WO2004014913A3 - Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors - Google Patents

Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors Download PDF

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Publication number
WO2004014913A3
WO2004014913A3 PCT/US2003/024914 US0324914W WO2004014913A3 WO 2004014913 A3 WO2004014913 A3 WO 2004014913A3 US 0324914 W US0324914 W US 0324914W WO 2004014913 A3 WO2004014913 A3 WO 2004014913A3
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WO
WIPO (PCT)
Prior art keywords
trifluormethyl
aminopurine
phosphodiesterase
inhibitors
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/024914
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French (fr)
Other versions
WO2004014913A2 (en
Inventor
Ruiping Liu
Allen T Hopper
Ashok Tehim
Hans-Jurgen E Hess
Yajing Rong
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Memory Pharmaceuticals Corp
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Memory Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Memory Pharmaceuticals Corp filed Critical Memory Pharmaceuticals Corp
Priority to CA002494028A priority Critical patent/CA2494028A1/en
Priority to EP03785075A priority patent/EP1529049B1/en
Priority to JP2004527913A priority patent/JP2005538134A/en
Priority to AU2003264017A priority patent/AU2003264017B2/en
Priority to DE60330150T priority patent/DE60330150D1/en
Priority to AT03785075T priority patent/ATE449099T1/en
Publication of WO2004014913A2 publication Critical patent/WO2004014913A2/en
Publication of WO2004014913A3 publication Critical patent/WO2004014913A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PDE4 inhibition is achieved by novel compounds of the Formula (I) wherein R1 and R2 are as defined herein.
PCT/US2003/024914 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors Ceased WO2004014913A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002494028A CA2494028A1 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
EP03785075A EP1529049B1 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
JP2004527913A JP2005538134A (en) 2002-08-08 2003-08-08 Phosphodiesterase 4 inhibitor
AU2003264017A AU2003264017B2 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
DE60330150T DE60330150D1 (en) 2002-08-08 2003-08-08 Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
AT03785075T ATE449099T1 (en) 2002-08-08 2003-08-08 DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40176502P 2002-08-08 2002-08-08
US60/401,765 2002-08-08

Publications (2)

Publication Number Publication Date
WO2004014913A2 WO2004014913A2 (en) 2004-02-19
WO2004014913A3 true WO2004014913A3 (en) 2004-07-29

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PCT/US2003/024914 Ceased WO2004014913A2 (en) 2002-08-08 2003-08-08 Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors

Country Status (9)

Country Link
US (3) US7332486B2 (en)
EP (1) EP1529049B1 (en)
JP (1) JP2005538134A (en)
CN (1) CN1688580A (en)
AT (1) ATE449099T1 (en)
AU (1) AU2003264017B2 (en)
CA (1) CA2494028A1 (en)
DE (1) DE60330150D1 (en)
WO (1) WO2004014913A2 (en)

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EP1383767A1 (en) * 2001-02-08 2004-01-28 Memory Pharmaceutical Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors
US7332486B2 (en) * 2002-08-08 2008-02-19 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
JP2005538133A (en) * 2002-08-08 2005-12-15 メモリー・ファーマシューティカルズ・コーポレイション Phosphodiesterase 4 inhibitor
NZ546611A (en) 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
BRPI0609509A2 (en) 2005-03-30 2010-04-13 Conforma Therapeutics Corp pharmaceutically acceptable compound or a polymorph, solvate, tautomer, enantiomer, prodrug or salt thereof, pharmaceutical composition, and, use of the pharmaceutically acceptable compound, polymorph, solvate, tautomer, enantiomer, prodrug or salt
WO2006123639A1 (en) * 2005-05-18 2006-11-23 Asahi Kasei Pharma Corporation Pyrimidine derivative
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US20070093510A1 (en) 2007-04-26
CA2494028A1 (en) 2004-02-19
DE60330150D1 (en) 2009-12-31
US7332486B2 (en) 2008-02-19
CN1688580A (en) 2005-10-26
WO2004014913A2 (en) 2004-02-19
AU2003264017B2 (en) 2010-05-27
AU2003264017A1 (en) 2004-02-25
US20080139583A1 (en) 2008-06-12
JP2005538134A (en) 2005-12-15
EP1529049B1 (en) 2009-11-18
EP1529049A2 (en) 2005-05-11
ATE449099T1 (en) 2009-12-15
US20100004236A1 (en) 2010-01-07

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