WO2003093462A3 - Immobilisation and stabilisation of virus - Google Patents

Immobilisation and stabilisation of virus Download PDF

Info

Publication number
WO2003093462A3
WO2003093462A3 PCT/GB2003/001797 GB0301797W WO03093462A3 WO 2003093462 A3 WO2003093462 A3 WO 2003093462A3 GB 0301797 W GB0301797 W GB 0301797W WO 03093462 A3 WO03093462 A3 WO 03093462A3
Authority
WO
WIPO (PCT)
Prior art keywords
virus
immobilisation
stabilisation
immobilized
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/001797
Other languages
French (fr)
Other versions
WO2003093462A2 (en
Inventor
Hugh Scott
Michael Mattey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Strathclyde
Original Assignee
University of Strathclyde
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Strathclyde filed Critical University of Strathclyde
Priority to JP2004501598A priority Critical patent/JP5486144B2/en
Priority to EP03725350A priority patent/EP1496919B1/en
Priority to US10/512,635 priority patent/US7482115B2/en
Priority to AU2003227890A priority patent/AU2003227890A1/en
Priority to DE60323077T priority patent/DE60323077D1/en
Publication of WO2003093462A2 publication Critical patent/WO2003093462A2/en
Publication of WO2003093462A3 publication Critical patent/WO2003093462A3/en
Anticipated expiration legal-status Critical
Priority to US12/336,656 priority patent/US20090214617A1/en
Ceased legal-status Critical Current

Links

Classifications

    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • D06M16/003—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic with enzymes or microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10151—Methods of production or purification of viral material
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2400/00—Specific information on the treatment or the process itself not provided in D06M23/00-D06M23/18
    • D06M2400/01—Creating covalent bondings between the treating agent and the fibre

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Textile Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)

Abstract

The present invention relates to a method for immobilization and optional stabilization of viruses whilst retaining the viral biological activity and the use of immobilized virus in therapy. In particular, the immobilized virus relates to immobilized bacteriophage and their use as an antibiotic or bacteriostatic agent and in the treatment of antibiotic-resistant infections.
PCT/GB2003/001797 2002-04-27 2003-04-28 Immobilisation and stabilisation of virus Ceased WO2003093462A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2004501598A JP5486144B2 (en) 2002-04-27 2003-04-28 Virus immobilization and stabilization
EP03725350A EP1496919B1 (en) 2002-04-27 2003-04-28 Immobilisation and stabilisation of virus
US10/512,635 US7482115B2 (en) 2002-04-27 2003-04-28 Immobilisation and stabilisation of virus
AU2003227890A AU2003227890A1 (en) 2002-04-27 2003-04-28 Immobilisation and stabilisation of virus
DE60323077T DE60323077D1 (en) 2002-04-27 2003-04-28 IMMOBILIZATION AND STABILIZATION OF VIRUSES
US12/336,656 US20090214617A1 (en) 2002-04-27 2008-12-17 Immobilisation and stabilisation of virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0209680.8 2002-04-27
GBGB0209680.8A GB0209680D0 (en) 2002-04-27 2002-04-27 Immobilisation and stabilisation of bacteriophage

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/336,656 Division US20090214617A1 (en) 2002-04-27 2008-12-17 Immobilisation and stabilisation of virus

Publications (2)

Publication Number Publication Date
WO2003093462A2 WO2003093462A2 (en) 2003-11-13
WO2003093462A3 true WO2003093462A3 (en) 2004-02-12

Family

ID=9935641

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/001797 Ceased WO2003093462A2 (en) 2002-04-27 2003-04-28 Immobilisation and stabilisation of virus

Country Status (9)

