WO2004016786A3 - Dna-expressionskonstrukt zur multiplen genexpression - Google Patents

Dna-expressionskonstrukt zur multiplen genexpression Download PDF

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Publication number
WO2004016786A3
WO2004016786A3 PCT/DE2003/002478 DE0302478W WO2004016786A3 WO 2004016786 A3 WO2004016786 A3 WO 2004016786A3 DE 0302478 W DE0302478 W DE 0302478W WO 2004016786 A3 WO2004016786 A3 WO 2004016786A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiple gene
gene expression
dna
expression
construct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2003/002478
Other languages
English (en)
French (fr)
Other versions
WO2004016786A2 (de
Inventor
Colin Smith
Antje Schildhauer
Burghardt Wittig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mologen AG
Original Assignee
Mologen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mologen AG filed Critical Mologen AG
Priority to DE50306394T priority Critical patent/DE50306394D1/de
Priority to EP03787725A priority patent/EP1530641B1/de
Priority to AU2003260243A priority patent/AU2003260243A1/en
Priority to DE10393455T priority patent/DE10393455D2/de
Publication of WO2004016786A2 publication Critical patent/WO2004016786A2/de
Publication of WO2004016786A3 publication Critical patent/WO2004016786A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft ein DNA-Expressionskonstrukt zur multiplen Genexpression, ferner ein Verfahren zu seiner Herstellung und ein Verbindungsmolekül (Linker) zur Verknüpfung von DNA-Expressionskassetten zur Herstellung eines DNA-Expressionskonstruktes zur multiplen Genexpression, sowie letztlich Verwendungsmöglichkeiten in der genetischen Vakzinierung.
PCT/DE2003/002478 2002-07-19 2003-07-19 Dna-expressionskonstrukt zur multiplen genexpression Ceased WO2004016786A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE50306394T DE50306394D1 (de) 2002-07-19 2003-07-19 Dna-expressionskonstrukt zur multiplen genexpression
EP03787725A EP1530641B1 (de) 2002-07-19 2003-07-19 Dna-expressionskonstrukt zur multiplen genexpression
AU2003260243A AU2003260243A1 (en) 2002-07-19 2003-07-19 Dna expression construct for multiple gene expression
DE10393455T DE10393455D2 (de) 2002-07-19 2003-07-19 DNA-Expressionskonstrukt zur multiplen Genexpression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233812 2002-07-19
DE10233812.4 2002-07-19

Publications (2)

Publication Number Publication Date
WO2004016786A2 WO2004016786A2 (de) 2004-02-26
WO2004016786A3 true WO2004016786A3 (de) 2004-06-03

Family

ID=31724046

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/002478 Ceased WO2004016786A2 (de) 2002-07-19 2003-07-19 Dna-expressionskonstrukt zur multiplen genexpression

Country Status (6)

Country Link
EP (1) EP1530641B1 (de)
AT (1) ATE352632T1 (de)
AU (1) AU2003260243A1 (de)
DE (2) DE50306394D1 (de)
ES (1) ES2280829T3 (de)
WO (1) WO2004016786A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1699480T3 (pl) 2003-12-30 2011-11-30 Mologen Ag Allogeniczny przeciwnowotworowy czynnik terapeutyczny
RU2410431C2 (ru) * 2005-11-25 2011-01-27 Мологен Аг Днк-конструкции для специфического ингибирования экспрессии генов посредством рнк-интерференции
GB201021873D0 (en) * 2010-12-23 2011-02-02 Mologen Ag DNA expression construct

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021322A1 (de) * 1996-11-13 1998-05-22 Soft Gene Gmbh Design-prinzip für die konstruktion von expressionskonstrukten für die gentherapie
US20020019049A1 (en) * 2000-04-26 2002-02-14 Si Lok Methods for enhancing the expression of a protein of interest by recombinant host cells
DE10048417A1 (de) * 2000-09-29 2002-04-11 Roche Diagnostics Gmbh Verbindungen mit verzweigtem Linker

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021322A1 (de) * 1996-11-13 1998-05-22 Soft Gene Gmbh Design-prinzip für die konstruktion von expressionskonstrukten für die gentherapie
US20020019049A1 (en) * 2000-04-26 2002-02-14 Si Lok Methods for enhancing the expression of a protein of interest by recombinant host cells
DE10048417A1 (de) * 2000-09-29 2002-04-11 Roche Diagnostics Gmbh Verbindungen mit verzweigtem Linker

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEEMAN NADRIAN C: "DNA nanotechnology: Novel DNA constructions", ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1998, Annual Reviews Inc. {a}, P.O. Box 10139, 4139 El Camino Way, Palo Alto, California 94306, USA Series: Annual Review of Biophysics and Biomolecular Structure (ISSN 1056-8700), pages 225 - 248, XP009022846, ISBN: 0-8243-1827-7 *

Also Published As

Publication number Publication date
ATE352632T1 (de) 2007-02-15
AU2003260243A1 (en) 2004-03-03
DE50306394D1 (de) 2007-03-15
EP1530641A2 (de) 2005-05-18
DE10393455D2 (de) 2005-06-16
ES2280829T3 (es) 2007-09-16
EP1530641B1 (de) 2007-01-24
WO2004016786A2 (de) 2004-02-26
AU2003260243A8 (en) 2004-03-03

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