WO2004033036A3 - Medical device for controlled drug delivery and cardiac monitoring and/or stimulation - Google Patents

Medical device for controlled drug delivery and cardiac monitoring and/or stimulation Download PDF

Info

Publication number
WO2004033036A3
WO2004033036A3 PCT/US2003/031596 US0331596W WO2004033036A3 WO 2004033036 A3 WO2004033036 A3 WO 2004033036A3 US 0331596 W US0331596 W US 0331596W WO 2004033036 A3 WO2004033036 A3 WO 2004033036A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
medical device
cardiac
patient
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/031596
Other languages
French (fr)
Other versions
WO2004033036A2 (en
Inventor
Barry Yomtov
Stephen J Herman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dare MB inc
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Priority to AT03773170T priority Critical patent/ATE458534T1/en
Priority to EP03773170A priority patent/EP1551505B1/en
Priority to DE60331455T priority patent/DE60331455D1/en
Priority to AU2003279842A priority patent/AU2003279842A1/en
Publication of WO2004033036A2 publication Critical patent/WO2004033036A2/en
Publication of WO2004033036A3 publication Critical patent/WO2004033036A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3629—Heart stimulators in combination with non-electric therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39—Heart defibrillators
    • A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Medical device and methods are provided for controlled drug delivery in a cardiac patient. The device includes an implantable drug delivery module comprising reservoirs containing a drug and a control means for selectively releasing an effective amount of drug from each reservoir; one or more electrodes or sensors for cardiac monitoring, stimulation, or both; and a microcontroller for controlling operational interaction of the drug delivery module and the cardiac electrode. The electrodes may comprise ECG monitoring, cardioversion, or cardiac pacing electrodes. A medical device also is provided for controlled delivery of drug to a patient having congestive heart failure, which includes an implantable drug delivery module comprising a natriuretic peptide and a release mechanism for selectively releasing a pharmaceutically effective amount of the natriuretic peptide into the patient; and a microcontroller for controlling the release mechanism, for example, in response to one or more monitored patient parameters.
PCT/US2003/031596 2002-10-04 2003-10-06 Medical device for controlled drug delivery and cardiac monitoring and/or stimulation Ceased WO2004033036A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AT03773170T ATE458534T1 (en) 2002-10-04 2003-10-06 MEDICAL DEVICE FOR CONTROLLED DRUG ADMINISTRATION AND CARDIAC MONITORING AND/OR HEART STIMULATION
EP03773170A EP1551505B1 (en) 2002-10-04 2003-10-06 Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
DE60331455T DE60331455D1 (en) 2002-10-04 2003-10-06 MEDICAL DEVICE FOR THE CONTROLLED MEDICAMENTAL ADMINISTRATION AND HEART CONTROL AND / OR HEART STIMULATION
AU2003279842A AU2003279842A1 (en) 2002-10-04 2003-10-06 Medical device for controlled drug delivery and cardiac monitoring and/or stimulation

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41600502P 2002-10-04 2002-10-04
US60/416,005 2002-10-04
US44455403P 2003-02-03 2003-02-03
US60/444,554 2003-02-03
US46016303P 2003-04-03 2003-04-03
US60/460,163 2003-04-03

Publications (2)

Publication Number Publication Date
WO2004033036A2 WO2004033036A2 (en) 2004-04-22
WO2004033036A3 true WO2004033036A3 (en) 2004-09-30

Family

ID=32096880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031596 Ceased WO2004033036A2 (en) 2002-10-04 2003-10-06 Medical device for controlled drug delivery and cardiac monitoring and/or stimulation

Country Status (6)

Country Link
US (1) US7917208B2 (en)
EP (1) EP1551505B1 (en)
AT (1) ATE458534T1 (en)
AU (1) AU2003279842A1 (en)
DE (1) DE60331455D1 (en)
WO (1) WO2004033036A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10308719B2 (en) 2015-01-26 2019-06-04 The University Of Chicago IL13Rα2 binding agents and use thereof in cancer treatment

Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
ATE290364T1 (en) * 1999-08-18 2005-03-15 Microchips Inc THERMALLY ACTIVATED MICROCHIP AS A CHEMICAL DISPENSER DEVICE
DE60027458T2 (en) * 1999-12-10 2007-07-05 Massachusetts Institute Of Technology, Cambridge MICROCHIP DRUG DISABLING SYSTEMS AND MANUFACTURING METHOD
ES2420279T3 (en) 2000-03-02 2013-08-23 Microchips, Inc. Microfabricated devices and methods for storage and selective exposure of chemicals
AU2002211629A1 (en) * 2000-10-10 2002-04-22 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
WO2002099457A1 (en) * 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
CA2451953A1 (en) * 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
JP4436258B2 (en) * 2002-08-16 2010-03-24 マイクロチップス・インコーポレーテッド Controlled release device and method
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US8303511B2 (en) * 2002-09-26 2012-11-06 Pacesetter, Inc. Implantable pressure transducer system optimized for reduced thrombosis effect
AU2004233869B2 (en) * 2003-04-25 2010-08-12 Boston Scientific Scimed, Inc. Solid drug formulation and device for storage and controlled delivery thereof
US7114312B2 (en) * 2003-07-17 2006-10-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US7392084B2 (en) 2003-09-23 2008-06-24 Cardiac Pacemakers, Inc. Demand-based cardiac function therapy
US7572226B2 (en) 2003-10-28 2009-08-11 Cardiac Pacemakers, Inc. System and method for monitoring autonomic balance and physical activity
JP2007512859A (en) * 2003-11-03 2007-05-24 マイクロチップス・インコーポレーテッド Medical device for sensing glucose
US7657312B2 (en) 2003-11-03 2010-02-02 Cardiac Pacemakers, Inc. Multi-site ventricular pacing therapy with parasympathetic stimulation
US20050245972A1 (en) * 2004-04-29 2005-11-03 Medtronic, Inc. Apparatus and methods for treating arrhythmia and lowering defibrillation threshold
US7260431B2 (en) 2004-05-20 2007-08-21 Cardiac Pacemakers, Inc. Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device
JP2008501037A (en) * 2004-06-01 2008-01-17 マイクロチップス・インコーポレーテッド Devices and methods for measuring and enhancing transport of drugs or analytes to / from medical implants
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
CA2575458C (en) * 2004-07-28 2015-06-02 Ardian, Inc. Methods and devices for renal nerve blocking
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
JP5107041B2 (en) 2004-09-01 2012-12-26 マイクロチップス・インコーポレーテッド Multi-cap reservoir device for controlled release or exposure of reservoir contents
AU2005302484A1 (en) * 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
JP5049787B2 (en) 2004-11-04 2012-10-17 マイクロチップス・インコーポレーテッド Cold pressure sealing method and apparatus
US7413846B2 (en) * 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
CN101076290B (en) 2004-12-09 2011-11-23 铸造品股份有限公司 Aortic valve repair
CA2595457A1 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US7587238B2 (en) 2005-03-11 2009-09-08 Cardiac Pacemakers, Inc. Combined neural stimulation and cardiac resynchronization therapy
US8067026B2 (en) * 2005-03-14 2011-11-29 Boston Scientific Scimed, Inc. Drug release regions for medical devices, which include polycyclic-structure-containing polymers
US7493161B2 (en) 2005-05-10 2009-02-17 Cardiac Pacemakers, Inc. System and method to deliver therapy in presence of another therapy
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US8892197B2 (en) 2005-07-29 2014-11-18 Medtronic, Inc. Method and apparatus to control conduction through the heart to treat cardiac conditions
WO2007066343A2 (en) * 2005-12-08 2007-06-14 Dan Furman Implantable biosensor assembly and health monitoring system
IL185609A0 (en) * 2007-08-30 2008-01-06 Dan Furman Multi function senssor
US7751883B2 (en) * 2006-04-25 2010-07-06 Eugenio Picano System and method for promoting coronary angiogenesis
US9026205B2 (en) * 2006-05-25 2015-05-05 Cochlear Limited Stimulating device
US7734341B2 (en) * 2006-06-06 2010-06-08 Cardiac Pacemakers, Inc. Method and apparatus for gastrointestinal stimulation via the lymphatic system
US7526337B2 (en) * 2006-06-06 2009-04-28 Cardiac Pacemakers, Inc. Method and device for lymphatic system monitoring
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7894906B2 (en) * 2006-06-06 2011-02-22 Cardiac Pacemakers, Inc. Amelioration of chronic pain by endolymphatic stimulation
US8126538B2 (en) * 2006-06-06 2012-02-28 Cardiac Pacemakers, Inc. Method and apparatus for introducing endolymphatic instrumentation