Country Link
US (2) US7482115B2 (en)
EP (2) EP1982723A1 (en)
JP (2) JP5486144B2 (en)
AT (1) ATE405279T1 (en)
AU (1) AU2003227890A1 (en)
DE (1) DE60323077D1 (en)
ES (1) ES2310658T3 (en)
GB (1) GB0209680D0 (en)
WO (1) WO2003093462A2 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040109853A1 (en) 2002-09-09 2004-06-10 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces
DE502004007131D1 (en) * 2003-03-04 2008-06-26 Nmi Univ Tuebingen METHOD FOR PRODUCING A CARRIER WITH IMMOBILIZED VIRUSES AND USE OF SUCH A CARRIER
WO2005026269A1 (en) * 2003-09-04 2005-03-24 Mcdaniel C Steven Microorganism coating components, coatings, and coated surfaces
EP2462940A1 (en) 2004-11-02 2012-06-13 Chr. Hansen A/S Stabilized bacteriophage formulations
MX2007005279A (en) * 2004-11-02 2008-03-11 Gangagen Life Sciences Inc Bacteriophage compositions.
WO2006063176A2 (en) * 2004-12-06 2006-06-15 The Government Of The Usa As Representedtd By The Secretary Of The Dept Of Health And Human Services Inhibition of biofilm formation using bacteriophage
US20090011485A1 (en) * 2005-02-07 2009-01-08 Takara Bio Inc. Method of retrovirus storage
GB0526176D0 (en) 2005-12-22 2006-02-01 Blaze Venture Technologies Ltd Particle binding
US20090209031A1 (en) * 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
US9364215B2 (en) * 2006-01-26 2016-06-14 Covidien Lp Medical device package
CA2604433A1 (en) * 2006-10-06 2008-04-06 Tyco Healthcare Group Lp Medical device package including self-puncturable port
FR2928656B1 (en) * 2008-03-14 2011-08-26 Biomerieux Sa METHOD FOR REAL - TIME DETECTION OF MICROORGANISMS IN A LIQUID CULTURE MEDIUM BY AGGLUTINATION.
US20120041287A1 (en) 2008-12-04 2012-02-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
US8388904B1 (en) 2008-12-22 2013-03-05 Reactive Surfaces, Ltd., Llp Equipment decontamination system and method
GB201110647D0 (en) 2011-06-23 2011-08-10 Fixed Phage Ltd Delivery of viral agents
WO2013048604A2 (en) * 2011-06-28 2013-04-04 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Controlled covalent attachment of bioactive bacteriophage for regulating biofilm development
GB201217097D0 (en) * 2012-09-25 2012-11-07 Fixed Phage Ltd Treatment of bacterial infection
US20160010077A1 (en) * 2013-02-28 2016-01-14 The University Of Southern Mississippi Covalent Attachment of Bacteriophages (Phages) to Polymeric Surfaces
GB201402139D0 (en) * 2014-02-07 2014-03-26 Fixed Phage Ltd Treatment of topical and systemic bacterial infections
AU2015241439B2 (en) 2014-03-31 2018-11-08 Kimberly-Clark Worldwide, Inc. Self-regenerating antimicrobial composition and method of use
BR112017022463B1 (en) * 2015-04-20 2021-10-13 Fixed Phage Limited COMPOSITION, FEED FOR CRUSTACEANS OR FISH AND METHODS OF MANUFACTURING THEM
US20170157186A1 (en) * 2015-12-02 2017-06-08 Smart Phage, Inc. Phage to treat bacteria on skin
EP3461345A1 (en) * 2017-09-28 2019-04-03 Fixed Phage Limited Anti-bacterial packaging
EP3616730A1 (en) 2018-08-28 2020-03-04 UPM-Kymmene Corporation Composition or matrix for storage of bacteriophages comprising nanofibrillar cellulose
AU2019382919A1 (en) 2018-11-22 2021-05-27 Fixed Phage Limited Production of immobilised bacteriophage
EP4714458A2 (en) 2019-04-10 2026-03-25 NexaBiome Limited Continuous treatment with plasma
GB201907796D0 (en) * 2019-05-31 2019-07-17 Aquila Bioscience Device and method for decontamination/disinfection
US11617773B2 (en) 2020-04-08 2023-04-04 Eligo Bioscience Elimination of colonic bacterial driving lethal inflammatory cardiomyopathy
CA3174093A1 (en) 2020-04-08 2021-10-14 Eligo Bioscience Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders
DK3922719T1 (en) 2020-06-12 2022-01-03 Eligo Bioscience SPECIFIC DECOLONIZATION OF ANTIBIOTIC-RESISTANT BACTERIA FOR PROPHYLATIC PURPOSES
US20230235361A1 (en) 2020-07-03 2023-07-27 Eligo Bioscience Method of containment of nucleic acid vectors introduced in a microbiome population
WO2022144381A1 (en) 2020-12-30 2022-07-07 Eligo Bioscience Microbiome modulation of a host by delivery of dna payloads with minimized spread
CN113755480B (en) * 2021-03-19 2023-12-05 威海纽普生物技术有限公司 Method for in vitro culture of cells by virus solid phase infection
WO2022238947A1 (en) 2021-05-12 2022-11-17 Biomx Ltd. Staphylococcus bacteriophage and uses thereof
EP4136974A1 (en) 2021-08-20 2023-02-22 Fixed Phage Limited Plasma treatment process and apparatus therefor
EP4475862A1 (en) 2022-02-08 2024-12-18 Oxford Silk Phage Technologies Ltd Method and apparatus for making an article from filaments containing bacteriophages
WO2023152549A1 (en) * 2022-02-11 2023-08-17 Phagelab Chile Spa Compositions for the treatment of e. coli and salmonella
WO2024013468A1 (en) 2022-07-11 2024-01-18 University Court Of The University Of St Andrews Functionalised metal-organic framework
GB202210435D0 (en) * 2022-07-15 2022-08-31 Carus Animal Health Ltd Agricultural compositions and methods
GB202210434D0 (en) * 2022-07-15 2022-08-31 Carus Animal Health Ltd Agricultural compositions and methods
GB2631119A (en) 2023-06-20 2024-12-25 Innovia Films Ltd Anti-bacterial article
GB202400580D0 (en) 2024-01-16 2024-02-28 Carus Animal Health Ltd Therapeutic compositions and methods
DE102024113842A1 (en) * 2024-05-16 2025-11-20 bifa Umweltinstitut GmbH Methods for reducing the bacterial load on or in an air conditioning system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006542A1 (en) * 1988-01-21 1989-07-27 Quadrant Bioresources Limited Preservation of viruses
WO1994024959A1 (en) * 1993-04-27 1994-11-10 Symbiotech, Inc. Method of detecting compounds utilizing chemically modified lambdoid bacteriophage
DE19828596A1 (en) * 1997-06-26 1999-02-11 A Daniela Dr Nodar Use of polyvalent bacteriophages
WO2001009370A2 (en) * 1999-07-30 2001-02-08 Profos Ag Detection and identification of bacterial strains
US20020001590A1 (en) * 2000-04-20 2002-01-03 Mount Sinai Hospital Antibacterial therapy for multi-drug resistant bacteria
WO2002007742A2 (en) * 2000-07-25 2002-01-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bacteriophage having multiple host range

