WO2003064496A3 - Biodegradable polymer - Google Patents

Biodegradable polymer Download PDF

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Publication number
WO2003064496A3
WO2003064496A3 PCT/US2002/033787 US0233787W WO03064496A3 WO 2003064496 A3 WO2003064496 A3 WO 2003064496A3 US 0233787 W US0233787 W US 0233787W WO 03064496 A3 WO03064496 A3 WO 03064496A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
biodegradable polymer
modify
cells
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/033787
Other languages
French (fr)
Other versions
WO2003064496A2 (en
WO2003064496A9 (en
Inventor
Yadong Wang
Guillermo Ameer
Robert S Langer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to DE60218061T priority Critical patent/DE60218061T2/en
Priority to JP2003564110A priority patent/JP2005516091A/en
Priority to AU2002365921A priority patent/AU2002365921A1/en
Priority to EP02806686A priority patent/EP1448656B1/en
Publication of WO2003064496A2 publication Critical patent/WO2003064496A2/en
Publication of WO2003064496A3 publication Critical patent/WO2003064496A3/en
Anticipated expiration legal-status Critical
Publication of WO2003064496A9 publication Critical patent/WO2003064496A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Insulating Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Confectionery (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

A biodegradable polymer comprising a condensation polymer of glycerol and a diacid. The polymer may be adapted for use as a tissue engineering construct. For example, it may be seeded with cells, or molecules may be attached to it to modify the metabolism and proliferation of cells or to modify the degradation rate and/or mechanism of the polymer. The polymer may also be exploited in a variety of medical and non-medical applications.
PCT/US2002/033787 2001-10-22 2002-10-22 Biodegradable polymer Ceased WO2003064496A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60218061T DE60218061T2 (en) 2001-10-22 2002-10-22 BIODEGRADABLE POLYMER
JP2003564110A JP2005516091A (en) 2001-10-22 2002-10-22 Biodegradable polymer
AU2002365921A AU2002365921A1 (en) 2001-10-22 2002-10-22 Biodegradable polymer
EP02806686A EP1448656B1 (en) 2001-10-22 2002-10-22 Biodegradable polymer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34043201P 2001-10-22 2001-10-22
US60/340,432 2001-10-22

Publications (3)

Publication Number Publication Date
WO2003064496A2 WO2003064496A2 (en) 2003-08-07
WO2003064496A3 true WO2003064496A3 (en) 2004-02-12
WO2003064496A9 WO2003064496A9 (en) 2004-04-29

Family

ID=27662941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033787 Ceased WO2003064496A2 (en) 2001-10-22 2002-10-22 Biodegradable polymer

Country Status (8)

