WO2004014913A3 - Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors - Google Patents

Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors Download PDF

Info

Publication number
WO2004014913A3
WO2004014913A3 PCT/US2003/024914 US0324914W WO2004014913A3 WO 2004014913 A3 WO2004014913 A3 WO 2004014913A3 US 0324914 W US0324914 W US 0324914W WO 2004014913 A3 WO2004014913 A3 WO 2004014913A3
Authority
WO
WIPO (PCT)
Prior art keywords
trifluormethyl
aminopurine
phosphodiesterase
inhibitors
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/024914
Other languages
French (fr)
Other versions
WO2004014913A2 (en
Inventor
Ruiping Liu
Allen T Hopper
Ashok Tehim
Hans-Jurgen E Hess
Yajing Rong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memory Pharmaceuticals Corp
Original Assignee
Memory Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharmaceuticals Corp filed Critical Memory Pharmaceuticals Corp
Priority to EP03785075A priority Critical patent/EP1529049B1/en
Priority to CA002494028A priority patent/CA2494028A1/en
Priority to AU2003264017A priority patent/AU2003264017B2/en
Priority to JP2004527913A priority patent/JP2005538134A/en
Priority to DE60330150T priority patent/DE60330150D1/en
Priority to AT03785075T priority patent/ATE449099T1/en
Publication of WO2004014913A2 publication Critical patent/WO2004014913A2/en
Publication of WO2004014913A3 publication Critical patent/WO2004014913A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PDE4 inhibition is achieved by novel compounds of the Formula (I) wherein R1 and R2 are as defined herein.
PCT/US2003/024914 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors Ceased WO2004014913A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP03785075A EP1529049B1 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
CA002494028A CA2494028A1 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
AU2003264017A AU2003264017B2 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
JP2004527913A JP2005538134A (en) 2002-08-08 2003-08-08 Phosphodiesterase 4 inhibitor
DE60330150T DE60330150D1 (en) 2002-08-08 2003-08-08 Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
AT03785075T ATE449099T1 (en) 2002-08-08 2003-08-08 DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40176502P 2002-08-08 2002-08-08
US60/401,765 2002-08-08

Publications (2)

Publication Number Publication Date
WO2004014913A2 WO2004014913A2 (en) 2004-02-19
WO2004014913A3 true WO2004014913A3 (en) 2004-07-29

Family

ID=31715731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/024914 Ceased WO2004014913A2 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors

Country Status (9)

