WO2003080545A3 - Substituted phenylacetic acids - Google Patents

Substituted phenylacetic acids Download PDF

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Publication number
WO2003080545A3
WO2003080545A3 PCT/US2003/008899 US0308899W WO03080545A3 WO 2003080545 A3 WO2003080545 A3 WO 2003080545A3 US 0308899 W US0308899 W US 0308899W WO 03080545 A3 WO03080545 A3 WO 03080545A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenylacetic acids
substituted phenylacetic
substituted
acids
phenylethanols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/008899
Other languages
French (fr)
Other versions
WO2003080545A2 (en
Inventor
Zuchun Zhao
Xin Chen
Jianchao Wang
Hongbin Sun
Jack Shih-Chieh Liang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CymaBay Therapeutics Inc
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003578306A priority Critical patent/JP2005520858A/en
Application filed by Metabolex Inc filed Critical Metabolex Inc
Priority to KR10-2004-7014829A priority patent/KR20050008661A/en
Priority to EP03736445A priority patent/EP1487843A4/en
Priority to NZ535603A priority patent/NZ535603A/en
Priority to MXPA04009040A priority patent/MXPA04009040A/en
Priority to BR0308537-6A priority patent/BR0308537A/en
Priority to CA002479338A priority patent/CA2479338A1/en
Priority to AU2003237787A priority patent/AU2003237787B2/en
Publication of WO2003080545A2 publication Critical patent/WO2003080545A2/en
Publication of WO2003080545A3 publication Critical patent/WO2003080545A3/en
Anticipated expiration legal-status Critical
Priority to NO20044436A priority patent/NO20044436L/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
PCT/US2003/008899 2002-03-20 2003-03-19 Substituted phenylacetic acids Ceased WO2003080545A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2003237787A AU2003237787B2 (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids
KR10-2004-7014829A KR20050008661A (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids
EP03736445A EP1487843A4 (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids
NZ535603A NZ535603A (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids
MXPA04009040A MXPA04009040A (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids.
JP2003578306A JP2005520858A (en) 2002-03-20 2003-03-19 Substituted phenylacetic acid
CA002479338A CA2479338A1 (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids
BR0308537-6A BR0308537A (en) 2002-03-20 2003-03-19 Compound, composition, and methods for treating type 2 diabetes and hyperuricemia, modulating insulin resistance and alleviating hyperlipidemia in an individual and prodrug agent
NO20044436A NO20044436L (en) 2002-03-20 2004-10-19 Substituted phenylacetic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36696102P 2002-03-20 2002-03-20
US60/366,961 2002-03-20

Publications (2)

Publication Number Publication Date
WO2003080545A2 WO2003080545A2 (en) 2003-10-02
WO2003080545A3 true WO2003080545A3 (en) 2004-01-22

Family

ID=28454828

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008899 Ceased WO2003080545A2 (en) 2002-03-20 2003-03-19 Substituted phenylacetic acids

Country Status (13)