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0271152A (en) * 1988-09-07 1990-03-09 Terumo Corp Manufacture of molding for solid phase immunity measurement
GB8918983D0 (en) * 1989-08-21 1989-10-04 Unilever Plc Composition for hygiene purposes
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
AU699322B2 (en) * 1994-04-05 1998-12-03 Exponential Biotherapies, Inc. Antibacterial therapy with genotypically modified bacteriophage
US5695777A (en) * 1994-05-10 1997-12-09 Medtronic, Inc. Absorptive wound dressing for wound healing promotion
GB9809414D0 (en) * 1998-05-02 1998-07-01 Scottish Crop Research Inst Method
US6225289B1 (en) * 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
GB9908195D0 (en) * 1999-04-09 1999-06-02 Microbiological Res Authority Treatment of intracellular infection
AU4971900A (en) * 1999-05-13 2000-12-05 Exponential Biotherapies, Inc. Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006542A1 (en) * 1988-01-21 1989-07-27 Quadrant Bioresources Limited Preservation of viruses
WO1994024959A1 (en) * 1993-04-27 1994-11-10 Symbiotech, Inc. Method of detecting compounds utilizing chemically modified lambdoid bacteriophage
DE19828596A1 (en) * 1997-06-26 1999-02-11 A Daniela Dr Nodar Use of polyvalent bacteriophages
WO2001009370A2 (en) * 1999-07-30 2001-02-08 Profos Ag Detection and identification of bacterial strains
US20020001590A1 (en) * 2000-04-20 2002-01-03 Mount Sinai Hospital Antibacterial therapy for multi-drug resistant bacteria
WO2002007742A2 (en) * 2000-07-25 2002-01-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bacteriophage having multiple host range

