WO2003095651A1 - Procede de production d'acide mevalonique - Google Patents

Procede de production d'acide mevalonique Download PDF

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Publication number
WO2003095651A1
WO2003095651A1 PCT/JP2003/005765 JP0305765W WO03095651A1 WO 2003095651 A1 WO2003095651 A1 WO 2003095651A1 JP 0305765 W JP0305765 W JP 0305765W WO 03095651 A1 WO03095651 A1 WO 03095651A1
Authority
WO
WIPO (PCT)
Prior art keywords
mevalonic acid
microorganism
coa
acetyl
producing mevalonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/005765
Other languages
English (en)
French (fr)
Inventor
Kazuhiko Tabata
Shin-Ichi Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to AU2003234790A priority Critical patent/AU2003234790A1/en
Priority to US10/513,759 priority patent/US20050287655A1/en
Priority to JP2004508516A priority patent/JPWO2003095651A1/ja
Priority to EP03728047A priority patent/EP1510583A1/en
Publication of WO2003095651A1 publication Critical patent/WO2003095651A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PCT/JP2003/005765 2002-05-10 2003-05-08 Procede de production d'acide mevalonique Ceased WO2003095651A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003234790A AU2003234790A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid
US10/513,759 US20050287655A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid
JP2004508516A JPWO2003095651A1 (ja) 2002-05-10 2003-05-08 メバロン酸の製造方法
EP03728047A EP1510583A1 (en) 2002-05-10 2003-05-08 Process for producing mevalonic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-135073 2002-05-10
JP2002135073 2002-05-10

Publications (1)

Publication Number Publication Date
WO2003095651A1 true WO2003095651A1 (fr) 2003-11-20

Family

ID=29416731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/005765 Ceased WO2003095651A1 (fr) 2002-05-10 2003-05-08 Procede de production d'acide mevalonique

Country Status (5)

Country Link
US (1) US20050287655A1 (ja)
EP (1) EP1510583A1 (ja)
JP (1) JPWO2003095651A1 (ja)
AU (1) AU2003234790A1 (ja)
WO (1) WO2003095651A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107418978A (zh) * 2017-06-24 2017-12-01 天津大学 一种利用生物柴油副产物制备金合欢烯的方法
JP2018502059A (ja) * 2014-11-12 2018-01-25 ビゾリス インコーポレイテッド メバロノラクトンから調製されるポリマーおよび誘導体

