WO2003088979A3 - Oligonucleotide issus des sequences codant pour la composante de surface de proteines d'enveloppe des virus des lymphomes / leucemies t chez les primates (ptlv) et leurs utilisations - Google Patents

Oligonucleotide issus des sequences codant pour la composante de surface de proteines d'enveloppe des virus des lymphomes / leucemies t chez les primates (ptlv) et leurs utilisations Download PDF

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Publication number
WO2003088979A3
WO2003088979A3 PCT/FR2003/001274 FR0301274W WO03088979A3 WO 2003088979 A3 WO2003088979 A3 WO 2003088979A3 FR 0301274 W FR0301274 W FR 0301274W WO 03088979 A3 WO03088979 A3 WO 03088979A3
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WIPO (PCT)
Prior art keywords
ptlv
oligonucleotides
viruses
envelope proteins
surface component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2003/001274
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English (en)
Other versions
WO2003088979A2 (fr
Inventor
Felix Jinhyun Kim
Nicolas Gabriel Albert Manel
Marc Khamous Michel Sitbon
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Centre National de la Recherche Scientifique CNRS
Universite de Montpellier
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Centre National de la Recherche Scientifique CNRS
Universite de Montpellier
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Publication date
Priority to AU2003246850A priority Critical patent/AU2003246850A1/en
Priority to CA002483327A priority patent/CA2483327A1/fr
Priority to US10/512,340 priority patent/US7507529B2/en
Priority to DE60328880T priority patent/DE60328880D1/de
Priority to AT03746850T priority patent/ATE440150T1/de
Priority to EP03746850A priority patent/EP1497467B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Montpellier filed Critical Centre National de la Recherche Scientifique CNRS
Priority to JP2003585731A priority patent/JP4541712B2/ja
Publication of WO2003088979A2 publication Critical patent/WO2003088979A2/fr
Publication of WO2003088979A3 publication Critical patent/WO2003088979A3/fr
Anticipated expiration legal-status Critical
Priority to US12/368,600 priority patent/US7947452B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

L’invention a pour objet l’utilisation d’oligonucléotides issus des séquences nucléotiques codant pour la région aminoterminale de la composante de surface (SU) des protéines d’enveloppe des virus des PTLV, pour la mise en oeuvre de procédés de détection de toute souche de PTLV, ou de virus apparentés aux PTLV, notamment pour la détection de nouveaux variants des PTLV, ou de virus comportant des séquences apparentées aux SU des PTLV. L’invention a également pour objet des couples d’amorces pour la mise en oeuvre de ces procédés de détection, ainsi que les nouveaux variants de PTLV ainsi détectés.
PCT/FR2003/001274 2002-04-22 2003-04-22 Oligonucleotide issus des sequences codant pour la composante de surface de proteines d'enveloppe des virus des lymphomes / leucemies t chez les primates (ptlv) et leurs utilisations Ceased WO2003088979A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002483327A CA2483327A1 (fr) 2002-04-22 2003-04-22 Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations
US10/512,340 US7507529B2 (en) 2002-04-22 2003-04-22 Oligonucleotides originating from sequences coding for the surface component of PTLV envelope proteins and their uses
DE60328880T DE60328880D1 (de) 2002-04-22 2003-04-22 Oligonukleotide von für die oberflächenkomponente des ptlv-hüllproteins codierenden sequenzen und verwendungen davon
AT03746850T ATE440150T1 (de) 2002-04-22 2003-04-22 Oligonukleotide von für die oberflächenkomponente des ptlv-hüllproteins codierenden sequenzen und verwendungen davon
EP03746850A EP1497467B1 (fr) 2002-04-22 2003-04-22 Oligonucleotide issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations
AU2003246850A AU2003246850A1 (en) 2002-04-22 2003-04-22 Oligonucleotides from sequences coding for the surface component of envelope proteins of primate t-cell leukaemia/lymphoma viruses (ptlv) and uses thereof
JP2003585731A JP4541712B2 (ja) 2002-04-22 2003-04-22 Ｐｔｌｖエンベロープタンパク質の表面成分をコードする配列を起源とするオリゴヌクレオチド及びそれらの使用
US12/368,600 US7947452B2 (en) 2002-04-22 2009-02-10 Oligonucleotides originating from sequences coding for the surface component of PTLV envelope proteins and their uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0205001A FR2838740A1 (fr) 2002-04-22 2002-04-22 Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations
FR02/05001 2002-04-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10512340 A-371-Of-International 2003-04-22
US12/368,600 Division US7947452B2 (en) 2002-04-22 2009-02-10 Oligonucleotides originating from sequences coding for the surface component of PTLV envelope proteins and their uses

Publications (2)

Publication Number Publication Date
WO2003088979A2 WO2003088979A2 (fr) 2003-10-30
WO2003088979A3 true WO2003088979A3 (fr) 2004-02-19

Family

ID=28686243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/001274 Ceased WO2003088979A2 (fr) 2002-04-22 2003-04-22 Oligonucleotide issus des sequences codant pour la composante de surface de proteines d'enveloppe des virus des lymphomes / leucemies t chez les primates (ptlv) et leurs utilisations

