WO2003096931A2 - Aortic filter - Google Patents

Aortic filter Download PDF

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Publication number
WO2003096931A2
WO2003096931A2 PCT/US2003/011666 US0311666W WO03096931A2 WO 2003096931 A2 WO2003096931 A2 WO 2003096931A2 US 0311666 W US0311666 W US 0311666W WO 03096931 A2 WO03096931 A2 WO 03096931A2
Authority
WO
WIPO (PCT)
Prior art keywords
filter
catheter
accordance
protection device
embolic protection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/011666
Other languages
French (fr)
Other versions
WO2003096931A3 (en
Inventor
Christopher R. Larson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Corp
Boston Scientific Scimed Inc
Original Assignee
Boston Scientific Corp
Scimed Life Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Corp, Scimed Life Systems Inc filed Critical Boston Scientific Corp
Priority to EP03721691A priority Critical patent/EP1511444B1/en
Priority to DE60319524T priority patent/DE60319524T2/en
Priority to AU2003224990A priority patent/AU2003224990A1/en
Publication of WO2003096931A2 publication Critical patent/WO2003096931A2/en
Publication of WO2003096931A3 publication Critical patent/WO2003096931A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/0105—Open ended, i.e. legs gathered only at one side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/011—Instruments for their placement or removal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical

Definitions

  • the present invention pertains to intravascular filtering devices. More particularly, the present invention pertains to devices for filtering embolic debris generated during a medical procedure.
  • Heart and vascular disease are majors problem in the United States and throughout the world. Conditions such as atherosclerosis result in blood vessels becoming blocked or narrowed. This blockage can result in lack of oxygenation of the heart, or other vital organ which has significant consequences since the heart muscle must be well oxygenated in order to maintain its blood pumping action.
  • Occluded, stenotic, or narrowed blood vessels may be treated with a number of relatively non-invasive medical procedures including percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA), and atherectomy.
  • Angioplasty techniques typically involve the use of a balloon catheter. The balloon catheter is advanced over a guidewire such that the balloon is positioned adjacent a stenotic lesion. The balloon is then inflated and the restriction of the vessel is opened. During an atherectomy procedure, the stenotic lesion may be mechanically cut away from the blood vessel wall using an atherectomy catheter.
  • embolic debris can be separated from the wall of the blood vessel. If this debris enters the circulatory system, it could block other vascular regions including the neural and pulmonary vasculature, both of which are highly undesirable. During angioplasty procedures, stenotic debris may also break loose due to manipulation of the blood vessel. Because of this debris, a number of devices, termed embolic protection devices, have been developed to filter out this debris.
  • a filter can be coupled to a tubular shaft.
  • the tubular shaft can serve dual purposes: to provides means for filtering a blood vessel and for providing means for guiding a therapeutic, ancillary or diagnostic device to an appropriate target site.
  • Figure 1 is a plan overview of an embolic protection device disposed within the aorta of a patient
  • Figure 3 is a top view of the embolic protection device illustrating the filter and a pull cord for collapsing the filter;
  • Figure 4 is a top view of an alternative embolic protection device illustrating the filter and a plurality of pull cords for collapsing the filter;
  • Figure 6 is a partial cross-sectional view of the embolic protection device disposed in a delivery sheath in a configuration suitable for navigating the vasculature of a patient.
  • Intravascular medical procedures such as angioplasty or atherectomy can generate embolic debris, which might obstruct vascular regions and cause tissue damage.
  • general navigation of medical devices through the vasculature can also generate embolic debris, for example, due to contact of the devices with vascular walls.. For example, advancing a medical device to engage the renal artery for an intervention (via the femoral artery and abdominal aorta) can cause embolic debris to become dislodged and, possibly, cause complications in the lower extremities.
  • FIG. 1 is a plan overview of an embolic protection device 10 disposed within the aorta 12 of a patient.