Country Link
EP (1) EP1448656B1 (en)
JP (1) JP2005516091A (en)
AT (1) ATE353347T1 (en)
AU (1) AU2002365921A1 (en)
DE (1) DE60218061T2 (en)
ES (1) ES2282521T3 (en)
PT (1) PT1448656E (en)
WO (1) WO2003064496A2 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550324A1 (en) * 2003-12-30 2005-07-14 Gumlink A/S Chewing gum comprising biodegradable polymers and having accelerated degradability
US7820732B2 (en) * 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US8282971B2 (en) 2005-08-22 2012-10-09 Kraft Foods Global Brands Llc Degradable chewing gum
US8268371B2 (en) 2005-08-22 2012-09-18 Kraft Foods Global Brands Llc Degradable chewing gum
US8287928B2 (en) 2005-08-22 2012-10-16 Kraft Foods Global Brands Llc Degradable chewing gum
US8263143B2 (en) 2005-08-22 2012-09-11 Kraft Foods Global Brands Llc Degradable chewing gum
WO2007082305A2 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
US8399012B2 (en) 2006-04-17 2013-03-19 Kimberly-Clark Worldwide, Inc. Degradable therapeutic delivery device
EP2124600A1 (en) * 2007-02-26 2009-12-02 Revolymer Limited Medicated chewing gum
EP2150202B1 (en) * 2007-05-14 2018-07-04 Covidien LP Biodegradable peptide releasing polymers
US8912304B2 (en) 2007-05-17 2014-12-16 Massachusetts Institute Of Technology Polyol-based polymers
FR2918307B1 (en) 2007-07-02 2009-10-09 Teknimed Sas Soc Par Actions S METHOD FOR MANUFACTURING BIODEGRADABLE, SYNTHETIC AND FLEXIBLE DIAPHYSARY SHUTTER
US7794645B2 (en) 2007-07-02 2010-09-14 Teknimed S.A. Method for producing a biodegradable, synthetic and flexible diaphyseal obturator
JP5777510B2 (en) 2008-05-09 2015-09-09 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ Biocompatible and biodegradable elastomeric polymers
EA201170297A1 (en) * 2008-08-09 2011-08-30 Массачусетс Инститьют Оф Текнолоджи IMPLANTABLE DEVICE FOR THE DELIVERY OF MEDICINES AND THE METHOD OF TREATMENT OF MALE URINS AND THE ENVIRONMENTAL TISSUES
ES2671252T3 (en) 2011-11-17 2018-06-05 Stratasys Ltd. System and method to manufacture a model of a body part using additive manufacturing with multiple materials
JP2015506734A (en) * 2011-12-22 2015-03-05 エーテーハー チューリヒ Patch structure for controlling wound healing
KR101891046B1 (en) * 2014-12-16 2018-08-22 보스톤 싸이엔티픽 싸이메드 인코포레이티드 Bioerodible polymer compositions
EP3416593B1 (en) * 2016-02-16 2024-04-03 Children's Medical Center Corporation Autonomously growing implantable device
EP3420020B1 (en) * 2016-02-25 2020-07-22 The Secant Group, LLC Composite containing poly(glycerol sebacate) filler
PL249565B1 (en) * 2022-07-06 2026-05-11 Politechnika Warszawska PGS absorbent material, especially for dressings, containing an active substance, method of obtaining PGS absorbent material and use of PGS absorbent material
FR3147807A1 (en) 2023-04-13 2024-10-18 Compagnie Generale Des Etablissements Michelin Process for the synthesis of a polyester from glycerol
CN120958060A (en) 2023-04-13 2025-11-14 米其林集团总公司 Synthesis method of glycerol polyester
CN121311524A (en) 2023-06-06 2026-01-09 米其林集团总公司 A method for synthesizing glycerol polyester and the glycerol polyester obtained therefrom
FR3156786A1 (en) 2023-12-13 2025-06-20 Compagnie Generale Des Etablissements Michelin Process for preparing a crosslinked polyester of glycerol and a dicarboxylic acid using a cyclic polycarboxylic anhydride, and corresponding crosslinked polyester
FR3156793B1 (en) 2023-12-13 2025-12-26 Michelin & Cie Crosslinked polyesters of glycerol and a dicarboxylic acid monomer exhibiting improved bioresorbability and/or degradation in aqueous media
FR3157868A1 (en) 2023-12-27 2025-07-04 Compagnie Generale Des Etablissements Michelin PHOTOCROSSLINKABLE COPOLYESTERS AND PROCESS FOR OBTAINING THE SAME BY POST-FUNCTIONALIZATION
FR3157867A1 (en) 2023-12-27 2025-07-04 Compagnie Generale Des Etablissements Michelin Process for synthesizing a polyester from polyols
FR3162752A1 (en) 2024-06-04 2025-12-05 Compagnie Generale Des Etablissements Michelin Process for preparing a crosslinked polyester of glycerol and a dicarboxylic acid using a cyclic carboxylic polyanhydride in the presence of a catalyst
FR3163372A1 (en) 2024-06-13 2025-12-19 Compagnie Generale Des Etablissements Michelin Process for preparing a crosslinked polyester of glycerol and a dicarboxylic acid using a cyclic carboxylic polyanhydride in the presence of a catalyst
FR3164379A1 (en) 2024-07-09 2026-01-16 Compagnie Generale Des Etablissements Michelin Silicone substitute and topical compositions containing it
FR3165269A1 (en) 2024-07-30 2026-02-06 Compagnie Generale Des Etablissements Michelin COMPOSITIONS OF PHOTORELINKABLE COPOLYESTERS
FR3165270A1 (en) 2024-07-30 2026-02-06 Compagnie Generale Des Etablissements Michelin COMPOSITIONS OF PHOTORELINKABLE COPOLYESTERS
FR3166151A1 (en) 2024-09-12 2026-03-13 Compagnie Generale Des Etablissements Michelin PROCESS FOR PRODUCING A CONTINUOUS POLYESTER FIBER OR YARN FROM GLYCEROL
WO2026087530A1 (en) 2024-10-22 2026-04-30 Compagnie Generale Des Etablissements Michelin Use of poly(2-oxazoline) for improving the extensibility of crosslinked glycerol polyesters

