WO2003093313A3 - Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein - Google Patents

Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein Download PDF

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Publication number
WO2003093313A3
WO2003093313A3 PCT/EP2003/004425 EP0304425W WO03093313A3 WO 2003093313 A3 WO2003093313 A3 WO 2003093313A3 EP 0304425 W EP0304425 W EP 0304425W WO 03093313 A3 WO03093313 A3 WO 03093313A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor viii
interaction
antagonists
low
lrp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/004425
Other languages
French (fr)
Other versions
WO2003093313A2 (en
Inventor
Koenraad Mertens
Arend Niels Bovenschen
Jan Voorberg
Manfred Rieger
Friedrich Scheiflinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Sanquin
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Sanquin
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Sanquin, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to EP03725109A priority Critical patent/EP1497330B1/en
Priority to AU2003227687A priority patent/AU2003227687B2/en
Priority to JP2004501452A priority patent/JP2005535588A/en
Priority to CA2484155A priority patent/CA2484155C/en
Priority to AT03725109T priority patent/ATE463514T1/en
Priority to DK03725109.7T priority patent/DK1497330T3/en
Priority to DE60332011T priority patent/DE60332011D1/en
Priority to US10/512,907 priority patent/US8586538B2/en
Publication of WO2003093313A2 publication Critical patent/WO2003093313A2/en
Publication of WO2003093313A3 publication Critical patent/WO2003093313A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor Vlll half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.
PCT/EP2003/004425 2002-04-29 2003-04-28 Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein Ceased WO2003093313A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP03725109A EP1497330B1 (en) 2002-04-29 2003-04-28 Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
AU2003227687A AU2003227687B2 (en) 2002-04-29 2003-04-28 Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein
JP2004501452A JP2005535588A (en) 2002-04-29 2003-04-28 Antagonists of the interaction between factor VIII and low density lipoprotein receptor-related proteins
CA2484155A CA2484155C (en) 2002-04-29 2003-04-28 Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
AT03725109T ATE463514T1 (en) 2002-04-29 2003-04-28 ANTAGONISTS OF THE INTERACTION BETWEEN FACTOR VIII AND LRP (ßLOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEINß)
DK03725109.7T DK1497330T3 (en) 2002-04-29 2003-04-28 Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein
DE60332011T DE60332011D1 (en) 2002-04-29 2003-04-28 ANTAGONISTS OF INTERACTION BETWEEN FACTOR VIII AND LRP (LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN)
US10/512,907 US8586538B2 (en) 2002-04-29 2003-04-28 Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37635102P 2002-04-29 2002-04-29
US60/376,351 2002-04-29

Publications (2)

Publication Number Publication Date
WO2003093313A2 WO2003093313A2 (en) 2003-11-13
WO2003093313A3 true WO2003093313A3 (en) 2004-07-29

Family

ID=29401334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/004425 Ceased WO2003093313A2 (en) 2002-04-29 2003-04-28 Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein

Country Status (10)

Country Link
US (1) US8586538B2 (en)
EP (1) EP1497330B1 (en)
JP (2) JP2005535588A (en)
AT (1) ATE463514T1 (en)
AU (1) AU2003227687B2 (en)
CA (1) CA2484155C (en)
DE (1) DE60332011D1 (en)
DK (1) DK1497330T3 (en)
ES (1) ES2343681T3 (en)
WO (1) WO2003093313A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592430B2 (en) 2003-09-10 2009-09-22 Amgen Fremont Antibodies to M-CSF

