WO2003102201A3 - Methods and materials for the production of d-lactic acid in yeast - Google Patents

Methods and materials for the production of d-lactic acid in yeast Download PDF

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Publication number
WO2003102201A3
WO2003102201A3 PCT/US2003/017310 US0317310W WO03102201A3 WO 2003102201 A3 WO2003102201 A3 WO 2003102201A3 US 0317310 W US0317310 W US 0317310W WO 03102201 A3 WO03102201 A3 WO 03102201A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
methods
lactic acid
yeast
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/017310
Other languages
French (fr)
Other versions
WO2003102201A2 (en
Inventor
Vineet Rajgarhia
Catherine Asleson Dundon
Stacey Olson
Pirkko Suominen
Ben Hause
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NatureWorks LLC
Original Assignee
Cargill Dow LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Dow LLC filed Critical Cargill Dow LLC
Priority to JP2004510438A priority Critical patent/JP2005528112A/en
Priority to AU2003240481A priority patent/AU2003240481B8/en
Priority to EP03731489A priority patent/EP1513923B1/en
Priority to CN038172941A priority patent/CN1735683B/en
Priority to BR0311453-8A priority patent/BR0311453A/en
Priority to CA002487296A priority patent/CA2487296A1/en
Priority to DE60315028T priority patent/DE60315028T2/en
Priority to UA20041210933A priority patent/UA80976C2/en
Publication of WO2003102201A2 publication Critical patent/WO2003102201A2/en
Publication of WO2003102201A3 publication Critical patent/WO2003102201A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Kluyveromyces cells, methods for making the Kluyveromyces cells, and their use in production of organic products, particularly D-lactic acid.
PCT/US2003/017310 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast Ceased WO2003102201A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2004510438A JP2005528112A (en) 2002-05-30 2003-05-30 Method for producing D-lactic acid in yeast and its material
AU2003240481A AU2003240481B8 (en) 2002-05-30 2003-05-30 Methods and materials for the production of D-lactic acid in yeast
EP03731489A EP1513923B1 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
CN038172941A CN1735683B (en) 2002-05-30 2003-05-30 Methods and materials for producing D-lactic acid in yeast
BR0311453-8A BR0311453A (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
CA002487296A CA2487296A1 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast
DE60315028T DE60315028T2 (en) 2002-05-30 2003-05-30 METHOD AND MATERIALS FOR THE PRODUCTION OF D-MILKY ACID IN YEAST
UA20041210933A UA80976C2 (en) 2002-05-30 2003-05-30 Processes and materials for production of d-lactic acid in yeast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38433302P 2002-05-30 2002-05-30
US60/384,333 2002-05-30

Publications (2)

Publication Number Publication Date
WO2003102201A2 WO2003102201A2 (en) 2003-12-11
WO2003102201A3 true WO2003102201A3 (en) 2004-03-18

Family

ID=29712012

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/016825 Ceased WO2003102200A2 (en) 2002-05-30 2003-05-30 Fermentation process using specific oxygen uptake rates as a process control
PCT/US2003/017329 Ceased WO2003102152A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of lactic acid in yeast
PCT/US2003/017310 Ceased WO2003102201A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of d-lactic acid in yeast

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/016825 Ceased WO2003102200A2 (en) 2002-05-30 2003-05-30 Fermentation process using specific oxygen uptake rates as a process control
PCT/US2003/017329 Ceased WO2003102152A2 (en) 2002-05-30 2003-05-30 Methods and materials for the production of lactic acid in yeast

Country Status (15)

