WO2003060157A3 - Fluid manipulation in a microfabricated reaction chamber system - Google Patents

Fluid manipulation in a microfabricated reaction chamber system Download PDF

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Publication number
WO2003060157A3
WO2003060157A3 PCT/GB2002/005945 GB0205945W WO03060157A3 WO 2003060157 A3 WO2003060157 A3 WO 2003060157A3 GB 0205945 W GB0205945 W GB 0205945W WO 03060157 A3 WO03060157 A3 WO 03060157A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction chamber
chamber system
port
microfabricated
fluid manipulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2002/005945
Other languages
French (fr)
Other versions
WO2003060157A2 (en
Inventor
Frank Karlsen
Klaus Drese
Olaf Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norchip AS
Original Assignee
Norchip AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0131061A external-priority patent/GB2383546B/en
Priority claimed from GB0225539A external-priority patent/GB0225539D0/en
Application filed by Norchip AS filed Critical Norchip AS
Priority to US10/498,827 priority Critical patent/US7867757B2/en
Priority to EP02806348A priority patent/EP1458473A2/en
Priority to AU2002356341A priority patent/AU2002356341A1/en
Publication of WO2003060157A2 publication Critical patent/WO2003060157A2/en
Priority to NO20033827A priority patent/NO20033827D0/en
Publication of WO2003060157A3 publication Critical patent/WO2003060157A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B01L3/50851—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a microfabricated reaction chamber system and a method of fluid transport. The system may be used, for example, in a method of carrying out a nucleic acid sequence amplification and detection process on a nucleic acid sample. The microfabricated chamber system comprises an inlet port and/or an outlet port and a variable volume chamber in fluid communication with said port(s), wherein altering the volume of the variable volume chamber effects and/or restricts flow of a fluid sample to and/or from said port(s).
PCT/GB2002/005945 2001-12-28 2002-12-30 Fluid manipulation in a microfabricated reaction chamber system Ceased WO2003060157A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/498,827 US7867757B2 (en) 2001-12-28 2002-12-30 Fluid manipulation in a microfabricated reaction chamber systems
EP02806348A EP1458473A2 (en) 2001-12-28 2002-12-30 Fluid manipulation in a microfabricated reaction chamber system
AU2002356341A AU2002356341A1 (en) 2001-12-28 2002-12-30 Fluid manipulation in a microfabricated reaction chamber system
NO20033827A NO20033827D0 (en) 2001-12-28 2003-08-28 Fluid manipulation in a microfabricated reaction chamber system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0131061A GB2383546B (en) 2001-12-28 2001-12-28 Fluid manipulation in a microfabricated reaction chamber system
GB0131061.4 2001-12-28
GB0225539.6 2002-11-01
GB0225539A GB0225539D0 (en) 2002-11-01 2002-11-01 Fluid manipulation in a microfabricated reaction chamber system

Publications (2)

Publication Number Publication Date
WO2003060157A2 WO2003060157A2 (en) 2003-07-24
WO2003060157A3 true WO2003060157A3 (en) 2003-12-24

Family

ID=26246910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/005945 Ceased WO2003060157A2 (en) 2001-12-28 2002-12-30 Fluid manipulation in a microfabricated reaction chamber system

Country Status (5)

Country Link
US (1) US7867757B2 (en)
EP (1) EP1458473A2 (en)
AU (1) AU2002356341A1 (en)
NO (1) NO20033827D0 (en)
WO (1) WO2003060157A2 (en)

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US8955013B2 (en) 1996-06-14 2015-02-10 Rovi Guides, Inc. Television schedule system and method of operation for multiple program occurrences
US9021538B2 (en) 1998-07-14 2015-04-28 Rovi Guides, Inc. Client-server based interactive guide with server recording
US9125169B2 (en) 2011-12-23 2015-09-01 Rovi Guides, Inc. Methods and systems for performing actions based on location-based rules
US9374560B2 (en) 2005-12-29 2016-06-21 Rovi Guides, Inc. Systems and methods for managing a status change of a multimedia asset in multimedia delivery systems

