WO2003083481A3 - Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen - Google Patents

Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen Download PDF

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Publication number
WO2003083481A3
WO2003083481A3 PCT/EP2003/003163 EP0303163W WO03083481A3 WO 2003083481 A3 WO2003083481 A3 WO 2003083481A3 EP 0303163 W EP0303163 W EP 0303163W WO 03083481 A3 WO03083481 A3 WO 03083481A3
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WIPO (PCT)
Prior art keywords
silica gel
spheroid
luminescent
autofluorescent
frequencies
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Ceased
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PCT/EP2003/003163
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English (en)
French (fr)
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WO2003083481A2 (de
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Detlef P Mueller-Schulte
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Priority to US10/509,712 priority Critical patent/US20050147974A1/en
Priority to AU2003223998A priority patent/AU2003223998A1/en
Priority to DE50311117T priority patent/DE50311117D1/de
Priority to EP03720372A priority patent/EP1490691B1/de
Priority to JP2003580862A priority patent/JP2005528466A/ja
Publication of WO2003083481A2 publication Critical patent/WO2003083481A2/de
Publication of WO2003083481A3 publication Critical patent/WO2003083481A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Silicon Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft sphärische, transparente Silicagel-Partikel mit hoher Lumineszenz, die durch Einkapseln einer oder mehrerer verschiedener lumineszierender Substanzen in eine Silicagel-Matrix erzeugt wird. Durch Variation der Konzentration der lumineszierenden Substanzen sowie durch Einkapseln von Substanzen unterschiedlicher Emissionsfrequenz lassen sich die Partikel als multiplexe Kodierungs- bzw. Markersysteme in der Bioanalytik und der Diagnostik einsetzen.
PCT/EP2003/003163 2002-03-30 2003-03-27 Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen Ceased WO2003083481A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/509,712 US20050147974A1 (en) 2002-03-30 2003-03-27 Luminescent, spherical, non-autofluorescent silica gel particles having variable emission intensities and frequencies
AU2003223998A AU2003223998A1 (en) 2002-03-30 2003-03-27 Luminescent, spheroid, non-autofluorescent silica gel particles having variable emission intensities and frequencies
DE50311117T DE50311117D1 (de) 2002-03-30 2003-03-27 Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen
EP03720372A EP1490691B1 (de) 2002-03-30 2003-03-27 Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen
JP2003580862A JP2005528466A (ja) 2002-03-30 2003-03-27 種々の発光強度及び周波数を有する発光性の球状非自己蛍光性シリカゲル

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10214019A DE10214019A1 (de) 2002-03-30 2002-03-30 Lumineszierende, sphärische, nicht autofluoreszierende Silicagel-Partikel mit veränderbaren Emissionsintensitäten und -frequenzen
DE10214019.7 2002-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/315,850 Continuation US20120149765A1 (en) 2003-03-03 2011-12-09 Sgk1 as diagnostic and therapeutic target

Publications (2)

Publication Number Publication Date
WO2003083481A2 WO2003083481A2 (de) 2003-10-09
WO2003083481A3 true WO2003083481A3 (de) 2004-03-25

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PCT/EP2003/003163 Ceased WO2003083481A2 (de) 2002-03-30 2003-03-27 Lumineszierende, sphärische, nicht autofluoreszierende silicagel-partikel mit veränderbaren emissionsintensitäten und -frequenzen

Country Status (8)

Country Link
US (1) US20050147974A1 (de)
EP (1) EP1490691B1 (de)
JP (1) JP2005528466A (de)
CN (1) CN1643379A (de)
AT (1) ATE421696T1 (de)
AU (1) AU2003223998A1 (de)
DE (2) DE10214019A1 (de)
WO (1) WO2003083481A2 (de)

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US8026328B2 (en) 2005-08-09 2011-09-27 University Of Sunderland Hydrophobic silica particles and methods of making same
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US8053744B2 (en) * 2009-04-13 2011-11-08 Src, Inc. Location analysis using nucleic acid-labeled tags
FR2952436B1 (fr) * 2009-11-10 2014-10-31 Commissariat Energie Atomique Materiau et procede pour pieger, detecter et quantifier des composes aromatiques heterocycliques et autres.
EP2531569B1 (de) 2010-02-02 2017-01-25 Ventana Medical Systems, Inc. Zusammensetzung und verfahren zur stabilisierung fluoreszierender partikel
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US8703493B2 (en) 2010-06-15 2014-04-22 Src, Inc. Location analysis using fire retardant-protected nucleic acid-labeled tags
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WO2012016357A1 (en) 2010-08-06 2012-02-09 Capitalbio Corporation Microarray-based assay integrated with particles for analyzing molecular interactions
CA2814552A1 (en) 2010-10-27 2012-05-03 Capitalbio Corporation Luminophore-labeled molecules coupled with particles for microarray-based assays
FR2993798B1 (fr) * 2012-07-25 2015-03-06 Commissariat Energie Atomique Procede de marquage d'un substrat metallique par incorporation de particules inorganiques luminescentes
CN103760355B (zh) 2013-12-05 2015-09-16 博奥生物集团有限公司 微阵列芯片检测中核苷酸序列的颗粒标记方法
DE102014110573A1 (de) 2014-07-25 2016-01-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mit einer Signatur auf Basis von superparamagnetischen und/oder weichmagnetischen Nanopartikeln versehener Gegenstand, Verfahren zu dessen Herstellung und Verwendung von superparamagnetischen und/oder weichmagnetischen Nanopartikeln zum Sichern von Gegenständen gegen Fälschung und Nachahmung
CN105419778B (zh) * 2015-12-22 2017-11-14 重庆益新阳工贸有限公司 一种含有石蜡的量子点复合材料及其制备方法
JP2019512171A (ja) 2016-02-29 2019-05-09 ロード コーポレーション 磁気レオロジー流体用添加剤
US10941057B2 (en) * 2017-04-28 2021-03-09 U.S. Environmental Protection Agency Highly tunable fluorescent core-shell particles for environmental release simulation and tracking applications
CN109540878B (zh) * 2018-11-12 2021-07-27 安庆师范大学 一种检测钡离子的试剂盒及其检测方法
WO2021017904A1 (en) * 2019-07-31 2021-02-04 Auiset Biotechnology Co. Ltd. Fabrication of fluorescent nanoparticles and their conjugates for in vitro and in vivo diagnostics
CN114032086B (zh) * 2020-12-25 2023-11-17 武汉大学 一种长余辉纳米探针组合在检测细菌生物被膜中的应用
CN115261013B (zh) * 2022-07-01 2024-06-14 西安邮电大学 一种稀土发光材料及其制备方法与应用

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Also Published As

Publication number Publication date
US20050147974A1 (en) 2005-07-07
ATE421696T1 (de) 2009-02-15
CN1643379A (zh) 2005-07-20
DE10214019A1 (de) 2003-10-16
JP2005528466A (ja) 2005-09-22
AU2003223998A8 (en) 2003-10-13
DE50311117D1 (de) 2009-03-12
EP1490691B1 (de) 2009-01-21
WO2003083481A2 (de) 2003-10-09
EP1490691A2 (de) 2004-12-29
AU2003223998A1 (en) 2003-10-13

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