US8401654B1 (en) * 2006-06-30 2013-03-19 Boston Scientific Neuromodulation Corporation Methods and systems for treating one or more effects of deafferentation
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US20080033260A1 (en) * 2006-08-03 2008-02-07 Microchips, Inc. Cardiac Biosensor Devices and Methods
US8905999B2 (en) * 2006-09-01 2014-12-09 Cardiac Pacemakers, Inc. Method and apparatus for endolymphatic drug delivery
US20090048518A1 (en) * 2006-12-10 2009-02-19 Cardio Art Technologies Ltd. Doppler motion sensor apparatus and method of using same
US9037244B2 (en) 2007-02-13 2015-05-19 Virender K. Sharma Method and apparatus for electrical stimulation of the pancreatico-biliary system
DE102007010326A1 (en) * 2007-03-02 2008-09-04 Up Management Gmbh & Co Med-Systems Kg Apparatus for infusion of at least one medication, e.g. anesthetics, automatically controls the delivery according to measured patient parameters during surgery
US20080294228A1 (en) * 2007-05-23 2008-11-27 Cardiac Pacemakers Method and device for controlled stimulation of lymphatic flow
WO2009054758A1 (en) * 2007-10-26 2009-04-30 St. Jude Medical Ab Methods and systems for drug titration
US20090137890A1 (en) * 2007-11-27 2009-05-28 Burnes John E Devices to monitor glucose levels and ischemia
US20090156921A1 (en) * 2007-12-18 2009-06-18 Huisun Wang Cardiac ablation catheter with oxygen saturation sensor
US8363871B2 (en) * 2008-03-31 2013-01-29 Cochlear Limited Alternative mass arrangements for bone conduction devices
CN102046069A (en) * 2008-05-12 2011-05-04 心脏技术有限公司 Method and system for monitoring a health condition
DE102008024447A1 (en) 2008-05-20 2009-11-26 Biotronik Crm Patent Ag Implantable shock electrode lead and implantable defibrillation assembly
US8834446B2 (en) * 2008-06-12 2014-09-16 DePuy Synthes Products, LLC Pulsatile flux drug delivery
US8886306B2 (en) * 2008-08-20 2014-11-11 Cardiac Pacemakers, Inc. Triggered high-output pacing therapy
US10603489B2 (en) 2008-10-09 2020-03-31 Virender K. Sharma Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage
US9079028B2 (en) 2008-10-09 2015-07-14 Virender K. Sharma Method and apparatus for stimulating the vascular system
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2011032099A1 (en) 2009-09-11 2011-03-17 The Board Of Trustees Of The University Of Illinois Methods of treating diastolic dysfunction and related conditions
US20120208762A1 (en) 2009-10-27 2012-08-16 The Board Of Trustees Of The University Of Illinois Methods of Diagnosing Diastolic Dysfunction
WO2011066552A2 (en) * 2009-11-30 2011-06-03 University Of South Florida Cubic silicon carbide implantable neural prosthetic
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
US8696740B2 (en) 2010-01-05 2014-04-15 The Johns Hopkins University Implantable pressure-actuated drug delivery systems and methods of manufacture and use
EP2528618A4 (en) 2010-01-27 2015-05-27 Univ Indiana Res & Tech Corp CONJUGATES OF GLUCAGON ANTAGONIST AND GIP AGONIST AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND OBESITY
ES2575160T3 (en) 2010-03-15 2016-06-24 The Board Of Trustees Of The University Of Illinois Inhibitors of the interactions that bind the alpha subunit of beta integrin-protein G
EP2582719B1 (en) 2010-06-16 2016-08-10 Indiana University Research and Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
CN107007348B (en) 2010-10-25 2019-05-31 美敦力Af卢森堡有限责任公司 Apparatus, system and method for estimation and feedback of neuromodulation therapy
EP2655401B1 (en) 2010-12-20 2016-03-09 The Regents of the University of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
WO2012088116A2 (en) 2010-12-22 2012-06-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
EP2678002A2 (en) 2011-02-25 2014-01-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
US20140221964A1 (en) * 2011-03-27 2014-08-07 Yong-Fu Xiao Systems and methods for local drug delivery to kidneys
EP2694150A1 (en) 2011-04-08 2014-02-12 Covidien LP Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US8663202B2 (en) * 2011-05-20 2014-03-04 Advastim, Inc. Wireless remote neurostimulator
CN103857408B (en) 2011-06-22 2017-04-12 印第安那大学科技研究公司 Glucagon/glp-1 receptor co-agonists
PT2747642T (en) 2011-08-25 2021-07-27 Microchips Biotech Inc Space-efficient containment devices and method of making same
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND PREPARATION METHODS