Also Published As

Publication number Publication date
AU2003227890A1 (en) 2003-11-17
EP1496919A2 (en) 2005-01-19
DE60323077D1 (en) 2008-10-02
EP1496919B1 (en) 2008-08-20
JP2012211135A (en) 2012-11-01
WO2003093462A2 (en) 2003-11-13
US20050220770A1 (en) 2005-10-06
JP5486144B2 (en) 2014-05-07
ATE405279T1 (en) 2008-09-15
JP5504302B2 (en) 2014-05-28
ES2310658T3 (en) 2009-01-16
US7482115B2 (en) 2009-01-27
GB0209680D0 (en) 2002-06-05
EP1982723A1 (en) 2008-10-22
JP2005523943A (en) 2005-08-11
AU2003227890A8 (en) 2003-11-17
US20090214617A1 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
WO2003093462A3 (en) Immobilisation and stabilisation of virus
TR200201484T2 (en) The use of lysing enzymes associated with bacterial phages for the preventive and curative treatment of various diseases
WO2006033995A3 (en) Thiazolidin-4-ones having anti-hepatitis b activity
ID27787A (en) COMPOUND, COMPOSITION AND METHODS FOR TREATMENT OR PREVENTION OF INFECTIONS CAUSED BY VIRUSES AND RELATED DISEASES
WO2007084413A3 (en) Methods for treating hepatitis c
GEP20084545B (en) Introducing tlr7 ligands and prodrugs thereof for the treatment of hepatitis c viral infection
GEP20104960B (en) USE OF [D-MeALa]3-[EtVal]4-CYCLOSPORIN FOR THE TREATMENT OF HEPATITIS C INFECTION AND PHARMACEUTICAL COMPOSITION COMPRISING SAID [D-MeAla]3-[EtVal]4-CYCLOSPORIN
MY141003A (en) Materials and methods for treating viral infections with a cysteamine compound
WO2007084435A8 (en) Methods for treating hepatitis c
WO2006101538A3 (en) Andrographolide derivatives to treat viral infections
WO2001055111A8 (en) Biaryl compounds, their preparation and their use in therapy
WO2003049674A3 (en) Method for treatment of enveloped viruses using jojoba oil esters
WO2007024628A3 (en) Ply-gbs mutant lysins
WO2008064072A3 (en) Anti-tsg101 antibodies and their uses for treatment of viral infections
WO2010014248A3 (en) Antiviral activity of the protein scytovirin and methods of use
WO2003037265A3 (en) Method of treating viral infections
WO2005062952A3 (en) Compositions and methods for modulating sirtuin activity
WO2005092924A8 (en) Rab9a, rab11a, and modulators thereof related to infectious disease
WO2008147468A3 (en) Compositions comprising virus-interacting layered phyllosilicates and a therapeutic agent, and methods of use
WO2007076091A3 (en) Treatment of viral infections using a tissue factor inhibitor
WO2007002639A3 (en) Non-nucleoside anti-hepacivirus agents and uses thereof
WO2004014316A3 (en) Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2004054603A3 (en) Use of beta-defensins for treating hiv infections
WO2007128765A3 (en) Compositions comprising lytic enzymes of bacteriophages for treating bacterial infections
AU2002333910A1 (en) Pharmaceutical composition for the treatment of viral, fungal and bacterial infections and applications of same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003725350

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2004501598

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2003725350

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10512635

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2003725350

Country of ref document: EP