Country Link
US (7) US20040029256A1 (en)
EP (4) EP2878675B1 (en)
JP (4) JP2005528112A (en)
CN (4) CN100335626C (en)
AT (1) ATE367436T1 (en)
AU (4) AU2003243366B2 (en)
BR (4) BR0311452A (en)
CA (3) CA2487296A1 (en)
DE (1) DE60315028T2 (en)
DK (1) DK2878675T3 (en)
ES (3) ES2642928T3 (en)
PT (1) PT1513923E (en)
UA (2) UA80976C2 (en)
WO (3) WO2003102200A2 (en)
ZA (3) ZA200409529B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534597B2 (en) 2002-05-30 2009-05-19 Cargill, Inc. Methods and materials for the production of L-lactic acid in yeast

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (en) 1997-09-12 1999-04-12 Biopolo S C A R L YEAST STRAWS FOR THE REPRODUCTION OF LACTIC ACID
US20070031950A1 (en) * 1998-09-11 2007-02-08 Winkler Aaron A Production of D-lactic acid with yeast
US7141410B2 (en) * 2000-11-22 2006-11-28 Natureworks Llc Methods and materials for the production of organic products in cells of Candida species
JP4711955B2 (en) 2003-05-02 2011-06-29 ネイチャーワークス・エル・エル・シー Genetically modified yeast and fermentation method using genetically modified yeast
JP4460876B2 (en) * 2003-11-07 2010-05-12 株式会社豊田中央研究所 Promoters in the presence of organic acids and their use
US20050112737A1 (en) * 2003-11-20 2005-05-26 A. E. Staley Manufacturing Co. Lactic acid producing yeast
JP4806904B2 (en) * 2004-07-09 2011-11-02 トヨタ自動車株式会社 Lactic acid production method
JP2006296377A (en) * 2005-04-25 2006-11-02 Toyota Central Res & Dev Lab Inc Transformant for organic acid production
JP2008545429A (en) * 2005-06-02 2008-12-18 カーギル インコーポレイテッド Genetically engineered Issatchencia orientalis species or nearby yeasts, and fermentation methods using these yeasts
ES2401339T3 (en) 2005-08-10 2013-04-18 University Of Florida Research Foundation, Inc. Materials and methods for efficient production of lactic acid
JP4692173B2 (en) * 2005-09-13 2011-06-01 東レ株式会社 Polypeptide having D-lactic acid dehydrogenase activity, gene encoding the same, and method for producing D-lactic acid
US7718405B2 (en) * 2005-09-19 2010-05-18 American Air Liquide, Inc. Use of pure oxygen in viscous fermentation processes
CA2623751A1 (en) 2005-09-22 2007-04-05 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
EP1975232A4 (en) * 2005-10-14 2009-07-29 Toray Industries Yeast and method of producing l-lactic acid
JP5121070B2 (en) 2005-11-23 2013-01-16 ネイチャーワークス・エル・エル・シー L- or D-lactate: Lactic acid-producing yeast in which ferricytochrome C oxidoreductase gene does not function
WO2007085443A2 (en) * 2006-01-24 2007-08-02 Purac Biochem Bv Genetic modification of homolactic thermophilic bacilli
ES2620770T3 (en) 2006-03-13 2017-06-29 Cargill, Incorporated Fermentation process that uses yeast cells that have an altered route from dihydroxyacetone phosphate to glycerol
JP5320692B2 (en) * 2006-06-28 2013-10-23 東レ株式会社 Yeast and method for producing L-lactic acid
US20080064076A1 (en) * 2006-09-11 2008-03-13 Saucedo Victor M Dissolved Oxygen Profile to Increase Fermentation Productivity and Economics
JP5141126B2 (en) * 2006-09-26 2013-02-13 東レ株式会社 Method for producing D-lactic acid by continuous fermentation
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
JP2010508013A (en) * 2006-10-31 2010-03-18 メタボリック エクスプローラー Method for biological production of 1,3-propanediol from glycerol in high yield
