WO2004007689A3 - Regulatory protein for nox enzymes - Google Patents

Regulatory protein for nox enzymes Download PDF

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Publication number
WO2004007689A3
WO2004007689A3 PCT/US2003/022246 US0322246W WO2004007689A3 WO 2004007689 A3 WO2004007689 A3 WO 2004007689A3 US 0322246 W US0322246 W US 0322246W WO 2004007689 A3 WO2004007689 A3 WO 2004007689A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
present
nucleotides
nox enzymes
regulatory protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/022246
Other languages
French (fr)
Other versions
WO2004007689A2 (en
Inventor
J David Lambeth
Guangjie Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Priority to CA002493061A priority Critical patent/CA2493061A1/en
Priority to AU2003256574A priority patent/AU2003256574A1/en
Priority to EP03764746A priority patent/EP1556079A2/en
Publication of WO2004007689A2 publication Critical patent/WO2004007689A2/en
Anticipated expiration legal-status Critical
Publication of WO2004007689A3 publication Critical patent/WO2004007689A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these nucleotides, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these nucleotides and proteins, and methods to determine the activity of drugs to affect the biological activity of the regulatory proteins of the present invention.
PCT/US2003/022246 2002-07-16 2003-07-16 Regulatory protein for nox enzymes Ceased WO2004007689A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002493061A CA2493061A1 (en) 2002-07-16 2003-07-16 Regulatory protein for nox enzymes
AU2003256574A AU2003256574A1 (en) 2002-07-16 2003-07-16 Regulatory protein for nox enzymes
EP03764746A EP1556079A2 (en) 2002-07-16 2003-07-16 Regulatory protein for nox enzymes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39617002P 2002-07-16 2002-07-16
US60/396,170 2002-07-16
US40564702P 2002-08-23 2002-08-23
US60/405,647 2002-08-23

Publications (2)

Publication Number Publication Date
WO2004007689A2 WO2004007689A2 (en) 2004-01-22
WO2004007689A3 true WO2004007689A3 (en) 2005-06-02

Family

ID=30118570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/022246 Ceased WO2004007689A2 (en) 2002-07-16 2003-07-16 Regulatory protein for nox enzymes

Country Status (5)

Country Link
US (2) US7029673B2 (en)
EP (1) EP1556079A2 (en)
AU (1) AU2003256574A1 (en)
CA (1) CA2493061A1 (en)
WO (1) WO2004007689A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1602926A1 (en) 2004-06-04 2005-12-07 University of Geneva Novel means and methods for the treatment of hearing loss and phantom hearing
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
US20100273854A1 (en) * 2007-06-15 2010-10-28 Hagar Kalinski Compositions and methods for inhibiting nadph oxidase expression
US20110288155A1 (en) 2008-12-18 2011-11-24 Elena Feinstein Sirna compounds and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE351905T1 (en) 1998-11-10 2007-02-15 Univ Emory MITOGENE REGULATORS
EP1285071A2 (en) 2000-05-15 2003-02-26 Emory University Novel dual oxidases as mitogenic and endocrine regulators
CA2429376A1 (en) 2000-11-16 2002-10-17 Emory University Mitogenic oxygenase regulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEISZT ET AL.: "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells", J. BIOL. CHEM., vol. 278, no. 22, May 2003 (2003-05-01), pages 20006 - 20012, XP008053404, DOI: doi:10.1074/jbc.M301289200 *
TAKEYA ET AL.: "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases", J. BIOL. CHEM., vol. 278, no. 27, July 2003 (2003-07-01), pages 25234 - 25246, XP008053403, DOI: doi:10.1074/jbc.M212856200 *

Also Published As

Publication number Publication date
AU2003256574A1 (en) 2004-02-02
EP1556079A2 (en) 2005-07-27
US7029673B2 (en) 2006-04-18
US20060035358A1 (en) 2006-02-16
US20040091466A1 (en) 2004-05-13
US7244590B2 (en) 2007-07-17
CA2493061A1 (en) 2004-01-22
WO2004007689A2 (en) 2004-01-22

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