  • Embolic protection device 10 generally comprises an elongate shaft 14 having a filter 16 coupled thereto.
  • shaft 14 is tubular and allows a second medical device 18 (e.g., a diagnostic, therapeutic, or guide catheter) to be disposed therein.
  • Embolic debris including plaque and other debris as known to those in the art
  • This debris may travel proximally (antegrade) in the bloodstream to the lower extremities, where it can cause tissue damage.
  • Embolic protection device 10 can be used to filter embolic debris generated during use of device 18 or other similar devices.
  • device 10 may also be used during other intravascular interventions. For example, device 10 may be used to place iliac stents or to place stents elsewhere within the vasculature when a retrograde approach is used.
  • Shaft 14 may be comprised of a polymer, metal, metal-polymer composite, or any other suitable materials.
  • Shaft 14 may be solid in cross-section, tubular, and/or comprise a catheter (e.g., a diagnostic, therapeutic, introducer sheath, or guide catheter).
  • catheter e.g., a diagnostic, therapeutic, introducer sheath, or guide catheter.
  • shaft 14 may be generally constructed according to techniques used to construct typical guide catheters.
  • Shaft 14 includes a proximal end (not shown), a distal end 22, and a lumen 24 extending therethrough.
  • Filter 16 may be disposed near distal end 22.
  • Filter 16 may be comprised of a polyurethane sheet and include at least one opening that may be, for example, formed by laser cutting. The holes or openings are sized to allow blood flow therethrough but restrict flow of debris or emboli floating in the body lumen or cavity.
  • Filter 16 may be, but not limited to, a generally cone-shape, and have a proximal end 25 and a distal end 26.
  • Proximal end 25 may be a narrow, "V-shaped end and can be fixedly secured or formed to shaft 14.
  • Distal end 26 has a relatively wide opening.
  • Filter 16 operates between a first generally collapsed configuration and a second generally expanded configuration for collecting debris in a body lumen.
  • Filter 16 may include a frame that is comprised of a self-expanding metal alloy (e.g., nickel-titanium alloy). According to this embodiment, filter 16 may be biased to be in the second (expanded) configuration.
  • a self-expanding metal alloy e.g., nickel-titanium alloy
  • Device 10 may include an outer sheath 28 disposed over at least a portion of shaft 14.
  • Sheath 28 may be a delivery sheath used during delivery of device 10 to the vasculature.
  • shaft 14 is disposed within sheath 28 so that filter 16 is at least partially collapsed therein.
  • a portion of filter 16 may extend distally from a distal end of sheath 28 as described below and shown in Figure 6.
  • FIG 2 is a plan overview of an embodiment of embolic protection device 10 where filter 16 is partially collapsed and configured for removal from the vasculature of the patient.
  • a number of different structures and methods can be utilized to remove device 10.
  • sheath 28 can be advanced distally over filter 16, collapsing filter 16 and encapsulating it within sheath 28. Once encapsulated within sheath 28, filter 16 (and device 10) can be removed by withdrawing proximally through the vasculature.
  • a pull cord or other device may be coupled to filter 16.
  • FIG 3 is a top view of embolic protection device 10 showing filter 16 and a pull cord 30 for collapsing filter 16.
  • Pull cord 30 may be disposed at or otherwise coupled to distal end 26 of filter 16. As shown, pull cord 30 is threaded through a portion of distal end 26 in a manner analogous to a stitch.
  • a distal end 32 of pull cord 30 may be generally fixed to a portion of distal end 26.
  • the individual stitches of pull cord 30 through distal end 32 are configured so that pull cord 30 can be tightened to collapse or otherwise decrease the circumference of filter 16 (as shown in Figure 2).
  • Pull cord 30 has at least one loop portion 34 that extends between distal end 26 of filter 16 and shaft 14.
  • shaft 14 includes a cord lumen 36 extending along the longitudinal axis of shaft 14.