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US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
WO2008091627A2 (en) 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
WO2008098227A2 (en) * 2007-02-09 2008-08-14 The Regents Of The University Of California Biofuel production by recombinant microorganisms
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
WO2008124523A1 (en) * 2007-04-04 2008-10-16 The Regents Of The University Of California Butanol production by recombinant microorganisms
CA2692893C (en) * 2007-06-01 2015-06-23 The Scripps Research Institute High throughput screening of genetically modified photosynthetic organisms
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
NZ583620A (en) * 2007-09-11 2012-08-31 Sapphire Energy Inc Methods of producing organic fuel products with photosynthetic organisms
CA2698801A1 (en) * 2007-09-11 2009-03-19 Sapphire Energy, Inc. Molecule production by photosynthetic organisms
CN101903530A (zh) * 2007-10-12 2010-12-01 加利福尼亚大学董事会 被改造以产生异丙醇的微生物
DK2235190T3 (en) 2007-12-13 2018-07-23 Danisco Us Inc COMPOSITIONS AND PROCEDURES FOR PRODUCING ISOPRENE
CN107090424A (zh) 2008-01-22 2017-08-25 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
EP3450550A1 (en) 2008-03-05 2019-03-06 Genomatica, Inc. Primary alcohol producing organisms
PL2265709T3 (pl) 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
JP2011518564A (ja) 2008-04-23 2011-06-30 ダニスコ・ユーエス・インク 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体
WO2009135074A2 (en) * 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
CA2735883C (en) 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US20100184178A1 (en) * 2008-09-15 2010-07-22 Zachary Quinn Beck Increased isoprene production using mevalonate kinase and isoprene synthase
MY169163A (en) 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
CA2746952A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
EP3865569B1 (en) 2009-04-30 2023-10-04 Genomatica, Inc. Organisms for the production of 1,3-butanediol
WO2010129936A1 (en) 2009-05-07 2010-11-11 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
KR20120036851A (ko) 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
PL2438036T3 (pl) 2009-06-04 2017-09-29 Genomatica, Inc. Sposób oddzielania składników brzeczki fermentacyjnej
BRPI1010581A2 (pt) 2009-06-04 2016-11-08 Genomatica Inc micro-organismos para a produção de 1,4-butanodiol e métodos relacionados
WO2010144746A2 (en) 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
US8715971B2 (en) 2009-09-09 2014-05-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
AU2010306785B2 (en) 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US20110097767A1 (en) 2009-10-23 2011-04-28 Priti Pharkya Microorganisms for the production of aniline
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
CN102753698A (zh) 2009-12-10 2012-10-24 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
SG181856A1 (en) * 2009-12-23 2012-07-30 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
CN102834508A (zh) 2010-01-29 2012-12-19 基因组股份公司 用于生物合成对甲苯甲酸和对苯二甲酸的微生物和方法
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20190006103A (ko) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
EP2702140B1 (en) 2011-04-29 2018-10-31 Danisco US Inc. Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
JP2014519811A (ja) * 2011-04-29 2014-08-21 ダニスコ・ユーエス・インク チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産
BR112014002661A2 (pt) 2011-08-04 2019-09-24 Danisco Us Inc produção de isopreno, precursores de isoprenoide, e isoprenoides com o uso de acetoacetil-coa sintase
BR112014008278A2 (pt) 2011-10-07 2017-04-18 Danisco Us Inc utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno
EP2794863A1 (en) 2011-12-23 2014-10-29 Danisco US Inc. Enhanced production of isoprene using host cells having decreased ispa activity
WO2013096917A1 (en) 2011-12-23 2013-06-27 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
CN111705028A (zh) 2012-06-04 2020-09-25 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
EP2935364A2 (en) 2012-12-21 2015-10-28 Danisco US Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
EP3425049A1 (en) 2013-04-10 2019-01-09 Danisco US Inc. Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
WO2014172596A2 (en) 2013-04-18 2014-10-23 Regents Of The University Of Minnesota Biosynthetic pathways and products
JP6744819B2 (ja) 2014-02-20 2020-08-19 ダニスコ・ユーエス・インク メバロン酸、イソプレン、イソプレノイド前駆体、イソプレノイド、およびアセチルＣｏＡ由来産物の生産向上のための組換え微生物
KR20200095534A (ko) 2017-12-07 2020-08-10 지머젠 인코포레이티드 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
KR102745457B1 (ko) * 2019-09-25 2024-12-23 한국생명공학연구원 메탄으로부터 탄소 수 4 이상인 화합물을 생산하는 방법 및 조성물
CN116376995B (zh) * 2022-04-02 2024-01-26 元素驱动(杭州)生物科技有限公司 一种利用苏氨酸制备甘氨酸、乙酰辅酶a及乙酰辅酶a衍生物的方法
CN119286752B (zh) * 2024-12-10 2025-07-11 杭州合碳创物科技有限公司 一种生产甲瓦龙酸的重组大肠杆菌及其应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2001042476A1 (fr) * 1999-12-08 2001-06-14 Haruo Seto Genes a origine actinomycete d'enzymes intervenant dans la voie du mevalonate

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TWI250210B (en) * 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2001042476A1 (fr) * 1999-12-08 2001-06-14 Haruo Seto Genes a origine actinomycete d'enzymes intervenant dans la voie du mevalonate

Non-Patent Citations (2)

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Title
BOLOTIN ALEXANDER ET AL.: "The complete genome sequence of the lactic acid bacterium lactococcus lactis ssp. lactis IL1403", GENOME RESEARCH, vol. 11, no. 5, 2001, pages 731 - 753, XP001109416 *
WILDING E. IMOGEN ET AL.: "Identification, evolution and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci", JOURNAL OF BACTERIOLOGY, vol. 182, no. 15, 2000, pages 4319 - 4327, XP002232852 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502059A (ja) * 2014-11-12 2018-01-25 ビゾリス インコーポレイテッド メバロノラクトンから調製されるポリマーおよび誘導体
CN107418978A (zh) * 2017-06-24 2017-12-01 天津大学 一种利用生物柴油副产物制备金合欢烯的方法

Also Published As

Publication number Publication date
JPWO2003095651A1 (ja) 2005-09-15
AU2003234790A1 (en) 2003-11-11
US20050287655A1 (en) 2005-12-29
EP1510583A1 (en) 2005-03-02

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