Citations (23)

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Publication number Priority date Publication date Assignee Title
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US3772064A (en) * 1971-07-13 1973-11-13 Westinghouse Electric Corp Pressure sensitive thermosetting resinous adhesive tapes
US4048256A (en) * 1976-06-01 1977-09-13 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4177596A (en) * 1978-02-21 1979-12-11 Dillow John P Appendage for a fishhook
US4205399A (en) * 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
EP0246341A1 (en) * 1986-05-20 1987-11-25 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
EP0427496A2 (en) * 1989-11-08 1991-05-15 MITSUI TOATSU CHEMICALS, Inc. Fishing tackle
US5116937A (en) * 1991-05-31 1992-05-26 E. I. Du Pont De Nemours And Company Water-swellable thermoplastic copolyetherester elastomer
EP0509814A2 (en) * 1991-04-19 1992-10-21 E.I. Du Pont De Nemours And Company Vascular prosthesis with an elastomer coating
US5295985A (en) * 1990-05-11 1994-03-22 E. I. Du Pont De Nemours And Company Polyesters and their use in compostable products such as disposable diapers
US5399665A (en) * 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
US5489298A (en) * 1991-01-24 1996-02-06 Autogenics Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure
EP0711506A2 (en) * 1994-10-14 1996-05-15 Rijksuniversiteit te Groningen Chewing gum
US5525646A (en) * 1991-03-04 1996-06-11 Lundgren; Dan Bioresorbable material and an article of manufacture made of such material for medical use
US5545212A (en) * 1991-12-18 1996-08-13 Terumo Kabushiki Kaisha Artificial blood vessel
EP0768329A2 (en) * 1995-10-02 1997-04-16 Ethicon, Inc. High strength, melt processable, lactide-rich, poly(lactide-co-p-dioxanone) copolymers
EP0807653A2 (en) * 1996-05-16 1997-11-19 Ethicon, Inc. Absorbable polyalkylene diglycolates
WO1998030617A1 (en) * 1997-01-11 1998-07-16 Smith & Nephew Plc Hydrogels
WO2000035297A1 (en) * 1998-12-17 2000-06-22 Wm. Wrigley Jr. Company Gum base and chewing gum containing edible polyesters
EP1038538A1 (en) * 1999-03-19 2000-09-27 IsoTis B.V. Muscle tissue engineering
US6160084A (en) * 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
WO2001076554A2 (en) * 2000-04-07 2001-10-18 Massachusetts Institute Of Technology Drug delivery composition and device

