WO2004019052A3 - Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten - Google Patents

Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten Download PDF

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Publication number
WO2004019052A3
WO2004019052A3 PCT/DE2003/002767 DE0302767W WO2004019052A3 WO 2004019052 A3 WO2004019052 A3 WO 2004019052A3 DE 0302767 W DE0302767 W DE 0302767W WO 2004019052 A3 WO2004019052 A3 WO 2004019052A3
Authority
WO
WIPO (PCT)
Prior art keywords
nuclear spin
mixture
producing liquids
liquid
high nuclear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2003/002767
Other languages
English (en)
French (fr)
Other versions
WO2004019052A2 (de
Inventor
Heinz Julius Jaensch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transmit Gesellschaft fuer Technologietransfer mbH
Philipps University of Marburg
Original Assignee
Transmit Gesellschaft fuer Technologietransfer mbH
Philipps University of Marburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transmit Gesellschaft fuer Technologietransfer mbH, Philipps University of Marburg filed Critical Transmit Gesellschaft fuer Technologietransfer mbH
Priority to DE50306322T priority Critical patent/DE50306322D1/de
Priority to EP03750276A priority patent/EP1530728B1/de
Priority to AU2003269676A priority patent/AU2003269676A1/en
Publication of WO2004019052A2 publication Critical patent/WO2004019052A2/de
Publication of WO2004019052A3 publication Critical patent/WO2004019052A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

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  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Vorgeschlagen wird ein Verfahren und eine Vorrichtung zur Herstellung hochkernspinpolarisierter Flüssigkeiten als Kontrastmittel für die NMR und MRI. Das Verfahren umfasst eine Mischung einer Flüssigkeit mit hoher T1-Zeit mit einer Flüssigkeit mit geringem Dampfdruck, sodass der Dampfdruck der Mischung 10^-2 mbar bei einer Temperatur von 20°C des Gemisches nicht übersteigt, und eine darauffolgende Bestrahlung der Flüssigkeitmischung mit einem kernspinpolarisierten Partikelstrahl.
PCT/DE2003/002767 2002-08-19 2003-08-18 Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten Ceased WO2004019052A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE50306322T DE50306322D1 (de) 2002-08-19 2003-08-18 Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten
EP03750276A EP1530728B1 (de) 2002-08-19 2003-08-18 Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten
AU2003269676A AU2003269676A1 (en) 2002-08-19 2003-08-18 Device and method for producing liquids with a high nuclear spin polarisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10238637A DE10238637A1 (de) 2002-08-19 2002-08-19 Verfahren und Vorrichtung zur Herstellung hoch kernspinpolarisierter Flüssigkeiten
DE10238637.4 2002-08-19

Publications (2)

Publication Number Publication Date
WO2004019052A2 WO2004019052A2 (de) 2004-03-04
WO2004019052A3 true WO2004019052A3 (de) 2004-05-06

Family

ID=31501871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/002767 Ceased WO2004019052A2 (de) 2002-08-19 2003-08-18 Vorrichtung und verfahren zur herstellung von hoch kernspinpolarisierten flüssigkeiten

Country Status (5)

Country Link
EP (1) EP1530728B1 (de)
AT (1) ATE352044T1 (de)
AU (1) AU2003269676A1 (de)
DE (2) DE10238637A1 (de)
WO (1) WO2004019052A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005017927A1 (de) * 2005-04-18 2006-10-26 Forschungszentrum Jülich GmbH Hyperpolarisation von Li und weiteren Kernen
EP1973118B1 (de) * 2005-12-28 2014-07-02 Takashi Suzuki Spin-isolationseinrichtung,
DE102008032825B3 (de) * 2008-07-11 2010-01-14 Siemens Aktiengesellschaft Strahlpumpe sowie Verfahren zu deren Betrieb

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051208A (en) * 1998-04-13 2000-04-18 Duke University In vivo magnetic resonance vascular imaging using laser-polarized gas microbubbles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424843C1 (de) * 1994-07-14 1996-02-01 Spectrospin Ag Mischvorrichtung und Verfahren zum Durchmischen von Fluiden in einer Hochdruck-NMR-Meßeinrichtung
DE19548977C1 (de) * 1995-12-28 1997-02-27 Bruker Analytische Messtechnik NMR-Meßzelle und Verfahren zur schnellen Mischung mindestens zweier Reaktionsfluide in der NMR-Meßzelle
DE19962330B4 (de) * 1999-12-23 2004-02-19 Ernst-Wilhelm Prof. Dr. Otten Verfahren und Vorrichtung zur Bestimmung der Magnetisierung elektronen- oder kernspinpolarisierter Medien
US6380737B1 (en) * 2001-07-10 2002-04-30 Varian, Inc. Apparatus and method utilizing sample transfer to and from NMR flow probes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051208A (en) * 1998-04-13 2000-04-18 Duke University In vivo magnetic resonance vascular imaging using laser-polarized gas microbubbles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EARLE M.J., SEDDON K.R.: "Ionic liquids. Green solvents for the future", PURE AND APPLIED CHEMISTRY, vol. 72, no. 7, 2000, pages 1391 - 1398, XP002266043 *
JÄNSCH H J ET AL: "A UHV compatible source for a highly polarized thermal atomic beam of radioactive /sup 8/Li", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION B (BEAM INTERACTIONS WITH MATERIALS AND ATOMS), DEC. 2000, ELSEVIER, NETHERLANDS, vol. 171, no. 4, pages 537 - 550, XP004221512, ISSN: 0168-583X *

Also Published As

Publication number Publication date
EP1530728A2 (de) 2005-05-18
DE50306322D1 (de) 2007-03-08
DE10238637A1 (de) 2004-03-11
EP1530728B1 (de) 2007-01-17
WO2004019052A2 (de) 2004-03-04
AU2003269676A1 (en) 2004-03-11
AU2003269676A8 (en) 2004-03-11
ATE352044T1 (de) 2007-02-15

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