Country Status (10)

Country Link
US (2) US7507529B2 (fr)
EP (1) EP1497467B1 (fr)
JP (1) JP4541712B2 (fr)
AT (1) ATE440150T1 (fr)
AU (1) AU2003246850A1 (fr)
CA (1) CA2483327A1 (fr)
DE (1) DE60328880D1 (fr)
ES (1) ES2328130T3 (fr)
FR (1) FR2838740A1 (fr)
WO (1) WO2003088979A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7108974B2 (en) 2001-03-02 2006-09-19 Isis Pharmaceuticals, Inc. Method for rapid detection and identification of bioagents
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information

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US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
FR2838740A1 (fr) * 2002-04-22 2003-10-24 Centre Nat Rech Scient Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP2458619B1 (fr) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Spectrométrie de masse avec filtration sélective d'ions par établissement de seuils numériques
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
WO2006135400A2 (fr) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Procedes pour l'identification rapide d'organismes recombinants
WO2006094238A2 (fr) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions utilisees pour identifier des virus secondaires
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
CA2616281C (fr) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Procede pour l'identification et la quantification rapide de variants d'acide nucleique
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
JP5420412B2 (ja) 2006-09-14 2014-02-19 アイビス バイオサイエンシズ インコーポレイティッド 病原体の同定のための標的全ゲノム増幅方法
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
EP2344893B1 (fr) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Systèmes et procédés de manipulation de microplaques
WO2010033599A2 (fr) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Cartouches de mélange, postes de mélange et kits, systèmes et procédés associés
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2396803A4 (fr) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ensembles sonde d'ionisation
WO2010104798A1 (fr) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Procédés de détection d'un bioagent
WO2010114842A1 (fr) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Systèmes, dispositifs et procédés de détection d'agent biologique
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011014811A1 (fr) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Amorces de capture et supports solides liés à une séquence de capture pour tests diagnostiques moléculaires
EP2462244B1 (fr) 2009-08-06 2016-07-20 Ibis Biosciences, Inc. Compositions de base déterminées non massiques pour détection d'acide nucléique
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
WO2011115840A2 (fr) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Recherche de parasites par le biais de la recherche d'endosymbiotes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384566A2 (fr) * 1989-01-27 1990-08-29 The Wistar Institute Amplification des séquences d'HTLV-I chez les patients atteints de sclérose multiple
WO2000046403A2 (fr) * 1999-02-03 2000-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OFHEALT H AND HUMAN SERVICES Procedes et reactifs pour la detection moleculaire de groupes de vih-1 m, n et o

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838740A1 (fr) * 2002-04-22 2003-10-24 Centre Nat Rech Scient Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384566A2 (fr) * 1989-01-27 1990-08-29 The Wistar Institute Amplification des séquences d'HTLV-I chez les patients atteints de sclérose multiple
WO2000046403A2 (fr) * 1999-02-03 2000-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OFHEALT H AND HUMAN SERVICES Procedes et reactifs pour la detection moleculaire de groupes de vih-1 m, n et o

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUBE S. ET AL.: "Degenerate and specific PCR assays for the detection of bovine leukaemia virus and primate T cell leukaemia/lymphoma virus pol DNA and RNA: phylogenetic comparisons of amplified sequences from cattle and primates from around the world.", JOURNAL OF GENERAL VIROLOGY, vol. 78, 1997, pages 1389 - 1398, XP002233752 *
GRAY G. S. ET AL.: "Envelope gene sequence of HTLV-1 isolate MT-2 and its comparison with other HTLV-1 isolates.", VIROLOGY, vol. 177, 1990, pages 391 - 395, XP008014557 *
RAMIREZ E. ET AL.: "Genetic characterization and phylogeny of human T-cell lymphotropic virus type I from Chile.", VIRUS RESEARCH, vol. 84, 20 March 2002 (2002-03-20), XP001148390 *
SUAREZ DAVID L ET AL: "Identification of hypervariable and conserved regions in the surface envelope gene in the bovine lentivirus.", VIROLOGY, vol. 212, no. 2, 1995, pages 728 - 733, XP002253831, ISSN: 0042-6822 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7108974B2 (en) 2001-03-02 2006-09-19 Isis Pharmaceuticals, Inc. Method for rapid detection and identification of bioagents
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information

Also Published As

Publication number Publication date
JP4541712B2 (ja) 2010-09-08
AU2003246850A8 (en) 2003-11-03
EP1497467A2 (fr) 2005-01-19
US20090186338A1 (en) 2009-07-23
US7507529B2 (en) 2009-03-24
US7947452B2 (en) 2011-05-24
JP2005538696A (ja) 2005-12-22
US20050287521A1 (en) 2005-12-29
DE60328880D1 (de) 2009-10-01
CA2483327A1 (fr) 2003-10-30
EP1497467B1 (fr) 2009-08-19
FR2838740A1 (fr) 2003-10-24
AU2003246850A1 (en) 2003-11-03
ATE440150T1 (de) 2009-09-15
ES2328130T3 (es) 2009-11-10
WO2003088979A2 (fr) 2003-10-30

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