Country Link
US (3) US7332486B2 (en)
EP (1) EP1529049B1 (en)
JP (1) JP2005538134A (en)
CN (1) CN1688580A (en)
AT (1) ATE449099T1 (en)
AU (1) AU2003264017B2 (en)
CA (1) CA2494028A1 (en)
DE (1) DE60330150D1 (en)
WO (1) WO2004014913A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100439370C (en) * 2001-02-08 2008-12-03 记忆药物公司 Trifluoromethylpurines as phosphodiesterase 4 inhibitors
US7332486B2 (en) * 2002-08-08 2008-02-19 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
AU2003261418B2 (en) * 2002-08-08 2010-05-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
MXPA06002997A (en) 2003-09-18 2007-02-08 Conforma Therapeutics Corp Novel heterocyclic compounds as hsp90-inhibitors.
AU2006230447A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
WO2006123639A1 (en) * 2005-05-18 2006-11-23 Asahi Kasei Pharma Corporation Pyrimidine derivative
BRPI0708337A2 (en) 2006-02-28 2011-05-24 Helicon Therapeutics Inc therapeutic pipirazines as pde4 inhibitors
FR2898057B1 (en) * 2006-03-06 2008-07-04 Centre Nat Rech Scient USE OF ADENINE-DERIVED COMPOUNDS FOR THE TREATMENT OF LUPUS
CL2007002994A1 (en) * 2006-10-19 2008-02-08 Wyeth Corp HETEROCICLIC DERIVATIVE COMPOUNDS CONTAINING SULFAMOIL, INHIBITORS OF HSP90; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT OF CANCER, SUCH AS CANCER OF BREAST, COLON AND PROSTATE, BETWEEN OTHERS.
WO2010083442A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2747835A1 (en) 2009-01-19 2010-07-22 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2308866A1 (en) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazoles and their use as fungicides
CN102762551A (en) 2009-12-21 2012-10-31 拜尔农作物科学股份公司 Thienylpyrimidinylpyrazoles and their use for controlling plant pathogens
US9630929B2 (en) 2011-10-31 2017-04-25 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
JP6014155B2 (en) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． Biaryl ether sulfonamides and their use as therapeutic agents
US9493464B2 (en) 2012-02-29 2016-11-15 The Scripps Research Institute Wee1 degradation inhibitors
SG11201408284VA (en) * 2012-05-22 2015-02-27 Xenon Pharmaceuticals Inc N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en) 2012-07-06 2018-09-11 Genentech, Inc. N-substituted benzamides and methods of use thereof
US9550775B2 (en) 2013-03-14 2017-01-24 Genentech, Inc. Substituted triazolopyridines and methods of use thereof
MX2015010775A (en) 2013-03-15 2016-04-25 Genentech Inc Substituted benzoxazoles and methods of use thereof.
CR20160296A (en) 2013-11-27 2016-09-20 Genentech Inc BENZAMIDS REPLACED AND METHODS TO USE THEM
CN106715418A (en) 2014-07-07 2017-05-24 基因泰克公司 Therapeutic compounds and methods of use thereof
KR102412146B1 (en) * 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 Sodium channel blockers
JP2018520107A (en) 2015-05-22 2018-07-26 ジェネンテック， インコーポレイテッド Substituted benzamide and method of use
EP3341353A1 (en) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutic compounds and methods of use thereof
CN108290881B (en) 2015-09-28 2021-12-07 健泰科生物技术公司 Therapeutic compounds and methods of use thereof
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3413788B1 (en) 2016-02-09 2025-08-06 Establishment Labs S.A. Transponders and sensors for implantable medical devices
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2018005533A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
AU2017347549A1 (en) 2016-10-17 2019-05-02 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP2020511511A (en) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド 4-Piperidin-N- (pyrimidin-4-yl) chroman-7-sulfonamide derivatives as sodium channel inhibitors
CN108395432A (en) * 2018-01-15 2018-08-14 吴江信凯医药科技有限公司 A kind of preparation method of 2- trifluoromethyls-adenine
AR114263A1 (en) 2018-02-26 2020-08-12 Genentech Inc THERAPEUTIC COMPOUNDS AND METHODS TO USE THEM
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (en) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 Therapeutic compounds and methods of use thereof
WO2021026803A1 (en) * 2019-08-14 2021-02-18 Novartis Ag Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098878A1 (en) * 2001-02-08 2002-12-12 Memory Pharmaceuticals Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919192A (en) 1972-05-22 1975-11-11 Icn Pharmaceuticals 5-Amino-4-substituted imidazole nucleotides
US3917583A (en) 1972-08-04 1975-11-04 Icn Pharmaceuticals 2-Substituted cyclic AMP derivatives
AR205247A1 (en) 1973-02-07 1976-04-21 Icn Pharmaceuticals PROCEDURE FOR PREPARING 2-SUBSTITUTED AMP DERIVATIVES
GB8817651D0 (en) 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
US5013829A (en) 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
US5935978A (en) 1991-01-28 1999-08-10 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
ES2102036T3 (en) 1992-06-15 1997-07-16 Celltech Therapeutics Ltd DERIVATIVES WITH GROUP PHENYL TRISUSTITUTED USED AS SELECTIVE INHIBITORS OF PHOSPHODIESTERASE IV.
DE4230755A1 (en) 1992-09-14 1994-03-17 Schering Ag Phosphodiesterase IV inhibitors for kidney and ureter disease treatment - with eg (4-(3-(cyclopentyl oxy) 4-methoxyphenyl-2-pyrrolidinone) being specific for kidney and ureter tissue relaxation
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
TW263495B (en) 1992-12-23 1995-11-21 Celltech Ltd
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
DE19702785A1 (en) 1997-01-27 1998-07-30 Bayer Ag New cyclic urea derivatives
CA2295106C (en) 1997-06-24 2007-03-13 Nikken Chemicals Co., Ltd. 3-anilino-2-cycloalkenone derivatives
CN1130363C (en) 1997-11-12 2003-12-10 三菱化学株式会社 Purine derivatives and medicaments containing them as active ingredients
CN1294590A (en) 1997-12-12 2001-05-09 欧罗赛铁克股份有限公司 Method for preparing 3-substituted adenine by 2-thioxanthine
JP3542482B2 (en) 1997-12-25 2004-07-14 日研化学株式会社 3-anilino-2-cycloalkenone derivatives
US6319928B1 (en) 1998-11-30 2001-11-20 Euro-Celtique, S.A. Purine derivatives having phosphodiesterase IV inhibition activity
DE19935209A1 (en) 1999-07-27 2001-02-08 Truss Michael C Treatment of urinary incontinence and related disorders, by increasing intracellular cyclic adenosine monophosphate concentration, e.g. using adenyl cyclase stimulant such as forskolin
GB0011802D0 (en) 2000-05-16 2000-07-05 Smithkline Beecham Method for enhancing cognitive function
US7332486B2 (en) * 2002-08-08 2008-02-19 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
AU2003261418B2 (en) 2002-08-08 2010-05-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098878A1 (en) * 2001-02-08 2002-12-12 Memory Pharmaceuticals Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOICHOT E ET AL: "ANTI-INFLAMMATORY ACTIVITIES OF A NEW SERIES OF SELECTIVE PHOSPHODIESTERASE 4 INHIBITORS DERIVED FROM 9-BENZYLADENINE", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 292, no. 2, 2000, pages 647 - 653, XP001106309, ISSN: 0022-3565 *
BOURGUIGNON J-J ET AL: "9-Benzyladenines: Potent and Selective cAMP Phosphodiesterase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 12, 1997, pages 1768 - 1770, XP002214955, ISSN: 0022-2623 *
MARTIN T J: "PDE4 INHIBITORS - A REVIEW OF THE RECENT PATENT LITERATURE", IDRUGS, CURRENT DRUGS LTD, GB, vol. 4, no. 3, 2001, pages 312 - 338, XP008006266, ISSN: 1369-7056 *