  • pull cord 30 may be pass through lumen 36 and extend proximally to a convenient location for a clinician to actuate or "pull" pull cord 30.
  • cord lumen 36 may be disposed more closely to the outer surface of shaft 14 than the inner surface. This later configuration may be described a being asymmetrically disposed.
  • FIG. 3 allows the clinician to minimize the release of captured embolic debris from filter 16 when collapsing filter 16.
  • Using pull cord 30 to collapse filter 16 allows the clinician to apply force to collapse filter 16 essentially at distal end 26 to contain debris within filter 16 during retrieval.
  • Pull cord 30 may be generally metallic or be comprised of any suitable material including polymers.
  • pull cord 30 may include a portion that comprised of or plated with a radiopaque material.
  • Radiopaque materials are understood to generally produce a relatively bright image on a fluoroscopy screen during a medical procedure. This relatively bright image aids the user of device 10 in determining its location.
  • Radiopaque materials include, but are not limited to, gold, platinum, and plastic material loaded with a radiopaque filler.
  • Figure 4 is a top view of an alternative filter 1 16 and pull cord 130 that are essentially the same in form and function as filter 16 and pull cord 130, except that pull cord 130 has a plurality of loops portions 134 extending between filter 1 16 and shaft 1 14.
  • Shaft 1 14 is essentially the same as shaft 14, except that shaft 1 14 include a plurality of cord lumens 136.
  • pull cord 130 essentially includes a plurality of pull cords (in this case four individual regions) that can be actuated to collapse filter 16 as described above.
  • FIG. 5 is a prospective view of an alternate filter 216 that is essentially the same in form and function as filter 16, except that filter 216 includes a non- filtering region 238 extending distally from distal end 226.
  • pull cords 30/130 can be coupled to a distal end 240 of non-filtering region 238 and then be used essentially as described above.
  • non-filtering region 238 may act as an extension of filter 216 to increase the holding capacity of embolic debris within filter 216. It can be appreciated that non-filtering region 238 is constructed to be solid (i.e., non- porous) in structure and would capture or filter only a minimum amount of embolic debris. Thus, if collapsing filter 216 dislodged any embolic debris, the debris would still be contained within non-filtering region 238 so that the debris can be effectively removed from the patient.
  • Figure 6 is a partial cross-sectional view of embolic protection device 10 disposed in delivery sheath 28 in a configuration suitable for navigating the vasculature of a patient.
  • sheath 28 may be configured over a portion of filter 16 so that filter 16 is collapsed and forms a tapered distal tip 42 to device 10.
  • Tapered distal tip 42 provides device 10 with a generally atraumatic distal end.
  • embolic protection device 10 can be advanced to a landing area within the aorta as shown in Figure 1.
  • Filter 16 may be expanded by advancing shaft 14 or retracting sheath 28.
  • Medical device 18 can then be advanced to renal artery 20.
  • Filter 16 can then be collapsed as shown in Figure 2 and withdrawn as shown in Figure 2.
  • Another filter may be advanced and positioned at the landing area if desired.
  • medical device 18 can be removed prior to collapsing and removing filter 16.

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Abstract

Devices and methods for filtering embolic debris from a body lumen. The present invention includes a filter coupled to an elongate shaft. In some embodiments, the shaft may be tubular so as to be capable of allowing a guiding, therapeutic, or diagnostic device to pass therethrough.

Description

AORTIC FILTER
Background of the nvention
1. Field of the Invention
The present invention pertains to intravascular filtering devices. More particularly, the present invention pertains to devices for filtering embolic debris generated during a medical procedure.
2. Description of the Related Art
Heart and vascular disease are majors problem in the United States and throughout the world. Conditions such as atherosclerosis result in blood vessels becoming blocked or narrowed. This blockage can result in lack of oxygenation of the heart, or other vital organ which has significant consequences since the heart muscle must be well oxygenated in order to maintain its blood pumping action.
