WO2004020645A3 - Chromosomal loci for the stringent control of gene activities via transcription activation systems - Google Patents

Chromosomal loci for the stringent control of gene activities via transcription activation systems Download PDF

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Publication number
WO2004020645A3
WO2004020645A3 PCT/EP2003/008713 EP0308713W WO2004020645A3 WO 2004020645 A3 WO2004020645 A3 WO 2004020645A3 EP 0308713 W EP0308713 W EP 0308713W WO 2004020645 A3 WO2004020645 A3 WO 2004020645A3
Authority
WO
WIPO (PCT)
Prior art keywords
transcription activation
chromosomal loci
stringent control
activation systems
activities via
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/008713
Other languages
French (fr)
Other versions
WO2004020645A2 (en
Inventor
Hermann Bujard
Kai Schoenig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Heidelberg
Original Assignee
Universitaet Heidelberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Heidelberg filed Critical Universitaet Heidelberg
Priority to DK03790868T priority Critical patent/DK1532260T3/en
Priority to CA002497263A priority patent/CA2497263A1/en
Priority to EP03790868A priority patent/EP1532260B1/en
Priority to DE60325222T priority patent/DE60325222D1/en
Priority to US10/525,785 priority patent/US7666668B2/en
Priority to AU2003263199A priority patent/AU2003263199B2/en
Publication of WO2004020645A2 publication Critical patent/WO2004020645A2/en
Publication of WO2004020645A3 publication Critical patent/WO2004020645A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Abstract

The invention relates to a method for obtaining a chromosomal locus for transgenesis of a multicellular eukaryotic organism, 'MEO', to a vector for transgenesis by homologous recombination of a MEO and to the use of such an vector for transgenesis by homologous recombination of a MEO and to the transgenic MEO thus obtainable.
PCT/EP2003/008713 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems Ceased WO2004020645A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DK03790868T DK1532260T3 (en) 2002-08-28 2003-08-06 Chromosomal lots allow for strict regulation of gene activities via transcriptional activation systems
CA002497263A CA2497263A1 (en) 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems
EP03790868A EP1532260B1 (en) 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems
DE60325222T DE60325222D1 (en) 2002-08-28 2003-08-06 CHROMOSOMETERS FOR STRINGENTLY CONTROLLING GENACTIVITY THROUGH TRANSCRIPTION CONTROL SYSTEMS
US10/525,785 US7666668B2 (en) 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems
AU2003263199A AU2003263199B2 (en) 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40634402P 2002-08-28 2002-08-28
US60/406,344 2002-08-28

Publications (2)

Publication Number Publication Date
WO2004020645A2 WO2004020645A2 (en) 2004-03-11
WO2004020645A3 true WO2004020645A3 (en) 2004-04-22

Family

ID=31978290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/008713 Ceased WO2004020645A2 (en) 2002-08-28 2003-08-06 Chromosomal loci for the stringent control of gene activities via transcription activation systems

Country Status (9)

Country Link
US (1) US7666668B2 (en)
EP (1) EP1532260B1 (en)
AT (1) ATE417116T1 (en)
AU (1) AU2003263199B2 (en)
CA (1) CA2497263A1 (en)
DE (1) DE60325222D1 (en)
DK (1) DK1532260T3 (en)
ES (1) ES2320442T3 (en)
WO (1) WO2004020645A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
WO2005056752A2 (en) 2003-10-24 2005-06-23 Gencia Corporation Methods and compositions for delivering polynucleotides
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
CA2652347A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
EP2364322A1 (en) 2008-10-28 2011-09-14 Pioneer Hi-Bred International Inc. Sulfonylurea-responsive repressor proteins
US9217289B2 (en) 2012-09-24 2015-12-22 Schlumberger Technology Corporation Casing drilling bottom hole assembly having wireless power and data connection
US9206644B2 (en) 2012-09-24 2015-12-08 Schlumberger Technology Corporation Positive displacement motor (PDM) rotary steerable system (RSS) and apparatus
US9217323B2 (en) 2012-09-24 2015-12-22 Schlumberger Technology Corporation Mechanical caliper system for a logging while drilling (LWD) borehole caliper
US9217299B2 (en) 2012-09-24 2015-12-22 Schlumberger Technology Corporation Drilling bottom hole assembly having wireless power and data connection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1092771A2 (en) * 1994-07-01 2001-04-18 Basf Aktiengesellschaft Tetracycline-regulated transcriptional modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912411A (en) * 1993-06-14 1999-06-15 University Of Heidelberg Mice transgenic for a tetracycline-inducible transcriptional activator

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1092771A2 (en) * 1994-07-01 2001-04-18 Basf Aktiengesellschaft Tetracycline-regulated transcriptional modulators

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARON U ET AL: "CO-REGULATION OF TWO GENE ACTIVITIES BY TETRACYCLINE VIA A BIDIRECTIONAL PROMOTER", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 17, 11 September 1995 (1995-09-11), pages 3605 - 3606, XP000775822, ISSN: 0305-1048 *
DATABASE EBI DNA SEQUENCES [online] 2 June 2002 (2002-06-02), "Mus musculus BAC clone RP23-111G16 from chromosome 6", XP002270147, retrieved from EBI Database accession no. AC122874 *
ST-ONGE L. ET AL.: "Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter", NUCL. ACIDS RES., vol. 24, no. 19, 1996, pages 3875 - 3877, XP002270146 *

Also Published As

Publication number Publication date
CA2497263A1 (en) 2004-03-11
US7666668B2 (en) 2010-02-23
WO2004020645A2 (en) 2004-03-11
ES2320442T3 (en) 2009-05-22
US20080141386A1 (en) 2008-06-12
EP1532260A2 (en) 2005-05-25
AU2003263199A1 (en) 2004-03-19
DE60325222D1 (en) 2009-01-22
DK1532260T3 (en) 2009-03-09
AU2003263199B2 (en) 2008-05-01
EP1532260B1 (en) 2008-12-10
ATE417116T1 (en) 2008-12-15

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