CN101743310A (en) 2006-12-07 2010-06-16 麻省理工学院 Retrofitting of the Global Transcription Machine
JP5130826B2 (en) * 2007-03-28 2013-01-30 東レ株式会社 Process for producing lactic acid by continuous fermentation
JP2008283917A (en) * 2007-05-18 2008-11-27 Toray Ind Inc Method for producing lactic acid
AU2008305655B2 (en) 2007-09-20 2013-10-31 Amyris, Inc. Production of isoprenoids
BRPI0818979A2 (en) * 2007-12-07 2014-10-14 Toray Industries "LACTATE DEHYDROGENASE EXPRESSION CASSETTE, TRANSFORMING Yeast CUP AND METHOD OF PRODUCING LACTIC ACID"
US8455239B2 (en) 2007-12-23 2013-06-04 Gevo, Inc. Yeast organism producing isobutanol at a high yield
CN101952448A (en) * 2007-12-23 2011-01-19 格沃股份有限公司 Yeast organism producing isobutanol at a high yield
CN101959568A (en) 2007-12-27 2011-01-26 格沃股份有限公司 Reclaim higher alcohol from dilute aqueous solution
WO2009099044A1 (en) * 2008-02-04 2009-08-13 Toray Industries, Inc. Method of producing lactic acid by continuous fermentation
US20090235951A1 (en) * 2008-03-18 2009-09-24 Legrande W E Environmentally Responsible Dental Floss and Packaging
JP4963488B2 (en) * 2008-04-23 2012-06-27 トヨタ自動車株式会社 Mutant yeast and substance production method using the same
US9012187B2 (en) * 2008-07-08 2015-04-21 Dsm Ip Assets B.V. Dicarboxylic acid production by fermentation at low pH
CA2738452C (en) 2008-10-03 2016-06-21 Metabolic Explorer Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator
EP2390342A1 (en) * 2009-01-23 2011-11-30 Agribioindustry Inc. Method for producing d-lactic acid, and method for increasing optical purity of d-lactic acid or yield of d-lactic acid relative to sugar in lactic acid
CN102459590B (en) * 2009-06-03 2014-10-29 东丽株式会社 Polypeptide having d-lactate dehydrogenase activity, polynucleotide encoding the polypeptide, and process for production of d-lactic acid
EP2446045A4 (en) * 2009-06-26 2017-04-19 GEVO, Inc. Recovery of higher alcohols from dilute aqueous solutions
MX2012000150A (en) 2009-07-02 2012-04-11 Verdezyne Inc Biological methods for preparing adipic acid.
JPWO2011013721A1 (en) * 2009-07-28 2013-01-10 三井化学株式会社 Lactic acid production method
BR112012002153A2 (en) 2009-07-30 2015-09-15 Metabolic Explorer Sa Mutant methylglyoxal synthase (mgs) for the production of biochemical material by fermentation
PL2470667T3 (en) 2009-08-27 2018-04-30 Dsm Ip Assets B.V. A method for producing dicarboxylic acid by fermentation
EP2485995A4 (en) * 2009-10-06 2015-12-02 Gevo Inc Integrated process to selectively convert renewable isobutanol to p-xylene
CA2794817C (en) 2010-04-21 2019-03-12 Dsm Ip Assets B.V. Cell suitable for fermentation of a mixed sugar composition
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
CA2807102C (en) 2010-07-31 2018-08-21 Myriant Corporation Improved fermentation process for the production of organic acids
CA2813513A1 (en) 2010-10-13 2012-04-19 Dsm Ip Assets B.V. Polypeptides with permease activity
CA2885934C (en) 2010-11-22 2018-05-01 Cargill, Incorporated Compositions and methods for increased ethanol titer from biomass
CN103502432A (en) 2010-11-22 2014-01-08 诺维信股份有限公司 Compositions and methods for producing 3-hydroxypropionic acid
EP2668281A4 (en) 2011-01-25 2015-08-26 Cargill Inc COMPOSITIONS AND METHODS FOR THE PRODUCTION OF SUCCINATE