Country Link
US (2) US7078421B2 (en)
EP (1) EP1487843A4 (en)
JP (1) JP2005520858A (en)
KR (1) KR20050008661A (en)
CN (2) CN101172983A (en)
AU (1) AU2003237787B2 (en)
BR (1) BR0308537A (en)
CA (1) CA2479338A1 (en)
MX (1) MXPA04009040A (en)
NO (1) NO20044436L (en)
NZ (1) NZ535603A (en)
WO (1) WO2003080545A2 (en)
ZA (1) ZA200407802B (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1587821T6 (en) * 2002-12-19 2025-05-26 Scripps Research Inst Compositions and methods for stabilizing trans-thyretin and inhibiting transthyretin misfolding
SE0301009D0 (en) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301010D0 (en) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (en) 2003-08-21 2009-11-10 استرازينيكا ايه بي Substiuted phenoxacetic as pharmaceutced compunds for treating respiratory diseases such as asthma and copd
EP2228369A1 (en) 2003-12-23 2010-09-15 Astex Therapeutics Ltd. Pyrazole derivatives as protein kinase modulators
CA2555814A1 (en) * 2004-02-18 2005-09-01 Metabolex, Inc. Alpha-(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
WO2005112913A1 (en) * 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
RU2006145872A (en) 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) SUBSTITUTED TRIAZOLES AS PPAR MODULATORS AND METHODS FOR PRODUCING THEM
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
US7622491B2 (en) * 2004-08-13 2009-11-24 Metabolex Inc. Modulators of PPAR and methods of their preparation
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
WO2006033285A1 (en) * 2004-09-24 2006-03-30 Semiconductor Energy Laboratory Co., Ltd. Light emitting device
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
EP1817282B1 (en) 2004-11-23 2011-07-20 AstraZeneca AB Phenoxyacetic acid derivatives useful for treating respiratory diseases
US8288438B2 (en) 2005-03-21 2012-10-16 Metabolex, Inc. Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer
US8343953B2 (en) 2005-06-22 2013-01-01 Astex Therapeutics Limited Pharmaceutical compounds
WO2006136837A2 (en) 2005-06-23 2006-12-28 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CN101316853B (en) * 2005-08-04 2014-09-24 西特里斯药业公司 Benzothiazoles and thiazolopyridines as modulators of SIRTUIN
US7345178B2 (en) * 2005-08-04 2008-03-18 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP1937632A1 (en) 2005-10-06 2008-07-02 Astra Zeneca AB Novel compounds
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
US20080255150A1 (en) * 2005-11-05 2008-10-16 Astrazeneca Ab Novel Compounds
ES2380683T3 (en) * 2005-12-15 2012-05-17 Astrazeneca Ab Diphenyl ethers, amides, sulphides and substituted methanes for the treatment of respiratory disease
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
JP5305462B2 (en) * 2007-03-27 2013-10-02 塩野義製薬株式会社 Method for producing N-phenyl-N'-phenylsulfonylpiperazine derivative
ES2569660T3 (en) 2007-06-08 2016-05-12 Mannkind Corporation IRE-1alpha inhibitors
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
UA100983C2 (en) * 2007-07-05 2013-02-25 Астразенека Аб Biphenyloxypropanoic acid as crth2 modulator and intermediates
CA2710016A1 (en) * 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
CN102388054B (en) 2008-12-19 2015-03-04 西特里斯药业公司 Thiazolopyridine sirtuin modulating compounds
RU2013114352A (en) 2010-09-15 2014-10-20 Ф. Хоффманн-Ля Рош Аг AZABENZENESIAZOLES, COMPOSITIONS AND METHODS OF APPLICATION
AU2011346670B2 (en) 2010-12-23 2015-05-07 Pfizer Inc. Glucagon receptor modulators
PH12013501557A1 (en) 2011-02-08 2019-06-03 Pfizer Glucagon receptor modulator
KR101395146B1 (en) 2011-02-09 2014-05-16 부산대학교 산학협력단 New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof
RU2013157388A (en) 2011-07-22 2015-08-27 Пфайзер Инк. QUINOLINYL MODULATORS OF THE GLUCAGON RECEPTOR
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
CN108329330B (en) * 2017-01-20 2021-05-04 复旦大学 2-Benzyloxyphenyloxazolopyridine compounds and their medicinal uses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077938A2 (en) * 1981-10-23 1983-05-04 Mitsubishi Kasei Corporation N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
