WO2003063820A3 - Demixing-stable granulate - Google Patents

Demixing-stable granulate Download PDF

Info

Publication number
WO2003063820A3
WO2003063820A3 PCT/EP2003/000972 EP0300972W WO03063820A3 WO 2003063820 A3 WO2003063820 A3 WO 2003063820A3 EP 0300972 W EP0300972 W EP 0300972W WO 03063820 A3 WO03063820 A3 WO 03063820A3
Authority
WO
WIPO (PCT)
Prior art keywords
demixing
granulate
stable
stable granulate
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/000972
Other languages
French (fr)
Other versions
WO2003063820A2 (en
Inventor
Franz Xaver Schwarz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Sandoz AG
Original Assignee
Sandoz GmbH
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT0017002A external-priority patent/AT500131A1/en
Priority claimed from AT0019202A external-priority patent/AT500132A1/en
Application filed by Sandoz GmbH, Sandoz AG filed Critical Sandoz GmbH
Priority to AU2003208358A priority Critical patent/AU2003208358A1/en
Priority to EP03706404A priority patent/EP1474104A2/en
Publication of WO2003063820A2 publication Critical patent/WO2003063820A2/en
Publication of WO2003063820A3 publication Critical patent/WO2003063820A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A process for the production of a granulate which is stable to segregation and which comprises granulate particles, which contain at least one β-lactama antibiotic and at least one β-lactamase inhibitor, useful for the production of pharmaceutical compositions.
PCT/EP2003/000972 2002-02-01 2003-01-31 Demixing-stable granulate Ceased WO2003063820A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003208358A AU2003208358A1 (en) 2002-02-01 2003-01-31 Demixing-stable granulate
EP03706404A EP1474104A2 (en) 2002-02-01 2003-01-31 Demixing-stable granulate

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT170/2002 2002-02-01
AT0017002A AT500131A1 (en) 2002-02-01 2002-02-01 ORGANIC CONNECTIONS
AT192/2002 2002-02-06
AT0019202A AT500132A1 (en) 2002-02-06 2002-02-06 ORGANIC CONNECTIONS

Publications (2)

Publication Number Publication Date
WO2003063820A2 WO2003063820A2 (en) 2003-08-07
WO2003063820A3 true WO2003063820A3 (en) 2004-01-15

Family

ID=27663978

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000972 Ceased WO2003063820A2 (en) 2002-02-01 2003-01-31 Demixing-stable granulate

Country Status (3)

Country Link
EP (1) EP1474104A2 (en)
AU (1) AU2003208358A1 (en)
WO (1) WO2003063820A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060159741A1 (en) * 2002-11-26 2006-07-20 Janez Kerc Pharmaceutical compositions comprising amoxicillin and clavulanic acid
EP1720533B1 (en) * 2004-02-24 2015-03-25 Sandoz Ag Amoxicillin instant granulate
WO2006072577A1 (en) * 2005-01-07 2006-07-13 Sandoz Ag Process for preparing granulates comprising amoxicillin
DE102005061290B4 (en) * 2005-12-20 2021-03-18 Heraeus Medical Gmbh Process for the production of antibiotic / antibiotic particles and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033564A1 (en) * 1996-03-13 1997-09-18 Biochemie Gesellschaft Mbh Agglomerates containing beta-lactam compounds
WO1999011261A1 (en) * 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients
EP1142574A1 (en) * 1997-02-14 2001-10-10 Smithkline Beecham Laboratoires Pharmaceutiques Pharmaceutical formulations comprising amoxycillin and clavulanate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033564A1 (en) * 1996-03-13 1997-09-18 Biochemie Gesellschaft Mbh Agglomerates containing beta-lactam compounds
EP1142574A1 (en) * 1997-02-14 2001-10-10 Smithkline Beecham Laboratoires Pharmaceutiques Pharmaceutical formulations comprising amoxycillin and clavulanate
WO1999011261A1 (en) * 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients

Also Published As

Publication number Publication date
EP1474104A2 (en) 2004-11-10
AU2003208358A1 (en) 2003-09-02
WO2003063820A2 (en) 2003-08-07

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