SG193589A1 (en) * 2011-03-29 2013-10-30 Nestec Sa Natural derivative of the lactobacilus johnsonii strain cncm i-1225, deficient in d-lactic acid production and with a further improved immune profile
US9512495B2 (en) 2011-04-07 2016-12-06 Virdia, Inc. Lignocellulose conversion processes and products
DK2697252T3 (en) 2011-04-11 2016-12-12 Cargill Inc Configurations and methods for increased ethanol production from biomass
CA2833312A1 (en) 2011-04-22 2012-10-26 Dsm Ip Assets B.V. Yeast cell capable of converting sugars including arabinose and xylose
US8728798B2 (en) 2011-05-03 2014-05-20 Verdezyne, Inc. Biological methods for preparing adipic acid
US8343752B2 (en) 2011-05-03 2013-01-01 Verdezyne, Inc. Biological methods for preparing adipic acid
CN102285664B (en) * 2011-05-27 2013-06-19 广西崇左市湘桂糖业有限公司 Special molecular sieve for separating L-lactic acid and D-lactic acid with simulated moving bed and preparation method thereof
CN103717746B (en) * 2011-08-11 2016-05-18 三井化学株式会社 Method for producing isopropanol by continuous culture
EP2807262A4 (en) * 2012-01-25 2015-12-30 Bioamber Internat S A R L PROCESSES FOR PRODUCING SUCCINATE
CN104093846B (en) * 2012-02-22 2017-03-22 诺维信公司 Advanced fermentation control
FR2988733B1 (en) * 2012-03-27 2016-02-05 Carbios RECOMBINANT MICROORGANISM
KR101438882B1 (en) * 2012-04-24 2014-09-05 씨제이제일제당 (주) Novel microorganism for producing D-type lactic acid
US9493851B2 (en) 2012-05-03 2016-11-15 Virdia, Inc. Methods for treating lignocellulosic materials
GB2518547B (en) 2012-05-03 2015-10-07 Virdia Ltd Method for the preparation of high purity lignin
WO2014003439A1 (en) * 2012-06-26 2014-01-03 한국생명공학연구원 Kluyveromyces marxianus strain having blocked ethanol production pathway, and use thereof
EP3901248A1 (en) 2012-07-25 2021-10-27 Cargill, Incorporated Yeast cells having reductive tca pathway from pyruvate to succinate and overexpressing an exogenous nad(p)+ transhydrogenase enzyme
EP2895593B1 (en) * 2012-09-14 2019-12-11 PTT Global Chemical Public Company Limited Production of organic acids by fermentation at low ph
PL2909305T3 (en) 2012-10-16 2019-06-28 Dsm Ip Assets B.V. Cells with improved pentose conversion
KR20150082241A (en) 2012-11-07 2015-07-15 디에스엠 아이피 어셋츠 비.브이. pH CONTROLLED YEAST PROPAGATION
WO2014076232A2 (en) 2012-11-19 2014-05-22 Novozymes A/S Isopropanol production by recombinant hosts using an hmg-coa intermediate
EP2925873B1 (en) 2012-11-30 2017-07-12 Novozymes, Inc. 3-hydroxypropionic acid production by recombinant yeasts
ES2757913T3 (en) 2013-06-18 2020-04-30 Calysta Inc Compositions and methods for the biological production of lactate from C1 compounds using lactic dehydrogenase transformants
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US9845484B2 (en) 2013-07-31 2017-12-19 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
BR112016016539A2 (en) 2014-01-16 2018-01-23 Calysta Inc carbohydrate enriched recombinant microorganisms
KR20150096019A (en) * 2014-02-13 2015-08-24 삼성전자주식회사 Yeast cell having enhanced genetic manipulation efficiency and use thereof
US9593350B2 (en) 2014-02-14 2017-03-14 Samsung Electronics Co., Ltd. Lactate dehydrogenase mutant, polynucleotide coding for the mutant, yeast cell including the polynucleotide, method of preparing the mutant, and method of producing the lactate using the same