US9415123B2 (en) 2011-10-10 2016-08-16 The Regents Of The University Of Michigan Polymeric nanoparticles for ultrasound imaging and therapy
HK1198810A1 (en) 2011-11-17 2015-06-12 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
CN104114183A (en) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 CTP-based insulin analogs for treatment of diabetes
CA2862443C (en) * 2011-12-30 2018-09-11 Kibur Medical, Inc. Implantable devices and methods for the evaluation of active agents
EP3348220B1 (en) 2012-03-08 2024-10-23 Medtronic Ardian Luxembourg S.à.r.l. Biomarker sampling in the context of neuromodulation devices and associated systems
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
AU2013274078A1 (en) 2012-06-14 2015-01-29 Ambrx, Inc. Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides
US9340600B2 (en) 2012-06-21 2016-05-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting GIP receptor activity
CN104583233B (en) 2012-06-21 2018-10-23 印第安纳大学研究及科技有限公司 Show the analog of the glucagon of GIP receptor actives
CN108383902A (en) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 Insulin analog dimer
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
CN104869888B (en) * 2012-12-21 2017-12-19 微芯片生物技术公司 Implantable medical device for minimally invasive insertion
SG11201506675PA (en) 2013-02-28 2015-09-29 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
JP6538645B2 (en) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Insulin-incretin complex
US10549035B2 (en) * 2014-01-31 2020-02-04 University Hospitals Health System, Inc. Systems and methods for intrathecal delivery of a pharmaceutical agent
US10189908B2 (en) 2014-02-05 2019-01-29 The University Of Chicago Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9937124B2 (en) 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
EP3250611B1 (en) 2015-01-26 2021-04-21 The University of Chicago Car t-cells recognizing cancer-specific il 13r-alpha2
US20180201937A1 (en) 2015-08-04 2018-07-19 The University Of Chicago Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
US10881788B2 (en) * 2015-10-30 2021-01-05 International Business Machines Corporation Delivery device including reactive material for programmable discrete delivery of a substance
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US12188893B2 (en) 2016-08-30 2025-01-07 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10751469B2 (en) * 2017-04-07 2020-08-25 Northwesten University Computer controlled pediatric regional anesthesia
CN108968976B (en) 2017-05-31 2022-09-13 心脏起搏器股份公司 Implantable medical device with chemical sensor
LT3645002T (en) 2017-06-30 2025-02-10 Amgen Inc. METHOD OF TREATING HEART FAILURE WITH CARDIAC SARCOMER ACTIVATORS
WO2019023093A1 (en) 2017-07-26 2019-01-31 Cardiac Pacemakers, Inc. Systems and methods for disambiguation of posture
TWI901940B (en) 2017-08-03 2025-10-21 美商安進公司 Interleukin-21 muteins and methods of treatment
CN109381195B (en) 2017-08-10 2023-01-10 心脏起搏器股份公司 Systems and methods including electrolyte sensor fusion
CN109419515B (en) 2017-08-23 2023-03-24 心脏起搏器股份公司 Implantable chemical sensor with staged activation
CN111051306B (en) 2017-09-08 2023-01-03 美国安进公司 Inhibitors of KRAS G12C and methods of use thereof
SI3826667T1 (en) 2017-09-18 2024-09-30 The Regents Of The University Of California Claudin6 antibodies and methods of treating cancer
CN109864746B (en) 2017-12-01 2023-09-29 心脏起搏器股份公司 Multimode analyte sensor for medical devices
CN109864747B (en) 2017-12-05 2023-08-25 心脏起搏器股份公司 Multimode analyte sensor optoelectronic interface
JP2019122373A (en) 2018-01-12 2019-07-25 アムジエン・インコーポレーテツド Anti-pd-1 antibodies and methods of treatment
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
CN108939211A (en) * 2018-07-31 2018-12-07 佛山市苔藓云链科技有限公司 A kind of transfusion monitoring system
US20200085776A1 (en) 2018-09-10 2020-03-19 Cardax, Inc. Methods of Reducing C-Reactive Protein and/or Treating Cardiovascular Disease
US10926024B2 (en) 2018-10-04 2021-02-23 Corvictus Llc Emergency medical intervention device
SG11202109986TA (en) 2019-03-20 2021-10-28 Univ California Claudin-6 antibodies and drug conjugates
WO2020191344A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
CA3136496A1 (en) 2019-04-09 2020-10-15 The Board Of Trustees Of The University Of Illinois Drug adsorbed highly porous activated carbon for enhanced drug delivery
WO2020223177A1 (en) 2019-04-29 2020-11-05 The Board Of Trustees Of The University Of Illinois Mek inhibitors for corneal scarring and neovascularization
