WO2003078454A3 - Polymer supported reagents for natural products purification - Google Patents

Polymer supported reagents for natural products purification Download PDF

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Publication number
WO2003078454A3
WO2003078454A3 PCT/EP2003/002635 EP0302635W WO03078454A3 WO 2003078454 A3 WO2003078454 A3 WO 2003078454A3 EP 0302635 W EP0302635 W EP 0302635W WO 03078454 A3 WO03078454 A3 WO 03078454A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer supported
natural products
reagents
supported reagents
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/002635
Other languages
French (fr)
Other versions
WO2003078454A2 (en
Inventor
Florian Thaler
Moreno Zamai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Priority to MXPA04009084A priority Critical patent/MXPA04009084A/en
Priority to AU2003218755A priority patent/AU2003218755A1/en
Priority to JP2003576458A priority patent/JP2005535567A/en
Priority to EP03712004A priority patent/EP1487862A2/en
Priority to CA002479355A priority patent/CA2479355A1/en
Priority to BR0308577-5A priority patent/BR0308577A/en
Publication of WO2003078454A2 publication Critical patent/WO2003078454A2/en
Publication of WO2003078454A3 publication Critical patent/WO2003078454A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)

Abstract

There is provided a method for the purification of bio-molecules after chemical modification using one or more insoluble polymer supported reagents. More particularly, the present invention provides a method for the fast purification of labeled bio-molecules using insoluble polymer supported quenching reagents. There are also provided novel polymer supported reagents of the formula (I): Rs-Sp-Re, wherein Rs is an insoluble polymer, Re is one or more reagent residues and Sp is one or more chemically robust spacer that join Rs and Re; and a process for their preparation.
PCT/EP2003/002635 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification Ceased WO2003078454A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA04009084A MXPA04009084A (en) 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification.
AU2003218755A AU2003218755A1 (en) 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification
JP2003576458A JP2005535567A (en) 2002-03-20 2003-03-12 Polymer-supported reagents for natural product purification
EP03712004A EP1487862A2 (en) 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification
CA002479355A CA2479355A1 (en) 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification
BR0308577-5A BR0308577A (en) 2002-03-20 2003-03-12 Polymer Supported Reagents for Natural Product Purification

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076087 2002-03-20
EP02076087.2 2002-03-20

Publications (2)

Publication Number Publication Date
WO2003078454A2 WO2003078454A2 (en) 2003-09-25
WO2003078454A3 true WO2003078454A3 (en) 2004-04-01

Family

ID=27838102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002635 Ceased WO2003078454A2 (en) 2002-03-20 2003-03-12 Polymer supported reagents for natural products purification

Country Status (7)

Country Link
EP (1) EP1487862A2 (en)
JP (1) JP2005535567A (en)
AU (1) AU2003218755A1 (en)
BR (1) BR0308577A (en)
CA (1) CA2479355A1 (en)
MX (1) MXPA04009084A (en)
WO (1) WO2003078454A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1660519B1 (en) * 2003-07-29 2014-05-14 Immunomedics, Inc. Conjugates comprising 2-[18F]fluoro-2-deoxy-D-glucose and a peptide molecule
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042230A1 (en) * 1996-05-03 1997-11-13 Warner-Lambert Company Rapid purification by polymer supported quench
WO2001019484A1 (en) * 1999-09-13 2001-03-22 Dyax Corporation Purification device and purification method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042230A1 (en) * 1996-05-03 1997-11-13 Warner-Lambert Company Rapid purification by polymer supported quench
US6306959B1 (en) * 1996-05-03 2001-10-23 Warner Lambert Company Rapid purification by polymer supported quench
US6506701B1 (en) * 1996-05-03 2003-01-14 Warner-Lambert Company Rapid purification by polymer supported quench
WO2001019484A1 (en) * 1999-09-13 2001-03-22 Dyax Corporation Purification device and purification method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICEWONGER R B ET AL: "Alternative base matrices for solid phase quenching reagents", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 14, April 2000 (2000-04-01), pages 2323 - 2326, XP004193757, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU2003218755A1 (en) 2003-09-29
BR0308577A (en) 2005-01-04
JP2005535567A (en) 2005-11-24
CA2479355A1 (en) 2003-09-25
WO2003078454A2 (en) 2003-09-25
EP1487862A2 (en) 2004-12-22
MXPA04009084A (en) 2004-12-06

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