JP6183263B2 (en) * 2014-03-28 2017-08-23 王子ホールディングス株式会社 Process for producing D-lactic acid with improved process for purification of D-lactic acid
ES2924896T3 (en) 2014-05-16 2022-10-11 Carbios Procedure for recycling mixed plastic items with PET
WO2016012429A1 (en) 2014-07-24 2016-01-28 Dsm Ip Assets B.V. Yeast cell with improved pentose transport
KR102245298B1 (en) 2014-09-05 2021-04-27 삼성전자주식회사 Genetically engineered yeast cell having enhanced EDC activity and producing lactate, method for producing yeast cell, and method for producing lactate using the same
US10214754B2 (en) 2014-10-10 2019-02-26 Jmtc Enzyme Corporation Transformant and its production process, and method for producing lactic acid
EP3778883A1 (en) 2014-10-21 2021-02-17 Carbios Polypeptide having a polyester degrading activity and uses thereof
WO2016081902A1 (en) 2014-11-20 2016-05-26 Full Cycle Bioplastics Inc. Producing polyhydroxyalkanoate copolymers from organic waste products
WO2016084963A1 (en) * 2014-11-28 2016-06-02 味の素株式会社 Method for producing isoprenoid compound
WO2016100910A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Recombinant host cells for the production of 3-hydroxypropionic acid
US10626242B2 (en) 2014-12-19 2020-04-21 Carbios Plastic compound and preparation process
SE538899C2 (en) 2015-02-03 2017-01-31 Stora Enso Oyj Method for treating lignocellulosic materials
EP3262161B1 (en) 2015-02-27 2021-06-30 Novozymes A/S Mutant host cells for the production of 3-hydroxypropionic acid
CN107532153A (en) 2015-03-13 2018-01-02 卡比奥斯公司 Novel polypeptide with polyester degrading activity and application thereof
US20180179499A1 (en) 2015-06-04 2018-06-28 Bioamber Inc. Biobased production of functionalized alpha-substituted acrylates and c4-dicarboxylates
CA2987842C (en) 2015-06-12 2024-01-02 Carbios Biodegradable polyester composition and uses thereof
WO2017035270A1 (en) 2015-08-24 2017-03-02 Novozymes A/S Beta-alanine aminotransferases for the production of 3-hydroxypropionic acid
EP3394264A1 (en) 2015-12-21 2018-10-31 Carbios Recombinant yeast cells producing polylactic acid and uses thereof
PL3458508T3 (en) 2016-05-19 2026-02-23 Carbios A process for degrading plastic products
US10787649B2 (en) 2016-07-13 2020-09-29 Dsm Ip Assets B.V. Malate dehyrogenases
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
EP3668306A4 (en) 2017-08-17 2021-06-09 Cargill, Incorporated Genetically modified haploidissatchenkia orientalis
WO2019159011A2 (en) * 2018-02-16 2019-08-22 Ptt Global Chemical Public Company Limited Microorganisms and processes for lactic acid production
US12338428B2 (en) 2018-03-30 2025-06-24 Inv Nylon Chemicals Americas, Llc Materials and methods for managing aerobic gas fermentation
US12065636B2 (en) 2018-03-30 2024-08-20 Inv Nylon Chemicals Americas, Llc High hydrogen utilization and gas recycle
KR102140596B1 (en) 2018-04-17 2020-08-04 에스케이이노베이션 주식회사 Novel Promotor from Organic Acid Resistant Yeast and Method for Expressing Target Gene Using The Same
KR102140597B1 (en) 2018-04-17 2020-08-03 에스케이이노베이션 주식회사 Acid Resistant Yeast Inhibited Ethanol Production and Method for Preparing Lactic Acid Using The Same