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004003144A2 (en) 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
EP1454632A1 (en) * 2003-02-07 2004-09-08 Aventis Behring GmbH, Intellectual Property/Legal Pharmaceutical preparation for the treatment of blood-clotting disorders containing factor VIII derived peptides
WO2006003183A1 (en) * 2004-07-02 2006-01-12 Alois Jungbauer Peptides for blocking fviii inhibitors
EP1816201A1 (en) 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
JP2009274958A (en) 2006-08-31 2009-11-26 Nara Prefecture Antibody promoting activation of blood coagulation factor viii
WO2008077616A1 (en) 2006-12-22 2008-07-03 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
JP5674650B2 (en) * 2008-06-04 2015-02-25 バイエル・ヘルスケア・エルエルシー FVIII mutein for the treatment of von Willebrand disease
EP2865760B1 (en) 2008-06-24 2017-10-11 CSL Behring GmbH Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
JP5394864B2 (en) * 2009-09-10 2014-01-22 アスモ株式会社 motor
WO2011095604A1 (en) * 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
CN104788557A (en) 2010-09-15 2015-07-22 诺沃—诺迪斯克有限公司 Factor VIII variants having a decreased cellular uptake
US9458223B2 (en) 2012-02-15 2016-10-04 Csl Behring Gmbh Von willebrand factor variants having improved factor VIII binding affinity
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
DK3164150T3 (en) 2014-07-02 2021-02-08 CSL Behring Lengnau AG MODIFIED BY WILLEBRAND FACTOR
SG11201706659WA (en) 2015-03-06 2017-09-28 Csl Behring Recombinant Facility Ag Modified von willebrand factor having improved half-life
CA2986626A1 (en) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Truncated von willebrand factor polypeptides for treating hemophilia
CA2986625A1 (en) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Methods for preparing modified von willebrand factor
SG11201805494WA (en) 2016-01-07 2018-07-30 Csl Behring Recombinant Facility Ag Mutated von willebrand factor
AU2017204955B2 (en) 2016-01-07 2021-04-01 CSL Behring Lengnau AG Mutated truncated von Willebrand Factor
DK3538133T3 (en) 2016-11-11 2021-04-19 CSL Behring Lengnau AG TRUNKED VON WILLEBRAND FACTOR POLYPEPTIDES FOR THE TREATMENT OF HEMOPHILIA
JP2020504082A (en) 2016-11-11 2020-02-06 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト Truncated von Willebrand factor polypeptide for extravascular administration in the treatment or prevention of blood clotting disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041816A1 (en) * 1995-06-12 1996-12-27 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Factor ix binding peptides, derived from factor viii and their use as inhibitors of blood coagulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU760678B2 (en) * 1998-05-08 2003-05-22 Stichting Sanquin Bloedvoorziening Method for diagnosis and treatment of haemophilia a patients with an inhibitor
AT409335B (en) * 1998-11-10 2002-07-25 Immuno Ag PHARMACEUTICAL PREPARATION CONTAINING A RECEPTOR ANTAGONIST FOR THE TREATMENT OF BLOOD COagulation disorders
DK1129186T4 (en) * 1998-11-10 2017-02-06 Stichting Sanquin Bloedvoorziening A factor VIII polypeptide having factor VIII: C activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041816A1 (en) * 1995-06-12 1996-12-27 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Factor ix binding peptides, derived from factor viii and their use as inhibitors of blood coagulation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOVENSCHEN N ET AL.: "Low Density Lipoprotein Receptor-related Protein and Factor IXa Share Structural Requirements for Binding to the A3 Domain of Coagulation Factor VIII", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 11, 14 March 2003 (2003-03-14), pages 9370 - 9377, XP002264413 *
LENTING P J ET AL: "THE SEQUENCE GLU-1811-LYS-1818 OF HUMAN BLOOD COAGULATION FACTOR VIII COMPRISES A BINDING SITE FOR ACTIVATED FACTOR IX", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 4, 26 January 1996 (1996-01-26), pages 1935 - 1940, XP002017258, ISSN: 0021-9258 *
NEELS JG ET AL.: "Interaction Between Factor VIII and LDL Receptor-related Protein", TRENDS IN CARDIOVASCULAR MEDICINE, vol. 10, 2000, pages 8 - 14, XP002264412 *
SAENKO EL ET AL.: "Role of the Low Density Lipoprotein-related Protein Receptor in Mediation of Factor VIII Catabolism", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 53, 31 December 1999 (1999-12-31), pages 37685 - 37692, XP002264411 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592430B2 (en) 2003-09-10 2009-09-22 Amgen Fremont Antibodies to M-CSF

Also Published As

Publication number Publication date
CA2484155A1 (en) 2003-11-13
JP2010202664A (en) 2010-09-16
US20080219983A1 (en) 2008-09-11
CA2484155C (en) 2015-10-13
ATE463514T1 (en) 2010-04-15
EP1497330B1 (en) 2010-04-07
WO2003093313A2 (en) 2003-11-13
DK1497330T3 (en) 2010-06-14
EP1497330A2 (en) 2005-01-19
AU2003227687A1 (en) 2003-11-17
AU2003227687B2 (en) 2009-10-15
ES2343681T3 (en) 2010-08-06
JP2005535588A (en) 2005-11-24
DE60332011D1 (en) 2010-05-20
US8586538B2 (en) 2013-11-19

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