WO2004011454A3 - Derives de quinolyl propyl piperidine et leur utilisation en tant qu’agents antimicrobiens - Google Patents

Derives de quinolyl propyl piperidine et leur utilisation en tant qu’agents antimicrobiens Download PDF

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Publication number
WO2004011454A3
WO2004011454A3 PCT/FR2003/002306 FR0302306W WO2004011454A3 WO 2004011454 A3 WO2004011454 A3 WO 2004011454A3 FR 0302306 W FR0302306 W FR 0302306W WO 2004011454 A3 WO2004011454 A3 WO 2004011454A3
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WO
WIPO (PCT)
Prior art keywords
alkyl
substituted
alkyloxy
ocf3
alkyloxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2003/002306
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English (en)
Other versions
WO2004011454A2 (fr
Inventor
Eric Bacque
Jean-Luc Malleron
Serge Mignani
Michel Tabart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to AU2003267528A priority Critical patent/AU2003267528A1/en
Publication of WO2004011454A2 publication Critical patent/WO2004011454A2/fr
Publication of WO2004011454A3 publication Critical patent/WO2004011454A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivés de quinolyl propyl pipéridine de formule générale (I) dans laquelle R1est NH2, alcoylamino, dialcoylamino, hydroxyamino, alcoyl alcoyloxy amino ou alcoyloxyamino, R2 est un radical carboxy, carboxyméthyle ou hydroxyméthyle, R3 est alcoyle (1 à 6C) substitué par phénylthio pouvant lui même porter 1 à 3 substituants [choisis parmi halogène, OH, alcoyle, alcoyloxy, CF3, OCF3, COOH,, alcoyloxycarbonyle, CN et NH2], par cycloalcoylthio (3 à 7 chaînons), ou par hétéroarylthio (5 à 6 chaînons) comprenant 1 à 4 hétéroatomes choisis parmi N, S et O et éventuellement lui même substitué [par halogène, OH, alcoyle, alcoyloxy, CF3, OCF3, =0, COOH, alcoyloxycarbonyle, CN ou NH2] ou R3 est propargyle substitué par phényle pouvant lui même porter 1 à 3 substituants [choisis parmi halogène, OH, alcoyle, alcoyloxy, CF3, OCF3, COOH,, alcoyloxycarbonyle, CN et NH2], ou substitué par cycloalcoyle contenant 3 à 7 chaînons ou substitué par hétéroaryle de 5 à 6 chaînons comprenant 1 à 4 hétéroatomes choisis parmi N, O ou S et éventuellement lui-même substitué [par halogène, OH, alcoyle, alcoyloxy, CF3, OCF3, =0, COOH, alcoyloxycarbonyle, CN ou NH2], et R4 est alcoyle (1 à 6C), alcényl-CH2-, alcynyl-CH2- (3 à 7C), cycloalcoyle ou cycloalcoyl alcoyl, sous leurs formes diastéréoisomères ou leurs mélanges, ainsi que leurs sels. Ces nouveaux dérivés sont des agents antimicrobiens particulièrement intéressants.
PCT/FR2003/002306 2002-07-23 2003-07-22 Derives de quinolyl propyl piperidine et leur utilisation en tant qu’agents antimicrobiens Ceased WO2004011454A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003267528A AU2003267528A1 (en) 2002-07-23 2003-07-22 Quinolyl propyl piperidine derivatives, preparation method and intermediates and compositions containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/09334 2002-07-23
FR0209334A FR2842807A1 (fr) 2002-07-23 2002-07-23 Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant

Publications (2)

Publication Number Publication Date
WO2004011454A2 WO2004011454A2 (fr) 2004-02-05
WO2004011454A3 true WO2004011454A3 (fr) 2004-04-08

Family

ID=30011413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002306 Ceased WO2004011454A2 (fr) 2002-07-23 2003-07-22 Derives de quinolyl propyl piperidine et leur utilisation en tant qu’agents antimicrobiens

Country Status (4)

Country Link
US (1) US6806277B2 (fr)
AU (1) AU2003267528A1 (fr)
FR (1) FR2842807A1 (fr)
WO (1) WO2004011454A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
NZ562034A (en) * 2005-03-31 2009-10-30 Janssen Pharmaceutica Nv Bicyclic pyrazole compounds as antibacterial agents
CA2635126A1 (fr) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Antibiotiques de type tetrahydropyranne
MX2009012117A (es) * 2007-05-09 2009-11-23 Pfizer Composiciones y derivados heterociclicos sustituidos y su uso farmaceutico como antibacterianos.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037635A1 (fr) * 1998-01-26 1999-07-29 Smithkline Beecham Plc Derives de quinoline utilises comme antibacteriens
WO2001025227A2 (fr) * 1999-09-17 2001-04-12 Aventis Pharma S.A. Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens
WO2002040474A2 (fr) * 2000-11-15 2002-05-23 Aventis Pharma S.A. Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens
WO2002072572A1 (fr) * 2001-03-13 2002-09-19 Aventis Pharma S.A. Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2354771A1 (fr) 1976-06-18 1978-01-13 Mar Pha Etu Expl Marques ((quinolyl-4)-3 propyl-1) -4 piperidines, leur preparation et leur utilisation comme medicaments
NL7908031A (nl) 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
FR2560877B1 (fr) * 1984-03-09 1986-09-05 Rhone Poulenc Sante Derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanamine et de (quinolyl-4)-1 (piperidyl-4)-3 propanamine, procedes pour leur preparation et medicaments les contenant
EP1144404A1 (fr) 1999-01-20 2001-10-17 Smithkline Beecham Plc Piperidinylquinolines utilisees comme inhibiteurs de la proteine tyrosine kinase
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
US6602884B2 (en) * 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037635A1 (fr) * 1998-01-26 1999-07-29 Smithkline Beecham Plc Derives de quinoline utilises comme antibacteriens
WO2001025227A2 (fr) * 1999-09-17 2001-04-12 Aventis Pharma S.A. Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens
WO2002040474A2 (fr) * 2000-11-15 2002-05-23 Aventis Pharma S.A. Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens
WO2002072572A1 (fr) * 2001-03-13 2002-09-19 Aventis Pharma S.A. Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
AU2003267528A1 (en) 2004-02-16
FR2842807A1 (fr) 2004-01-30
WO2004011454A2 (fr) 2004-02-05
US20040058919A1 (en) 2004-03-25
US6806277B2 (en) 2004-10-19
AU2003267528A8 (en) 2004-02-16

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