JP2022530241A (en) 2019-04-30 2022-06-28 インスチトゥート デ メディシーナ モリクラール ジョアン ロボ アントゥネス RANK pathway inhibitor combined with CDK inhibitor
EP3986441A1 (en) 2019-06-24 2022-04-27 Amgen Inc. Inhibition of sirp-gamma for cancer treatment
CA3151422A1 (en) 2019-08-30 2021-03-04 Research Institute At Nationwide Children's Hospital Copper-atsm for treating neurodegenerative disorders associated with mitochondrial dysfunction
CN114615903A (en) * 2019-10-29 2022-06-10 日本烟草国际股份有限公司 Aerosol generating inhalation device and method
TW202216778A (en) 2020-07-15 2022-05-01 美商安進公司 Tigit and cd112r blockade
WO2022093786A1 (en) 2020-10-29 2022-05-05 Cardiac Pacemakers, Inc. Integrated thermo-photonic chemical sensor
TW202233189A (en) 2020-11-12 2022-09-01 美商安進公司 Methods of treating heart failure by administering omecamtiv mecarbil
IL303494A (en) * 2020-12-10 2023-08-01 Baropace Inc Treating drug resistant hypertension and heart failure with preserved ejection fraction by combined treatment with baropacing and beta blockers
US20250282870A1 (en) 2021-01-20 2025-09-11 Bioentre Llc Ctla4-binding proteins and methods of treating cancer
US20240342487A1 (en) * 2021-08-25 2024-10-17 Baropace, Inc. Systems and methods for cardiac pacing using beta blockers
WO2023137161A1 (en) 2022-01-14 2023-07-20 Amgen Inc. Triple blockade of tigit, cd112r, and pd-l1
US12121695B2 (en) 2022-07-18 2024-10-22 Medphlow, Llc Integrated cartridge assembly for administration of drugs
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4360031A (en) * 1980-09-11 1982-11-23 Medtronic, Inc. Drug dispensing irrigatable electrode
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
US5156148A (en) * 1987-10-06 1992-10-20 Leonard Bloom System for treating a malfunctioning heart
WO1994021237A1 (en) * 1993-03-15 1994-09-29 The Board Of Regents Of The University Of Michigan System for controlled release of antiarrhythmic agents
WO2000007497A1 (en) * 1998-08-07 2000-02-17 Infinite Biomedical Technologies, Incorporated Implantable myocardial ischemia detection, indication and action technology
WO2002030264A2 (en) * 2000-10-10 2002-04-18 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
WO2004026281A2 (en) * 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146026A (en) * 1977-03-15 1979-03-27 Montalvo Victor H Filter mask
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4731051A (en) * 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
GB8422876D0 (en) * 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
DE3735137A1 (en) * 1987-10-16 1989-05-03 Siemens Ag ARRANGEMENT FOR DISPENSING MEDICINES IN AN IMPLANTABLE MEDICAL DEVICE
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5067491A (en) * 1989-12-08 1991-11-26 Becton, Dickinson And Company Barrier coating on blood contacting devices
US5167625A (en) * 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5524338A (en) * 1991-10-22 1996-06-11 Pi Medical Corporation Method of making implantable microelectrode
US5193539A (en) * 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5338307A (en) * 1993-03-09 1994-08-16 Ethicon, Inc. Adaptor cap for trocar assembly
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5368704A (en) * 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US5971931A (en) * 1994-03-29 1999-10-26 Raff; Gilbert Lewis Biologic micromonitoring methods and systems
US5562715A (en) * 1994-12-01 1996-10-08 Czura; John J. Cardiac pulse generator
US5591217A (en) * 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
US5556421A (en) * 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5992769A (en) * 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
US5713954A (en) * 1995-06-13 1998-02-03 Abiomed R&D, Inc. Extra cardiac ventricular assist device
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
WO1997029802A2 (en) * 1996-02-20 1997-08-21 Advanced Bionics Corporation Improved implantable microstimulator and systems employing the same
DE19610293C1 (en) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Electronically-breakable microencapsulation system for sensitive materials
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
DE19716683C1 (en) 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Miniature encapsulation device for sensitive materials
IL121286A0 (en) * 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US6001090A (en) * 1998-02-09 1999-12-14 Lenhart; Douglas Thermal pharmaceutical delivery system