Occluded, stenotic, or narrowed blood vessels may be treated with a number of relatively non-invasive medical procedures including percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA), and atherectomy. Angioplasty techniques typically involve the use of a balloon catheter. The balloon catheter is advanced over a guidewire such that the balloon is positioned adjacent a stenotic lesion. The balloon is then inflated and the restriction of the vessel is opened. During an atherectomy procedure, the stenotic lesion may be mechanically cut away from the blood vessel wall using an atherectomy catheter.
During angioplasty and atherectomy procedures, embolic debris can be separated from the wall of the blood vessel. If this debris enters the circulatory system, it could block other vascular regions including the neural and pulmonary vasculature, both of which are highly undesirable. During angioplasty procedures, stenotic debris may also break loose due to manipulation of the blood vessel. Because of this debris, a number of devices, termed embolic protection devices, have been developed to filter out this debris.
Embolic debris can also be generated when performing an intravascular procedure at a location away from the heart. For example, engaging or treating the renal artery may generate embolic debris. Because of the potential dangers of embolic debris obstructing blood vessels and/or capillaries, it is important to consider capturing and/or removing debris at all areas of the vasculature. Brief Summary of the Invention
The present invention incorporates design and manufacturing refinements to embolic protection devices. In some embodiments, a filter can be coupled to a tubular shaft. The tubular shaft can serve dual purposes: to provides means for filtering a blood vessel and for providing means for guiding a therapeutic, ancillary or diagnostic device to an appropriate target site.
Brief Description of the Several Views of the Drawings
Figure 1 is a plan overview of an embolic protection device disposed within the aorta of a patient;
Figure 2 is a plan overview of an embodiment of an embolic protection device where the filter is partially collapsed and configured for removal from the vasculature of the patient;
Figure 3 is a top view of the embolic protection device illustrating the filter and a pull cord for collapsing the filter;
Figure 4 is a top view of an alternative embolic protection device illustrating the filter and a plurality of pull cords for collapsing the filter;
Figure 5 is a prospective view of an alternative embodiment of a filter for use with an embolic protection device; and
Figure 6 is a partial cross-sectional view of the embolic protection device disposed in a delivery sheath in a configuration suitable for navigating the vasculature of a patient.
Detailed Description of the Invention
The following description should be read with reference to the drawings wherein like reference numerals indicate like elements throughout the several views. The detailed description and drawings illustrate example embodiments of the claimed invention.
Intravascular medical procedures such as angioplasty or atherectomy can generate embolic debris, which might obstruct vascular regions and cause tissue damage. In addition, general navigation of medical devices through the vasculature can also generate embolic debris, for example, due to contact of the devices with vascular walls.. For example, advancing a medical device to engage the renal artery for an intervention (via the femoral artery and abdominal aorta) can cause embolic debris to become dislodged and, possibly, cause complications in the lower extremities.
Figure 1 is a plan overview of an embolic protection device 10 disposed within the aorta 12 of a patient. Embolic protection device 10 generally comprises an elongate shaft 14 having a filter 16 coupled thereto. In some embodiments, shaft 14 is tubular and allows a second medical device 18 (e.g., a diagnostic, therapeutic, or guide catheter) to be disposed therein. Embolic debris (including plaque and other debris as known to those in the art) may be generated when trying to engage, for example, the renal artery 20 with device 18. This debris may travel proximally (antegrade) in the bloodstream to the lower extremities, where it can cause tissue damage. Embolic protection device 10 can be used to filter embolic debris generated during use of device 18 or other similar devices. Moreover, device 10 may also be used during other intravascular interventions. For example, device 10 may be used to place iliac stents or to place stents elsewhere within the vasculature when a retrograde approach is used.