WO2019213033A1 (en) 2018-05-02 2019-11-07 Invista North America S.A.R.L. Materials and methods for maximizing biosynthesis through alteration of pyruvate-acetyl-coa-tca balance in species of the genera ralstonia and cupriavidus and organisms related thereto
US11702680B2 (en) 2018-05-02 2023-07-18 Inv Nylon Chemicals Americas, Llc Materials and methods for controlling PHA biosynthesis in PHA-generating species of the genera Ralstonia or Cupriavidus and organisms related thereto
TWI719317B (en) * 2018-06-13 2021-02-21 遠東新世紀股份有限公司 Method for producing lactic acid
CN109097293B (en) * 2018-07-13 2021-10-26 广东利世康低碳科技有限公司 Gene recombination pichia pastoris capable of degrading and utilizing kitchen waste to generate lactic acid
KR102736070B1 (en) 2018-10-08 2024-12-02 에스케이이노베이션 주식회사 Recombinant Acid Resistant Yeast Inhibited alcohol production and Method for Preparing Lactic Acid Using The Same
US20210403928A1 (en) 2018-11-30 2021-12-30 Utilization Of Carbon Dioxide Institute Co., Ltd. Lactic Acid-Producing Hydrogenophilus Bacterium Transformant
EP4012020A4 (en) 2019-08-09 2022-08-17 Utilization of Carbon Dioxide Institute Co.,Ltd. TRANSGENIC BACTERIA OF THE GENUS HYDROGENOPHILUS PRODUCING LACTIC ACID
WO2021034276A2 (en) * 2019-08-19 2021-02-25 Ptt Global Chemical Public Company Limited Yeast having improvement of lactic acid tolerance and use thereof
TWI730383B (en) * 2019-08-21 2021-06-11 遠東新世紀股份有限公司 Recombinant strain of candida spp., and the preparation process and uses thereof
KR20210041903A (en) 2019-10-08 2021-04-16 에스케이이노베이션 주식회사 Recombinant Acid Resistant Yeast Inhibited Lactate Metabolism and Alcohol Production and Method for Preparing Lactic Acid Using The Same
KR20210128742A (en) 2020-04-17 2021-10-27 에스케이이노베이션 주식회사 Recombinant Acid Resistant Yeast Inhibited Glycerol Production and Method for Preparing Lactic Acid Using The Same
KR20210158676A (en) 2020-06-24 2021-12-31 에스케이이노베이션 주식회사 Recombinant Acid Resistant Yeast Having Improbed Lactic Acid Productivity
RU2752896C1 (en) * 2020-12-04 2021-08-11 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" - ГосНИИгенетика) Strain of yeast schizosaccharomyces pombe, producing l-lactic acid, containing genes of three different heterologous lactate dehydrogenases in chromosome
KR102287114B1 (en) * 2021-01-25 2021-08-06 씨제이제일제당 주식회사 Novel cytosine permease variant and a method for producing L-tryptophan using the same
WO2022241027A1 (en) * 2021-05-13 2022-11-17 Lygos, Inc. Recombinant host cells and methods for producing l-lactic acid
CN113430127B (en) * 2021-07-07 2024-01-12 江南大学 A recombinant bacterium that produces L-lactic acid and its application
CN118256415A (en) * 2021-09-29 2024-06-28 上海肆芃科技有限公司 Genetically engineered strain for producing polylactic acid and method for producing polylactic acid
US12049660B2 (en) 2021-11-03 2024-07-30 Wisconsin Alumni Research Foundation Gene duplications for crabtree-warburg-like aerobic xylose fermentation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002136293A (en) * 2000-08-23 2002-05-14 Toray Ind Inc Microorganism and method for producing D-lactic acid
US6485947B1 (en) * 1999-05-21 2002-11-26 Cargill Dow Polymers, Llc Production of lactate using crabtree negative organisms in varying culture conditions