JPS60109578A (en) * 1983-11-17 1985-06-15 Mitsubishi Chem Ind Ltd 3-(substituted phenyl)-5-substituted-1,3,4-oxazolin-2-one compound and herbicide containing said compound as active component
US5476946A (en) * 1993-02-09 1995-12-19 Bayer Aktiengesellschaft 1-aryltriazolin(ethi)ones
US6506747B1 (en) * 1998-06-05 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072585A (en) * 1960-01-13 1963-01-08 American Cyanamid Co Vinylbenzyloxy phenylbenzotriazoles
FR1451171A (en) * 1961-04-21 1966-01-07 Jacques Logeais Soc D Expl Des Etherified and esterified derivatives of 2-o-hydroxyphenyl-oxadiazole-1, 3, 4 and process for their preparation
US3444299A (en) 1964-02-07 1969-05-13 American Cyanamid Co Methods for the control and prevention of helminths with phenylbenzothiazolium compounds
GB1097053A (en) 1964-03-16 1967-12-29 Dow Chemical Co Substituted benzothiazolium compounds and complexes thereof for use in animal husbandry
US3558778A (en) 1966-10-27 1971-01-26 Dow Chemical Co Methods and compositions for use in animal husbandry
US3674836A (en) 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
BE754245A (en) 1969-08-01 1970-12-31 Sumitomo Chemical Co PHENOXY CARBOXYLIC ACID DERIVATIVES
FR2082478A5 (en) * 1970-03-17 1971-12-10 Thomson Csf
GB1341222A (en) * 1970-04-17 1973-12-19 Takeda Chemical Industries Ltd Oxadiazole derivatives
DE2358789A1 (en) * 1973-02-07 1975-06-05 Merck Patent Gmbh HYDRATROPASIC ACID DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
IL44356A (en) * 1973-03-13 1977-10-31 Merck Patent Gmbh Phenoxyacetic acid derivatives and processes for their preparation
US4053626A (en) * 1973-03-13 1977-10-11 Merck Patent Gesellschaft Mit Beschrankter Haftung Cholesterol level-lowering phenoxyacetic acids
US3876791A (en) 1973-11-30 1975-04-08 Uniroyal Inc Control of acarids using certain benzothiazoles or benzothiazolines
DE2415867A1 (en) * 1974-04-02 1975-10-09 Merck Patent Gmbh PHENOXY ALCANOL DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
US3894057A (en) * 1974-05-28 1975-07-08 Hoechst Co American Tetrahydrobenzofuranylphenoxycarboxylic acids, esters
US4001268A (en) 1974-08-07 1977-01-04 The United States Of America As Represented By The Secretary Of The Air Force Substituted phenyl-benzimidazo compounds
JPS6039072B2 (en) 1976-07-28 1985-09-04 藤沢薬品工業株式会社 N-substituted phenylamino fatty acid derivatives
JPS5371071A (en) 1976-12-08 1978-06-24 Teijin Ltd Alpha-phenoxyacetic acid derivs.
FR2455587A1 (en) 1979-05-04 1980-11-28 Continental Pharma BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR CONDITIONS AND COMPOSITIONS CONTAINING THEM
US4508882A (en) 1981-08-24 1985-04-02 Asahi Glass Company Ltd. Benzotriazole compound and homopolymer or copolymers thereof
DE3236730A1 (en) 1982-10-04 1984-04-05 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING BENZOXAZOLYL AND BENZTHIAZOLYLOXYPHENOXYPROPION ACID DERIVATIVES
US4528311A (en) 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
JPS6140266A (en) * 1984-08-01 1986-02-26 Morishita Seiyaku Kk Pyrazole derivative
JPS6140270A (en) * 1984-08-01 1986-02-26 Morishita Seiyaku Kk Pyridazinone derivative
US4714762A (en) 1986-10-31 1987-12-22 Warner-Lambert Company Antiarteriosclerotic substituted benzimidazol-2-yl-and 3H-imidazo[4,5-b]pyridin-2-yl-phenoxy-alkanoic acids and salts and esters thereof
JPH0670025B2 (en) 1987-08-07 1994-09-07 鐘紡株式会社 Benzothiazole derivative and antirheumatic agent containing the compound as an active ingredient
GB8720365D0 (en) 1987-08-28 1987-10-07 Sandoz Ltd Organic compounds
US4863802A (en) 1987-12-31 1989-09-05 General Electric Company UV-stabilized coatings
JPH01305069A (en) 1988-05-31 1989-12-08 Shionogi & Co Ltd Benzotriazole derivative and fluorescent light emitting reagent containing the same derivative
CA2034309C (en) 1990-01-22 1997-04-01 Takashi Iwaki Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus
US5281571A (en) * 1990-10-18 1994-01-25 Monsanto Company Herbicidal benzoxazinone- and benzothiazinone-substituted pyrazoles