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US6319241B1 (en) * 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6161047A (en) * 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6243608B1 (en) * 1998-06-12 2001-06-05 Intermedics Inc. Implantable device with optical telemetry
US6941171B2 (en) * 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
JP2000151148A (en) * 1998-11-13 2000-05-30 Mitsumi Electric Co Ltd Cord connection structure for portable electronic devices
US6289237B1 (en) * 1998-12-22 2001-09-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus for energizing a remote station and related method
US6112116A (en) * 1999-02-22 2000-08-29 Cathco, Inc. Implantable responsive system for sensing and treating acute myocardial infarction
US6178349B1 (en) * 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6923784B2 (en) * 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6587719B1 (en) * 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US6804558B2 (en) * 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
ATE290364T1 (en) * 1999-08-18 2005-03-15 Microchips Inc THERMALLY ACTIVATED MICROCHIP AS A CHEMICAL DISPENSER DEVICE
US6442434B1 (en) 1999-10-19 2002-08-27 Abiomed, Inc. Methods and apparatus for providing a sufficiently stable power to a load in an energy transfer system
WO2001035928A1 (en) * 1999-11-17 2001-05-25 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
WO2001037926A1 (en) 1999-11-22 2001-05-31 Abiomed, Inc. Apparatus for transferring energy across a boundary
DE60027458T2 (en) * 1999-12-10 2007-07-05 Massachusetts Institute Of Technology, Cambridge MICROCHIP DRUG DISABLING SYSTEMS AND MANUFACTURING METHOD
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
ES2420279T3 (en) * 2000-03-02 2013-08-23 Microchips, Inc. Microfabricated devices and methods for storage and selective exposure of chemicals
WO2001091902A2 (en) * 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6726920B1 (en) * 2000-09-22 2004-04-27 Durect Corporation Implantable drug delivery patch
US6773429B2 (en) * 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
EP1331965B1 (en) * 2000-10-26 2008-07-16 Medtronic, Inc. Apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
CA2426944A1 (en) * 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
JP2004512104A (en) * 2000-10-26 2004-04-22 メドトロニック・インコーポレーテッド Method and apparatus for protecting heart tissue from seizures
DE10063612C2 (en) 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Microsystem for controlling the delivery of active ingredients from an active ingredient reservoir as well as implant with microsystem
US6666821B2 (en) * 2001-01-08 2003-12-23 Medtronic, Inc. Sensor system
CA2432438C (en) * 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
WO2002058551A2 (en) * 2001-01-22 2002-08-01 Integrated Sensing Systems, Inc. Wireless mems capacitive sensor for physiologic parameter measurement
DE10103330B4 (en) * 2001-01-25 2009-04-30 Siemens Ag Medical system for monitoring a blood clotting measured value of a patient
US6571125B2 (en) * 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7338522B2 (en) 2001-02-13 2008-03-04 Second Sight Medical Products, Inc. Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress
US7181287B2 (en) * 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6453195B1 (en) * 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US6733485B1 (en) * 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
WO2002096512A1 (en) * 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
US6973718B2 (en) * 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
WO2002099457A1 (en) 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
CA2451953A1 (en) 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6969369B2 (en) * 2002-04-22 2005-11-29 Medtronic, Inc. Implantable drug delivery system responsive to intra-cardiac pressure
JP4436258B2 (en) * 2002-08-16 2010-03-24 マイクロチップス・インコーポレーテッド Controlled release device and method
AU2003278766A1 (en) * 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
AU2003284018A1 (en) * 2002-10-04 2004-05-04 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
KR20140134338A (en) * 2003-09-11 2014-11-21 테라노스, 인코포레이티드 Medical device for analyte monitoring and drug delivery
US20060041296A1 (en) * 2004-08-23 2006-02-23 Medtronic, Inc. Novel medical electrode configurations