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384553A (en) * 1965-04-08 1968-05-21 Ceskoslovenska Akademie Ved Method and equipment for aerobic fermentation on liquid culture mediums
IL39710A (en) 1972-06-19 1975-04-25 Imi Inst For Res & Dev Recovery of acids from aqueous solutions by solvent extraction
US4064015A (en) * 1975-05-12 1977-12-20 New Brunswick Scientific Co., Inc. Control of biosynthesis in submerged culture
US4771001A (en) 1986-03-27 1988-09-13 Neurex Corp. Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
US5132456A (en) 1991-05-07 1992-07-21 The Regents Of The University Of California Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine
JP3012377B2 (en) * 1991-10-11 2000-02-21 名糖産業株式会社 Low thermostable protease, its related products and its production method
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5420304A (en) 1992-03-19 1995-05-30 Biopak Technology, Ltd. Method to produce cyclic esters
FR2693463B1 (en) * 1992-07-08 1994-09-02 Rhone Poulenc Rorer Sa Yeast promoter and its use.
US5338822A (en) 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
AT398982B (en) 1993-02-18 1995-02-27 Vogelbusch Gmbh METHOD FOR SEPARATING AND PURIFYING LACTIC ACID
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
IL109003A (en) 1994-03-16 1999-09-22 Yissum Res Dev Co Process and extractant composition for extracting water-soluble carboxylic and mineral acids
JPH08173170A (en) * 1994-05-25 1996-07-09 Kirin Brewery Co Ltd Transformation system of Candida utilis yeast and expression of heterologous gene by it
DK0875579T3 (en) 1997-05-03 2007-10-22 Nestle Sa Preparation of L (+) lactate
IT1294728B1 (en) * 1997-09-12 1999-04-12 Biopolo S C A R L YEAST STRAWS FOR THE REPRODUCTION OF LACTIC ACID
US6229046B1 (en) * 1997-10-14 2001-05-08 Cargill, Incorported Lactic acid processing methods arrangements and products
US6046002A (en) * 1998-01-05 2000-04-04 The Board Of Trustees Of The Leland Stanford Junior University Highly parallel and sensitive method for identifying drugs and drug targets
WO2000029604A1 (en) * 1998-11-18 2000-05-25 The University Of Akron Production of biological materials by simultaneous aerobic and anaerobic respiration
US6268189B1 (en) * 2000-03-24 2001-07-31 The United States Of America As Represented By The Secretary Of Agriculture Fungal lactate dehydrogenase gene and constructs for the expression thereof
DK1332222T3 (en) * 2000-11-03 2009-07-06 Genentech Inc Metabolic changes in fermentations expressing recombinant proteins
CN1955299A (en) 2000-11-22 2007-05-02 内特尔沃克公司 Methods and materials for the synthesis of organic products
US7141410B2 (en) * 2000-11-22 2006-11-28 Natureworks Llc Methods and materials for the production of organic products in cells of Candida species
KR100426990B1 (en) * 2001-06-27 2004-04-13 삼성전자주식회사 Reference voltage generator for generating programmable reference voltage according to external codes
EP1484407B1 (en) * 2002-03-11 2011-10-26 Toyota Jidosha Kabushiki Kaisha Method of controlling ethanol production and mass production of lactic acid and transformant therefor
ATE367436T1 (en) 2002-05-30 2007-08-15 Natureworks Llc METHOD AND MATERIALS FOR PRODUCING D-LACTIC ACID IN YEAST
JP4395132B2 (en) * 2003-05-22 2010-01-06 株式会社豊田中央研究所 DNA encoding a protein having D-lactate dehydrogenase activity and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485947B1 (en) * 1999-05-21 2002-11-26 Cargill Dow Polymers, Llc Production of lactate using crabtree negative organisms in varying culture conditions
JP2002136293A (en) * 2000-08-23 2002-05-14 Toray Ind Inc Microorganism and method for producing D-lactic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534597B2 (en) 2002-05-30 2009-05-19 Cargill, Inc. Methods and materials for the production of L-lactic acid in yeast

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