Shaft 14 may be comprised of a polymer, metal, metal-polymer composite, or any other suitable materials. Shaft 14 may be solid in cross-section, tubular, and/or comprise a catheter (e.g., a diagnostic, therapeutic, introducer sheath, or guide catheter). For example, shaft 14 may be generally constructed according to techniques used to construct typical guide catheters. Shaft 14 includes a proximal end (not shown), a distal end 22, and a lumen 24 extending therethrough.
Filter 16 may be disposed near distal end 22. Filter 16 may be comprised of a polyurethane sheet and include at least one opening that may be, for example, formed by laser cutting. The holes or openings are sized to allow blood flow therethrough but restrict flow of debris or emboli floating in the body lumen or cavity.
Filter 16 may be, but not limited to, a generally cone-shape, and have a proximal end 25 and a distal end 26. Proximal end 25 may be a narrow, "V-shaped end and can be fixedly secured or formed to shaft 14. Distal end 26 has a relatively wide opening. Filter 16 operates between a first generally collapsed configuration and a second generally expanded configuration for collecting debris in a body lumen. Filter 16 may include a frame that is comprised of a self-expanding metal alloy (e.g., nickel-titanium alloy). According to this embodiment, filter 16 may be biased to be in the second (expanded) configuration.
Device 10 may include an outer sheath 28 disposed over at least a portion of shaft 14. Sheath 28 may be a delivery sheath used during delivery of device 10 to the vasculature. To use sheath 28 as a delivery sheath, shaft 14 is disposed within sheath 28 so that filter 16 is at least partially collapsed therein. In some embodiments, a portion of filter 16 may extend distally from a distal end of sheath 28 as described below and shown in Figure 6. With filter 16 collapsed within sheath 28, device 10 can be advanced through the vasculature to a desired location. Once at the desired location, sheath 28 can be retracted proximally relative to shaft 14, allowing filter 16 to shift to the second (expanded) configuration.
Figure 2 is a plan overview of an embodiment of embolic protection device 10 where filter 16 is partially collapsed and configured for removal from the vasculature of the patient. A number of different structures and methods can be utilized to remove device 10. For example, sheath 28 can be advanced distally over filter 16, collapsing filter 16 and encapsulating it within sheath 28. Once encapsulated within sheath 28, filter 16 (and device 10) can be removed by withdrawing proximally through the vasculature. Alternatively, a pull cord or other device may be coupled to filter 16. Some of these embodiments are illustrated in sections taken through line A- A in Figures 3-4.
Figure 3 is a top view of embolic protection device 10 showing filter 16 and a pull cord 30 for collapsing filter 16. Pull cord 30 may be disposed at or otherwise coupled to distal end 26 of filter 16. As shown, pull cord 30 is threaded through a portion of distal end 26 in a manner analogous to a stitch. A distal end 32 of pull cord 30 may be generally fixed to a portion of distal end 26. Moreover, the individual stitches of pull cord 30 through distal end 32 are configured so that pull cord 30 can be tightened to collapse or otherwise decrease the circumference of filter 16 (as shown in Figure 2).
Pull cord 30 has at least one loop portion 34 that extends between distal end 26 of filter 16 and shaft 14. In some embodiments, shaft 14 includes a cord lumen 36 extending along the longitudinal axis of shaft 14. According to this embodiment, pull cord 30 may be pass through lumen 36 and extend proximally to a convenient location for a clinician to actuate or "pull" pull cord 30. It can be appreciated that the precise location of cord lumen 36 within shaft 14 may be altered without departing from the spirit of the invention. For example, cord lumen 36 may be disposed more closely to the outer surface of shaft 14 than the inner surface. This later configuration may be described a being asymmetrically disposed.
To collapse filter 16 with pull cord 30, the clinician actuates or pulls pull cord 30 in the proximal direction. When pulled, pull cord 30 tightens within distal end 26 and tends to decrease the circumference of filter 16. Once partially collapsed, sheath 28 may be advanced over filter 16 so that device 10 can be removed from the vasculature.