Patent Citations (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1489744A (en) * 1920-12-22 1924-04-08 Barrett Co Resin and process of producing the same
US3772064A (en) * 1971-07-13 1973-11-13 Westinghouse Electric Corp Pressure sensitive thermosetting resinous adhesive tapes
US4048256A (en) * 1976-06-01 1977-09-13 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4205399A (en) * 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4177596A (en) * 1978-02-21 1979-12-11 Dillow John P Appendage for a fishhook
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
EP0246341A1 (en) * 1986-05-20 1987-11-25 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
EP0427496A2 (en) * 1989-11-08 1991-05-15 MITSUI TOATSU CHEMICALS, Inc. Fishing tackle
US5295985A (en) * 1990-05-11 1994-03-22 E. I. Du Pont De Nemours And Company Polyesters and their use in compostable products such as disposable diapers
US5489298A (en) * 1991-01-24 1996-02-06 Autogenics Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure
US5525646A (en) * 1991-03-04 1996-06-11 Lundgren; Dan Bioresorbable material and an article of manufacture made of such material for medical use
EP0509814A2 (en) * 1991-04-19 1992-10-21 E.I. Du Pont De Nemours And Company Vascular prosthesis with an elastomer coating
US5116937A (en) * 1991-05-31 1992-05-26 E. I. Du Pont De Nemours And Company Water-swellable thermoplastic copolyetherester elastomer
US5545212A (en) * 1991-12-18 1996-08-13 Terumo Kabushiki Kaisha Artificial blood vessel
US5399665A (en) * 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
EP0711506A2 (en) * 1994-10-14 1996-05-15 Rijksuniversiteit te Groningen Chewing gum
EP0768329A2 (en) * 1995-10-02 1997-04-16 Ethicon, Inc. High strength, melt processable, lactide-rich, poly(lactide-co-p-dioxanone) copolymers
EP0807653A2 (en) * 1996-05-16 1997-11-19 Ethicon, Inc. Absorbable polyalkylene diglycolates
WO1998030617A1 (en) * 1997-01-11 1998-07-16 Smith & Nephew Plc Hydrogels
US6160084A (en) * 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
WO2000035297A1 (en) * 1998-12-17 2000-06-22 Wm. Wrigley Jr. Company Gum base and chewing gum containing edible polyesters
EP1038538A1 (en) * 1999-03-19 2000-09-27 IsoTis B.V. Muscle tissue engineering
WO2001076554A2 (en) * 2000-04-07 2001-10-18 Massachusetts Institute Of Technology Drug delivery composition and device

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANDERSON J.M. & AL: "Biodegradation and biocompatiblity of PLA and PLGA microspheres", ADVANCED DRUG DELIVERY REVIEWS, vol. 28, 1997, pages 5 - 24, XP002249688 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 1998 (1998-11-01), MALEKZADEH REZA ET AL: "Isolation of human osteoblast-like cells and in vitro amplification for tissue engineering.", XP002249690, Database accession no. PREV199900037640 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; November 1977 (1977-11-01), ROSENBLATT M ET AL: "Synthesis of a fragment of human parathyroid hormore, hPTH-(44-68).", XP002249689, Database accession no. NLM915904 *
DE GROOT J H ET AL: "Use of porous polyurethanes for meniscal reconstruction and meniscal prostheses", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 17, no. 2, 1996, pages 163 - 173, XP004032814, ISSN: 0142-9612 *
GAO J. & AL: "Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells", JOURNAL OF BIOMEDICAL MATERIAL RESEARCH, vol. 42, 1998, pages 417 - 424, XP002249687 *
JOURNAL OF MEDICINAL CHEMISTRY. UNITED STATES NOV 1977, vol. 20, no. 11, November 1977 (1977-11-01), pages 1452 - 1456, ISSN: 0022-2623 *
JOURNAL OF PERIODONTOLOGY, vol. 69, no. 11, November 1998 (1998-11-01), pages 1256 - 1262, ISSN: 0022-3492 *
NAGATA M ET AL: "SYNTHESIS, CHARACTERIZATION, AND ENZYMATIC DEGRADATION OF NETWORK ALIPHATIC COPOLYESTERS", JOURNAL OF POLYMER SCIENCE, POLYMER CHEMISTRY EDITION, JOHN WILEY AND SONS. NEW YORK, US, vol. 37, no. 13, 1 July 1999 (1999-07-01), pages 2005 - 2011, XP000829804, ISSN: 0360-6376 *

Also Published As

Publication number Publication date
ES2282521T3 (en) 2007-10-16
ATE353347T1 (en) 2007-02-15
EP1448656A2 (en) 2004-08-25
WO2003064496A2 (en) 2003-08-07
WO2003064496A9 (en) 2004-04-29
AU2002365921A1 (en) 2003-09-02
DE60218061T2 (en) 2007-11-15
DE60218061D1 (en) 2007-03-22
PT1448656E (en) 2007-05-31
EP1448656B1 (en) 2007-02-07
JP2005516091A (en) 2005-06-02

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