltd. Cyclyc peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide
CN108350440A (en) 2015-08-17 2018-07-31 阿雷克森制药公司 Manufacture of Alkaline Phosphates
JP6868617B2 (en) 2015-09-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド Identifying effective dosing regimens for tissue-nonspecific alkaline phosphatase (TNSALP) enzyme replacement therapy for hypophosphataseemia
JP2018533571A (en) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド Methods for treating cranial suture early healing disease in a patient
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
US10898549B2 (en) 2016-04-01 2021-01-26 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
JP7613826B2 (en) 2016-04-01 2025-01-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド Treating muscle weakness with alkaline phosphatase
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3500289B1 (en) 2016-08-18 2024-10-09 Alexion Pharmaceuticals, Inc. Asfotase alfa for use in treating tracheobronchomalacia
US20180194824A1 (en) * 2016-12-14 2018-07-12 University Of Iowa Research Foundation Musclin peptides and methods of use thereof
EP3600383A4 (en) 2017-03-31 2020-10-28 Alexion Pharmaceuticals, Inc. METHODS FOR TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS
US11065009B2 (en) 2018-02-08 2021-07-20 Covidien Lp Vascular expandable devices
US11065136B2 (en) 2018-02-08 2021-07-20 Covidien Lp Vascular expandable devices
US11913039B2 (en) 2018-03-30 2024-02-27 Alexion Pharmaceuticals, Inc. Method for producing recombinant alkaline phosphatase
US12268733B2 (en) 2018-08-10 2025-04-08 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
CA3161266A1 (en) 2019-12-09 2021-06-17 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
AU2021337652B2 (en) 2020-09-04 2025-01-30 Alexion Pharmaceuticals, Inc. Methods for treating bone mineralization disorders
BR112023016048A2 (en) 2021-02-12 2023-11-14 Alexion Pharma Inc ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700361B2 (en) 2003-06-16 2010-04-20 Takeda Pharmaceutical Company Limited Secretory or membrane protein expressed in skeletal muscles
US7470668B2 (en) * 2005-08-24 2008-12-30 Enobia Pharma Inc. Method of use of specific natriuretic peptide receptor c ligands, transgenic non-human mammals expressing specific natriuretic peptide receptor c antagonists and cells thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No relevant documents disclosed *

Also Published As

Publication number Publication date
WO2003054005A2 (en) 2003-07-03
US20050143562A1 (en) 2005-06-30
ATE505480T1 (en) 2011-04-15
AU2002356392A8 (en) 2003-07-09
EP1458749A2 (en) 2004-09-22
AU2002356392A1 (en) 2003-07-09
US7425531B2 (en) 2008-09-16
EP1458749B1 (en) 2011-04-13
US20030125258A1 (en) 2003-07-03
DE60239763D1 (en) 2011-05-26
CA2469972A1 (en) 2003-07-03

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