The embodiment shown in Figure 3 allows the clinician to minimize the release of captured embolic debris from filter 16 when collapsing filter 16. Using pull cord 30 to collapse filter 16 allows the clinician to apply force to collapse filter 16 essentially at distal end 26 to contain debris within filter 16 during retrieval.
Pull cord 30 may be generally metallic or be comprised of any suitable material including polymers. In some embodiments, pull cord 30 may include a portion that comprised of or plated with a radiopaque material. Radiopaque materials are understood to generally produce a relatively bright image on a fluoroscopy screen during a medical procedure. This relatively bright image aids the user of device 10 in determining its location. Radiopaque materials include, but are not limited to, gold, platinum, and plastic material loaded with a radiopaque filler.
Figure 4 is a top view of an alternative filter 1 16 and pull cord 130 that are essentially the same in form and function as filter 16 and pull cord 130, except that pull cord 130 has a plurality of loops portions 134 extending between filter 1 16 and shaft 1 14. Shaft 1 14 is essentially the same as shaft 14, except that shaft 1 14 include a plurality of cord lumens 136. Thus, pull cord 130 essentially includes a plurality of pull cords (in this case four individual regions) that can be actuated to collapse filter 16 as described above.
Figure 5 is a prospective view of an alternate filter 216 that is essentially the same in form and function as filter 16, except that filter 216 includes a non- filtering region 238 extending distally from distal end 226. According to this embodiment, pull cords 30/130 can be coupled to a distal end 240 of non-filtering region 238 and then be used essentially as described above.
In some embodiments, non-filtering region 238 may act as an extension of filter 216 to increase the holding capacity of embolic debris within filter 216. It can be appreciated that non-filtering region 238 is constructed to be solid (i.e., non- porous) in structure and would capture or filter only a minimum amount of embolic debris. Thus, if collapsing filter 216 dislodged any embolic debris, the debris would still be contained within non-filtering region 238 so that the debris can be effectively removed from the patient.
Figure 6 is a partial cross-sectional view of embolic protection device 10 disposed in delivery sheath 28 in a configuration suitable for navigating the vasculature of a patient. In some embodiments, sheath 28 may be configured over a portion of filter 16 so that filter 16 is collapsed and forms a tapered distal tip 42 to device 10. Tapered distal tip 42 provides device 10 with a generally atraumatic distal end.
In use, embolic protection device 10 can be advanced to a landing area within the aorta as shown in Figure 1. Filter 16 may be expanded by advancing shaft 14 or retracting sheath 28. Medical device 18 can then be advanced to renal artery 20. Filter 16 can then be collapsed as shown in Figure 2 and withdrawn as shown in Figure 2. Another filter may be advanced and positioned at the landing area if desired. Alternately, medical device 18 can be removed prior to collapsing and removing filter 16.
It should be understood that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed.

Claims

Claims What is claimed is:
1. An embolic protection device, comprising: an elongate tubular shaft having a proximal end, a distal end, and a lumen extending therethrough; a filter coupled to the shaft proximate the distal end, the filter having a distal mouth region; a sheath slidably disposed about the shaft; and a pull cord coupled to the mouth portion and extending proximally along a longitudinal axis of the shaft such that such that altering the position of the pull cord shifts the filter between a first generally collapsed configuration and a second generally expanded configuration.
2. The embolic protection device in accordance with claim 1, wherein the filter is biased to be in the second configuration.
3. The embolic protection device in accordance with claim 1, wherein the shaft further comprises a second lumen extending along the longitudinal axis of the shaft.
4. The embolic protection device in accordance with claim 3, wherein at least a portion of the pull cord is disposed within the second lumen.
5. The embolic protection device in accordance with claim 3, wherein the shaft further comprises one or more additional lumens.
6. The embolic protection device in accordance with claim 5, further comprising one or more additional pull cords, each additional pull cord being disposed in one of additional lumen additional.