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ES2312475T3 (en) 2000-10-11 2009-03-01 United Video Properties, Inc. SYSTEMS AND METHODS TO PROVIDE DATA STORAGE IN SERVERS OF A MEDIA DELIVERY SYSTEM UNDER DEMAND.
US7493646B2 (en) 2003-01-30 2009-02-17 United Video Properties, Inc. Interactive television systems with digital video recording and adjustable reminders
WO2005066372A2 (en) * 2003-12-31 2005-07-21 Applera Corporation Quantitative amplification and detection of small numbers of target polynucleotides
GB0426082D0 (en) * 2004-11-26 2004-12-29 Norchip As A device for carrying out biological assays
US20060275852A1 (en) * 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US20070154163A1 (en) 2005-12-29 2007-07-05 United Video Properties, Inc. Systems and methods for creating aggregations of episodes of series programming in order
CN101505872B (en) 2006-06-23 2011-12-28 意法半导体股份有限公司 Assembly of a microfluidic device for analysis of biological material
EP2040833A1 (en) * 2006-07-14 2009-04-01 Aviza Technology, Ltd. Microfluidic devices
CN1996009B (en) * 2007-01-10 2010-05-19 博奥生物有限公司 A microfluidic device and method of use for multi-sample analysis
CA2675172A1 (en) * 2007-01-12 2008-07-17 Environmental Biotechnology Crc Pty Limited Sample handling device
WO2008118098A1 (en) * 2007-03-26 2008-10-02 Agency For Science, Technology And Research Fluid cartridge, pump and fluid valve arrangement
GB0710957D0 (en) 2007-06-07 2007-07-18 Norchip As A device for carrying out cell lysis and nucleic acid extraction
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
EP2328681B1 (en) 2008-07-15 2014-11-26 L3 Technology Limited Assay test card
US10063934B2 (en) 2008-11-25 2018-08-28 Rovi Technologies Corporation Reducing unicast session duration with restart TV
JP5766178B2 (en) 2009-03-24 2015-08-19 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ Slipchip apparatus and method
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
GB0912509D0 (en) 2009-07-17 2009-08-26 Norchip As A microfabricated device for metering an analyte
FR2950358B1 (en) * 2009-09-18 2015-09-11 Biomerieux Sa SIMPLIFIED NUCLEIC ACID AMPLIFICATION DEVICE AND METHOD FOR IMPLEMENTING THE SAME
GB201113992D0 (en) 2011-08-12 2011-09-28 Molecular Vision Ltd Device
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
CN103849548A (en) 2012-12-03 2014-06-11 三星电子株式会社 Reagent container for amplifying nucleic acid, method of preparing the reagent container, method of storing the reagent, and microfluidic system for nucleic acid analysis
KR102046101B1 (en) * 2012-12-03 2019-11-18 삼성전자주식회사 Reagent container for amplification nucleic acid, method for manufacturing the same, method for storing the reagent, and micro-fluidic system for analysis of nucleic acid
JP6351702B2 (en) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド System, method and apparatus for operating a deformable fluid container
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
JP7372150B2 (en) * 2017-02-02 2023-10-31 ユニバーシティ オブ メリーランド，カレッジ パーク Trap array for robust microfluidic sample digitization
US11198128B2 (en) 2018-09-05 2021-12-14 International Business Machines Corporation Microfluidic device with array of chambers for encoding detectable information
US20220016625A1 (en) * 2019-01-17 2022-01-20 Siemens Healthcare Diagnostics Inc. Flow cell using peltier module as prime mover for polymerase chain reaction
JP2024502039A (en) * 2020-12-29 2024-01-17 コンビナティ インコーポレイテッド Devices and methods for sample dispensing
CN113444624A (en) * 2021-06-21 2021-09-28 清华大学深圳国际研究生院 Nucleic acid detection chip driven by tensile force and nucleic acid detection equipment
CN114887564B (en) * 2022-07-12 2022-12-13 杭州沈氏节能科技股份有限公司 Microchannel reactor
US12415172B2 (en) 2022-12-22 2025-09-16 Synthego Corporation Systems and method for automated oligonucleotide synthesis

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8955013B2 (en) 1996-06-14 2015-02-10 Rovi Guides, Inc. Television schedule system and method of operation for multiple program occurrences
US9021538B2 (en) 1998-07-14 2015-04-28 Rovi Guides, Inc. Client-server based interactive guide with server recording
US9055319B2 (en) 1998-07-14 2015-06-09 Rovi Guides, Inc. Interactive guide with recording
US9055318B2 (en) 1998-07-14 2015-06-09 Rovi Guides, Inc. Client-server based interactive guide with server storage
US9118948B2 (en) 1998-07-14 2015-08-25 Rovi Guides, Inc. Client-server based interactive guide with server recording
US9154843B2 (en) 1998-07-14 2015-10-06 Rovi Guides, Inc. Client-server based interactive guide with server recording
US9226006B2 (en) 1998-07-14 2015-12-29 Rovi Guides, Inc. Client-server based interactive guide with server recording
US9232254B2 (en) 1998-07-14 2016-01-05 Rovi Guides, Inc. Client-server based interactive television guide with server recording
US9374560B2 (en) 2005-12-29 2016-06-21 Rovi Guides, Inc. Systems and methods for managing a status change of a multimedia asset in multimedia delivery systems
US9125169B2 (en) 2011-12-23 2015-09-01 Rovi Guides, Inc. Methods and systems for performing actions based on location-based rules

Also Published As

Publication number Publication date
AU2002356341A1 (en) 2003-07-30
US7867757B2 (en) 2011-01-11
AU2002356341A8 (en) 2003-07-30
EP1458473A2 (en) 2004-09-22
WO2003060157A2 (en) 2003-07-24
US20050089863A1 (en) 2005-04-28
NO20033827D0 (en) 2003-08-28

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