US5278314A (en) 1991-02-12 1994-01-11 Ciba-Geigy Corporation 5-thio-substituted benzotriazole UV-absorbers
ES2141197T3 (en) * 1993-03-19 2000-03-16 Merck & Co Inc DERIVATIVES OF PHENOXYPHENYLACETIC ACID.
US5874431A (en) 1993-08-28 1999-02-23 Cancer Research Campaign Technology Limited Benzazole compounds
EP0774965A4 (en) * 1994-08-08 1997-10-29 Merck & Co Inc Phenoxyphenylacetic acid derivatives
US5496826A (en) 1994-09-02 1996-03-05 Bristol-Myers Squibb Company Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides
US5455152A (en) 1994-09-27 1995-10-03 Eastman Kodak Company Benzotriazole based UV absorbing monomers and photographic elements containing polymers formed from them
US5700819A (en) 1994-11-29 1997-12-23 Grelan Pharmaceutical Co., Ltd. 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
GB9503946D0 (en) 1995-02-28 1995-04-19 Cancer Res Campaign Tech Benzazole compounds
US5500332A (en) 1995-04-26 1996-03-19 Eastman Kodak Company Benzotriazole based UV absorbers and photographic elements containing them
US5766834A (en) 1996-05-17 1998-06-16 Eastman Kodak Company Photographic element containing ultraviolet absorbing polymer
US6184235B1 (en) 1996-08-14 2001-02-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as MCP-1 antagonists
CA2219269A1 (en) * 1996-10-29 1998-04-29 Novartis Ag Novel herbicides
KR100496318B1 (en) 1996-11-22 2005-06-20 시바 스페셜티 케미칼스 홀딩 인크. Use of selected benzotriazole derivatives for protecting human and animal skin and hair from the harmful effects of UV radiation
JP3714574B2 (en) 1997-03-26 2005-11-09 ダイセル化学工業株式会社 Ultraviolet absorber, method for producing the same and synthetic resin composition
US5942532A (en) 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
ES2216322T3 (en) 1997-11-07 2004-10-16 Taiho Pharmaceutical Company, Limited DERIVATIVES OF BENCIMIDAZOLS AND SALTS OF THESE LAST ACCEPTABLE ON THE PHARMACEUTICAL PLANE.
AU3979199A (en) * 1998-05-12 1999-11-29 American Home Products Corporation 11-aryl-benzo{b}naphtho{2,3-d}furans and 11-aryl-benzo{b}naphtho{2,3-d}thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6013659A (en) 1998-09-04 2000-01-11 University Of Pittsburgh Methods of reducing tumor colony number using novel benzothiazole compounds
HUP0104987A3 (en) 1998-12-18 2002-09-30 Axys Pharmaceuticals Inc South Benzimidazole or indole derivatives protease inhibitors, and pharmaceutical compositions containing them
CZ20013424A3 (en) 1999-12-27 2002-02-13 Japan Tobacco Inc. Compounds with fused rings and their use as medicaments
DE10014645A1 (en) * 2000-03-24 2001-09-27 Merck Patent Gmbh New amidino-aryl substituted biphenyl derivatives and analogs as Factor Xa inhibitors, are useful for treating thrombosis, myocardial infarction, arteriosclerosis, inflammation, apoplexy or angina pectoris
ATE432261T1 (en) * 2002-03-18 2009-06-15 Merck Frosst Canada Ltd PDE4 INHIBITORS WITH HETEROBIDGE SUBSTITUTED 8-ARYLCINOLINE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077938A2 (en) * 1981-10-23 1983-05-04 Mitsubishi Kasei Corporation N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
JPS60109578A (en) * 1983-11-17 1985-06-15 Mitsubishi Chem Ind Ltd 3-(substituted phenyl)-5-substituted-1,3,4-oxazolin-2-one compound and herbicide containing said compound as active component
US5476946A (en) * 1993-02-09 1995-12-19 Bayer Aktiengesellschaft 1-aryltriazolin(ethi)ones
US6506747B1 (en) * 1998-06-05 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1487843A4 *

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US7642358B2 (en) 2010-01-05
BR0308537A (en) 2005-02-09
US20060264630A1 (en) 2006-11-23
MXPA04009040A (en) 2005-01-25
CA2479338A1 (en) 2003-10-02
EP1487843A2 (en) 2004-12-22
US20040029933A1 (en) 2004-02-12
EP1487843A4 (en) 2010-03-10
WO2003080545A2 (en) 2003-10-02
CN1653073A (en) 2005-08-10
ZA200407802B (en) 2006-11-29
US7078421B2 (en) 2006-07-18
AU2003237787B2 (en) 2008-12-18
AU2003237787A1 (en) 2003-10-08
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KR20050008661A (en) 2005-01-21

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