7. The embolic protection device in accordance with claim 1, wherein the filter includes a filtering portion comprising filtering material and an extension portion comprised of non-filtering material, wherein the mouth region is disposed at the extension portion.
8. The embolic protection device in accordance with claim 1, further comprising a medical device slidably disposed within the lumen.
9. An embolic protection device, comprising: a catheter having a proximal end, a distal end, and a lumen extending therethrough; wherein the lumen is sized to allow a second catheter to be slidably disposed therein; a filter coupled to the catheter proximate the distal end, the filter having a distal mouth region; wherein the filter is adapted and configured to shift between a first generally collapsed configuration and a second generally expanded configuration; a sheath slidably disposed about the catheter; and a pull cord coupled to the mouth portion and extending proximally along a longitudinal axis of the catheter such that such that altering the position of the pull cord shifts the filter between the first and the second configuration.
10. The embolic protection device in accordance with claim 9, wherein the filter is biased to be in the second configuration.
11. The embolic protection device in accordance with claim 9, wherein the catheter further comprises a second lumen extending along the longitudinal axis thereof.
12. The embolic protection device in accordance with claim 1 1, wherein at least a portion of the pull cord is disposed within the second lumen.
13. The embolic protection device in accordance with claim 11, wherein the catheter further comprises one or more additional lumens.
14. The embolic protection device in accordance with claim 13, further comprising one or more additional pull cords, each additional pull cord being disposed in one of the additional lumens.
15. The embolic protection device in accordance with claim 9, wherein the filter includes a filtering portion comprising filtering material and an extension portion comprised of non-filtering material, wherein the mouth region is disposed at the extension portion.
16. An embolic protection device, comprising: a catheter having a proximal end, a distal end, and a lumen extending therethrough; wherein the lumen is sized to allow a second catheter to be slidably disposed therein; a filter coupled to the catheter proximate the distal end, the filter having a distal mouth region; means for shifting the filter between a first generally collapsed configuration and a second generally expanded configuration, wherein the means for shifting the filter is coupled to the mouth region of the filter; and a sheath slidably disposed about the catheter.
17. The embolic protection device in accordance with claim 16, wherein means for shifting the filter includes a pull cord coupled to the filter and extending proximally along a longitudinal axis of the catheter such that such that altering the position of the pull cord shifts the filter between the first configuration and the second configuration.
18. A method of filtering embolic debris from a blood vessel, comprising the steps of: providing a first catheter having a proximal end, a distal end, at least one lumen extending therethrough, a filter disposed near the distal end; advancing the first catheter and delivery sheath through a blood vessel to a landing area; deploying the filter at the landing area; advancing a second catheter through the lumen of the first catheter for placement in a renal artery; and capturing embolic debris with the filter.
19. The method in accordance with claim 18, further comprising the step of disposing at least a portion of the first catheter within a delivery sheath.
20. The method in accordance with claim 18, further comprising the step of actuating a pull cord to at least partially collapse the filter.
21. The method in accordance with claim 20, wherein the first catheter includes a second lumen disposed along the longitudinal axis thereof and the pull cord extends through the second lumen and outside of the blood vessel, and wherein the step of actuating the pull cord includes proximally pulling the pull cord from outside the blood vessel.
22. The method in accordance with claim 20, wherein the filter includes a first portion being comprised of filter material and a second portion being comprised of non-filter material, and wherein the step of actuating the pull cord includes at least partially collapsing the non-filter material.
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DE60319524T2 (en) 2009-03-26
ATE387893T1 (en) 2008-03-15
AU2003224990A1 (en) 2003-12-02
ATE462374T1 (en) 2010-04-15
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US7585309B2 (en) 2009-09-08
DE60319524D1 (en) 2008-04-17
EP1929977A2 (en) 2008-06-11
WO2003096931A3 (en) 2004-03-04
EP1511444A2 (en) 2005-03-09
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EP1929977A3 (en) 2008-06-25
EP1929977B1 (en) 2010-03-31

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