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4360031A (en) * 1980-09-11 1982-11-23 Medtronic, Inc. Drug dispensing irrigatable electrode
US5156148A (en) * 1987-10-06 1992-10-20 Leonard Bloom System for treating a malfunctioning heart
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
WO1994021237A1 (en) * 1993-03-15 1994-09-29 The Board Of Regents Of The University Of Michigan System for controlled release of antiarrhythmic agents
WO2000007497A1 (en) * 1998-08-07 2000-02-17 Infinite Biomedical Technologies, Incorporated Implantable myocardial ischemia detection, indication and action technology
WO2002030264A2 (en) * 2000-10-10 2002-04-18 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
WO2004026281A2 (en) * 2002-09-23 2004-04-01 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COLUCCI W. S. ET AL.: "Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 343, 27 July 2000 (2000-07-27), pages 246 - 253, XP009033850 *
IZRAILTYAN I., ET AL.: "EARLY DETECTION OF ACUTE ALLOGRAFT REJECTION BY LINEAR AND NONLINEAR ANALYSIS OF HEART RATE VARIABILITY", CARDIOTHORACIC TRANSPLANTATION, vol. 120, no. 4, October 2000 (2000-10-01), pages 737 - 745, XP009025870 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10308719B2 (en) 2015-01-26 2019-06-04 The University Of Chicago IL13Rα2 binding agents and use thereof in cancer treatment
US10851169B2 (en) 2015-01-26 2020-12-01 The University Of Chicago Conjugates of IL13Rα2 binding agents and use thereof in cancer treatment

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