Also Published As

Publication number Publication date
AU2003264017A1 (en) 2004-02-25
US7332486B2 (en) 2008-02-19
US20100004236A1 (en) 2010-01-07
AU2003264017B2 (en) 2010-05-27
ATE449099T1 (en) 2009-12-15
DE60330150D1 (en) 2009-12-31
US20070093510A1 (en) 2007-04-26
JP2005538134A (en) 2005-12-15
EP1529049A2 (en) 2005-05-11
CA2494028A1 (en) 2004-02-19
EP1529049B1 (en) 2009-11-18
WO2004014913A2 (en) 2004-02-19
CN1688580A (en) 2005-10-26
US20080139583A1 (en) 2008-06-12

Similar Documents

Publication Publication Date Title
WO2004014913A3 (en) Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
WO2005061458A3 (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
WO2002074726A3 (en) Aniline derivatives useful as phosphodiesterase 4 inhibitors
HK1053831A1 (en) Kinase inhibitors as therapeutic agents
WO2004018465A3 (en) Benzonaphthyridines with pde 3/4 inhibiting activity
WO2004018451A8 (en) Pyridazinone-derivatives as pde4 inhibitors
SG168409A1 (en) Pyrazole derivatives as phosphodiesterase 4 inhibitors
WO2002020489A3 (en) QUINOLINE INHIBITORS OF cGMP PHOSPHODIESTERASE
WO2004018449A8 (en) Piperidine-derivatives as pde4 inhibitors
WO2003072553A8 (en) N-aryl-2-oxazolidinone-5-carboxamides and their derivates and their use as antibacterials
WO2003006425A3 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
WO2004018457A8 (en) Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors
WO2007056159A3 (en) Hydrazone derivatives and uses thereof
AU2002357773A1 (en) 1,6 naphthyridines useful as inhibitors of syk kinase
HK1046687A1 (en) Quinazoline derivatives
WO2004094375A3 (en) 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
EP1019389A4 (en) Epothilone derivatives
WO2002085906A3 (en) Phthalazinones derivatives useful as pde4/7 inhibitors
MXPA04003516A (en) 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes.
EP1477490A4 (en) Pyrrolopyrimidine derivative
WO2005028474A3 (en) Pyrazoloquinoline derivatives as chk-1 inhibitors
HK1047276A1 (en) Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors
WO2004030664A3 (en) New compounds for the inhibition of undesired cell proliferation and use thereof
WO2003002580A8 (en) 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
WO2006110173A3 (en) Novel compounds

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2494028

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003264017

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003785075

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2004527913

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 20038239779

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2003785075

Country of ref document: EP