WO2004028475A3 - Glycosylceramide analogues - Google Patents

Glycosylceramide analogues Download PDF

Info

Publication number
WO2004028475A3
WO2004028475A3 PCT/US2003/030611 US0330611W WO2004028475A3 WO 2004028475 A3 WO2004028475 A3 WO 2004028475A3 US 0330611 W US0330611 W US 0330611W WO 2004028475 A3 WO2004028475 A3 WO 2004028475A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
glycosylceramide
glycosylceramide analogues
moiety
immunomodulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/030611
Other languages
French (fr)
Other versions
WO2004028475A2 (en
Inventor
Zi-Hua Jiang
Sham Gandhi
Rao R Koganty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncothyreon Canada Inc
Original Assignee
Biomira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomira Inc filed Critical Biomira Inc
Priority to EP03798776A priority Critical patent/EP1572114A2/en
Priority to AU2003277021A priority patent/AU2003277021A1/en
Priority to US10/529,393 priority patent/US20060116331A1/en
Priority to CA002500478A priority patent/CA2500478A1/en
Publication of WO2004028475A2 publication Critical patent/WO2004028475A2/en
Anticipated expiration legal-status Critical
Publication of WO2004028475A3 publication Critical patent/WO2004028475A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Glycosylceramide analogues are disclosed in which the ceramide moiety and optionally the carbohydrate moiety are modified or replaced. These analogues are useful as immunomodulators, antitumor agents, and as other pharmaceutical agents.
PCT/US2003/030611 2002-09-27 2003-09-29 Glycosylceramide analogues Ceased WO2004028475A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03798776A EP1572114A2 (en) 2002-09-27 2003-09-29 Glycosylceramide analogues
AU2003277021A AU2003277021A1 (en) 2002-09-27 2003-09-29 Glycosylceramide analogues
US10/529,393 US20060116331A1 (en) 2002-09-27 2003-09-29 Glycosylceramide analogues
CA002500478A CA2500478A1 (en) 2002-09-27 2003-09-29 Glycosylceramide analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41388202P 2002-09-27 2002-09-27
US60/413,882 2002-09-27

Publications (2)

Publication Number Publication Date
WO2004028475A2 WO2004028475A2 (en) 2004-04-08
WO2004028475A3 true WO2004028475A3 (en) 2006-01-05

Family

ID=32043311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030611 Ceased WO2004028475A2 (en) 2002-09-27 2003-09-29 Glycosylceramide analogues

Country Status (5)

Country Link
US (1) US20060116331A1 (en)
EP (1) EP1572114A2 (en)
AU (1) AU2003277021A1 (en)
CA (1) CA2500478A1 (en)
WO (1) WO2004028475A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10226476B2 (en) 2001-03-26 2019-03-12 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US9717754B2 (en) 2003-02-27 2017-08-01 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
WO2005032462A2 (en) 2003-02-27 2005-04-14 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
US20070184058A1 (en) * 2003-02-27 2007-08-09 Yaron Ilan Glucocerebroside treatment of pulmonary or respiratory diseases or disorders
ATE503014T1 (en) * 2003-11-04 2011-04-15 Geron Corp RNA AMIDATE AND THIOAMIDATEUR RNAI
WO2005120574A1 (en) * 2004-06-11 2005-12-22 Riken Drug having regulatory cell ligand contained in liposome
US7550598B2 (en) 2004-08-18 2009-06-23 Takeda Pharmaceutical Company Limited Kinase inhibitors
KR101377116B1 (en) * 2004-08-27 2014-03-24 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 Ceramide derivatives as modulators of immunity and autoimmunity
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
WO2006060117A2 (en) 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methods for inhibition of nkt cells
WO2006058243A2 (en) * 2004-11-24 2006-06-01 Yale University Leishmania antigens and related compositions and uses
KR100764678B1 (en) * 2005-07-13 2007-10-09 재단법인서울대학교산학협력재단 Intranasal vaccine composition comprising alpha-galactosyl ceramide as an adjuvant
EP1776963A1 (en) * 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
EP1897557A1 (en) * 2006-09-07 2008-03-12 Helmholtz-Zentrum für Infektionsforschung GmbH Use of glycolipids as adjuvants
JP5357782B2 (en) 2007-02-21 2013-12-04 バクシネックス インコーポレーティッド Regulation of NKT cell activity by antigen-loaded CD1d molecules
AU2014201215B2 (en) * 2008-06-16 2016-05-05 Academia Sinica Globo h and related anti-cancer vaccines with novel glycolipid adjuvants
JP2011524375A (en) * 2008-06-16 2011-09-01 アカデミア シニカ Compositions that induce immune responses specific to GloboH and SSEA3 and their use in cancer therapy
WO2010027108A1 (en) * 2008-09-08 2010-03-11 国立大学法人東京工業大学 Fluorescent sugar derivative compound and sensor using same
AU2010203451B2 (en) * 2009-01-08 2016-06-30 Albert Einstein College Of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
WO2011149881A2 (en) * 2010-05-24 2011-12-01 Children's Medical Center Corporation Methods for the treatment and prevention of inflammatory diseases
EP2811831B1 (en) 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
EP2906576B1 (en) 2012-10-12 2019-09-11 The Brigham and Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
KR102167438B1 (en) 2013-02-08 2020-10-19 백시넥스 인코포레이티드 Modified glycolipids and methods of making and using the same
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
JP6051258B2 (en) * 2015-04-15 2016-12-27 ライオン株式会社 How to test susceptibility to dyslipidemia
CN109232701B (en) * 2017-07-10 2021-05-28 西南大学 Sweet potato antitumor active monomer, sweet potato antitumor extract and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202357A (en) * 1982-06-16 1993-04-13 Lever Brothers Company, Division Of Conopco, Inc. Skin treatment composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US655372A (en) * 1897-11-29 1900-08-07 Irvin E Rockwell Letter-file.
DE4408248A1 (en) * 1994-03-11 1995-09-14 Hoechst Ag Physiologically acceptable and physiologically degradable carbohydrate mimetics, process for their preparation and their use
US6255336B1 (en) * 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US5973128A (en) * 1996-11-22 1999-10-26 The Hospital For Sick Children Research And Development Lp Glycolipid mimics and methods of use thereof
US6417167B1 (en) * 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
DE69840528D1 (en) * 1997-04-10 2009-03-19 Kyowa Hakko Kirin Co Ltd NKT cell activators containing alpha-glycosylceramides
AU2001268564A1 (en) * 2000-06-22 2002-01-02 The Brigham And Women's Hospital, Inc. Alpha-glycosylceramides for treating bacterial and fungal infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202357A (en) * 1982-06-16 1993-04-13 Lever Brothers Company, Division Of Conopco, Inc. Skin treatment composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10226476B2 (en) 2001-03-26 2019-03-12 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants

Also Published As

Publication number Publication date
US20060116331A1 (en) 2006-06-01
CA2500478A1 (en) 2004-04-08
AU2003277021A8 (en) 2004-04-19
EP1572114A2 (en) 2005-09-14
WO2004028475A2 (en) 2004-04-08
AU2003277021A1 (en) 2004-04-19

Similar Documents

Publication Publication Date Title
IL176005A0 (en) 2,6-bisheteroaryl-4-aminopyrimidine derivatives and pharmaceutical compositions containing the same
AU2003291726A1 (en) Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
MX260183B (en) Rinse-off skin conditioning compositions.
IL206831A0 (en) Glucopyranosyl derivatives and pharmaceutical compositions containing the same
ZA200302039B (en) Paclitaxel-based antitumor formulation.
ZA200003998B (en) Pharmaceutical compositions.
AU2003228666A1 (en) Lapachone delivery systems, compositions and uses related thereto
WO2002053625A3 (en) Certain silicone polyethers, methods for making them and uses
AU2003277021A1 (en) Glycosylceramide analogues
ZA200500877B (en) Antimicrobial aza-bicyclic derivatives, their compositions and uses.
IL195935A0 (en) 18-methyl-19-nor-androst-4-en 17,17-spiroether (18-methyl-19-nor-20-spirox-4-en-3-one) and pharmaceutical preparations containing the same
IL174479A (en) Hemiasterlin derivatives, pharmaceutical compositions comprising the same and uses thereof
WO2004021967A3 (en) Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent
AP2004003066A0 (en) Pharmaceutical compositions based on azetidine derivatives.
MXPA03002105A (en) Pharmaceutical compositions.
IL181216A0 (en) 3, 5-seco-4-norcholestane derivatives and pharmaceutical compositions containing the same
IL166730A0 (en) N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-Ä1,3,4-oxadiazol-2-ylÜphenyl)pyridine-3-sulphonamide as an anticancer agent
WO2006056696A3 (en) 2-alcoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof
WO2007002191A3 (en) Methods for the preparation of 9-deazapurine derivatives
AUPS300502A0 (en) Generating one or more linear blends
PL374761A1 (en) N-benzodioxolyl, n-benzodioxanyl and n-benzodioxepinyl arylcarbonxamide derivatives, and pharmaceutical compositions comprising them
AP2006003530A0 (en) Immunogenic HIV compositions and related methods.
WO2005060981A3 (en) Pharmaceutical compositions
NO20052478D0 (en) Vitamin D analogues, compositions comprising the analogues and their use.
ZA200502464B (en) Synergistic compositions for the prevention and treatment of acquired immunodeficiency syndrome.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2500478

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003798776

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003798776

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006116331

Country of ref document: US

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 10529393

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10529393

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP